The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839

NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease

Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

Rajagopalan, S., Kurz, S. D., Münzel, T. F., Tarpey, M. M., Freeman, B. Α., Griendling, K. K., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118623 · Cited by 2,467

Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis

Galis, Z. S., & Khatri, J. J. (2002) · Circulation Research · doi:10.1161/res.90.3.251 · Cited by 1,965

Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly.

Galis, Z. S., & Khatri, J. J. (2002) · PubMed · Cited by 1,787

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652

Transcriptional regulation of the NADPH oxidase isoform, Nox1, in colon epithelial cells: Role of GATA-binding factor(s)

Brewer, A. C., Sparks, E., & Shah, A. M. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.022 · Cited by 51

EXPRESSION OF CONCERN: Superoxide from NADPH oxidase upregulates type 5 phosphodiesterase in human vascular smooth muscle cells: inhibition with iloprost and NONOate

Muzaffar, S., Shukla, N., Bond, M., Sala‐Newby, G. B., Newby, A. C., Angelini, G. D., & Jeremy, J. Y. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.300 · Cited by 49

NADPH oxidase subunits (NOX-1, p22phox, Rac-1) and tacrolimus-induced nephrotoxicity in a rat renal transplant model

Khanna, A. K., & Pieper, G. M. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl608 · Cited by 49

New Triterpenoid Saponins from Ilex cornuta and Their Protective Effects against H2O2-Induced Myocardial Cell Injury

Li, S., Zhao, J., Liu, Y., Chen, Z., Xu, Q., Khan, I. A., & Yang, S. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4046667 · Cited by 48

Low-Density Lipoprotein Cholesterol Determines Oxidative Stress and Endothelial Dysfunction in Saphenous Veins From Patients With Coronary Artery Disease

Al‐Benna, S., Hamilton, C., McClure, J., Rogers, P. N., Berg, G. A., Ford, I., Delles, C., & Dominiczak, A. F. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000193626.22269.45 · Cited by 47

Vitamin B6 Compounds are Capable of Reducing the Superoxide Radical and Lipid Peroxide Levels Induced by H2O2 in Vascular Endothelial Cells in Culture

Mahfouz, M. M., Zhou, S. Q., & Kummerow, F. A. (2009) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.79.4.218 · Cited by 45

Endodontic Infection and Endothelial Dysfunction Are Associated with Different Mechanisms in Men and Women

Cotti, E., Zedda, A. M., Deidda, M., Piras, A., Flore, G., Ideo, F., Madeddu, C., Pau, V., & Mercuro, G. G. (2015) · Journal of Endodontics · doi:10.1016/j.joen.2015.01.037 · Cited by 46

Dextromethorphan reduces oxidative stress and inhibits atherosclerosis and neointima formation in mice

Liu, S., Li, Y., Shi, G. Y., Tang, S., Jiang, S., Huang, C., Liu, P., Hong, J., & Wu, H. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp043 · Cited by 48

Role of Oxidative Stress in Remodeling of the Myocardial Microcirculation in Hypertension

Zhu, X.-Y., Daghini, E., Chade, A., Rodriguez-Porcel, M. G., Claudio Napoli, A., Lerman, A., & Lerman, L. O. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000227469.40826.01 · Cited by 44

Effects of Valsartan or Amlodipine on Endothelial Function and Oxidative Stress after One Year Follow-up in Patients with Essential Hypertension

Hirooka, Y., Kimura, Y., Sagara, Y., Ito, K., & Sunagawa, K. (2008) · Clinical and Experimental Hypertension · doi:10.1080/10641960802071000 · Cited by 45

Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress

Oishi, P. E., Wiseman, D. A., Sharma, S., Kumar, S., Hou, Y., Datar, S. A., Azakie, A., Johengen, M. J., Harmon, C., Fratz, S., et al. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00146.2007 · Cited by 45

NADPH oxidase-2 inhibition restores contractility and intracellular calcium handling and reduces arrhythmogenicity in dystrophic cardiomyopathy

González, D. R., Treuer, A. V., Lamirault, G., Mayo, V., Cao, Y., Dulce, R. A., & Hare, J. M. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00890.2013 · Cited by 45

Effect of tempol on altered angiotensin II and acetylcholine-mediated vascular responses in thoracic aorta isolated from rats with insulin resistance

Viswanad, B., Srinivasan, K. K., Kaul, C. L., & Ramarao, P. (2006) · Pharmacological Research · doi:10.1016/j.phrs.2005.11.002 · Cited by 45

Oxidative and nitrosative stress in pediatric pulmonary hypertension: Roles of endothelin-1 and nitric oxide

Black, S. M., & Fineman, J. R. (2006) · Vascular Pharmacology · doi:10.1016/j.vph.2006.08.005 · Cited by 45

The NADPH oxidase inhibitor apocynin induces nitric oxide synthesis via oxidative stress

Riganti, C., Costamagna, C., Doublier, S., Miraglia, E., Polimeni, M., Bosìa, A., & Ghigo, D. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.12.013 · Cited by 45

Procyanidins from grape pomace are suitable inhibitors of human endothelial NADPH oxidase

Álvarez, E., Rodiño‐Janeiro, B. K., Jerez, M., Ucieda‐Somoza, R., Núñez, M. J., & González‐Juanatey, J. R. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24011 · Cited by 45

Protective effect of telmisartan against cadmium-induced nephrotoxicity in mice

Fouad, A. A., & Jresat, I. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.04.019 · Cited by 44

Neuroprotective Effects of Apocynin and Galantamine During the Chronic Administration of Scopolamine in an Alzheimer’s Disease Model

Joseph, E., Villalobos-Acosta, D. M. Á., Torres-Ramos, M., Farfán‐García, E. D., Gómez‐López, M., Miliar-García, Á., Fragoso-Vázquez, M. J., García-Marín, I. D., Correa‐Basurto, J., & Rosales‐Hernández, M. C. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01426-5 · Cited by 44

Expression of mRNA for ROS-generating NADPH oxidases in the aging stomach

Salles, N., Szántó, I., Herrmann, F. R., Armenian, B., STUMM, M., STAUFFER, E., MICHEL, J., & KRAUSE, K. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.01.007 · Cited by 44

Fibroblast growth factor 18 alleviates stress-induced pathological cardiac hypertrophy in male mice

Chen, G., An, N., Shen, J., Chen, H., Chen, Y., Sun, J. M., Hu, Z., Qiu, J., Jin, C., He, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36895-1 · Cited by 43

Telmisartan treatment attenuates arsenic-induced hepatotoxicity in mice

Fouad, A. A., Al-Mulhim, A. S., & Jresat, I. (2012) · Toxicology · doi:10.1016/j.tox.2012.06.015 · Cited by 43

Toll-Like Receptor 2 (TLR2) Knockout Abrogates Diabetic and Obese Phenotypes While Restoring Endothelial Function via Inhibition of NOX1

Guo, Z., Zhang, Y., Liu, C., Youn, J. Y., & Cai, H. “. (2021) · Diabetes · doi:10.2337/db20-0591 · Cited by 44

Angiotensin II Type 1 Receptor Antagonist and Angiotensin-Converting Enzyme Inhibitor Altered the Activation of Cu/Zn-Containing Superoxide Dismutase in the Heart of Stroke-Prone Spontaneously Hypertensive Rats

Tanaka, M., Umemoto, S., Kawahara, S., Kubo, M., Shinichi, I. T. O. H., Umeji, K., & Matsuzaki, M. (2005) · Hypertension Research · doi:10.1291/hypres.28.67 · Cited by 43

Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations

Ngo, D. T. M., Stafford, I., Sverdlov, A. L., Qi, W., Wuttke, R. D., Zhang, Y., Kelly, D. J., Weedon, H., Smith, M., Kennedy, J. A., et al. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01084.x · Cited by 42

Atorvastatin and sildenafil lower blood pressure and improve endothelial dysfunction, but only atorvastatin increases vascular stores of nitric oxide in hypertension

Guimarães, D. A., Rizzi, É., Ceron, C. S., Pinheiro, L. C., Gerlach, R. F., & Tanus-Santos, J. E. (2013) · Redox Biology · doi:10.1016/j.redox.2013.11.004 · Cited by 42

Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress

Siu, K. L., Gao, L., & Cai, H. “. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.713149 · Cited by 44

Evidence Against a Role for NADPH Oxidase Modulating Hepatic Vascular Tone in Cirrhosis

Gracia‐Sancho, J., Laviña, B., Rodrı́guez-Vilarrupla, A., Brandes, R. P., Fernández, M., Bosch, J., & García‐Pagán, J. C. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.021 · Cited by 42

Free radicals and antioxidants in cardiovascular diseases

Abrescia, P., & Golino, P. (2005) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.3.1.159 · Cited by 42

Apocynin normalizes hyperreactivity to phenylephrine in mesenteric arteries from cholesterol-fed mice by improving endothelium-derived hyperpolarizing factor response

Matsumoto, T., Miyamori, K., Kobayashi, T., & Kamata, K. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.07.012 · Cited by 42

Molecular pathology of aging and its implications for senescent coronary atherosclerosis

McEwen, J. E., Zimniak, P., Mehta, J. L., & Reis, R. J. S. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000175517.50181.89 · Cited by 41

Periodontal Pathogen Accelerates Lipid Peroxidation and Atherosclerosis

Jia, R., Kurita‐Ochiai, T., Oguchi, S., & Yamamoto, M. (2013) · Journal of Dental Research · doi:10.1177/0022034513475625 · Cited by 41

Endothelial Dysfunction in Rat Mesenteric Resistance Artery after Transient Middle Cerebral Artery Occlusion

Martínez‐Revelles, S., Jiménez‐Altayó, F., Caracuel, L., Pérez-Asensio, F. J., Planas, A. M., & Vila, E. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.134619 · Cited by 40

Candesartan reduces superoxide production after global cerebral ischemia

Sugawara, T., Kinouchi, H., Oda, M., Shoji, H., Omae, T., & Mizoi, K. (2005) · Neuroreport · doi:10.1097/00001756-200503150-00004 · Cited by 41

Vascular NAD(P)H oxidase mediates endothelial dysfunction in basilar arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats

Matsumoto, T., Kobayashi, T., Wachi, H., Seyama, Y., & Kamata, K. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.06.005 · Cited by 41

The pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity

Kiss, L., & Szabó, C. (2005) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762005000900007 · Cited by 41

Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization

Delpón, E., Caballero, R., Gómez, R. J., Núñez, L., & Tamargo, J. L. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.01.006 · Cited by 41

Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2/ET-1 axis-controlled ERK1/2 pathway

Shi, X., Li, P., Herb, M., Liu, H., Wang, M., Wang, X., Feng, Y., van Beers, T., Xia, N., Li, H., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03075-x · Cited by 43

Nephroprotective Effect of Telmisartan in Rats with Ischemia/Reperfusion Renal Injury

Fouad, A. A., Qureshi, H. A., Al‐Sultan, A. I., Yacoubi, M. T., & Al-Melhim, W. N. (2010) · Pharmacology · doi:10.1159/000269779 · Cited by 40

An update on ACE2 amplification and its therapeutic potential

Márquez, A., Wysocki, J. A., Pandit, J. A., & BATLLE, D. C. (2020) · Acta Physiologica · doi:10.1111/apha.13513 · Cited by 40

Regulation of TRPML1 channel activity and inflammatory exosome release by endogenously produced reactive oxygen species in mouse podocytes

Li, G., Huang, D., Li, N., Ritter, J. K., & Li, P. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102013 · Cited by 41

The Effect of Social Environment on Markers of Vascular Oxidative Stress and Inflammation in the Watanabe Heritable Hyperlipidemic Rabbit

Nation, D. A., Gonzales, J. A., Mendez, A. J., Zaias, J., Szeto, A., Brooks, L. G., Paredes, J., D’Angola, A., Schneiderman, N., & McCabe, P. M. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181646753 · Cited by 39

Potentially Reduced Exposure Cigarettes Accelerate Atherosclerosis: Evidence for the Role of Nicotine

Catanzaro, D. F., Zhou, Y. Y., Chen, R., Yu, F., Catanzaro, S., Lorenzo, M. S. D., Subbaramaiah, K., Zhou, X. K., Praticò, D., Dannenberg, A. J., et al. (2007) · Cardiovascular Toxicology · doi:10.1007/s12012-007-0027-z · Cited by 39

Preventive Effects of Nutritional Doses of Polyphenolic Molecules on Cardiac Fibrosis Associated with Metabolic Syndrome: Involvement of Osteopontin and Oxidative Stress

Sutra, T., Oiry, C., Azay, J., Youl, E., Magous, R., Teissèdre, P., Cristol, J., & Cros, G. H. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf802357g · Cited by 39

Angiotensin II type 1 receptor blocker attenuates the activation of ERK and NADPH oxidase by mechanical strain in mesangial cells in the absence of angiotensin II

Yatabe, J., Sanada, H., Yatabe, M., Hashimoto, S., Yoneda, M., Felder, R. A., José, P. A., & Watanabe, T. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00580.2007 · Cited by 39

Targeted Interception of Signaling Reactive Oxygen Species in the Vascular Endothelium

Han, J., Shuvaev, V. V., & Muzykantov, V. R. (2012) · Therapeutic Delivery · doi:10.4155/tde.11.151 · Cited by 39

Potential Biomarkers in Diabetic Retinopathy

Adki, K. M., & Kulkarni, Y. A. (2020) · Current Diabetes Reviews · doi:10.2174/1573399816666200217092022 · Cited by 39

Interleukin-10 counteracts impaired endothelium-dependent relaxation induced by ANG II in murine aortic rings

Zemse, S. M., Hilgers, R. H. P., & Webb, R. C. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00456.2006 · Cited by 39

Therapeutic potential of the epidermal growth factor receptor transactivation in hypertension: a convergent signaling pathway of vascular tone, oxidative stress, and hypertrophic growth downstream of vasoactive G-protein-coupled receptors?This paper is one of a selection of papers published in this Special Issue, entitled Young Investigators' Forum.

Fernández-Patrón, C. (2007) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y06-097 · Cited by 39

Contribution of Vascular NAD(P)H Oxidase to Endothelial Dysfunction in Heart Failure and the Therapeutic Effects of HMG-CoA Reductase Inhibitor

Takayama, T., Wada, A., Tsutamoto, T., Ohnishi, M., Fujii, M., Isono, T., & Horie, M. (2004) · Circulation Journal · doi:10.1253/circj.68.1067 · Cited by 39

Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo

Noguchi, K., Hamadate, N., Matsuzaki, T., Sakanashi, M., Nakasone, J., Uchida, T., Arakaki, K., Kubota, H., Ishiuchi, S., Masuzaki, H., et al. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01089.2010 · Cited by 38

Redox regulation of gasotransmission in the vascular system: A focus on angiogenesis

Mistry, R. K., & Brewer, A. C. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.025 · Cited by 37

Renin angiotensin system and gender differences in dopaminergic degeneration

Rodriguez-Perez, A. I., Valenzuela, R., Joglar, B., Garrido‐Gil, P., Guerra, M. J., & Labandeira-García, J. L. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-58 · Cited by 38

Nox-generated ROS modulate glucose uptake in a leukaemic cell line

Prata, C., Maraldi, T., Fiorentini, D., Zambonin, L., Hakim, G., & Landi, L. (2008) · Free Radical Research · doi:10.1080/10715760802047344 · Cited by 38

Abnormal nitric oxide production in aged rat mesenteric arteries is mediated by NAD(P)H oxidase-derived peroxide

Zhou, X., Bohlen, H. G., Unthank, J. L., & Miller, S. J. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00325.2009 · Cited by 38

Primed Polymorphonuclear Leukocytes, Oxidative Stress, and Inflammation Antecede Hypertension in the Sabra Rat

Sela, S., Mazor, R., Amsalam, M., Yagil, C., Yagil, Y., & Kristal, B. (2004) · Hypertension · doi:10.1161/01.hyp.0000144480.10207.34 · Cited by 38

8-Hydroxy-2-deoxyguanosine prevents plaque formation and inhibits vascular smooth muscle cell activation through Rac1 inactivation

Huh, J. Y., Son, D. J., Lee, Y., Lee, J., Kim, B., Lee, H. M., Jo, H., Choi, S., Ha, H., & Chung, M.-H. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.023 · Cited by 39

Pretreatment with Astragaloside IV protects human umbilical vein endothelial cells from hydrogen peroxide induced oxidative stress and cell dysfunction via inhibiting eNOS uncoupling and NADPH oxidase – ROS – NF-κB pathway

Xu, C., Tang, F., Lü, M., Yang, J., Han, R., Mei, M., Hu, J., & Wang, H. (2016) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0572 · Cited by 37

Upregulation of Intermediate-Conductance Ca2+-Activated K+ Channels (KCNN4) in Porcine Coronary Smooth Muscle Requires NADPH Oxidase 5 (NOX5)

Gole, H. K. A., Tharp, D. L., & Bowles, D. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105337 · Cited by 36

Intracranial Atherosclerotic Disease and Incident Dementia: The ARIC Study (Atherosclerosis Risk in Communities)

Zhao, D., Güallar, E., Qiao, Y., Knopman, D. S., Palatino, M. C., Gottesman, R. F., Mosley, T. H., & Wasserman, B. A. (2024) · Circulation · doi:10.1161/circulationaha.123.067003 · Cited by 39

Vascular Protection in Brain Ischemia

Rodríguez‐Yáñez, M., Castellanos, M., Blanco, M., Mosquera, E., & Castillo, J. (2006) · Cerebrovascular Diseases · doi:10.1159/000091700 · Cited by 36

Fibroblast-to-myofibroblast switch is mediated by NAD(P)H oxidase generated reactive oxygen species

Alili, L., Sack, M., Puschmann, K., & Brenneisen, P. (2013) · Bioscience Reports · doi:10.1042/bsr20130091 · Cited by 36

Effects of chronic insulin on endothelial dysfunction of basilar arteries from established streptozotocin-diabetic rats

Matsumoto, T., Yoshiyama, S., Wakabayashi, K., Kobayashi, T., & Kamata, K. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.09.044 · Cited by 35

Delayed preconditioning prevents ischemia/reperfusion-induced endothelial injury in rats: role of ROS and eNOS

He, X., Zhao, M. F., Bi, X., Yu, X., & Zang, W. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.160 · Cited by 35

Comparative effects ofN-acetyl- l -cysteine and ramipril on arterial hypertension, insulin resistance, and oxidative stress in chronically glucose-fed rats

Midaoui, A. E., Ismael, M. A., Lu, H., Fantus, I. G., de Champlain, J., & Couture, R. (2008) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y08-090 · Cited by 35

Short-term pretreatment with low-dose hydrogen peroxide enhances the efficacy of bone marrow cells for therapeutic angiogenesis

Kubo, M., Li, T., Suzuki, R., Ohshima, M., Qin, S., & Hamano, K. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00786.2006 · Cited by 35

Increased superoxide anion production is associated with early atherosclerosis and cardiovascular dysfunctions in a rabbit model

Collin, B., Busseuil, D., Zeller, M., Perrin‐Sarrado, C., Barthez, O., Duvillard, L., Vergely, C., Bardou, M., Dumas, M., Cottin, Y., et al. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-9263-y · Cited by 35

Rutaecarpine prevents hypoxia–reoxygenation-induced myocardial cell apoptosis via inhibition of NADPH oxidases

Bao, M., Dai, W., Li, Y., & Hu, C.-P. (2011) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y11-006 · Cited by 35

Nicotinamide Adenine Dinucleotide Phosphate Oxidase: A Promiscuous Therapeutic Target for Cardiovascular Drugs?

Muzaffar, S., Shukla, N., & Jeremy, J. Y. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.09.001 · Cited by 35

Captopril and telmisartan treatments attenuate cadmium‐induced testicular toxicity in rats

Fouad, A. A., & Jresat, I. (2011) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2011.00974.x · Cited by 34

Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration

Fouad, A. A., Al‐Sultan, A. I., Yacoubi, M. T., & Gomaa, W. M. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.04.007 · Cited by 34

Effects of combined radiofrequency radiation exposure on levels of reactive oxygen species in neuronal cells

Kang, K. A., Lee, H. C., Lee, J., Mi-Na, H. O. N. G., Park, M.-J., Lee, Y., Choi, H. D., Kim, N., Ko, Y.-G., & Lee, J. (2013) · Journal of Radiation Research · doi:10.1093/jrr/rrt116 · Cited by 34

Cocoa, diabetes, and hypertension: should we eat more chocolate?

Fraga, C. G. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.3.541 · Cited by 34

Anthrax Lethal Toxin Suppresses Murine Cardiomyocyte Contractile Function and Intracellular Ca2+ Handling via a NADPH Oxidase-Dependent Mechanism

Kandadi, M. R., Hua, Y., Ma, H., Li, Q., Kuo, S.-R., Frankel, A. E., & Ren, J. T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013335 · Cited by 33

Hypertension in an Animal Model of HELLP Syndrome is Associated With Activation of Endothelin 1

Morris, R., Spencer, S., Kyle, P. B., Williams, J. M., Harris, A., Owens, M. Y., & Wallace, K. L. (2015) · Reproductive Sciences · doi:10.1177/1933719115592707 · Cited by 33

Subcellular localization of nicotinamide adenine dinucleotide phosphate oxidase subunits in neurons and astroglia of the rat medial nucleus tractus solitarius: Relationship with tyrosine hydroxylase immunoreactive neurons

Glass, M. J., Huang, J., Oselkin, M., Tarsitano, M., Wang, G., Iadecola, C., & Pickel, V. M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.051 · Cited by 31

Pulmonary Endothelial Cell NOX

Damico, R. L., Zulueta, J. J., & Hassoun, P. M. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0331rt · Cited by 32

Novel Concept in the Mechanism of Injury and Protection of Gastric Mucosa: Role of Renin-Angiotensin System and Active Metabolites of Angiotensin

Brzozowski, T., Ptak‐Belowska, A., Kwiecień, S., Krzysiek-Mączka, G., Strzałka, M., Drozdowicz, D., Pajdo, R., Olszanecki, R., Korbut, R., Konturek, S. J., et al. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712803413953 · Cited by 33

NAD(P)H oxidase in paraventricular nucleus contributes to the effect of angiotensin II on cardiac sympathetic afferent reflex

Zhang, Y., Yang, Y., Zhang, F., Zhong, M., Shi, Z., Gao, X.-Y., Wang, W., & Zhu, G. (2006) · Brain Research · doi:10.1016/j.brainres.2006.01.113 · Cited by 33

Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension

Youn, J. Y., Wang, T., Blair, J., Laude, K. M., Oak, J., McCann, L. A., Harrison, D. G., & Cai, H. “. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00835.2011 · Cited by 32

Deficiency of Nox2 prevents angiotensin II-induced inward remodeling in cerebral arterioles

Chan, S., & Baumbach, G. L. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00133 · Cited by 32

Superoxide auto-augments superoxide formation and upregulates gp91phox expression in porcine pulmonary artery endothelial cells: Inhibition by iloprost

Muzaffar, S., Shukla, N., Angelini, G. D., & Jeremy, J. Y. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.03.047 · Cited by 32

Angiotensin-(1–7) blocks the angiotensin II-stimulated superoxide production

Polizio, A. H., Gironacci, M. M., Tomaro, M. L., & Peña, C. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.04.004 · Cited by 32

Zinc pyrithione salvages reperfusion injury by inhibiting NADPH oxidase activation in cardiomyocytes

Kasi, V., Bodiga, S., Kommuguri, U. N., Sankuru, S., & Bodiga, V. L. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.05.130 · Cited by 32

Superoxide anions involved in sympathoexcitation and pressor effects of salusin‐β in paraventricular nucleus in hypertensive rats

Sun, H., Zhang, L., Fan, Z. ‐., Chen, D., Zhang, L., Gao, X., Kang, Y., & Zhu, G. (2013) · Acta Physiologica · doi:10.1111/apha.12188 · Cited by 31

Potential role of antioxidants in the treatment of portal hypertension

Rodrı́guez-Vilarrupla, A., Bosch, J., & García‐Pagán, J. C. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.11.008 · Cited by 30

Protective effects of captopril in diabetic rats exposed to ischemia/reperfusion renal injury

Fouad, A. A., Al-Mulhim, A. S., Jresat, I., & Morsy, M. A. (2012) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2012.01585.x · Cited by 30

Angiotensin II-triggered kinase signaling cascade in the central nervous system

Bali, A., & Jaggi, A. S. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0041 · Cited by 30

12/15-Lipoxygenase Contributes to Platelet-derived Growth Factor-induced Activation of Signal Transducer and Activator of Transcription 3

Blažević, T., Schwaiberger, A. V., Schreiner, C. E., Schachner, D., Schaible, A. M., Grojer, C. S., Atanasov, A. G., Werz, O., Dirsch, V. M., & Heiß, E. H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.489013 · Cited by 30

Acute inhibition of superoxide formation and Rac1 activation by nitric oxide and iloprost in human vascular smooth muscle cells in response to the thromboxane A2 analogue, U46619

Muzaffar, S., Shukla, N., Bond, M., Sala‐Newby, G. B., Angelini, G. D., Newby, A. C., & Jeremy, J. Y. (2008) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2008.01.008 · Cited by 30

Effects of resveratrol and flavonols on cardiovascular function: Physiological mechanisms

Yap, S., Qin, C. X., & Woodman, O. L. (2010) · BioFactors · doi:10.1002/biof.111 · Cited by 30

Xanthine Oxidase Interaction with Vascular Endothelial Growth Factor in Human Endothelial Cell Angiogenesis

Kou, B., Ni, J., Vatish, M., & Singer, D. R. J. (2008) · Microcirculation · doi:10.1080/10739680701651495 · Cited by 30

N-Ethylmaleimide-sensitive factor: a redox sensor in exocytosis

Lowenstein, C. J., & Tsuda, H. (2006) · Biological Chemistry · doi:10.1515/bc.2006.173 · Cited by 30

Inflammation induced changes in arachidonic acid metabolism in cat LES circular muscle

Cheng, L., Cao, W., Behar, J., Biancani, P., & Harnett, K. M. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00327.2004 · Cited by 30

Increased Circulating Levels of 3-Nitrotyrosine Autoantibodies

Daiber, A., & Münzel, T. F. (2012) · Circulation · doi:10.1161/circulationaha.112.143214 · Cited by 30

Therapeutic Challenges and Emerging Treatment Targets for Pulmonary Hypertension in Left Heart Disease

Lteif, C., Ataya, A., & Duarte, J. D. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.020633 · Cited by 29

Are we over oxidized? Oxidative stress, cardio-vascular disease, and the future of intervention studies with antioxidants

Dusting, G. J., & Triggle, C. R. (2005) · Vascular Health and Risk Management · doi:10.2147/vhrm.1.2.93.64080 · Cited by 30

Salusin-β in rostral ventrolateral medulla increases sympathetic outflow and blood pressure via superoxide anions in hypertensive rats

Zhang, L., Ding, L., Zhang, F., Gao, R., Chen, Q., Li, Y., Kang, Y., & Zhu, G. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000143 · Cited by 29

Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers

Halıcı, Z., Polat, B., Çadırcı, E., Topçu, A., Karakuş, E., Köse, D., Albayrak, A., & Bayır, Y. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.09.011 · Cited by 29

Novel Treatment of Hypertension by Specifically Targeting E2F for Restoration of Endothelial Dihydrofolate Reductase and eNOS Function Under Oxidative Stress

Li, H., Li, Q., Zhang, Y., Liu, W., Gu, B., Narumi, T., Siu, K. L., Youn, J. Y., Liu, P., Yang, X., et al. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11643 · Cited by 29

Xanthine oxidase-derived extracellular superoxide anions stimulate activator protein 1 activity and hypertrophy in human vascular smooth muscle via c-Jun N-terminal kinase and p38 mitogen-activated protein kinases

Matesanz, N., Lafuente, N., Azcutia, V., Martı́n, D., Cuadrado, A., Nevado, J., Rodríguez‐Mañas, L., Sánchez‐Ferrer, C. F., & Peiró, C. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e328013e7c4 · Cited by 29

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

Drummond, G. R., Selemidis, S., Griendling, K. K., & Sobey, C. G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3403 · Cited by 899

Vascular NAD(P)H oxidases: specific features, expression, and regulation

Lassegue, B. P., & Clempus, R. E. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00758.2002 · Cited by 1,026

Delineating the NOX-Mediated Promising Therapeutic Strategies for the Management of Various Cardiovascular Disorders: A Comprehensive Review

Upadhyay, R. K., Kumar, K., Vishwakarma, V. K., Singh, N., Narang, R., Parakh, N., Yadav, M., Yadav, S., Kumar, S., Goyal, A., et al. (2024) · Current Vascular Pharmacology · doi:10.2174/0115701611308870240910115023 · Cited by 6

NADPH Oxidases in Cardiovascular Health and Disease

Cave, A. C., Brewer, A. C., Narayanapanicker, A., Ray, R., Grieve, D. J., Walker, S., & Shah, A. M. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.691 · Cited by 630

NADPH oxidases in the vasculature: Molecular features, roles in disease and pharmacological inhibition

Selemidis, S., Sobey, C. G., Wingler, K., Schmidt, H. H. H. W., & Drummond, G. R. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.08.005 · Cited by 249