Chapter 6 Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase
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The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase that has been strongly implicated in the expression of specific forms of hippocampus-dependent memory. We review evidence that PKA is required for hippocampus-dependent memory in mammals, and we highlight some of the proteins that have been implicated as targets of PKA. Future directions and open questions regarding the role of PKA in memory storage are also described.
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LTF and LTP both rely on PKA and ERK activation.
“For example, LTF and LTP both rely on PKA and ERK activation12,92,98”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [98]
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- Authors
- Abel, T., & Nguyen, P. V.
- Affiliations
- University of Pennsylvania (US)
- University of Alberta (CA)
- Corresponding author
- Nguyen, Peter V.
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2008
- Volume
- 169
- Pages
- 97-115
- ISSN
- 0079-6123 (ISSN-L)
- PMC
- PMC2914307
- OpenAlex
- W309050847
- Cited by
- 198
- References
- 172
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 9 · 2023: 6 · 2022: 11 · 2021: 7 · 2020: 7 · 2019: 14 · 2018: 8 · 2017: 12 · 2016: 10 · 2015: 11 · 2014: 16 · 2013: 16 · 2012: 13
- FWCI
- 20.81
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Pennsylvania
- National Institute for Health and Care Research
- National Institutes of Health
- Canadian Institutes of Health Research
- National Institute of Mental Health (R01MH060244)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- protein kinase A, hippocampal-dependent memory, long-term memory consolidation, declarative memory, memory storage, serine/threonine kinase
- MeSH terms
- Animals, Hippocampus, Memory, Synapses, Long-Term Potentiation, Cyclic AMP-Dependent Protein Kinases
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