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Auditory-Evoked Spike Firing in the Lateral Amygdala and Pavlovian Fear Conditioning
Open accessAbstract
Amygdala neuroplasticity has emerged as a candidate substrate for Pavlovian fear memory. By this view, conditional stimulus (CS)-evoked activity represents a mnemonic code that initiates the expression of fear behaviors. However, a fear state may nonassociatively enhance sensory processing, biasing CS-evoked activity in amygdala neurons. Here we describe experiments that dissociate auditory CS-evoked spike firing in the lateral amygdala (LA) and both conditional fear behavior and LA excitability in rats. We found that the expression of conditional freezing and increased LA excitability was neither necessary nor sufficient for the expression of conditional increases in CS-evoked spike firing. Rather, conditioning-related changes in CS-evoked spike firing were solely determined by the associative history of the CS. Thus, our data support a model in which associative activity in the LA encodes fear memory and contributes to the expression of learned fear behaviors.
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“Several lines of indirect evidence support the idea that this plasticity occurs as a result of a Hebbian mechanism through which depolarization of LA pyramidal neurons by the shock US coincident with weaker activation of the same cells by auditory CS inputs results in fear learning (8–18).”
From Optical activation of lateral amygdala pyramidal cells instructs associative fear learning (2010) · cites this paper as [11]
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Metadata
- Authors
- Goosens, K. A., Hobin, J. A., & Maren, S.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Maren, Stephen
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 40
- Issue
- 5
- Pages
- 1013-1022
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2003951007
- Cited by
- 135
- References
- 53
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 8 · 2020: 2 · 2019: 3 · 2018: 7 · 2017: 9 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 9 · 2012: 6
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3516 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH065961, R29MH57865)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- lateral amygdala, fear conditioning, fear memory, associative learning, fear expression
- MeSH terms
- Action Potentials, Amygdala, Animals, Conditioning, Classical, Evoked Potentials, Auditory, Fear, Male, Neuronal Plasticity, Rats, Long-Evans, Rats
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