Cited by 155Spinal Cord Injury ResearchNerve injury and regenerationNeuroinflammation and Neurodegeneration Mechanisms

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Features of skin-coincubated macrophages that promote recovery from spinal cord injury

Bomstein, Yonit, Marder, Jonathan B., Vitner, Karen, Smirnov, Igor, Lisaey, Galit, Butovsky, Oleg, Fulga, Valentin, Yoles, Eti·2003·Journal of Neuroimmunology

DOI 10.1016/s0165-5728(03)00260-1

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Abstract

Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The macrophages express elevated levels of cell-surface molecules CD80, CD86, CD54 and MHC-II, markers characteristic of antigen presenting cells (APCs). Additionally, skin-coincubation elevates secretion of interleukin-1 beta (IL-1 beta) and Brain-Derived Neurotrophic Factor (BDNF), and reduces secretion of tumor necrosis factor alpha (TNF-alpha). We propose that macrophages activated by skin-coincubation bolster neuroprotective immune activity in the spinal cord, making the environment less cytotoxic and less hostile to axonal regeneration.

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Authors: Bomstein, Y., Marder, J. B., Vitner, K., Smirnov, I., Lisaey, G., Butovsky, O., Fulga, V., & Yoles, E.
Affiliations: Weizmann Institute of Science (IL)
Corresponding author: Yoles, Eti
ORCID: Marder, Jonathan B.
Smirnov, Igor
Butovsky, Oleg
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 2003-09
Volume: 142
Issue: 1-2
Pages: 10-16
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/s0165-5728(03)00260-1
OpenAlex: W1986913334
Cited by: 155
References: 48
Citations by year: 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 12 · 2013: 12 · 2012: 14
FWCI: 6.80
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: spinal cord injury, macrophages, antigen-presenting cells, CD80, CD86, MHC class II, IL-1β, brain-derived neurotrophic factor, TNF-α, motor recovery, neuroprotection, axon regeneration
MeSH terms: Animals, Antigen-Presenting Cells, Behavior, Animal, Macrophage Activation, Macrophages, Male, Motor Activity, Skin, Spinal Cord Injuries, Injections, Intralesional, Cytokines, Rats, Sprague-Dawley, Rats

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Features of skin-coincubated macrophages that promote recovery from spinal cord injury

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