Cited by 314Genomics and Chromatin DynamicsNuclear Structure and FunctionEpigenetics and DNA Methylation

The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.

Heterochromatin Effects on the Frequency and Duration of LCR-Mediated Gene Transcription

Open access

Milot, Eric, Strouboulis, John, Trimborn, Tolleiv, Wijgerde, Mark, de Boer, Ernie, Langeveld, An, Tan-Un, Kian, Vergeer, Wilma, Yannoutsos, Nikos, Grosveld, Frank, Fraser, Peter·1996·Cell

DOI 10.1016/s0092-8674(00)81327-6

Open this paper in CoChat — free account Open PDF

Abstract

Locus control regions (LCRs) are responsible for initiating and maintaining a stable tissue-specific open chromatin structure of a locus. In transgenic mice, LCRs confer high level expression on linked genes independent of position in the mouse genome. Here we show that an incomplete LCR loses this property when integrated into heterochromatic regions. Two disruption mechanisms were observed. One is classical position-effect variegation, resulting in continuous transcription in a clonal subpopulation of cells. The other is a novel mechanism resulting in intermittent gene transcription in all cells. We conclude that only a complete LCR fully overcomes heterochromatin silencing and that it controls the level of transcription by ensuring activity in all cells at all times rather than directly controlling the rate of transcription.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s0092-8674(00)81327-6

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Position-independent, high-level expression of the human β-globin gene in transgenic mice
Grosveld, F. G., van Assendelft, G. B., Greaves, D. R., & Kollias, G. A. (1987) · Cell · doi:10.1016/0092-8674(87)90584-8 · Cited by 1,908
Self-citation
The "beta-like-globin" gene domain in human erythroid cells.
Tuan, D., Solomon, W., Li, Q., & London, I. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.19.6384 · Cited by 601
Transcription complex stability and chromatin dynamics in vivo
Wijgerde, M., Grosveld, F. G., & Fraser, P. (1995) · Nature · doi:10.1038/377209a0 · Cited by 471
Self-citation
A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.Preprint
Forrester, W. C., Epner, E. M., Driscoll, M. C., Enver, T., Brice, M. C., Papayannopoulou, T., & Groudine, M. T. (1990) · Genes & Development · doi:10.1101/gad.4.10.1637 · Cited by 464
Functional Aspects of Satellite DNA and Heterochromatin
John, B., & Miklos, G. L. G. (1979) · International review of cytology · doi:10.1016/s0074-7696(08)61473-4 · Cited by 420
Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids
Forrester, W. C., Takegawa, S., Papayannopoulou, T., Stamatoyannopoulos, G., & Groudine, M. T. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.24.10159 · Cited by 418
Position effects on eukaryotic gene expression
Wilson, C., Bellen, H. J., & Gehring, W. J. (1990) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.06.110190.003335 · Cited by 379
Locus Control Region Function and Heterochromatin-Induced Position Effect Variegation
Festenstein, R., Tolaini, M., Corbella, P., Mamalaki, C., Parrington, J. M., Fox, M., Miliou, A., Jones, M., & Kioussis, D. (1996) · Science · doi:10.1126/science.271.5252.1123 · Cited by 362
Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.Preprint
Fiering, S., Epner, E. M., Robinson, K. M., Zhuang, Y., Telling, A., Hu, M., Martin, D. I. K., Enver, T., Ley, T. J., & Groudine, M. T. (1995) · Genes & Development · doi:10.1101/gad.9.18.2203 · Cited by 334
A dominant control region from the human β-globin locus conferring integration site-independent gene expression
Talbot, D., Collis, P., Antoniou, M. N., Vidal, M., Grosveld, F. G., & Greaves, D. R. (1989) · Nature · doi:10.1038/338352a0 · Cited by 330
Self-citation

Show all 42 references

Research works printed but not linked: 1

Heintz, 1928, Das heterochromatin der Moose, I, Jahresber. Wiss. Botanik., 69, 762

Sorted by citations

Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus
Tolhuis, B., Palstra, R.-J., Splinter, E., Grosveld, F., & de Laat, W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00781-5 · Cited by 1,344
Self-citation
Active genes dynamically colocalize to shared sites of ongoing transcription
Osborne, C. S., Chakalova, L., Brown, K. E., Carter, D., Horton, A., Debrand, E., Goyenechea, B., Mitchell, J. A., Lopes, S. M. C. D. S., Reik, W., et al. (2004) · Nature Genetics · doi:10.1038/ng1423 · Cited by 1,080
Self-citation
Long-Range Control of Gene Expression: Emerging Mechanisms and Disruption in Disease
Kleinjan, D. A., & van Heyningen, V. (2004) · The American Journal of Human Genetics · doi:10.1086/426833 · Cited by 886
Going the Distance: A Current View of Enhancer Action
Blackwood, E. M., & Kadonaga, J. T. (1998) · Science · doi:10.1126/science.281.5373.60 · Cited by 836
The evolutionary dynamics of eukaryotic gene order
Hurst, L. D., Pál, C., & Lercher, M. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1319 · Cited by 730
FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation
Tsang, A. P., Visvader, J. E., Turner, C. A., Fujiwara, Y., Yu, C., Weiss, M. J., Crossley, M., & Orkin, S. H. (1997) · Cell · doi:10.1016/s0092-8674(00)80318-9 · Cited by 712
Looping versus linking: toward a model for long-distance gene activationPreprint
Bulger, M., & Groudine, M. T. (1999) · Genes & Development · doi:10.1101/gad.13.19.2465 · Cited by 483
The transcription factor GATA6 is essential for early extraembryonic development
Koutsourakis, M., Langeveld, A., Patient, R. K., Beddington, R. S. P., & Grosveld, F. G. (1999) · Development · doi:10.1242/dev.126.4.723 · Cited by 454
Self-citation
Site- and Time-Specific Gene Targeting in the Mouse
METZGER, D., & Chambon, P. (2001) · Methods · doi:10.1006/meth.2001.1159 · Cited by 456
Locus control regions
Li, Q., Peterson, K. R., Fang, X., & Stamatoyannopoulos, G. (2002) · Blood · doi:10.1182/blood-2002-04-1104 · Cited by 456
Position effect in human genetic disease
Kleinjan, D. A. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.10.1611 · Cited by 370
Spatial organization of gene expression: the active chromatin hub
de Laat, W. L., & Grosveld, F. G. (2003) · Chromosome Research · doi:10.1023/a:1024922626726 · Cited by 354
Self-citation
Large-scale chromatin unfolding and remodeling induced by VP16 acidic activation domain
Tumbar, T., Sudlow, G., & Belmont, A. S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.7.1341 · Cited by 351
Sox2 regulatory sequences direct expression of a β-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells
Zappone, M., Galli, R., Catena, R., Meani, N., Biasi, S. D., Mattei, E., Tiveron, C., Vescovi, A. L., Lovell-Badge, R. H., Ottolenghi, S., et al. (2000) · Development · doi:10.1242/dev.127.11.2367 · Cited by 349
Intergenic Transcription and Developmental Remodeling of Chromatin Subdomains in the Human β-globin Locus
Gribnau, J. H., Diderich, K. E. M., Pruzina, S., Calzolari, R., & Fraser, P. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80432-3 · Cited by 338
Self-citation
Remote control of gene transcription
West, A. G., & Fraser, P. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi104 · Cited by 302
Self-citation
Site-specific integrase-mediated transgenesis in mice via pronuclear injection
Tasic, B., Hippenmeyer, S., Wang, C., Gamboa, M., Zong, H., Chen-Tsai, Y., & Luo, L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019507108 · Cited by 246
DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing
Saveliev, A., Everett, C. M., Sharpe, T., Webster, Z., & Festenstein, R. (2003) · Nature · doi:10.1038/nature01596 · Cited by 258
Unravelling heterochromatin: competition between positive and negative factors regulates accessibility
Dillon, N., & Festenstein, R. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02648-3 · Cited by 260
The Heme-Bach1 Pathway in the Regulation of Oxidative Stress Response and Erythroid Differentiation
Igarashi, K., & Sun, J. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.107 · Cited by 248
Regulation of IL-4 Gene Expression by Distal Regulatory Elements and GATA-3 at the Chromatin Level
Lee, G. R., Fields, P. E., & Flavell, R. A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00125-x · Cited by 240
Regulation of the Th2 Cytokine Locus by a Locus Control Region
Lee, G. R., Fields, P. E., Griffin, T. J., & Flavell, R. A. (2003) · Immunity · doi:10.1016/s1074-7613(03)00179-1 · Cited by 234
Locus control regions of mammalian β-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights
Hardison, R., Slightom, J. L., Gumucio, D. L., Goodman, M., Stojanovic, N., & Miller, W. (1997) · Gene · doi:10.1016/s0378-1119(97)00474-5 · Cited by 230
Locus control regions: coming of age at a decade plus
Li, Q., Harju, S., & Peterson, K. R. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01780-1 · Cited by 229
Molecular mechanisms of male germ cell differentiation
Hecht, N. B. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199807)20:7 · Cited by 434
Inefficient processing impairs release of RNA from the site of transcription
Custódio, N., Carmo‐Fonseca, M., Geraghty, F., Periera, H. S., Grosveld, F. G., & Antoniou, M. N. (1999) · The EMBO Journal · doi:10.1093/emboj/18.10.2855 · Cited by 220
Self-citation
Unfolding the mysteries of heterochromatin
Wallrath, L. L. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80135-4 · Cited by 220
Evolution of Hemoglobin and Its Genes
Hardison, R. C. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011627 · Cited by 217
The role of insulator elements in defining domains of gene expression
Geyer, P. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80134-7 · Cited by 217
Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain–KAP-1 Corepressor Interaction Is Essential
Lechner, M. S., Begg, G. E., Speicher, D. W., & Rauscher, F. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.17.6449-6465.2000 · Cited by 210
The Evolution of Trichromatic Color Vision by Opsin Gene Duplication in New World and Old World PrimatesPreprint
Dulai, K. S., von Dornum, M., Mollon, J. D., & Hunt, D. M. (1999) · Genome Research · doi:10.1101/gr.9.7.629 · Cited by 210
Epigenetic silencing of a foreign gene in nuclear transformants of Chlamydomonas.
Cerutti, H. D., Johnson, A. M., Gillham, N. W., & Boynton, J. E. (1997) · The Plant Cell · doi:10.1105/tpc.9.6.925 · Cited by 206
Gene Silencing Quantitatively Controls the Function of a Developmental trans-Activator
Hutchins, A. S., Mullen, A. C., Lee, H. W., Sykes, K. J., High, F. A., Hendrich, B., Bird, A. P., & Reiner, S. L. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00564-6 · Cited by 211
Duplication and Maintenance of Heterochromatin Domains
Taddei, A., Roche, D. M. J., Sibarita, J., Turner, B. M., & Almouzni, G. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.6.1153 · Cited by 202
Compartmentalization of Interphase Chromosomes Observed in Simulation and Experiment
Münkel, C., Eils, R., Dietzel, S., Zink, D., Mehring, C., Wedemann, G., Cremer, T. J., & Langowski, J. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2361 · Cited by 204
Super-enhancers include classical enhancers and facilitators to fully activate gene expression
Blayney, J. W., Francis, H., Rampasekova, A., Camellato, B., Mitchell, L., Stolper, R., Cornell, L., Babbs, C., Boeke, J. D., Higgs, D. R., et al. (2023) · Cell · doi:10.1016/j.cell.2023.11.030 · Cited by 196
Plasmodium falciparum var Genes Are Regulated by Two Regions with Separate Promoters, One Upstream of the Coding Region and a Second within the Intron
Calderwood, M. S., Gannoun-Zaki, L., Wellems, T. E., & Deitsch, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213065200 · Cited by 194
The Effect of Distance on Long-Range Chromatin Interactions
Dillon, N., Trimborn, T., Strouboulis, J., Fraser, P., & Grosveld, F. G. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80014-3 · Cited by 191
Self-citation
Th2-Specific Chromatin Remodeling and Enhancer Activity in the Th2 Cytokine Locus Control Region
Fields, P. E., Lee, G. R., Kim, S. T., Bartsevich, V. V., & Flavell, R. A. (2004) · Immunity · doi:10.1016/j.immuni.2004.10.015 · Cited by 189
The β-Globin LCR Is Not Necessary for an Open Chromatin Structure or Developmentally Regulated Transcription of the Native Mouse β-Globin Locus
Epner, E., Reik, A., Cimbora, D., Telling, A., Bender, M. A., Fiering, S., Enver, T., Martin, D. I. K., Kennedy, M., Keller, G., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80144-6 · Cited by 183
Effects of altered gene order or orientation of the locus control region on human β-globin gene expression in mice
Tanimoto, K., Liu, Q., Bungert, J., & Engel, J. D. (1999) · Nature · doi:10.1038/18698 · Cited by 178
Chromatin Structure and Gene Regulation in the Immune System
Smale, S. T., & Fisher, A. G. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064739 · Cited by 176
Interphase Cell Cycle Dynamics of a Late-Replicating, Heterochromatic Homogeneously Staining Region: Precise Choreography of Condensation/Decondensation and Nuclear Positioning
Li, G., Sudlow, G., & Belmont, A. S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.5.975 · Cited by 175
Heterochromatin function in complex genomes
Henikoff, S. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(99)00034-7 · Cited by 173
CRISPR-Cas9-mediated homology-directed repair for precise gene editing
Liao, H., Wu, J., VanDusen, N. J., Li, Y., & Zheng, Y. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102344 · Cited by 197
Multiple interactions between regulatory regions are required to stabilize an active chromatin hub
Patrinos, G. P., de Krom, M., de Boer, E., Langeveld, A., Imam, A. M. A., Strouboulis, J., de Laat, W., & Grosveld, F. G. (2004) · Genes & Development · doi:10.1101/gad.289704 · Cited by 170
Self-citation
Distinct Mechanisms Control RNA Polymerase II Recruitment to a Tissue-Specific Locus Control Region and a Downstream Promoter
Johnson, K. D., Christensen, H. M., Zhao, B. M., & Bresnick, E. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00309-4 · Cited by 168
Transgene Repeat Arrays Interact With Distant Heterochromatin and Cause Silencing in cis and trans
Dorer, D. R., & Henikoff, S. (1997) · Genetics · doi:10.1093/genetics/147.3.1181 · Cited by 163
The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells
Reik, A., Telling, A., Zitnik, G., Cimbora, D., Epner, E., & Groudine, M. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.5992 · Cited by 163
Genomic Rearrangements Resulting in PLP1 Deletion Occur by Nonhomologous End Joining and Cause Different Dysmyelinating Phenotypes in Males and Females
Inoue, K., Osaka, H., Thurston, V. C., Clarke, J. T. R., Yoneyama, A., Rosenbarker, L., Bird, T. D., Hodes, M. E., Shaffer, L. G., & Lupski, J. R. (2002) · The American Journal of Human Genetics · doi:10.1086/342728 · Cited by 164
Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions
Lee, G. R., Spilianakis, C. G., & Flavell, R. A. (2004) · Nature Immunology · doi:10.1038/ni1148 · Cited by 158
Heterochromatin structure and function
Dillon, N. (2004) · Biology of the Cell · doi:10.1016/j.biolcel.2004.06.003 · Cited by 160
The degree of phenotypic correction of murine β-thalassemia intermedia following lentiviral-mediated transfer of a human γ-globin gene is influenced by chromosomal position effects and vector copy number
Persons, D. A., Hargrove, P. W., Allay, E. R., Hanawa, H., & Nienhuis, A. W. (2003) · Blood · doi:10.1182/blood-2002-07-2211 · Cited by 155
Hypoplasia of pancreatic islets in transgenic mice expressing activin receptor mutants.
Yamaoka, T., Idehara, C., Yano, M., Matsushita, T., Yamada, T., Ii, S., Moritani, M., Hata, J., Sugino, H., Noji, S., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2769 · Cited by 154
Histone acetylation beyond promoters: long‐range acetylation patterns in the chromatin world*
Forsberg, E. C., & Bresnick, E. H. (2001) · BioEssays · doi:10.1002/bies.1117 · Cited by 153
Sequences flanking the centromere of human chromosome 10 are a complex patchwork of arm-specific sequences, stable duplications and unstable sequences with homologies to telomeric and other centromeric locations
Jackson, M. S. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.2.205 · Cited by 150
Binding of Ikaros to the λ5 promoter silences transcription through a mechanism that does not require heterochromatin formation
Sabbattini, P. M. R., Lundgren, M., Georgiou, A., Chow, C.-M., Warnes, G., & Dillon, N. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2812 · Cited by 149
Mechanisms of developmental control of transcription in the murine α- and β-globin lociPreprint
Trimborn, T., Gribnau, J. H., Grosveld, F. G., & Fraser, P. (1999) · Genes & Development · doi:10.1101/gad.13.1.112 · Cited by 145
Self-citation
The human β‐globin locus control region: A center of attraction
Levings, P. P., & Bungert, J. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2002.02797.x · Cited by 144
Locus control regions: overcoming heterochromatin-induced gene inactivation in mammals
Kioussis, D., & Festenstein, R. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80008-1 · Cited by 144
Transgenes encompassing dual-promoter CpG islands from the human TBP and HNRPA2B1 loci are resistant to heterochromatin-mediated silencing
Antoniou, M. N., Harland, L., Mustoe, T., Williams, S., Holdstock, J., Yagüe, E., Mulcahy, T., Griffiths, M. N. D., Edwards, S., Ioannou, P. A., et al. (2003) · Genomics · doi:10.1016/s0888-7543(03)00107-1 · Cited by 145
Activation by locus control regions?
Grosveld, F. G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80023-9 · Cited by 143
Self-citation
Locus control regions, chromatin activation and transcription
Fraser, P., & Grosveld, F. G. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80012-4 · Cited by 141
Self-citation
Chapter 4 β‐Globin Regulation and Long‐Range Interactions
Palstra, R., de Laat, W., & Grosveld, F. (2008) · Advances in genetics · doi:10.1016/s0065-2660(07)00004-1 · Cited by 131
Self-citation
Enhancer Blocking by the Drosophila gypsy Insulator Depends Upon Insulator Anatomy and Enhancer Strength
Scott, K. C., Taubman, A. D., & Geyer, P. (1999) · Genetics · doi:10.1093/genetics/153.2.787 · Cited by 125
Transcriptional Behavior of LCR Enhancer Elements Integrated at the Same Chromosomal Locus by Recombinase-Mediated Cassette Exchange
Bouhassira, E. E., Westerman, K. A., & Leboulch, P. (1997) · Blood · doi:10.1182/blood.v90.9.3332 · Cited by 124
Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context- dependent manner
Festenstein, R., Sharghi-Namini, S., Fox, M., Roderick, K., Tolaini, M., Norton, T., Saveliev, A., Kioussis, D., & Singh, P. B. (1999) · Nature Genetics · doi:10.1038/70579 · Cited by 123
Transcription Factor Dosage Affects Changes in Higher Order Chromatin Structure Associated with Activation of a Heterochromatic Gene
Lundgren, M., Chow, C.-M., Sabbattini, P. M. R., Georgiou, A., Minaee, S., & Dillon, N. (2000) · Cell · doi:10.1016/s0092-8674(00)00177-x · Cited by 122
Sequential Recruitment of HAT and SWI/SNF Components to Condensed Chromatin by VP16
Memedula, S., & Belmont, A. S. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00048-4 · Cited by 126
Evidence for Distinct CD4 Silencer Functions at Different Stages of Thymocyte Differentiation
Taniuchi, I., Sunshine, M. J., Festenstein, R., & Littman, D. R. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00735-9 · Cited by 121
Cytogenetic rearrangements involving the loss of the Sonic Hedgehog gene at 7q36 cause holoprosencephaly
Roessler, E., Ward, D. E., Gaudenz, K., Belloni, E., Scherer, S. W., Donnai, D., Siegel‐Bartelt, J., Tsui, L., & Muenke, M. (1997) · Human Genetics · doi:10.1007/s004390050486 · Cited by 116
Extended β-globin locus control region elements promote consistent therapeutic expression of a γ-globin lentiviral vector in murine β-thalassemia
Hanawa, H., Hargrove, P. W., Kepes, S., Srivastava, D. K., Nienhuis, A. W., & Persons, D. A. (2004) · Blood · doi:10.1182/blood-2004-03-0863 · Cited by 114
Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain
Johnson, K. D., Grass, J. A., Boyer, M. E., Kiekhaefer, C. M., Blobel, G. A., Weiss, M. J., & Bresnick, E. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192285999 · Cited by 113
Neighboring Genes Show Correlated Evolution in Gene Expression
Ghanbarian, A. T., & Hurst, L. D. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv053 · Cited by 112
Variegated gene expression in mice
Dobie, K. W. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01097-4 · Cited by 109
Functional gene expression domains: defining the functional unit of eukaryotic gene regulation
Dillon, N., & Sabbattini, P. M. R. (2000) · BioEssays · doi:10.1002/1521-1878(200007)22:7 · Cited by 100
Current and future alternative therapies for beta-thalassemia major
Dreuzy, E. D., Bhukhai, K., Leboulch, P., & Payen, E. (2016) · Biomedical Journal · doi:10.1016/j.bj.2015.10.001 · Cited by 104
Dividing the empire: boundary chromatin elements delimit the territory of enhancers
Udvardy, A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.1 · Cited by 101
Lactoferrin uptake by the rat liver. Characterization of the recognition site and effect of selective modification of arginine residues.
Ziere, G. J., van Dijk, M. C., Bijsterbosch, M. K., & van Berkel, T. J. C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49900-6 · Cited by 99
Do LCRs Open Chromatin Domains?
Higgs, D. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81761-4 · Cited by 98
Developmental regulation of DNA replication timing at the human β globin locus
Simon, I., Tenzen, T., Mostoslavsky, R., Fibach, E., Lande, L., Milot, É., Gribnau, J. H., Grosveld, F. G., Fraser, P., & Cedar, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.6150 · Cited by 97
Self-citation
Long range interaction of cis‐DNA elements mediated by architectural transcription factor Bach1
Yoshida, C., Tokumasu, F., Hohmura, K. I., Bungert, J., Hayashi, N., Nagasawa, T., Engel, J. D., Yamamoto, M. P., Takeyasu, K., & Igarashi, K. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00291.x · Cited by 96
Chromatin interaction mechanism of transcriptional control in vivo
Gribnau, J. H., de Boer, E., Trimborn, T., Wijgerde, M., Milot, É., Grosveld, F. G., & Fraser, P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.20.6020 · Cited by 94
Self-citation
Transcriptional Regulation of vav, a Gene Expressed Throughout the Hematopoietic Compartment
Ogilvy, S., Elefanty, A. G., Visvader, J. E., Bath, M. L., Harris, A. W., & Adams, J. M. (1998) · Blood · doi:10.1182/blood.v91.2.419 · Cited by 93
Heterochromatin protein 1 binds transgene arrays
Fanti, L., Dorer, D. R., Berloco, M. F., Henikoff, S., & Pimpinelli, S. (1998) · Chromosoma · doi:10.1007/s004120050310 · Cited by 93
Targeting a SWI/SNF-related chromatin remodeling complex to the β-globin promoter in erythroid cells
Lee, C. H., Murphy, M. R., Lee, J., & Chung, J. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12311 · Cited by 92
Gene regulation and large-scale chromatin organization in the nucleus
Dillon, N. (2006) · Chromosome Research · doi:10.1007/s10577-006-1027-8 · Cited by 88
Hypersensitive Site 2 Specifies a Unique Function within the Human β-Globin Locus Control Region To Stimulate Globin Gene Transcription
Bungert, J., Tanimoto, K., Patel, S. M., Liu, Q., Fear, M. W., & Engel, J. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.3062 · Cited by 89
Developmental Specificity of the Interaction between the Locus Control Region and Embryonic or Fetal Globin Genes in Transgenic Mice with an HS3 Core Deletion
Navas, P. A., Peterson, K. R., Li, Q., Skarpidi, E., Rohde, A. D., Shaw, S. E., Clegg, C. H., Asano, H., & Stamatoyannopoulos, G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4188 · Cited by 88
A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer
Yannoutsos, N., Barreto, V. M., Misulovin, Z., Gazumyan, A., Yu, W., Rajewsky, N., Peixoto, B. R., Eisenreich, T., & Nussenzweig, M. C. (2004) · Nature Immunology · doi:10.1038/ni1053 · Cited by 87
Self-citation
Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer-promoter interactionsPreprint
Forrester, W. C., Fernández, L. Á., & Grosschedl, R. (1999) · Genes & Development · doi:10.1101/gad.13.22.3003 · Cited by 84
A Functional Rhodopsin-Green Fluorescent Protein Fusion Protein Localizes Correctly in Transgenic Xenopus laevis Retinal Rods and Is Expressed in a Time-dependent Pattern
Moritz, O. L., Tam, B. M., Papermaster, D. S., & Nakayama, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101476200 · Cited by 83
Chromatin remodeling of the interleukin-2 gene: Distinct alterations in the proximal versus distal enhancer regions
Ward, S. B., Hernández‐Hoyos, G., Chen, F., Waterman, M. L., Reeves, R., & Rothenberg, E. V. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.12.2923 · Cited by 81
Gene targeting by TALEN-induced homologous recombination in goats directs production of β-lactoglobulin-free, high-human lactoferrin milk
Cui, C., Song, Y., Liu, J., Ge, H., Li, Q., Huang, H. M., Hu, L., Zhu, H., Jin, Y., & Zhang, Y. (2015) · Scientific Reports · doi:10.1038/srep10482 · Cited by 79
The Human β Globin Locus Introduced by YAC Transfer Exhibits a Specific and Reproducible Pattern of Developmental Regulation in Transgenic Mice
Porcu, S., Kitamura, M., Witkowska, E., Zhang, Z., Mutero, A., Lin, C. J., Chang, J., & Gaensler, K. M. L. (1997) · Blood · doi:10.1182/blood.v90.11.4602 · Cited by 79
Prospects for the genetic transformation of arthropods
Ashburner, M., Hoy, M. A., & Peloquin, J. J. (1998) · Insect Molecular Biology · doi:10.1046/j.1365-2583.1998.00084.x · Cited by 76
Erythroid Krüppel‐like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5′HS3 of the β‐globin locus control region
Tewari, R., Gillemans, N., Wijgerde, M., Nuez, B., Lindern, M. V., Grosveld, F. G., & Philipsen, S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.8.2334 · Cited by 77
Self-citation
Precise genome-editing in human diseases: mechanisms, strategies and applications
Zheng, Y., Li, Y., Zhou, K., Li, T., VanDusen, N. J., & Hua, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01750-2 · Cited by 91
Locus control regions and epigenetic chromatin modifiers
Festenstein, R., & Kioussis, D. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00060-5 · Cited by 76
A New Regulatory Region of the IL-2 Locus That Confers Position-Independent Transgene Expression
Yui, M. A., Hernández‐Hoyos, G., & Rothenberg, E. V. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1730 · Cited by 75

Authors: Milot, E., Strouboulis, J., Trimborn, T., Wijgerde, M., de Boer, E., Langeveld, A., Tan-Un, K., Vergeer, W., Yannoutsos, N., Grosveld, F., & Fraser, P.
Affiliations: National Institute for Medical Research (GB)
Erasmus MC (NL)
Corresponding author: Grosveld, Frank
ORCID: Strouboulis, John
Tan-Un, Kian
Grosveld, Frank
Fraser, Peter
Venue: Cell
Publisher: Elsevier BV
Published: 1996-10
Volume: 87
Issue: 1
Pages: 105-114
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)81327-6
OpenAlex: W2151390187
Cited by: 314
References: 42
Citations by year: 2025: 2 · 2024: 4 · 2023: 2 · 2021: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 8
FWCI: 13.11
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6133 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: locus control region, heterochromatin, position effect variegation, gene transcription, transcriptional silencing, tissue-specific gene expression, open chromatin, transgenic mice
MeSH terms: Animals, Centromere, Chromosome Mapping, Deoxyribonuclease I, Erythrocytes, Gene Expression Regulation, Globins, Heterochromatin, Humans, Mice, Transgenic, Regulatory Sequences, Nucleic Acid, RNA, Messenger, Time Factors, Transcription, Genetic, Deoxyribonucleases, Type II Site-Specific, Single-Strand Specific DNA and RNA Endonucleases, Sequence Deletion, Gene Dosage, Transgenes, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Heterochromatin Effects on the Frequency and Duration of LCR-Mediated Gene Transcription

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks