The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Features of skin-coincubated macrophages that promote recovery from spinal cord injury
Abstract
Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The macrophages express elevated levels of cell-surface molecules CD80, CD86, CD54 and MHC-II, markers characteristic of antigen presenting cells (APCs). Additionally, skin-coincubation elevates secretion of interleukin-1 beta (IL-1 beta) and Brain-Derived Neurotrophic Factor (BDNF), and reduces secretion of tumor necrosis factor alpha (TNF-alpha). We propose that macrophages activated by skin-coincubation bolster neuroprotective immune activity in the spinal cord, making the environment less cytotoxic and less hostile to axonal regeneration.
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“Additional experiments by the same group showed that skin derived macrophage populations also promoted functional recovery when injected into spinal cord lesions [133].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [133]
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Metadata
- Authors
- Bomstein, Y., Marder, J. B., Vitner, K., Smirnov, I., Lisaey, G., Butovsky, O., Fulga, V., & Yoles, E.
- Affiliations
- Weizmann Institute of Science (IL)
- Corresponding author
- Yoles, Eti
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 142
- Issue
- 1-2
- Pages
- 10-16
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W1986913334
- Cited by
- 155
- References
- 48
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 12 · 2013: 12 · 2012: 14
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- spinal cord injury, macrophages, antigen-presenting cells, CD80, CD86, MHC class II, IL-1β, brain-derived neurotrophic factor, TNF-α, motor recovery, neuroprotection, axon regeneration
- MeSH terms
- Animals, Antigen-Presenting Cells, Behavior, Animal, Macrophage Activation, Macrophages, Male, Motor Activity, Skin, Spinal Cord Injuries, Injections, Intralesional, Cytokines, Rats, Sprague-Dawley, Rats
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