N-methyl-d-aspartate channel and consciousness: From signal coincidence detection to quantum computing

Freitas da Rocha, Armando; Pereira, Alfredo; Bezerra Coutinho, Francisco Antonio

doi:10.1016/s0301-0082(00)00069-1

Cited by 41Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchPhilosophy and Theoretical Science

N-methyl-d-aspartate channel and consciousness: From signal coincidence detection to quantum computing

Freitas da Rocha, Armando, Pereira, Alfredo, Bezerra Coutinho, Francisco Antonio·2001·Progress in Neurobiology

DOI 10.1016/s0301-0082(00)00069-1

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Abstract

Research on Blindsight, Neglect/Extinction and Phantom limb syndromes, as well as electrical measurements of mammalian brain activity, have suggested the dependence of vivid perception on both incoming sensory information at primary sensory cortex and reentrant information from associative cortex. Coherence between incoming and reentrant signals seems to be a necessary condition for (conscious) perception. General reticular activating system and local electrical synchronization are some of the tools used by the brain to establish coarse coherence at the sensory cortex, upon which biochemical processes are coordinated. Besides electrical synchrony and chemical modulation at the synapse, a central mechanism supporting such a coherence is the N-methyl-D-aspartate channel, working as a 'coincidence detector' for an incoming signal causing the depolarization necessary to remove Mg(2+), and reentrant information releasing the glutamate that finally prompts Ca(2+) entry. We propose that a signal transduction pathway activated by Ca(2+) entry into cortical neurons is in charge of triggering a quantum computational process that accelerates inter-neuronal communication, thus solving systemic conflict and supporting the unity of consciousness.

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Recent theoretical work has proposed that conscious processing may arise at classical-quantum interfaces within neural tissue, particularly in calcium-dependent synaptic mechanisms, astrocytic hydro-ionic waves, and ion-water interactions.
“Recent theoretical work has proposed that conscious processing may arise at classical-quantum interfaces within neural tissue, particularly in calcium-dependent synaptic mechanisms [51], astrocytic hydro-ionic waves, and ion–water interactions in the extracellular milieu [52].”
From Quantum-Inspired and Non-Classical Approaches to Consciousness: Models, Evidence and Constraints (2026) · cites this paper as [51]

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McComas, A. J., & Cupido, C. M. (1999) · Clinical Neurophysiology · doi:10.1016/s1388-2457(99)00067-x · Cited by 11 · see citing works
Alice in quantumland
Gilmore, R. L. (1994) · Cited by 9 · see citing works

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The ‘conscious pilot’ — dendritic synchrony moves through the brain to mediate consciousness.
Hameroff, S. (2010) · Journal of Biological Physics · doi:10.1007/s10867-009-9148-x · Cited by 107 · see citing works
Classical-quantum interfaces in living neural tissue supporting conscious functions
(2020) · Advances in Quantum Chemistry · doi:10.1016/bs.aiq.2020.08.002 · Cited by 6 · see citing works
Quantum-Inspired and Non-Classical Approaches to Consciousness: Models, Evidence and Constraints
Arias-Carrión, O., Ortega-Robles, E., & Manjarrez, E. (2026) · Brain Sciences · doi:10.3390/brainsci16040386 · Cited by 1 · see citing works
“Recent theoretical work has proposed that conscious processing may arise at classical-quantum interfaces within neural tissue, particularly in calcium-dependent synaptic mechanisms [51], astrocytic hydro-ionic waves, and ion–water interactions in the extracellular milieu [52].”

Authors: Freitas da Rocha, A., Pereira, A., & Bezerra Coutinho, F. A.
Affiliations: Universidade Estadual Paulista (Unesp) (BR)
ORCID: Pereira, Alfredo
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2001-08
Volume: 64
Issue: 6
Pages: 555-573
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/s0301-0082(00)00069-1
OpenAlex: W2107787470
Cited by: 41
References: 117
Citations by year: 2026: 1 · 2025: 1 · 2023: 2 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
FWCI: 0.18
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
UNESP Institutional Repository (São Paulo State University) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Philosophy and Theoretical Science
Keywords: NMDA receptor, consciousness, coincidence detection, blindsight, neglect syndrome, extinction, phantom limb, primary sensory cortex, association cortex, reticular activating system, electrical synchronization, calcium influx, magnesium removal, glutamate, signal transduction, quantum computing, unity of consciousness
MeSH terms: Animals, Calcium, Cerebral Cortex, Consciousness, Humans, Magnesium, Models, Biological, Nerve Net, Perception, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Pyramidal Cells, Glutamic Acid

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N-methyl-d-aspartate channel and consciousness: From signal coincidence detection to quantum computing

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