The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839

NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease

Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

Rajagopalan, S., Kurz, S. D., Münzel, T. F., Tarpey, M. M., Freeman, B. Α., Griendling, K. K., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118623 · Cited by 2,467

Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis

Galis, Z. S., & Khatri, J. J. (2002) · Circulation Research · doi:10.1161/res.90.3.251 · Cited by 1,965

Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly.

Galis, Z. S., & Khatri, J. J. (2002) · PubMed · Cited by 1,787

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652

Telmisartan Attenuates Colon Inflammation, Oxidative Perturbations and Apoptosis in a Rat Model of Experimental Inflammatory Bowel Disease

Arab, H. H., Al‐Shorbagy, M. Y., Abdallah, D. M., & Nassar, N. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097193 · Cited by 136

Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction

Qin, F., Simeone, M., & Patel, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.04.021 · Cited by 135

Role of mitochondria in angiotensin II-induced reactive oxygen species and mitogen-activated protein kinase activation

Zhang, G., LU, X., KIMURA, S., & Nishiyama, A. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.07.014 · Cited by 134

Modulation of the Inflammatory Response in Cardiovascular Disease

Granger, D. N., Vowinkel, T., & Petnehazy, T. (2004) · Hypertension · doi:10.1161/01.hyp.0000123070.31763.55 · Cited by 134

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model

Ongali, B., Nicolakakis, N., Tong, X., Aboulkassim, T., Papadopoulos, P., Rosa‐Neto, P., Lecrux, C., Imboden, H., & Hamel, É. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.04.018 · Cited by 135

The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells

Djordjevic, T., Pogrebniak, A., BelAiba, R. S., Bonello, S., Wotzlaw, C., Acker, H., Hess, J., & Görlach, A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.09.036 · Cited by 134

Treatment of Hypertension in Patients With Coronary Artery Disease

Rosendorff, C., Lackland, D. T., Allison, M., Aronow, W. S., Black, H. R., Blumenthal, R. S., Cannon, C. P., de Lemos, J. A., Elliott, W. J., Findeiss, L., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.02.038 · Cited by 135

Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke

Hong, H., Zeng, J.-S., Kreulen, D. L., Kaufman, D. I., & Chen, A. F. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01270.2005 · Cited by 131

Angiotensin II Type 1 Receptor Blockers Reduce Urinary Oxidative Stress Markers in Hypertensive Diabetic Nephropathy

Ogawa, S., Mori, T., Nako, K., KATO, T., Takeuchi, K., & Ito, S. (2006) · Hypertension · doi:10.1161/01.hyp.0000203826.15076.4b · Cited by 131

The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes

Youn, J. Y., Gao, L., & Cai, H. (2012) · Diabetologia · doi:10.1007/s00125-012-2557-6 · Cited by 128

Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease

Garrido‐Gil, P., Joglar, B., Rodriguez-Perez, A. I., Guerra, M. J., & Labandeira-García, J. L. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-38 · Cited by 127

Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone

Ding, Y., Chen, Z., Liu, S., Che, D., Vetter, M. L., & Chang, C. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357055119 · Cited by 127

Mitochondrial Pathophysiology, Reactive Oxygen Species, and Cardiovascular Diseases

Gao, L., Laude, K. M., & Cai, H. “. (2008) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2007.10.004 · Cited by 128

Redox regulation of Nox proteins

Pendyala, S., & Natarajan, V. (2010) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2010.09.016 · Cited by 128

Endothelium-derived Hyperpolarizing Factor

Bryan, R. M., You, J., Golding, E. M., & Marrelli, S. P. (2005) · Anesthesiology · doi:10.1097/00000542-200506000-00028 · Cited by 125

Regulation of NADPH Oxidase in Vascular Endothelium: The Role of Phospholipases, Protein Kinases, and Cytoskeletal Proteins

Pendyala, S., Usatyuk, P. V., Gorshkova, I. A., Garcia, J. G. N., & Natarajan, V. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2231 · Cited by 124

Nitrosative Stress and Its Association with Cardiometabolic Disorders

Pérez-Torres, I., Manzano-Pech, L., Rubio-Ruiz, M. E., Soto, M. E., & Guarner‐Lans, V. (2020) · Molecules · doi:10.3390/molecules25112555 · Cited by 129

Leptin Regulates Cardiomyocyte Contractile Function Through Endothelin-1 Receptor–NADPH Oxidase Pathway

Dong, F., Zhang, X., & Ren, J. T. (2005) · Hypertension · doi:10.1161/01.hyp.0000198555.51645.f1 · Cited by 123

Deletion of Angiotensin II Type 2 Receptor Exaggerated Atherosclerosis in Apolipoprotein E–Null Mice

Iwai, M., Chen, R., Li, Z., Shiuchi, T., Suzuki, J., Ide, A., Tsuda, M., Okumura, M., Min, L., Mogi, M., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.525550 · Cited by 123

Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification

Li, S., Du, ‬., Dolence, E. K., Fang, C. X., Mayer, G. E., Ceylan‐Isik, A. F., LaCour, K. H., Yang, X., Wilbert, C. J., Sreejayan, N., et al. (2005) · Aging Cell · doi:10.1111/j.1474-9728.2005.00146.x · Cited by 122

Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease

Sixt, S., Beer, S., Bluher, M., Korff, N., Peschel, T., Sonnabend, M., Teupser, D., Thiery, J., Adams, V., Schuler, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehp398 · Cited by 122

Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice

Al-Magableh, M., Kemp‐Harper, B. K., & Hart, J. L. (2014) · Hypertension Research · doi:10.1038/hr.2014.125 · Cited by 118

Role of Uncoupled Endothelial Nitric Oxide Synthase in Abdominal Aortic Aneurysm Formation

Gao, L., Siu, K. L., Chalupský, K., Nguyen, A. H., Chen, P., Weintraub, N. L., Galis, Z. S., & Cai, H. “. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.181644 · Cited by 118

Oxidative stress and hypertension

Harrison, D. G., Góngora, M. C., Guzik, T. J., & Widder, J. D. (2007) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2006.11.006 · Cited by 120

Enhanced mitochondrial superoxide in hyperglycemic endothelial cells: direct measurements and formation of hydrogen peroxide and peroxynitrite

Quijano, C., Castro, L., Peluffo, G., Valez, V., & Radí, R. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00761.2007 · Cited by 120

Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: A role for Nrf2 in vascular protection in diabetes

He, M., Siow, R. C. M., Sugden, D., Gao, L., Cheng, X., & Mann, G. E. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.12.008 · Cited by 116

Angiotensin-(1–7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K/Akt and MAPK/ERK signaling pathways

Zhang, F., Ren, X., Zhao, M., Zhou, B. R., & Han, Y. (2016) · Scientific Reports · doi:10.1038/srep34621 · Cited by 117

Aspirin-triggered lipoxin A4 blocks reactive oxygen species generation in endothelial cells: A novel antioxidative mechanism

Nascimento-Silva, V., Arruda, M. A., Barja‐Fidalgo, C., & Fierro, I. M. (2007) · Thrombosis and Haemostasis · doi:10.1160/th06-06-0315 · Cited by 117

An Ezrin/Calpain/PI3K/AMPK/eNOS s1179 Signaling Cascade Mediating VEGF-Dependent Endothelial Nitric Oxide Production

Youn, J. Y., Wang, T., & Cai, H. “. (2008) · Circulation Research · doi:10.1161/circresaha.108.178467 · Cited by 117

Nox1, 2, 4, 5: Counting out oxidative stress

Wingler, K., Hermans, J., Schiffers, P., Moens, A., Paul, M., & Schmidt, H. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01249.x · Cited by 113

Nox Activator 1

Niu, X.-L., Madamanchi, N. R., Vendrov, A. E., Tchivilev, I., Rojas, M., Madamanchi, C., Brandes, R. P., Krause, K. H., Humphries, J., Smith, A., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.908319 · Cited by 116

Endothelial delivery of antioxidant enzymes loaded into non-polymeric magnetic nanoparticles

Chorny, M., Hood, E. D., Levy, R. J., & Muzykantov, V. R. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.05.003 · Cited by 114

The human Nox4: gene, structure, physiological function and pathological significance

Guo, S., & Chen, X. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1036276 · Cited by 114

Atrial Fibrillation Therapy Now and in the Future

Woods, C. E., & Olgin, J. E. (2014) · Circulation Research · doi:10.1161/circresaha.114.302362 · Cited by 109

Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia.

Mann, G. E., Niehueser-Saran, J., Watson, A., Gao, L., Ishii, T., de Winter, P., & Siow, R. C. M. (2007) · PubMed · Cited by 111

Role of NADPH oxidase in the brain injury of intracerebral hemorrhage

Tang, J., Liu, J., Zhou, C., Ostanin, D. V., Grisham, M. B., Granger, D. N., & Zhang, J. H. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03292.x · Cited by 109

Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kγ-dependent manner

Awad, A., Kandalam, V., Chakrabarti, S., Wang, X., Penninger, J. M., Davidge, S. T., Oudit, G. Y., & Kassiri, Z. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00351.2009 · Cited by 109

Nox2, Ca 2+ , and Protein Kinase C Play a Role in Angiotensin II-Induced Free Radical Production in Nucleus Tractus Solitarius

Wang, G., Anrather, J., Glass, M. J., Tarsitano, M., Zhou, P., Frys, K. A., Pickel, V. M., & Iadecola, C. (2006) · Hypertension · doi:10.1161/01.hyp.0000236647.55200.07 · Cited by 109

Gene expression profiling of scrapie-infected brain tissue

Riemer, C., Neidhold, S., Burwinkel, M., Schwarz, A., Schultz, J., Krätzschmar, J., Mönning, U., & Baier, M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.124 · Cited by 108

EXPRESSION OF CONCERN: H2S‐donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: role of protein kinases A and G

Muzaffar, S., Jeremy, J. Y., Sparatore, A., Soldato, P. D., Angelini, G. D., & Shukla, N. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.326 · Cited by 108

Involvement of microglial RhoA/Rho-kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors

Villar-Cheda, B., Dominguez-Meijide, A., Joglar, B., Rodriguez-Perez, A. I., Guerra, M. J., & Labandeira-Garcia, J. L. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.04.010 · Cited by 104

Mechanisms of Homocysteine-Induced Glomerular Injury and Sclerosis

Yi, F., & Li, P. (2007) · American Journal of Nephrology · doi:10.1159/000110876 · Cited by 107

Salvianolic acid B from Salvia miltiorrhiza inhibits tumor necrosis factor-α (TNF-α)-induced MMP-2 upregulation in human aortic smooth muscle cells via suppression of NAD(P)H oxidase-derived reactive oxygen species

Zhang, H., & Wang, S. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.03.007 · Cited by 106

Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging

Olson, E. S., Orozco, J., Wu, Z. B., Malone, C. D., Yi, B.-H., Gao, W. F., Eghtedari, M., Wang, J., & Mattrey, R. F. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.06.055 · Cited by 106

Suppressing renal NADPH oxidase to treat diabetic nephropathy

Tojo, A., Asaba, K., & Onozato, M. L. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.8.1011 · Cited by 106

The Mosaic Theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension

Harrison, D. G. (2013) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2012.11.007 · Cited by 104

Mechanistic insights into folic acid-dependent vascular protection: Dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: A novel HPLC-based fluorescent assay for DHFR activity

Gao, L., Chalupský, K., Stefani, E., & Cai, H. “. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.07.025 · Cited by 105

Exogenous Hydrogen Sulfide Inhibits Superoxide Formation, NOX-1 Expression and Rac1 Activity in Human Vascular Smooth Muscle Cells

Muzaffar, S., Shukla, N., Bond, M., Newby, A. C., Angelini, G. D., Sparatore, A., Soldato, P. D., & Jeremy, J. Y. (2008) · Journal of Vascular Research · doi:10.1159/000129686 · Cited by 105

Angiotensin II Receptor Type 1-Mediated Vascular Oxidative Stress and Proinflammatory Gene Expression in Aldosterone-Induced Hypertension: The Possible Role of Local Renin-Angiotensin System

Hirono, Y., Yoshimoto, T., Suzuki, N., Sugiyama, T., Sakurada, M., Takai, S., Kobayashi, N., Shichiri, M., & Hirata, Y. (2007) · Endocrinology · doi:10.1210/en.2006-1157 · Cited by 105

Contribution of oxidative stress to pulmonary arterial hypertension

DeMarco, V. G. (2010) · World Journal of Cardiology · doi:10.4330/wjc.v2.i10.316 · Cited by 104

NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac muscle cells: Effects of apocynin

Qin, F., Patel, R., Chen, Y., & Liu, W. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.010 · Cited by 104

ROS-mediated platelet generation: a microenvironment-dependent manner for megakaryocyte proliferation, differentiation, and maturation

Chen, S., Su, Y., & Wang, J. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.253 · Cited by 105

Chemical and Biochemical Mechanisms Underlying the Cardioprotective Roles of Dietary Organopolysulfides

Tocmo, R., Liang, D., Lin, Y., & Huang, D. (2015) · Frontiers in Nutrition · doi:10.3389/fnut.2015.00001 · Cited by 102

Blockade of AT1 Receptor Reduces Apoptosis, Inflammation, and Oxidative Stress in Normotensive Rats with Intracerebral Hemorrhage

Jung, K., Chu, K., Lee, S., Kim, S.-J., Song, E., Kim, E., Park, D.-K., Sinn, D.-I., Kim, J., Kim, M., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.120097 · Cited by 102

Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFκB signaling via attenuating ROS generation

Kuo, W., Wang, W., Tsai, C., Way, C.-L., Hsu, H.-H., & Chen, L.-M. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.080 · Cited by 101

Hypertension, Angiotensin, and Stroke: Beyond Blood Pressure

Iadecola, C., & Gorelick, P. B. (2004) · Stroke · doi:10.1161/01.str.0000115162.16321.aa · Cited by 101

New roles for old pathways? A circuitous relationship between reactive oxygen species and cyclo-oxygenase in hypertension

Hernanz, R., Briones, A. M., Salaíces, M., & Alonso, M. J. (2013) · Clinical Science · doi:10.1042/cs20120651 · Cited by 100

D5dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure

Yang, Z., Asico, L. D., Yu, P., Wang, Z., Jones, J. E., Escano, C. S., Wang, X., Quinn, M. T., Sibley, D. R., Romero, G. G., et al. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00434.2005 · Cited by 98

ROS and PDFG-β receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration

Shimizu, H., Hirose, Y., Nishijima, F., Tsubakihara, Y., & Miyazaki, H. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00206.2009 · Cited by 100

Functional Role of NADPH Oxidase in Activation of Platelets

Chłopicki, S., Olszanecki, R., Janiszewski, M., Laurindo, F. R. M., Panz, T., & Międzobrodzki, J. (2004) · Antioxidants and Redox Signaling · doi:10.1089/1523086041361640 · Cited by 99

Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer’s disease

Canobbio, I., Abubaker, A. A., Visconte, C., Torti, M., & Pula, G. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00065 · Cited by 102

Chapter 14 Cerebral vascular dysregulation in the ischemic brain

(2008) · Handbook of Clinical Neurology · doi:10.1016/s0072-9752(08)01914-3 · Cited by 98

Aging-related changes in the nigral angiotensin system enhances proinflammatory and pro-oxidative markers and 6-OHDA-induced dopaminergic degeneration

Villar‐Cheda, B., Valenzuela, R., Rodriguez-Perez, A. I., Guerra, M. J., & Labandeira-García, J. L. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.08.006 · Cited by 98

Hydrogen Peroxide Inhibits Cytochrome P450 Epoxygenases

Larsen, B. T., Gutterman, D. D., Sato, A., Toyama, K., Campbell, W. B., Zeldin, D. C., Manthati, V. L., Falck, J. R., & Miura, H. (2007) · Circulation Research · doi:10.1161/circresaha.107.159129 · Cited by 98

Role of CaMKII in hydrogen peroxide activation of ERK1/2, p38 MAPK, HSP27 and actin reorganization in endothelial cells

Nguyen, A., Chen, P., & Cai, H. “. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.061 · Cited by 98

Differential upregulation of Nox homologues of NADPH oxidase by tumor necrosis factor‐α in human aortic smooth muscle and embryonic kidney cells

Moe, K. T., Aulia, S., Jiang, F., Chua, Y. L., Koh, T. H., Wong, M. C. S., & Dusting, G. J. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00304.x · Cited by 100

Nitric Oxide, NAD(P)H Oxidase, and Atherosclerosis

Müller, G. M., & Morawietz, H. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2403 · Cited by 98

CaM Kinase II-dependent pathophysiological signalling in endothelial cells

Cai, H. “., Liu, D., & Garcia, J. G. N. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm010 · Cited by 97

Oxidized Low-Density Lipoprotein Activates p66 Shc via Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1, Protein Kinase C-β, and c-Jun N-Terminal Kinase Kinase in Human Endothelial Cells

Shi, Y., Cosentino, F., Camici, G. G., Akhmedov, A., Vanhoutte, P. M., Tanner, F. C., & Lüscher, T. F. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.229260 · Cited by 99

NOX signaling in molecular cardiovascular mechanisms involved in the blood pressure homeostasis

Santillo, M., Colantuoni, A., Mondola, P., Guida, B., & Damiano, S. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00194 · Cited by 95

NADPH Oxidases and Their Role in Atherosclerosis

Poznyak, A. V., Grechko, A. V., Orekhova, V. A., Khotina, V. A., Ivanova, E. A., & Orekhov, A. N. (2020) · Biomedicines · doi:10.3390/biomedicines8070206 · Cited by 99

Nigral and striatal regulation of angiotensin receptor expression by dopamine and angiotensin in rodents: implications for progression of Parkinson’s disease

Villar‐Cheda, B., Rodríguez‐Pallares, J., Valenzuela, R., Muñoz, A., Guerra, M. J., Baltatu, O. C., & Labandeira-García, J. L. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07448.x · Cited by 92

Zinc and the Diabetic Heart

Song, Y., Wang, J., Li, X., & Cai, L. (2005) · BioMetals · doi:10.1007/s10534-005-3689-7 · Cited by 95

Effect of telmisartan on levels of IL ‐1, TNF ‐α, down‐regulated COX ‐2, MMP ‐2, MMP ‐9 and RANKL / RANK in an experimental periodontitis model

de Araújo, A. A., Souza, T. O., de Moura, L. M., Brito, G. A. D. C., Aragão, K. S., Araújo, L. D. S., de Medeiros, C. A. X., Alves, M. S. C. F., & Júnior, R. F. D. A. (2013) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12160 · Cited by 95

Role of Aβ-receptor for advanced glycation endproducts interaction in oxidative stress and cytosolic phospholipase A2 activation in astrocytes and cerebral endothelial cells

Askarova, S., Yang, X., Sheng, W., Sun, G. Y., & Lee, J. C.-M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.038 · Cited by 92

Protective Effects of Angiotensin II Interruption: Evidence for Antiinflammatory Actions

Dagenais, N. J., & Jamali, F. (2005) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.2005.25.9.1213 · Cited by 94

Angiotensin II Induces a Region-Specific Hyperplasia of the Ascending Aorta Through Regulation of Inhibitor of Differentiation 3

Owens, A. P., Subramanian, V., Moorleghen, J. J., Guo, Z., McNamara, C. A., Cassis, L. A., & Daugherty, A. (2009) · Circulation Research · doi:10.1161/circresaha.109.212837 · Cited by 97

Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat

Whaley‐Connell, A. T., Govindarajan, G., Habibi, J., Hayden, M. R., Cooper, S. A., Wei, Y., Ma, L., Qazi, M. A., Link, D. C., Karuparthi, P. R., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00632.2006 · Cited by 92

Diet‐induced obesity in Sprague–Dawley rats causes microvascular and neural dysfunction

Davidson, E. P., Coppey, L. J., Calcutt, N. A., Oltman, C. L., & Yorek, M. A. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1088 · Cited by 91

Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR

Briones, A. M., Tabet, F., Callera, G. E., Montezano, A. C. I., Yogi, Á., He, Y., Quinn, M. T., Salaíces, M., & Touyz, R. M. (2011) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2011.02.001 · Cited by 89

Noxa1 is a central component of the smooth muscle NADPH oxidase in mice

Ambasta, R. K., Schreiber, J. G., Janiszewski, M., Busse, R., & Brandes, R. P. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.12.035 · Cited by 89

Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications

Szabó, C. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2005.02.015 · Cited by 89

Targeting reactive oxygen species in hypertension

Cifuentes-Pagano, E., & Pagano, P. J. (2006) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000214776.19233.68 · Cited by 88

Asymmetric Dimethylarginine and Reactive Oxygen Species

Wilcox, C. S. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.187310 · Cited by 85

Reactive oxygen species mediate Endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells

Daou, G. B., & Srivastava, A. K. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.018 · Cited by 87

Insulin Generates Free Radicals by an NAD(P)H, Phosphatidylinositol 3′-Kinase-Dependent Mechanism in Human Skin Fibroblasts Ex Vivo

Ceolotto, G., Bevilacqua, M., Papparella, I., Baritono, E., Franco, L., Corvaja, C., Mazzoni, M., Semplicini, A., & Avogaro, A. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1344 · Cited by 87

Reactive oxygen species and erectile dysfunction: possible role of NADPH oxidase

Jeremy, J. Y., Jones, R. A., Koupparis, A. J., Hotston, M. R., Persad, R. A., Angelini, G. D., & Shukla, N. (2006) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901523 · Cited by 86

Oxidative Stress and Obesity: The Chicken or the Egg?

Aroor, A. R., & DeMarco, V. G. (2014) · Diabetes · doi:10.2337/db14-0424 · Cited by 85

Inhibition of ceramide–redox signaling pathway blocks glomerular injury in hyperhomocysteinemic rats

Yi, F., Zhang, A. Y., Li, N., Muh, R. W., Fillet, M., Renert, A.-F., & Li, P.-L. (2006) · Kidney International · doi:10.1038/sj.ki.5001517 · Cited by 85

Deletion of Protein Tyrosine Phosphatase 1b Improves Peripheral Insulin Resistance and Vascular Function in Obese, Leptin-Resistant Mice via Reduced Oxidant Tone

Ali, M. I., Ketsawatsomkron, P., de Chantemèle, E. J. B., MINTZ, J. D., Muta, K., Salet, C., Black, S. M., Tremblay, M. L., Fulton, D. J., Marrero, M. B., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.206318 · Cited by 85

Excess Salt Causes Cerebral Neuronal Apoptosis and Inflammation in Stroke-Prone Hypertensive Rats Through Angiotensin II-Induced NADPH Oxidase Activation

Yamamoto, E., Tamamaki, N., Nakamura, T., Kataoka, K., Tokutomi, Y., Dong, Y., Fukuda, M., Matsuba, S., Ogawa, H., & Kim‐Mitsuyama, S. (2008) · Stroke · doi:10.1161/strokeaha.108.517284 · Cited by 86

NOX isoforms in the development of abdominal aortic aneurysm

Siu, K. L., Li, Q., Zhang, Y., Guo, J. F., Youn, J. Y., Du, J., & Cai, H. “. (2016) · Redox Biology · doi:10.1016/j.redox.2016.11.002 · Cited by 84

The pathobiology of diabetic vascular complications—cardiovascular and kidney disease

Gray, S. P., & Jandeleit-Dahm, K. A. M. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1146-1 · Cited by 85

The Angiotensin II AT1Receptor Structure-Activity Correlations in the Light of Rhodopsin Structure

Oliveira, L., Costa-Neto, C. M., Nakaie, C. R., Schreier, S., Shimuta, S. I., & Paiva, A. C. M. (2007) · Physiological Reviews · doi:10.1152/physrev.00040.2005 · Cited by 84

Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice

Sugiyama, H., Kobayashi, M., Wang, D.-H., Sunami, R., Maeshima, Y., Yamasaki, Y., Masuoka, N., Kira, S., & Makino, H. (2005) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfi045 · Cited by 83

Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat

DeMarco, V. G., Habibi, J., Whaley‐Connell, A. T., Schneider, R. I., Heller, R. L., Bosanquet, J. P., Hayden, M. R., Delcour, K. S., Cooper, S. A., Andresen, B. T., et al. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00953.2007 · Cited by 82

Reactive oxygen species from NADPH oxidase contribute to altered pulmonary vascular responses in piglets with chronic hypoxia-induced pulmonary hypertension

Fike, C. D., Slaughter, J. C., Kaplowitz, M. R., Zhang, Y., & Aschner, J. L. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00047.2008 · Cited by 81

Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels

Pandey, D., Patel, A., Patel, V., Chen, F., Qian, J., Wang, Y., Barman, S. A., Venema, R. C., Stepp, D. W., Daniel Rudic, R., et al. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00910.2011 · Cited by 81

Triggering Mitochondrial Radical Release: A New Function for NADPH Oxidases

Brandes, R. P. (2005) · Hypertension · doi:10.1161/01.hyp.0000165019.32059.b2 · Cited by 79

Adventitial growth factor signalling and vascular remodelling: Potential of perivascular gene transfer from the outside-in

Siow, R., & Churchman, A. T. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.06.007 · Cited by 80

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

Drummond, G. R., Selemidis, S., Griendling, K. K., & Sobey, C. G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3403 · Cited by 899

Vascular NAD(P)H oxidases: specific features, expression, and regulation

Lassegue, B. P., & Clempus, R. E. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00758.2002 · Cited by 1,026

Delineating the NOX-Mediated Promising Therapeutic Strategies for the Management of Various Cardiovascular Disorders: A Comprehensive Review

Upadhyay, R. K., Kumar, K., Vishwakarma, V. K., Singh, N., Narang, R., Parakh, N., Yadav, M., Yadav, S., Kumar, S., Goyal, A., et al. (2024) · Current Vascular Pharmacology · doi:10.2174/0115701611308870240910115023 · Cited by 6

NADPH Oxidases in Cardiovascular Health and Disease

Cave, A. C., Brewer, A. C., Narayanapanicker, A., Ray, R., Grieve, D. J., Walker, S., & Shah, A. M. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.691 · Cited by 630

NADPH oxidases in the vasculature: Molecular features, roles in disease and pharmacological inhibition

Selemidis, S., Sobey, C. G., Wingler, K., Schmidt, H. H. H. W., & Drummond, G. R. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.08.005 · Cited by 249