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Cited by 150Stress Responses and CortisolSexual Differentiation and DisordersAdrenal Hormones and Disorders

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Neonatal sex hormones have `organizational' effects on the hypothalamic-pituitary-adrenal axis of male rats

McCormick, Cheryl M, Furey, Brinley F, Child, Meredith, Sawyer, Meghan J, Donohue, Sean M·1998·Developmental Brain Research
DOI 10.1016/s0165-3806(97)00155-7
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Abstract

Sex hormones have activational effects on the hypothalamic-pituitary-adrenal (HPA) axis in adulthood: For example, corticosterone release is influenced by gonadal status. These experiments investigated whether sex hormones have organizational effects on the HPA axis of male rats: Do sex hormones have relatively permanent effects on its development? In adults, both neonatal (neoGDX) and adult gonadectomy (adult GDX) resulted in elevated corticosterone (CORT) levels in response to stress compared to intact rats. Five days of testosterone propionate (TP) replacement was not as effective at attenuating CORT levels in neoGDX rats as in adult GDX rats. Neonatal GDX elevated corticosterone binding globulin (CBG) levels, whereas adult GDX was without effect. In Experiment 2 the effects of neonatal gonadectomy and neonatal treatment with either TP, estradiol benzoate (EB), or oil vehicle was examined. Despite 14 days of hormone replacement, neoGDX showed elevated CORT levels in response to stress compared to all other groups. A single neonatal dose of TP or EB in neoGDX rats eliminated the increased responsiveness. Neonatal TP and EB were without effect in sham-operated rats. Plasma CBG levels were elevated in neoGDX groups regardless of neonatal hormone treatment. Corticosteroid receptor binding levels were examined in various brain areas and the pituitary in two groups most different in their androgen experience: NeoGDX and shams that did not receive treatments as adults. NeoGDX had…

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Metadata

Authors
McCormick, C. M., Furey, B. F., Child, M., Sawyer, M. J., & Donohue, S. M.
Affiliations
Bates College (US)
Corresponding author
McCormick, Cheryl M
ORCID
McCormick, Cheryl M
Venue
Developmental Brain Research
Publisher
Elsevier BV
Published
1998-02
Volume
105
Issue
2
Pages
295-307
ISSN
0165-3806 (ISSN-L)
DOI
10.1016/s0165-3806(97)00155-7
OpenAlex
W2089554392
Cited by
150
References
4
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 4 · 2013: 3 · 2012: 4
FWCI
2.05
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Developmental Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Howard Hughes Medical Institute
  • Andrew W. Mellon Foundation
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
organizational effects, activational effects, sex hormones, hypothalamic-pituitary-adrenal axis, testosterone propionate, estradiol benzoate, corticosterone, glucocorticoid receptor, mineralocorticoid receptor, stress response, male rats, hormone replacement therapy
MeSH terms
Animals, Animals, Newborn, Corticosterone, Estrogens, Hypothalamo-Hypophyseal System, Male, Orchiectomy, Pituitary-Adrenal System, Receptors, Steroid, Sex Differentiation, Gonadal Steroid Hormones, Stress, Psychological, Testosterone, Transcortin, Rats

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