The DOI matches its Crossref record; 311 of the 311 references it cites were found in a registry or an index.
The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y
Abstract
This review aims to give a brief overview of NPY receptor distribution and physiology in the brain and summarizes series of studies, test by test and region by region, aimed at identification receptor subtypes and neuronal circuitry mediating anxiolytic-like effects of NPY. We conclude that from four known NPY receptor subtypes in the rat (Y(1), Y(2), Y(4), Y(5)), only the NPY Y(1) receptor can be linked to anxiety-regulation with certainty in the forebrain, and that NPY Y(2) receptor may have a role in the pons. Microinjection studies with NPY and NPY receptor antagonists support the hypothesis that the amygdala, the dorsal periaqueductal gray matter, dorsocaudal lateral septum and locus coeruleus form a neuroanatomical substrate that mediates anxiolytic-like effects of NPY. The release of NPY in these areas is likely phasic, as NPY receptor antagonists are silent on their own. However, constant NPY-ergic tone seems to exist in the dorsal periaqueductal gray, the only brain region where NPY Y(1) receptor antagonists had anxiogenic-like effects. We conclude that endogenous NPY has an important role in reducing anxiety and serves as a physiological stabilizer of neural activity in circuits involved in the regulation of arousal and anxiety.
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“From animal studies it is known that NPY mediates anxiolysis e.g. by inhibiting amygdalar activation and increasing calcineurin-induced synaptic remodelling in the basolateral amygdala (via the Y 1 receptor), counteracting the anxiogenic effect of CRH, reducing noradrenergic activity in the locus coeruleus and inhibiting excitatory neurotransmission in the dorsal periaqueductal grey (Kask et al.,”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Kask et al., 2002
In the citing paper
“NPY is the most abundant peptide in the brain and is expressed from the medullary brainstem to the cerebral cortex (for review, see [175]).”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [175]
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“Local injections of NPY agonists (Kask et al., 2002) and site-specific deletion of Y2 receptors in amygdaloid nuclei performed by our group demonstrated an important role of the amygdala in Y1 and Y2 receptor-mediated mechanisms of NPY on emotional behavior (Tasan et al., 2007).”
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Metadata
- Authors
- Kask, A., Harro, J., von Hörsten, S., Redrobe, J. P., Dumont, Y., & Quirion, R.
- Affiliations
- National Institute of Chemical Physics and Biophysics (EE)
- University of Tartu (EE)
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Kask, Ants
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 26
- Issue
- 3
- Pages
- 259-283
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W1987735575
- Cited by
- 358
- References
- 311
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 14 · 2023: 12 · 2022: 8 · 2021: 12 · 2020: 13 · 2019: 16 · 2018: 12 · 2017: 10 · 2016: 11 · 2015: 13 · 2014: 21 · 2013: 13 · 2012: 18
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neuropeptide Y, NPY receptors, Y1 receptor, Y2 receptor, Y4 receptor, Y5 receptor, anxiolytic effects, anxiety regulation, neurocircuitry, amygdala, dorsal periaqueductal gray, locus coeruleus, NPY receptor antagonists, arousal
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Brain, Brain Chemistry, Humans, Neuropeptide Y, Anti-Anxiety Agents, Receptors, Neuropeptide Y, Models, Animal
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