Cited by 289Phytochemicals and Medicinal PlantsMedicinal Plants and Bioactive CompoundsBiofield Effects and Biophysics

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Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum

Bhattacharya, A, Ghosal, S, Bhattacharya, S.K·2001·Journal of Ethnopharmacology

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Abstract

The antioxidant activity of Withania somnifera (WS) glycowithanolides was assessed in chronic footshock stress induced changes in rat brain frontal cortex and striatum. The stress procedure, given once daily for 21 days, induced an increase in superoxide dismutase (SOD) and lipid peroxidation (LPO) activity, with concomitant decrease in catalase (CAT) and glutathione peroxidase (GPX) activities in both the brain regions. WS glycowithanolides (WSG), administered orally 1 h prior to the stress procedure for 21 days, in the doses of 10, 20 and 50 mg/kg, induced a dose-related reversal of the stress effects. Thus, WSG tended to normalise the augmented SOD and LPO activities and enhanced the activities of CAT and GPX. The results indicate that, at least part of chronic stress-induced pathology may be due to oxidative stress, which is mitigated by WSG, lending support to the clinical use of the plant as an antistress adaptogen.

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Bhattacharya, S.K., 1998. Behavioural and physiological perturbations induced by chronic unpredictable footshock stress in rats. Effect of a standardized extract of Withania somnifera (Ashwagandha). Proceedings of International Conference on Stress Adaptation, Prophylaxis and Treatment, Bose Institute, Calcutta, p. 39.

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Authors: Bhattacharya, A., Ghosal, S., & Bhattacharya, S. K.
Affiliations: Institute of Medical Sciences (IN)
Corresponding author: Bhattacharya, S.K
ORCID: Ghosal, S
Venue: Journal of Ethnopharmacology
Publisher: Elsevier BV
Published: 2001-01
Volume: 74
Issue: 1
Pages: 1-6
ISSN: 0378-8741 (ISSN-L)
DOI: 10.1016/s0378-8741(00)00309-3
OpenAlex: W2002991717
Cited by: 288
References: 27
Citations by year: 2026: 9 · 2025: 5 · 2024: 9 · 2023: 16 · 2022: 14 · 2021: 20 · 2020: 12 · 2019: 6 · 2018: 14 · 2017: 15 · 2016: 8 · 2015: 19 · 2014: 21 · 2013: 20 · 2012: 13
FWCI: 11.65
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Ethnopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Bioactive Compounds
Health Sciences › Medicine › Complementary and alternative medicine › Biofield Effects and Biophysics
Keywords: Withania somnifera, antioxidant activity, oxidative stress, lipid peroxidation, superoxide dismutase, catalase, glutathione peroxidase, frontal cortex, striatum, adaptogens
MeSH terms: Administration, Oral, Animals, Antioxidants, Brain, Chronic Disease, Dose-Response Relationship, Drug, Electroshock, Free Radicals, Glutathione Peroxidase, Male, Plant Extracts, Stress, Physiological, Superoxide Dismutase, Lipid Peroxidation, Rats, Wistar, Solanaceae, Rats

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Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum

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