Error-Prone DNA Polymerases

DNA Repair and Mutagenesis

Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683 · see citing works

DNA repair and mutagenesis

Bootsma, D., & Hoeijmakers, J. H. J. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81408-9 · Cited by 2,285 · see citing works

DNA Replication Fidelity

Kunkel, T. A., & Bebenek, K. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.497 · Cited by 1,003 · see citing works

The Y-Family of DNA Polymerases

Ohmori, H., Friedberg, E. C., Fuchs, R. P., Goodman, M. F., Hanaoka, F., Hinkle, D. C., Kunkel, T. A., Lawrence, C. W., Livneh, Z., Nohmi, T., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00278-7 · Cited by 882 · see citing works

Excision of Deoxyribose Phosphate Residues by DNA Polymerase β During DNA Repair

Matsumoto, Y., & Kim, K. (1995) · Science · doi:10.1126/science.7624801 · Cited by 683 · see citing works

Crystal Structure of a Y-Family DNA Polymerase in Action

Ling, H., Boudsocq, F., Woodgate, R., & Yang, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00515-3 · Cited by 610 · see citing works

Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis

Tang, M., Pham, P., Shen, X., Taylor, J.-S., O'Donnell, M., Woodgate, R., & Goodman, M. F. (2000) · Nature · doi:10.1038/35010020 · Cited by 443 · see citing works

Low fidelity DNA synthesis by human DNA polymerase-η

Matsuda, T., Bebenek, K., Masutani, C., Hanaoka, F., & Kunkel, T. A. (2000) · Nature · doi:10.1038/35010014 · Cited by 372 · see citing works

Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η

Haracska, L., Yu, S.-L., Johnson, R. E., Prakash, L., & Prakash, S. (2000) · Nature Genetics · doi:10.1038/78169 · Cited by 349 · see citing works

Structure of the Catalytic Core of S. cerevisiae DNA Polymerase η

Trincão, J., Johnson, R. E., Escalante, C. R., Prakash, S., Prakash, L., & Aggarwal, A. K. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00306-9 · Cited by 344 · see citing works

Identification of an Intrinsic 5′-Deoxyribose-5-phosphate Lyase Activity in Human DNA Polymerase λ

García–Díaz, M., Bębenek, K., Kunkel, T. A., & Blanco, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106336200 · Cited by 230 · see citing works

Role of DNA Polymerase η in the Bypass of a (6-4) TT Photoproduct

Johnson, R. E., Haracska, L., Prakash, S., & Prakash, L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3558-3563.2001 · Cited by 199 · see citing works

Crystal Structure of a DinB Lesion Bypass DNA Polymerase Catalytic Fragment Reveals a Classic Polymerase Catalytic Domain

Zhou, B.-L., Pata, J. D., & Steitz, T. A. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00310-0 · Cited by 198 · see citing works

5'-Deoxyribose Phosphate Lyase Activity of Human DNA Polymerase ɩ in Vitro

Bębenek, K., Tissier, A., Frank, E. G., McDonald, J. P., Prasad, R., Wilson, S. H., Woodgate, R., & Kunkel, T. A. (2001) · Science · doi:10.1126/science.1058386 · Cited by 197 · see citing works

Role of Yeast and Human DNA Polymerase in Error-free Replication of Damaged DNAPreprint

Prakash, S., Johnson, R. E., Washington, M. T., Haracska, L., Kondratick, C. M., & Prakash, L. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.51 · Cited by 18 · see citing works

Human DNA Polymerase : A Novel DNA Polymerase of Unknown Biological Function Encoded by the DINB1 GenePreprint

Gerlach, V. L., Feaver, W. J., Fischhaber, P. L., Richardson, J. A., Aravind, L., Koonin, E. V., Bębenek, K., Kunkel, T. A., & Friedberg, E. C. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.41 · Cited by 12 · see citing works

DNA Replication Fidelity

Kunkel, T. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400006200 · Cited by 754 · see citing works

Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations

Friedberg, E. C., Wagner, R., & Radman, M. (2002) · Science · doi:10.1126/science.1070236 · Cited by 443 · see citing works

Mechanisms of transcription-coupled DNA repair

Svejstrup, J. Q. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm703 · Cited by 380 · see citing works

Dial 9–1–1 for DNA damage: the Rad9–Hus1–Rad1 (9–1–1) clamp complex

Parrilla-Castellar, E. R., Arlander, S. J. H., & Karnitz, L. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.032 · Cited by 342 · see citing works

Structures of Mismatch Replication Errors Observed in a DNA Polymerase

Johnson, S. J., & Beese, L. S. (2004) · Cell · doi:10.1016/s0092-8674(04)00252-1 · Cited by 300 · see citing works

Suffering in silence: the tolerance of DNA damage

Friedberg, E. C. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1781 · Cited by 271 · see citing works

Functions of DNA polymerases

Bebenek, K., & Kunkel, T. A. (2004) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(04)69005-x · Cited by 258 · see citing works

Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the β‐clamp

Bunting, K. A., Roe, S. M., & Pearl, L. H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg568 · Cited by 225 · see citing works

Origins of Spontaneous Mutations: Specificity and Directionality of Base-Substitution, Frameshift, and Sequence-Substitution Mutageneses

Maki, H. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.042602.094806 · Cited by 191 · see citing works

Quantitative Analysis of Translesion DNA Synthesis across a Benzo[a]pyrene-Guanine Adduct in Mammalian Cells

Avkin, S., Goldsmith, M., Velasco-Miguel, S., Geacintov, N. E., Friedberg, E. C., & Livneh, Z. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409155200 · Cited by 177 · see citing works

Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways

Jaspers, N. G. J., Raams, A., Kelner, M. J., Ng, J. M. Y., Yamashita, Y. M., Takeda, S., McMorris, T. C., & Hoeijmakers, J. H. J. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00166-0 · Cited by 165 · see citing works

Structural Insights into the Origins of DNA Polymerase Fidelity

Beard, W. A., & Wilson, S. H. (2003) · Structure · doi:10.1016/s0969-2126(03)00051-0 · Cited by 157 · see citing works

A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

Langerak, P., Nygren, A. O. H., Krijger, P. H. L., van den Berk, P. C. M., & Jacobs, H. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070902 · Cited by 151 · see citing works

The structure of T. aquaticus DNA polymerase III is distinct from eukaryotic replicative DNA polymerases.

Bailey, S., Wing, R. A., & Steitz, T. (2006) · Cell · doi:10.1016/j.cell.2006.07.027 · Cited by 145 · see citing works

Tuberculosis Chemotherapy: the Influence of Bacillary Stress and Damage Response Pathways on Drug Efficacy

Warner, D. F., & Mizrahi, V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00060-05 · Cited by 135 · see citing works

Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity

Beard, W. A., Shock, D. D., Vande Berg, B. J., & Wilson, S. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m210036200 · Cited by 129 · see citing works

Role of DNA Polymerase η in the UV Mutation Spectrum in Human Cells

Stary, A., Kannouche, P. L., Lehmann, A. R., & Sarasin, A. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211838200 · Cited by 127 · see citing works

Functions of human DNA polymerases η, κ and ι suggested by their properties, including fidelity with undamaged DNA templates

Kunkel, T. A., Pavlov, Y. I., & Bebenek, K. (2003) · DNA Repair · doi:10.1016/s1568-7864(02)00224-0 · Cited by 125 · see citing works

Altered DNA Polymerase ι Expression in Breast Cancer Cells Leads to a Reduction in DNA Replication Fidelity and a Higher Rate of Mutagenesis

Jin, Y., Chen, Z., Liu, Y., Hickey, R. J., & Malkas, L. H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0603 · Cited by 115 · see citing works

Mechanism of DNA Polymerization Catalyzed by Sulfolobus solfataricus P2 DNA Polymerase IV

Fiala, K. A., & Suo, Z. (2004) · Biochemistry · doi:10.1021/bi035746z · Cited by 114 · see citing works

Replication of damaged DNA in mammalian cells: new solutions to an old problem

Lehmann, A. R. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00227-0 · Cited by 111 · see citing works

Increased Susceptibility to UV-Induced Skin Carcinogenesis in Polymerase η–deficient Mice

Lin, Q., Clark, A. B., McCulloch, S. D., Yuan, T., Bronson, R. T., Kunkel, T. A., & Kucherlapati, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1862 · Cited by 95 · see citing works

Yeast MPH1 Gene Functions in an Error-Free DNA Damage Bypass Pathway That Requires Genes From Homologous Recombination, but Not From Postreplicative Repair

Schürer, K. A., Rudolph, C. J., Ulrich, H. D., & Kramer, W. (2004) · Genetics · doi:10.1534/genetics.166.4.1673 · Cited by 99 · see citing works

Enzymatic switching for efficient and accurate translesion DNA replication.

McCulloch, S. D., Kokoska, R., Chilkova, O., Welch, C. M., Johansson, E., Burgers, P., & Kunkel, T. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh777 · Cited by 97 · see citing works

A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks

Durando, M., Tateishi, S., & Vaziri, C. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt016 · Cited by 87 · see citing works

Preferential Misincorporation of Purine Nucleotides by Human DNA Polymerase η Opposite Benzo[a]pyrene 7,8-Diol 9,10-Epoxide Deoxyguanosine Adducts

Chiapperino, D., Kroth, H., Kramarczuk, I. H., Sayer, J. M., Masutani, C., Hanaoka, F., Jerina, D. M., & Cheh, A. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112139200 · Cited by 87 · see citing works

Structural and Functional Elucidation of the Mechanism Promoting Error-prone Synthesis by Human DNA Polymerase κ Opposite the 7,8-Dihydro-8-oxo-2′-deoxyguanosine Adduct

Irimia, A., Eoff, R. L., Guengerich, F. P., & Egli, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.003905 · Cited by 85 · see citing works

DNA mismatch repair and p53 function are major determinants of the rate of development of cisplatin resistance

Lin, X., & Howell, S. B. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0491 · Cited by 83 · see citing works

Structure of a High Fidelity DNA Polymerase Bound to a Benzo[a]pyrene Adduct That Blocks Replication

Hsu, G. W., Huang, X., Luneva, N. P., Geacintov, N. E., & Beese, L. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411276200 · Cited by 82 · see citing works

Two-step error-prone bypass of the (+)- and (−)-trans-anti-BPDE-N2-dG adducts by human DNA polymerases η and κ

Zhang, Y., Wu, X., Guo, D., Rechkoblit, O., Geacintov, N. E., & Wang, Z. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00249-x · Cited by 78 · see citing works

Role of DNA polymerase in the bypass of abasic sites in yeast cells

Zhao, B. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh710 · Cited by 78 · see citing works

Diversify or Die: Generation of Diversity in Response to Stress

Aertsen, A., & Michiels, C. W. (2005) · Critical Reviews in Microbiology · doi:10.1080/10408410590921718 · Cited by 73 · see citing works

Involvement of Error-Prone DNA Polymerase IV in Stationary-Phase Mutagenesis in Pseudomonas putida

Tegova, R., Tover, A., Tarassova, K., Tark‐Dame, M., & Kivisaar, M. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.9.2735-2744.2004 · Cited by 72 · see citing works

Observing Translesion Synthesis of an Aromatic Amine DNA Adduct by a High-fidelity DNA Polymerase

Hsu, G. W., Kiefer, J. R., Burnouf, D., Bécherel, O. J., Fuchs, R. P., & Beese, L. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409224200 · Cited by 72 · see citing works

Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7

Li, Y., Dutta, S., Doublié, S., Bdour, H. M., Taylor, J., & Ellenberger, T. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb792 · Cited by 69 · see citing works

Lesion Bypass Activities of Human DNA Polymerase μ

Zhang, Y., Wu, X., Guo, D., Rechkoblit, O., Taylor, J., Geacintov, N. E., & Wang, Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207297200 · Cited by 67 · see citing works

Functions of Eukaryotic DNA Polymerases

Shcherbakova, P. V., Bębenek, K., & Kunkel, T. A. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.8.re3 · Cited by 69 · see citing works

Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes

Goldman, G. H., & Käfer, E. (2004) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2003.12.001 · Cited by 67 · see citing works

CpG dinucleotides and the mutation rate of non-CpG DNAPreprint

Walser, J., Ponger, L., & Furano, A. V. (2008) · Genome Research · doi:10.1101/gr.076455.108 · Cited by 62 · see citing works

Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase ι

Vaisman, A., Frank, E. G., Iwai, S., Ohashi, E., Ohmori, H., Hanaoka, F., & Woodgate, R. (2003) · DNA repair · doi:10.1016/s1568-7864(03)00094-6 · Cited by 59 · see citing works

Considering the cancer consequences of altered DNA polymerase function

Kunkel, T. A. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00027-8 · Cited by 55 · see citing works

DNA polymerase I acts in translesion synthesis mediated by the Y‐polymerases in Bacillus subtilis

Duigou, S., Ehrlich, S. D., Noirot, P. H., & Noirot‐Gros, M. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04725.x · Cited by 54 · see citing works

Local Deformations Revealed by Dynamics Simulations of DNA Polymerase β with DNA Mismatches at the Primer Terminus

Yang, L., Beard, W. A., Wilson, S. H., Roux, B., Broyde, S. B., & Tamar Schlick, A. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00617-4 · Cited by 53 · see citing works

Translesion synthesis of 7,8-dihydro-8-oxo-2′-deoxyguanosine by DNA polymerase eta in vivo

Lee, D.-H., & Pfeifer, G. P. (2008) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2008.02.006 · Cited by 53 · see citing works

Common structural features of nucleic acid polymerases

Cramer, P. (2002) · BioEssays · doi:10.1002/bies.10127 · Cited by 50 · see citing works

Mutagenesis of Benzo[a]pyrene Diol Epoxide in Yeast: Requirement for DNA Polymerase ζ and Involvement of DNA Polymerase η

Xie, Z., Braithwaite, E. K., Guo, D., Zhao, B., Geacintov, N. E., & Wang, Z. (2003) · Biochemistry · doi:10.1021/bi0346704 · Cited by 46 · see citing works

Cognizance of Molecular Methods for the Generation of Mutagenic Phage Display Antibody Libraries for Affinity Maturation

Lim, C. C., Choong, Y. S., & Lim, T. S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081861 · Cited by 44 · see citing works

The Role of Polymerase η in Somatic Hypermutation Determined by Analysis of Mutations in a Patient with Xeroderma Pigmentosum Variant

Yavuz, Ş., Yavuz, A. S., Kraemer, K. H., & Lipsky, P. E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3825 · Cited by 43 · see citing works

The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage

Colgin, L. M., Hackmann, A. F. M., Emond, M. J., & Monnat, R. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032655699 · Cited by 43 · see citing works

Effect of manganese on in vitro replication of damaged DNA catalyzed by the herpes simplex virus type-1 DNA polymerase

Villani, G. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf463 · Cited by 40 · see citing works

The p-benzoquinone DNA adducts derived from benzene are highly mutagenic

Xie, Z., Zhang, Y., Guliaev, A. B., Shen, H., Hang, B., Singer, B. C., & Wang, Z. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.08.012 · Cited by 40 · see citing works

tRNA‐nucleotidyltransferases: Highly unusual RNA polymerases with vital functions

Vörtler, S., & Mörl, M. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.078 · Cited by 38 · see citing works

polι-dependent lesion bypass in vitro

Vaisman, A., Frank, E. G., McDonald, J. P., Tissier, A., & Woodgate, R. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00248-8 · Cited by 38 · see citing works

Pol , Pol and Rev1 together are required for G to T transversion mutations induced by the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells

Zhao, B. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj446 · Cited by 38 · see citing works

A RecA Protein Surface Required for Activation of DNA Polymerase V

Gruber, A. J., Erdem, A. L., Sabat, G., Karata, K., Jaszczur, M. M., Vo, D. D., Olsen, T. M., Woodgate, R., Goodman, M. F., & Cox, M. M. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005066 · Cited by 37 · see citing works

In vivo deamination of cytosine-containing cyclobutane pyrimidine dimers in E. coli: a feasible part of UV-mutagenesis

Burger, A., Fix, D. F., Liu, H., Hays, J. B., & Bockrath, R. C. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00310-x · Cited by 33 · see citing works

An Active Site Aromatic Triad in Escherichia coli DNA Pol IV Coordinates Cell Survival and Mutagenesis in Different DNA Damaging Agents

Benson, R. W., Norton, M., Lin, I., Comb, W. D., & Godoy, V. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019944 · Cited by 31 · see citing works

The Use of Non‐natural Nucleotides to Probe Template‐Independent DNA Synthesis

Berdis, A. J., & McCutcheon, D. C. (2007) · ChemBioChem · doi:10.1002/cbic.200700096 · Cited by 31 · see citing works

Tissue-specific time courses of spontaneous mutation frequency and deviations in mutation pattern are observed in middle to late adulthood in Big Blue mice

Hill, K. A., Halangoda, A., Heinmöller, P., Hagman, K. D. F., Chitaphan, C., Longmate, J., Scaringe, W. A., Wang, J., & Sommer, S. S. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20119 · Cited by 31 · see citing works

Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress

Tsao, W.-C., & Eckert, K. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103255 · Cited by 28 · see citing works

Multiple Strategies for Translesion Synthesis in Bacteria

Ippoliti, P. J., DeLateur, N. A., Jones, K. M., & Beuning, P. J. (2012) · Cells · doi:10.3390/cells1040799 · Cited by 28 · see citing works

Conformational Changes during Nucleotide Selection by Sulfolobus solfataricus DNA Polymerase Dpo4

Eoff, R. L., Sánchez-Ponce, R., & Guengerich, F. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.009506 · Cited by 28 · see citing works

Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine–thymine tracts

Zhang, W., Svarovskaia, E. S., Barr, R., & Pathak, V. K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152186199 · Cited by 28 · see citing works

The L561A Substitution in the Nascent Base-Pair Binding Pocket of RB69 DNA Polymerase Reduces Base Discrimination

Zhang, H., Rhee, C., Bębenek, A., Drake, J. W., Wang, J., & Konigsberg, W. H. (2006) · Biochemistry · doi:10.1021/bi052099y · Cited by 27 · see citing works

Rational Attempts to Optimize Non-Natural Nucleotides for Selective Incorporation Opposite an Abasic Site

Zhang, X., Donnelly, A. C., Lee, I., & Berdis, A. J. (2006) · Biochemistry · doi:10.1021/bi060418v · Cited by 27 · see citing works

Examining the potential role of DNA polymerases η and ζ in triplet repeat instability in yeast

Dixon, M. J. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00095-2 · Cited by 24 · see citing works

Spontaneous multiple mutations show both proximal spacing consistent with chronocoordinate events and alterations with p53-deficiency

Hill, K. A., Wang, J., Hagman, K. D. F., Scaringe, W. A., & Sommer, S. S. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.05.005 · Cited by 24 · see citing works

Exploring the Effects of Active Site Constraints on HIV-1 Reverse Transcriptase DNA Polymerase Fidelity

Cramer, J., Strerath, M., Marx, A., & Restle, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207854200 · Cited by 22 · see citing works

Adaptation to Endoplasmic Reticulum Stress Enhances Resistance of Oral Cancer Cells to Cisplatin by Up-Regulating Polymerase η and Increasing DNA Repair Efficiency

Chen, C.-Y., Kawasumi, M., Lan, T.-Y., Poon, C.-L., Lin, Y.-S., Wu, P.-J., Chen, Y.-C., Chen, B., Wu, C., Lo, J., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010355 · Cited by 22 · see citing works

The DinB•RecA complex of Escherichia coli mediates an efficient and high‐fidelity response to ubiquitous alkylation lesions

Cafarelli, T. M., Rands, T. J., & Godoy, V. G. (2013) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21826 · Cited by 21 · see citing works

Lesion bypass DNA polymerases replicate across non-DNA segments

Maor-Shoshani, A., Ben-Ari, V., & Livneh, Z. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2433503100 · Cited by 20 · see citing works

A Review of Stable Isotope Labeling and Mass Spectrometry Methods to Distinguish Exogenous from Endogenous DNA Adducts and Improve Dose–Response Assessments

Lü, K., Hsiao, Y.-C., Liu, C., Schoeny, R. S., Gentry, R., & Starr, T. B. (2021) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.1c00212 · Cited by 17 · see citing works

Accommodation of a 1S-(−)-Benzo[c]phenanthrenyl-N6-dA Adduct in the Y-Family Dpo4 DNA Polymerase Active Site: Structural Insights through Molecular Dynamics Simulations

Wang, L., Wu, M., Yan, S. F., Patel, D. J., Geacintov, N. E., & Broyde, S. B. (2005) · Chemical Research in Toxicology · doi:10.1021/tx049786v · Cited by 17 · see citing works

Residues in the fingers domain of the translesion DNA polymerase DinB enable its unique participation in error-prone double-strand break repair

Tashjian, T. F., Danilowicz, C., Molza, A.-E., Nguyen, B. H., Prévost, C., Prentiss, M. G., & Godoy, V. G. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006233 · Cited by 16 · see citing works

Model of the developing tumorigenic phenotype in mammalian cells and the roles of sustained stress and replicative senescence

Karpinets, T. V., & Foy, B. D. (2004) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2003.11.005 · Cited by 15 · see citing works

Trans-Lesion DNA Polymerases May Be Involved in Yeast Meiosis

Arbel‐Eden, A., Joseph-Strauss, D., Masika, H., Printzental, O., Rachi, E., & Simchen, G. (2013) · G3 Genes Genomes Genetics · doi:10.1534/g3.113.005603 · Cited by 16 · see citing works

Amino Acid Substitutions at Conserved Tyrosine 52 Alter Fidelity and Bypass Efficiency of Human DNA Polymerase η

Glick, E., Chau, J. S., Vigna, K. L., McCulloch, S. D., Adman, E. T., Kunkel, T. A., & Loeb, L. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300686200 · Cited by 16 · see citing works

BP[dG]-induced distortions to DNA polymerase and DNA duplex: A detailed mechanism of BP adducts blocking replication

Wu, Z., Peng, L., Hu, Y., Xie, T., Yan, H., Wan, H., Liu, W., Liang, L., Xie, Z., Liu, K., et al. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111325 · Cited by 15 · see citing works

A new proofreading mechanism for lesion bypass by DNA polymerase‐λ

Crespan, E., Maga, G., & Hübscher, U. (2011) · EMBO Reports · doi:10.1038/embor.2011.226 · Cited by 14 · see citing works

Yeast POL5 Is an Evolutionarily Conserved Regulator of rDNA Transcription Unrelated to Any Known DNA Polymerases

Yang, W., Rogozin, I. B., & Koonin, E. V. (2003) · Cell Cycle · doi:10.4161/cc.2.2.329 · Cited by 14 · see citing works

Molecular Mechanisms of Carcinogenesis

Malejka‐Giganti, D., & Tretyakova, N. Y. (2005) · Chemical and functional properties of food components series · doi:10.1201/9781420039269.ch2 · Cited by 12 · see citing works

Mutagenic DNA repair potential inPseudomonasspp., and characterization of therulABPcoperon from the highly mutable strainPseudomonas cichorii302959

Zhang, S., & Sundin, G. W. (2004) · Canadian Journal of Microbiology · doi:10.1139/w03-105 · Cited by 12 · see citing works

Somatic microindels in human cancer: the insertions are highly error-prone and derive from nearby but not adjacent sense and antisense templates

Scaringe, W. A., Li, K., Gu, D., Hagman, K. D. F., Chen, Z., Hill, K. A., & Sommer, S. S. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn190 · Cited by 11 · see citing works

A nuclear 3′–5′ exonuclease proofreads for the exonuclease-deficient DNA polymerase α

Brown, K. R., Weatherdon, K. L., Galligan, C. L., & Skalski, V. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00115-5 · Cited by 11 · see citing works

Signal Transduction in the Escherichia coli SOS Response

Foti, J. J., Simmons, L. A., Beuning, P., & Walker, G. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00258-8 · Cited by 7 · see citing works

Multiple PolK (POLK) transcripts in mammalian testis

Guo, C., Gao, T., Confer, N., Velasco-Miguel, S., & Friedberg, E. C. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.10.006 · Cited by 10 · see citing works

Impact of Chemical Adducts on Translesion Synthesis in Replicative and Bypass DNA Polymerases: From Structure to Function

Eoff, R. L., Egli, M., & Guengerich, F. P. (2010) · Wiley eBooks · doi:10.1002/9783527630110.ch13 · Cited by 9 · see citing works

Selection of dinB Alleles Suppressing Survival Loss upon dinB Overexpression in Escherichia coli

Benson, R. W., Cafarelli, T. M., Rands, T. J., Lin, I., & Godoy, V. G. (2014) · Journal of Bacteriology · doi:10.1128/jb.01782-14 · Cited by 9 · see citing works

Mouse models of DNA polymerases

Menezes, M. R., & Sweasy, J. B. (2012) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21731 · Cited by 9 · see citing works

On the role of proofreading exonuclease in bypass of a 1,2 d(GpG) cisplatin adduct by the herpes simplex virus-1 DNA polymerase

Arana, M. E., Song, L., Gac, N. T. L., Parris, D. S., Villani, G., & Boehmer, P. E. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.02.006 · Cited by 9 · see citing works

Lupus autoantibodies to native DNA preferentially bind DNA presented on PolIV

Kumar, S., Bunting, K. A., Kalsi, J., Hinks, J. A., Latchman, D. S., Pearl, L. H., & Isenberg, D. A. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02090.x · Cited by 7 · see citing works

Altered translesion synthesis in E. coli Pol V mutants selected for increased recombination inhibition

Sommer, S., Bécherel, O. J., Coste, G., Bailone, A., & Fuchs, R. P. (2003) · DNA repair · doi:10.1016/j.dnarep.2003.08.008 · Cited by 7 · see citing works

Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing

Rudolph, C. J., Schürer, K. A., & Kramer, W. (2006) · Springer eBooks · doi:10.1007/7050_003 · Cited by 7 · see citing works

Comprehensive Mutational Landscape of Yeast Mutator Strains Reveals the Genetic Basis of Mutational Signatures in Cancer

Liu, L., Sun, D., & Liu, H. (2025) · Molecular Biology and Evolution · doi:10.1093/molbev/msaf252 · Cited by 5 · see citing works

Mechanisms for High Fidelity DNA Replication

McElhinny, S. A. N., Pursell, Z. F., & Kunkel, T. A. (2009) · Royal Society of Chemistry eBooks · doi:10.1039/9781847559852-00086 · Cited by 5 · see citing works

Effect of pH on the Misincorporation Rate of DNA Polymerase η

Nishimoto, N., Suzuki, M., & Izuta, S. (2016) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00900 · Cited by 4 · see citing works

Structures of human telomerase with BIBR1532 reveal novel mechanism of inhibition

Wang, Y., Liu, B., He, Y., & Feigon, J. F. (2026) · Nature Chemical Biology · doi:10.1038/s41589-026-02238-6 · Cited by 4 · see citing works

Enzymatic synthesis of ligand-bearing oligonucleotides for the development of metal-responsive DNA materials

Takezawa, Y., & Shionoya, M. (2024) · Organic & Biomolecular Chemistry · doi:10.1039/d4ob00947a · Cited by 4 · see citing works

DNA Replication Fidelity

Friedberg, E. C., & Fischhaber, P. L. (2006) · Encyclopedia of Life Sciences · doi:10.1038/npg.els.0006172 · Cited by 4 · see citing works

Master Molecule, Heal Thyself

Friedberg, E. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.x114.572115 · Cited by 3 · see citing works

Body Shaping under Water Stress: Osmosensing and Osmoregulation of Solute Transport in Bacteria

Morbach, S., & Krämer, R. (2002) · ChemBioChem · doi:10.1002/1439-7633(20020503)3:5 · Cited by 114 · see citing works

Eukaryotic error-prone DNA polymerases: The presumed roles in replication, repair, and mutagenesis

Krutyakov, V. M. (2006) · Molecular Biology · doi:10.1134/s0026893306010018 · Cited by 18 · see citing works

Bumps in the road: how replicative DNA polymerases see DNA damage

Hogg, M., Wallace, S. S., & Doublié, S. (2005) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2005.01.014 · Cited by 58 · see citing works

Bypassing Death

(2000) · Science · doi:10.1126/science.290.5491.409c

The anatomy of infidelity.

Ellenberger, T., & Silvian, L. F. (2001) · Nature Structural Biology · doi:10.1038/nsb1001-827 · Cited by 11 · see citing works