Cited by 135Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchMemory Processes and Influences

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Auditory-Evoked Spike Firing in the Lateral Amygdala and Pavlovian Fear Conditioning

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Abstract

Amygdala neuroplasticity has emerged as a candidate substrate for Pavlovian fear memory. By this view, conditional stimulus (CS)-evoked activity represents a mnemonic code that initiates the expression of fear behaviors. However, a fear state may nonassociatively enhance sensory processing, biasing CS-evoked activity in amygdala neurons. Here we describe experiments that dissociate auditory CS-evoked spike firing in the lateral amygdala (LA) and both conditional fear behavior and LA excitability in rats. We found that the expression of conditional freezing and increased LA excitability was neither necessary nor sufficient for the expression of conditional increases in CS-evoked spike firing. Rather, conditioning-related changes in CS-evoked spike firing were solely determined by the associative history of the CS. Thus, our data support a model in which associative activity in the LA encodes fear memory and contributes to the expression of learned fear behaviors.

Overview

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Crossref · 10.1016/s0896-6273(03)00728-1

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55 of 55 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 1

  1. Hitchcock, 1989, Sensitization of the startle reflex by footshock, Behav. Neurosci., 103, 509, 10.1037/0735-7044.103.3.509 · DOI

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Metadata

Authors
Goosens, K. A., Hobin, J. A., & Maren, S.
Affiliations
University of Michigan (US)
Corresponding author
Maren, Stephen
Venue
Neuron
Publisher
Elsevier BV
Published
2003-12
Volume
40
Issue
5
Pages
1013-1022
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2003951007
Cited by
135
References
53
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 8 · 2020: 2 · 2019: 3 · 2018: 7 · 2017: 9 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 9 · 2012: 6
FWCI
3.58
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Funders
National Institute of Mental Health (R01MH065961, R29MH57865)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
lateral amygdala, fear conditioning, fear memory, associative learning, fear expression
MeSH terms
Action Potentials, Amygdala, Animals, Conditioning, Classical, Evoked Potentials, Auditory, Fear, Male, Neuronal Plasticity, Rats, Long-Evans, Rats

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