Cited by 358Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

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The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y

Kask, Ants, Harro, Jaanus, von Hörsten, Stephan, Redrobe, John P., Dumont, Yvan, Quirion, Rémi·2002·Neuroscience & Biobehavioral Reviews

DOI 10.1016/s0149-7634(01)00066-5

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Abstract

This review aims to give a brief overview of NPY receptor distribution and physiology in the brain and summarizes series of studies, test by test and region by region, aimed at identification receptor subtypes and neuronal circuitry mediating anxiolytic-like effects of NPY. We conclude that from four known NPY receptor subtypes in the rat (Y(1), Y(2), Y(4), Y(5)), only the NPY Y(1) receptor can be linked to anxiety-regulation with certainty in the forebrain, and that NPY Y(2) receptor may have a role in the pons. Microinjection studies with NPY and NPY receptor antagonists support the hypothesis that the amygdala, the dorsal periaqueductal gray matter, dorsocaudal lateral septum and locus coeruleus form a neuroanatomical substrate that mediates anxiolytic-like effects of NPY. The release of NPY in these areas is likely phasic, as NPY receptor antagonists are silent on their own. However, constant NPY-ergic tone seems to exist in the dorsal periaqueductal gray, the only brain region where NPY Y(1) receptor antagonists had anxiogenic-like effects. We conclude that endogenous NPY has an important role in reducing anxiety and serves as a physiological stabilizer of neural activity in circuits involved in the regulation of arousal and anxiety.

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Authors: Kask, A., Harro, J., von Hörsten, S., Redrobe, J. P., Dumont, Y., & Quirion, R.
Affiliations: National Institute of Chemical Physics and Biophysics (EE)
University of Tartu (EE)
Douglas Mental Health University Institute (CA)
Corresponding author: Kask, Ants
ORCID: Kask, Ants
Harro, Jaanus
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2002-05
Volume: 26
Issue: 3
Pages: 259-283
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/s0149-7634(01)00066-5
OpenAlex: W1987735575
Cited by: 358
References: 311
Citations by year: 2026: 6 · 2025: 12 · 2024: 14 · 2023: 12 · 2022: 8 · 2021: 12 · 2020: 13 · 2019: 16 · 2018: 12 · 2017: 10 · 2016: 11 · 2015: 13 · 2014: 21 · 2013: 13 · 2012: 18
FWCI: 2.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neuropeptide Y, NPY receptors, Y1 receptor, Y2 receptor, Y4 receptor, Y5 receptor, anxiolytic effects, anxiety regulation, neurocircuitry, amygdala, dorsal periaqueductal gray, locus coeruleus, NPY receptor antagonists, arousal
MeSH terms: Animals, Anxiety, Behavior, Animal, Brain, Brain Chemistry, Humans, Neuropeptide Y, Anti-Anxiety Agents, Receptors, Neuropeptide Y, Models, Animal

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The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y

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