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Rapid Actin-Based Plasticity in Dendritic Spines

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Fischer, Maria, Kaech, Stefanie, Knutti, Darko, Matus, Andrew·1998·Neuron

DOI 10.1016/s0896-6273(00)80467-5

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Abstract

Dendritic spines have been proposed as primary sites of synaptic plasticity in the brain. Consistent with this hypothesis, spines contain high concentrations of actin, suggesting that they might be motile. To investigate this possibility, we made video recordings from hippocampal neurons expressing actin tagged with green fluorescent protein (GFP-actin). This reagent incorporates into actin-containing structures and allows the visualization of actin dynamics in living neurons. In mature neurons, recordings of GFP fluorescence revealed large actin-dependent changes in dendritic spine shape, similar to those inferred from previous studies using fixed tissues. Visible changes occurred within seconds, suggesting that anatomical plasticity at synapses can be extremely rapid. As well as providing a molecular basis for structural plasticity, the presence of motile actin in dendritic spines implicates the postsynaptic element as a primary site of this phenomenon.

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Authors: Fischer, M., Kaech, S., Knutti, D., & Matus, A.
Affiliations: Friedrich Miescher Institute (CH)
Corresponding author: Matus, Andrew
ORCID: Kaech, Stefanie
Venue: Neuron
Publisher: Elsevier BV
Published: 1998-05
Volume: 20
Issue: 5
Pages: 847-854
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)80467-5
OpenAlex: W2111916392
Cited by: 905
References: 40
Citations by year: 2026: 4 · 2025: 7 · 2024: 5 · 2023: 12 · 2022: 16 · 2021: 21 · 2020: 18 · 2019: 17 · 2018: 22 · 2017: 17 · 2016: 33 · 2015: 28 · 2014: 31 · 2013: 30 · 2012: 34
FWCI: 20.16
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5556 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: dendritic spines, actin dynamics, synaptic plasticity, structural plasticity, hippocampal neurons, spine motility, postsynaptic elements
MeSH terms: Actins, Animals, Cell Line, Dendrites, Fibroblasts, Hippocampus, Indicators and Reagents, Luminescent Proteins, Neuronal Plasticity, Neurons, Synapses, Thiazoles, Cytochalasin D, Microscopy, Video, Bridged Bicyclo Compounds, Heterocyclic, Nucleic Acid Synthesis Inhibitors, Cell Size, Green Fluorescent Proteins, Rats, Thiazolidines

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Rapid Actin-Based Plasticity in Dendritic Spines

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