The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Features of skin-coincubated macrophages that promote recovery from spinal cord injury
Abstract
Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The macrophages express elevated levels of cell-surface molecules CD80, CD86, CD54 and MHC-II, markers characteristic of antigen presenting cells (APCs). Additionally, skin-coincubation elevates secretion of interleukin-1 beta (IL-1 beta) and Brain-Derived Neurotrophic Factor (BDNF), and reduces secretion of tumor necrosis factor alpha (TNF-alpha). We propose that macrophages activated by skin-coincubation bolster neuroprotective immune activity in the spinal cord, making the environment less cytotoxic and less hostile to axonal regeneration.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Additional experiments by the same group showed that skin derived macrophage populations also promoted functional recovery when injected into spinal cord lesions [133].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [133]
Citations
Cites
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats
BASSO, D. M., BEATTIE, M. S., & BRESNAHAN, J. C. (1995) · Journal of Neurotrauma · doi:10.1089/neu.1995.12.1 · Cited by 3,963
The many faces of macrophage activation
Mosser, D. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0602325 · Cited by 1,902
Basso, D. M., Beattie, M. S., & Bresnahan, J. C. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0098 · Cited by 1,470
Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats
Rapalino, O., Lazarov-Spiegler, O., Agranov, E., Velan, G. J., Yoles, E., Fraidakis, M., Soloman, A., Gepstein, R., Katz, A., Belkin, M., et al. (1998) · Nature Medicine · doi:10.1038/nm0798-814 · Cited by 788
Self-citationA Monitored Contusion Model of Spinal Cord Injury in the Rat
Gruner, J. A. (1992) · Journal of Neurotrauma · doi:10.1089/neu.1992.9.123 · Cited by 748
Popovich, P. G., Guan, Z., Wei, P. Y., Huitinga, I., van Rooijen, N., & Stokes, B. T. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7118 · Cited by 692
Secondary Cell Death and the Inflammatory Reaction After Dorsal Hemisection of the Rat Spinal Cord
Dusart, I., & Schwab, M. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00983.x · Cited by 567
Acute Inflammatory Response in Spinal Cord Following Impact Injury
Carlson, S. L., Parrish, M. E., Springer, J. E., Doty, K. D., & Dossett, L. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6785 · Cited by 495
Cited by
Sorted by citations
Therapeutic interventions after spinal cord injury
Thuret, S., Moon, L. D. F., & Gage, F. H. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1955 · Cited by 1,022
Donnelly, D. J., & Popovich, P. G. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.06.009 · Cited by 995
Brown, B. N., Ratner, B. D., Goodman, S. B., Amar, S., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.034 · Cited by 926
“promoted functional recovery when injected into spinal cord lesions [133].”
BackgroundShechter, R., London, A., Varol, C., Raposo, C., Cusimano, M., Yovel, G., Rolls, A., Mack, M., Pluchino, S., Martino, G., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000113 · Cited by 770
Spinal Cord Injury Scarring and Inflammation: Therapies Targeting Glial and Inflammatory Responses
Orr, M. B., & Gensel, J. C. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0631-6 · Cited by 596
Metadata
- Authors
- Bomstein, Y., Marder, J. B., Vitner, K., Smirnov, I., Lisaey, G., Butovsky, O., Fulga, V., & Yoles, E.
- Affiliations
- Weizmann Institute of Science (IL)
- Corresponding author
- Yoles, Eti
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 142
- Issue
- 1-2
- Pages
- 10-16
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W1986913334
- Cited by
- 155
- References
- 48
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 12 · 2013: 12 · 2012: 14
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- spinal cord injury, macrophages, antigen-presenting cells, CD80, CD86, MHC class II, IL-1β, brain-derived neurotrophic factor, TNF-α, motor recovery, neuroprotection, axon regeneration
- MeSH terms
- Animals, Antigen-Presenting Cells, Behavior, Animal, Macrophage Activation, Macrophages, Male, Motor Activity, Skin, Spinal Cord Injuries, Injections, Intralesional, Cytokines, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
