Cited by 117Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionIon channel regulation and function

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Calcium Dynamics of Spines Depend on Their Dendritic Location

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Holthoff, Knut, Tsay, David, Yuste, Rafael·2002·Neuron

DOI 10.1016/s0896-6273(02)00576-7

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Abstract

Dendritic spines are morphologically and functionally heterogeneous. To understand this diversity, we use two-photon imaging of layer 5 neocortical pyramidal cells and measure action potential-evoked [Ca(2+)]i transients in spines. Spine calcium kinetics are controlled by (i) the diameter of the parent dendrite, (ii) the length of the spine neck, and (iii) the strength of spine calcium pumps. These factors produce different calcium dynamics in spines from basal, proximal apical, and distal apical dendrites, differences that are more pronounced without exogenous buffers. In proximal and distal apical dendrites, different calcium dynamics correlate with different susceptibility to synaptic depression, and modifying calcium kinetics in spines changes the expression of long-term depression. Thus, the spine location apparently determines its calcium dynamics and synaptic plasticity. Our results highlight the precision in design of neocortical neurons.

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Authors: Holthoff, K., Tsay, D., & Yuste, R.
Affiliations: Columbia University (US)
Corresponding author: Holthoff, Knut
ORCID: Holthoff, Knut
Yuste, Rafael
Venue: Neuron
Publisher: Elsevier BV
Published: 2002-01
Volume: 33
Issue: 3
Pages: 425-437
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(02)00576-7
OpenAlex: W1979356066
Cited by: 117
References: 49
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2017: 2 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 2
FWCI: 4.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4215 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Eye Institute (EY-11787, R01EY013237, EY 13237, R01EY011787)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: dendritic spines, calcium dynamics, calcium transients, calcium pump, synaptic depression, long-term depression, synaptic plasticity, layer 5 pyramidal neurons, neocortex, calcium buffering
MeSH terms: Animals, Calcium, Dendrites, Fluorescent Dyes, Mathematics, Models, Biological, Models, Neurological, Neuronal Plasticity, Statistics as Topic, Visual Cortex, Pyramidal Cells, Patch-Clamp Techniques, Microscopy, Confocal, Mice, In Vitro Techniques

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Calcium Dynamics of Spines Depend on Their Dendritic Location

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