Tissue inhibitors of metalloproteinases: evolution, structure and function

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.

Gomis-R¨th, F.-X., Maskos, K., Betz, M., Bergner, A., Huber, R., Suzuki, K., Yoshida, N., Nagase, H., Brew, K., Bourenkov, G. P., et al. (1997) · Nature · doi:10.1038/37995 · Cited by 619

Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3

Baker, A. H., George, S. J., Zaltsman, A. B., Murphy, G., & Newby, A. C. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690217 · Cited by 286

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry

Visse, R., & Nagase, H. (2003) · Circulation Research · doi:10.1161/01.res.0000070112.80711.3d · Cited by 4,575

Strategies for MMP inhibition in cancer: innovations for the post-trial era

Overall, C. M., & López-Otín, C. (2002) · Nature Reviews Cancer · doi:10.1038/nrc884 · Cited by 1,349

Molecular mechanisms of blood vessel growth

Conway, E. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00281-9 · Cited by 1,030

Metalloproteinases and their inhibitors: Regulators of wound healing

Gill, S. E., & Parks, W. C. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.10.024 · Cited by 742

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

Mu, D., Cambier, S., Fjellbirkeland, L., Baron, J. L., Munger, J. S., Kawakatsu, H., Sheppard, D., Broaddus, V. C., & Nishimura, S. L. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200109100 · Cited by 729

The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis

Oh, J., Takahashi, R., Kondo, S., Mizoguchi, A., Adachi, E., Sasahara, R. M., Nishimura, S., Imamura, Y., Kitayama, H., Alexander, D. B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00597-9 · Cited by 728

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

Rosenberg, G. A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70016-x · Cited by 594

Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin

Fisher, G. J., Quan, T., Purohit, T., Shao, Y., Cho, M. K., He, T., Varani, J., Kang, S., & Voorhees, J. J. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080599 · Cited by 487

Novel functions of TIMPs in cell signaling

Chirco, R., Liu, X.-W., Jung, K.-K., & Kim, H.-R. C. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-7893-x · Cited by 401

Matrix metalloproteinases in brain development and remodeling: Synaptic functions and targets

Ethell, I. M., & Ethell, D. W. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21273 · Cited by 378

Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer’s disease.

Lorenzl, S. (2003) · Neurochemistry International · doi:10.1016/s0197-0186(03)00004-4 · Cited by 243

The ECM path of senescence in aging: components and modifiers

Levi, N., Papismadov, N., Solomonov, I., Sagi, I., & Krizhanovsky, V. (2020) · The FEBS Journal · doi:10.1111/febs.15282 · Cited by 219

Matrix metalloproteases and their inhibitors are produced by overlapping populations of activated astrocytes

Muir, E. M., Adcock, K. H., Morgenstern, D. A., Clayton, R., von Stillfried, N., Rhodes, K., Ellis, C., Fawcett, J. W., & Rogers, J. H. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00132-8 · Cited by 206

Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system

Gardner, J., & Ghorpade, A. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10835 · Cited by 199

Extracellular matrix alterations in hypertensive vascular remodeling

Lemarié, C. A., Tharaux, P.-L., & Lehoux, S. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.09.018 · Cited by 192

Endogenous inhibitors of angiogenesis

Ribatti, D. (2009) · Leukemia Research · doi:10.1016/j.leukres.2008.11.019 · Cited by 191

Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis

Robert, S., Gicquel, T., Victoni, T., Valença, S., Barreto, E., Bailly-Maître, B., Boichot, E., & Lagente, V. (2016) · Bioscience Reports · doi:10.1042/bsr20160107 · Cited by 190

Expression profile of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in mature human odontoblasts and pulp tissue

Palosaari, H., Pennington, C. J., Larmas, M., Edwards, D. R., Tjäderhane, L., & Salo, T. (2003) · European Journal Of Oral Sciences · doi:10.1034/j.1600-0722.2003.00026.x · Cited by 188

Tissue inhibitors of metalloproteinases and programmed cell death: Conundrums, controversies and potential implications

Mannello, F., & Gazzanelli, G. (2001) · Apoptosis · doi:10.1023/a:1012493808790 · Cited by 185

Mesenchymal stem cells inhibit both endogenous and exogenous MMPs via secreted TIMPs

Lozito, T. P., & Tuan, R. S. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22344 · Cited by 171

“Social Life” of Senescent Cells: What Is SASP and Why Study It?

Borodkina, A. V., Deryabin, P. I., Giukova, А. А., & Nikolsky, N. N. (2018) · Acta Naturae · doi:10.32607/20758251-2018-10-1-4-14 · Cited by 170

Molecular and cellular basis of rheumatoid joint destruction

Karouzakis, E., Neidhart, M., Gay, R. E., & Gay, S. (2006) · Immunology Letters · doi:10.1016/j.imlet.2006.04.011 · Cited by 167

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction

Bär, C., de Jesus, B. B., Serrano, R., Tejera, A., Ayuso, E., Jimenez, V., Formentini, I., Bobadilla, M., Mizrahi, J., de Martino, A., et al. (2014) · Nature Communications · doi:10.1038/ncomms6863 · Cited by 162

Matrix metalloproteinases and cellular fibrinolytic activity

Lijnen, H. R. (2002) · Biochemistry (Moscow) · doi:10.1023/a:1013908332232 · Cited by 167

Cardiac remodeling and failure

Fedak, P. W. M., Verma, S., Weisel, R. D., & Li, R.-K. (2005) · Cardiovascular Pathology · doi:10.1016/j.carpath.2005.01.005 · Cited by 120

From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes

Byun, H.-O., Lee, Y.-K., Kim, J.-M., & Yoon, G. (2015) · BMB Reports · doi:10.5483/bmbrep.2015.48.10.122 · Cited by 115

Structural and Enzymatic Characterization of Drosophila Dm2-MMP, a Membrane-bound Matrix Metalloproteinase with Tissue-specific Expression

Llano, E., Adam, G., Pendás, A. M., Quesada, V., Sánchez, L. M., Santamarı́a, I., Noselli, S., & López-Otı́n, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200121200 · Cited by 100

Matrix Metalloproteinases as New Targets in Alzheimer’s Disease: Opportunities and Challenges

Zipfel, P., Rochais, C., Baranger, K., Rivera, S., & Dallemagne, P. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00352 · Cited by 94

Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies

Lindbohm, J. V., Mars, N., Walker, K. A., Singh‐Manoux, A., Livingston, G., Brunner, E. J., Sipilä, P. N., Saksela, K., Ferrie, J. E., Lovering, R. C., et al. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12419 · Cited by 70

Impaired Degradation of Matrix Collagen in Human Gingival Fibroblasts by the Antiepileptic Drug Phenytoin

Kato, T., Okahashi, N., Kawai, S., Kato, T., Inaba, H., Morisaki, I., & Amano, A. (2005) · Journal of Periodontology · doi:10.1902/jop.2005.76.6.941 · Cited by 65

Metalloproteinase-Dependent Shedding of Low-Density Lipoprotein Receptor-Related Protein-1 Ectodomain Decreases Endocytic Clearance of Endometrial Matrix Metalloproteinase-2 and -9 at Menstruation

Selvais, C., Gaide Chevronnay, H. P., Lemoine, P., Dedieu, S., Henriet, P., Courtoy, P. J., Marbaix, E., & Emonard, H. (2009) · Endocrinology · doi:10.1210/en.2009-0015 · Cited by 54

Severe Persistent Allergic Rhinitis. Inflammation but No Histologic Features of Structural Upper Airway Remodeling

Eifan, A. O., Orban, N. T., Jacobson, M. R., & Durham, S. R. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201502-0339oc · Cited by 49

Smoking Dependent Alterations in Bone Formation and Inflammation Represent Major Risk Factors for Complications Following Total Joint Arthroplasty

Ehnert, S., Aspera-Werz, R. H., Ihle, C., Trost, M., Zirn, B., Flesch, I., Schröter, S., Relja, B., & Nussler, A. K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8030406 · Cited by 45

Activity of matrix metallo proteinases (MMPs) and the tissue inhibitor of MMP (TIMP)-1 in electromagnetic field-exposed THP-1 cells

Patruno, A., Pesce, M., Marrone, A., Speranza, L., Grilli, A., De Lutiis, M. A., Felaco, M., & Reale, M. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.23024 · Cited by 42

Neuronal TIMP‐1 release accompanies astrocytic MMP‐9 secretion and enhances astrocyte proliferation induced by β‐amyloid 25–35 fragment

Hernández‐Guillamon, M., Delgado, P., Ortega, L., Pares, M., Rosell, A., García‐Bonilla, L., Fernández‐Cadenas, I., Borrell‐Pagès, M., Boada, M., & Montaner, J. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22034 · Cited by 39

Could statins constitute a novel treatment for endometriosis? Systematic review of the literature

Gibran, L., Maranhão, R. C., Abrão, M. S., Baracat, E. C., & Podgaec, S. (2014) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2014.05.028 · Cited by 29

A microarray study to characterize the molecular mechanism of TIMP-3-mediated tumor rejection

Lam, P., Sian Lim, K., Mei Wang, S., & Hui, K. M. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.02.028 · Cited by 22

Preventing obesity, insulin resistance and type 2 diabetes by targeting MT1-MMP

Asthana, P., & Wong, H. L. X. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167081 · Cited by 13