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Calcium Dynamics of Spines Depend on Their Dendritic Location
Open accessAbstract
Dendritic spines are morphologically and functionally heterogeneous. To understand this diversity, we use two-photon imaging of layer 5 neocortical pyramidal cells and measure action potential-evoked [Ca(2+)]i transients in spines. Spine calcium kinetics are controlled by (i) the diameter of the parent dendrite, (ii) the length of the spine neck, and (iii) the strength of spine calcium pumps. These factors produce different calcium dynamics in spines from basal, proximal apical, and distal apical dendrites, differences that are more pronounced without exogenous buffers. In proximal and distal apical dendrites, different calcium dynamics correlate with different susceptibility to synaptic depression, and modifying calcium kinetics in spines changes the expression of long-term depression. Thus, the spine location apparently determines its calcium dynamics and synaptic plasticity. Our results highlight the precision in design of neocortical neurons.
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“dendritic diameter is thought to be an important contributor to signal integration and transduction in dendrites (Sorra and Harris, 2000;Holthoff et al., 2002)”
From Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy (2005) · cites this paper as Holthoff et al., 2002
In the citing paper
“Nevertheless, morphology does play a role, as long and thin necks prevent the diffusion of calcium, whereas shorter and thicker necks allow for better diffusional coupling with the dendrite (Majewska et al., 2000; Holthoff et al., 2002; Sabatini et al., 2002; Korkotian et al., 2004; Noguchi et al., 2005).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Holthoff et al., 2002
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Dendritic Excitability and Synaptic Plasticity
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“Insofar as dendritic diameter is thought to be an important contributor to signal integration and transduction in dendrites (Sorra and Harris, 2000; Holthoff et al., 2002), dendritic tortuosity is thought to alter temporal integration of convergent afferents (Knowles et al., 1999), and dendritic…”
BackgroundSpine-Neck Geometry Determines NMDA Receptor-Dependent Ca2+ Signaling in Dendrites
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Self-citation
Metadata
- Authors
- Holthoff, K., Tsay, D., & Yuste, R.
- Affiliations
- Columbia University (US)
- Corresponding author
- Holthoff, Knut
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 33
- Issue
- 3
- Pages
- 425-437
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1979356066
- Cited by
- 117
- References
- 49
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2017: 2 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 2
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY-11787, R01EY013237, EY 13237, R01EY011787)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- dendritic spines, calcium dynamics, calcium transients, calcium pump, synaptic depression, long-term depression, synaptic plasticity, layer 5 pyramidal neurons, neocortex, calcium buffering
- MeSH terms
- Animals, Calcium, Dendrites, Fluorescent Dyes, Mathematics, Models, Biological, Models, Neurological, Neuronal Plasticity, Statistics as Topic, Visual Cortex, Pyramidal Cells, Patch-Clamp Techniques, Microscopy, Confocal, Mice, In Vitro Techniques
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