Differential Fear Conditioning Induces Reciprocal Changes in the Sensory Responses of Lateral Amygdala Neurons to the CS+ and CS−
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In classical fear conditioning, a neutral sensory stimulus (CS) acquires the ability to elicit fear responses after pairing to a noxious unconditioned stimulus (US). As amygdala lesions prevent the acquisition of fear responses and the lateral amygdaloid (LA) nucleus is the main input station of the amygdala for auditory afferents, the effect of auditory fear conditioning on the sensory responsiveness of LA neurons has been examined. Although conditioning was shown to increase CS-evoked LA responses, the specificity of the changes in responsiveness was not tested. Because conditioning might induce nonspecific increases in LA responses to auditory afferents, we re-examined this issue in conscious, head-restrained cats using a differential conditioning paradigm where only one of two tones (CS+but not CS−) was paired to the US. Differential conditioning increased unit and field responses to the CS+, whereas responses to the CS− decreased. Such changes have never been observed in the amygdala except in cases where the CS− had been paired to the US before and fear responses not extinguished. This suggests that fear conditioning is not only accompanied by potentiation of amygdalopetal pathways conveying the CS+ but also by the depression of sensory inputs unpaired to noxious stimuli.
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Several lines of indirect evidence support the idea that this plasticity occurs as a result of a Hebbian mechanism through which depolarization of LA pyramidal neurons by the shock US coincident with weaker activation of the same cells by auditory CS inputs results in fear learning.
“Several lines of indirect evidence support the idea that this plasticity occurs as a result of a Hebbian mechanism through which depolarization of LA pyramidal neurons by the shock US coincident with weaker activation of the same cells by auditory CS inputs results in fear learning (8–18).”
From Optical activation of lateral amygdala pyramidal cells instructs associative fear learning (2010) · cites this paper as [10]
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Self-citation
- Authors
- Collins, D. R., & Paré, D.
- Affiliations
- Université Laval (CA)
- ORCID
- Paré, Denis
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-03-01
- Volume
- 7
- Issue
- 2
- Pages
- 97-103
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC311326
- OpenAlex
- W2150451377
- Cited by
- 171
- References
- 45
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 7 · 2016: 6 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 3
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- differential fear conditioning, lateral amygdala, auditory fear conditioning, sensory responsiveness, fear extinction, single-unit responses, field response, cats
- MeSH terms
- Acoustic Stimulation, Amygdala, Animals, Auditory Pathways, Cats, Conditioning, Psychological, Discrimination, Psychological, Electric Stimulation, Electromyography, Electrophysiology, Evoked Potentials, Auditory, Extinction, Psychological, Fear, Head, Neurons, Reaction Time, Restraint, Physical
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