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Chapter 6 Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase

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Abel, Ted, Nguyen, Peter V.·2008·Progress in Brain Research

Abstract

The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase that has been strongly implicated in the expression of specific forms of hippocampus-dependent memory. We review evidence that PKA is required for hippocampus-dependent memory in mammals, and we highlight some of the proteins that have been implicated as targets of PKA. Future directions and open questions regarding the role of PKA in memory storage are also described.

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Crossref · 10.1016/s0079-6123(07)00006-4

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Authors
Abel, T., & Nguyen, P. V.
Affiliations
  • University of Pennsylvania (US)
  • University of Alberta (CA)
Corresponding author
Nguyen, Peter V.
Venue
Progress in Brain Research
Publisher
Elsevier
Published
2008
Volume
169
Pages
97-115
ISSN
0079-6123 (ISSN-L)
OpenAlex
W309050847
Cited by
198
References
172
Citations by year
2026: 4 · 2025: 13 · 2024: 9 · 2023: 6 · 2022: 11 · 2021: 7 · 2020: 7 · 2019: 14 · 2018: 8 · 2017: 12 · 2016: 10 · 2015: 11 · 2014: 16 · 2013: 16 · 2012: 13
FWCI
20.81
Type
book chapter
Language
en
Open access
Locations
  • Progress in brain research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • University of Pennsylvania
  • National Institute for Health and Care Research
  • National Institutes of Health
  • Canadian Institutes of Health Research
  • National Institute of Mental Health (R01MH060244)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
protein kinase A, hippocampal-dependent memory, long-term memory consolidation, declarative memory, memory storage, serine/threonine kinase
MeSH terms
Animals, Hippocampus, Memory, Synapses, Long-Term Potentiation, Cyclic AMP-Dependent Protein Kinases

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