Cited by 1,944Nerve injury and regenerationCell death mechanisms and regulationNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.

Neurotrophin signal transduction in the nervous system

Kaplan, David R, Miller, Freda D·2000·Current Opinion in Neurobiology

DOI 10.1016/s0959-4388(00)00092-1

Open this paper in CoChat — free account

Abstract

Neurotrophins use two types of receptors, the Trk tyrosine kinase receptors and the p75 neurotrophin receptor (p75NTR), to regulate the growth, development, survival and repair of the nervous system. These receptors can either collaborate with or inhibit each other's actions to mediate neurotrophin effects. The development and survival of neurons is thus based upon the functional interplay of the signals generated by Trk and p75NTR. In the past two years, the signaling pathways used by these receptors, including Akt and MAPK-induced signaling via Trk, and JNK, p53, and NF-kappaB signaling via p75NTR, have been identified. In addition, a number of novel p75NTR-interacting proteins have been identified that transmit growth, survival, and apoptotic signals.

Integrity signals

Registry

Crossref · 10.1016/s0959-4388(00)00092-1

Cites

123 of 123 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Neuronal Cell Death: Retraction
Hagg, T. (1999) · Science · doi:10.1126/science.285.5426.337h · Cited by 13
Retracted
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216
Regulation of neuronal survival by the serine-threonine protein kinase Akt
Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., & Greenberg, M. E. (1997) · Science · doi:10.1126/science.275.5300.661 · Cited by 2,436
Self-citation
Phosphatidylinositol-3-OH kinase direct target of Ras
Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., & Downward, J. (1994) · Nature · doi:10.1038/370527a0 · Cited by 1,954
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,908
Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
Peso, L. D., González-Garcı́a, M., Page, C., Herrera, R., & Nuñez, G. (1997) · Science · doi:10.1126/science.278.5338.687 · Cited by 1,797
The PI3K‒PDK1 connection: more than just a road to PKB
Vanhaesebroeck, B., & Alessi, D. R. (2000) · Biochemical Journal · doi:10.1042/bj3460561 · Cited by 1,649

Show all 122 references

Sorted by citations

Items 501–600 of 1,001

Activity Regulates Positive and Negative Neurotrophin-Derived Signals to Determine Axon Competition
Singh, K. K., & Miller, F. D. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.049 · Cited by 76
Self-citation
Brain-Derived Neurotrophic Factor and trkB Signaling in Parasympathetic Neurons: Relevance to Regulating α7-Containing Nicotinic Receptors and Synaptic Function
Zhou, X., Nai, Q., Chen, M., Dittus, J. D., Howard, M. J., & Margiotta, J. F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0055-04.2004 · Cited by 74
Neurogenic and Neurotrophic Effects of BDNF Peptides in Mouse Hippocampal Primary Neuronal Cell Cultures
Cardenas-Aguayo, M. D. C., Kazim, S. F., Grundke-Iqbal, I., & Iqbal, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053596 · Cited by 73
Disruption of hippocampus-regulated behavioural and cognitive processes by heterozygous constitutive deletion of SynGAP
Muhia, M., Yee, B. K., Feldon, J., Markopoulos, F., & Knuesel, I. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07079.x · Cited by 71
The emerging role of furin in neurodegenerative and neuropsychiatric diseases
Zhang, Y., Gao, X., Bai, X., Yao, S., Chang, Y., & Gao, G. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00313-1 · Cited by 80
Myelin suppresses axon regeneration by PIR‐B/SHP‐mediated inhibition of Trk activity
Fujita, Y., Endo, S., Takai, T., & Yamashita, T. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.55 · Cited by 75
N-myc Promotes Survival and Induces S-Phase Entry of Postmitotic Sympathetic Neurons
Wartiovaara, K., Barnabé‐Heider, F., Miller, F. D., & Kaplan, D. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00815.2002 · Cited by 74
Self-citation
The expression of neurotrophins and their receptors in the prenatal and adult human testis: evidence for functions in Leydig cells
Müller, D., Davidoff, M. S., Bargheer, O., Paust, H.-J., Pusch, W., Koeva, Y. A., Ježek, D., Holstein, A. F., & Middendorff, R. (2006) · Histochemistry and Cell Biology · doi:10.1007/s00418-006-0155-8 · Cited by 74
Neurite outgrowth induced by spicatoside A, a steroidal saponin, via the tyrosine kinase A receptor pathway
Hur, J., Lee, P., Moon, E., Kang, I., Kim, S., Oh, M. S., & Kim, S. Y. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.08.016 · Cited by 74
Intracellular sphingosine 1‐phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons
Zhang, Y. H., Vasko, M. R., & Nicol, G. D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.111575 · Cited by 73
Truncated tyrosine kinase B brain‐derived neurotrophic factor receptor directs cortical neural stem cells to a glial cell fate by a novel signaling mechanism
Cheng, A., Coksaygan, T., Tang, H., Khatri, R. G., Balice‐Gordon, R. J., Rao, M. S., & Mattson, M. P. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04337.x · Cited by 74
GDNF and protection of adult central catecholaminergic neurons
Pascual, A., Hidalgo‐Figueroa, M., Gómez-Díaz, R., & López‐Barneo, J. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-10-0125 · Cited by 72
Effects of prenatal alcohol exposure on brain-derived neurotrophic factor and its receptor tyrosine kinase B in offspring
Feng, M., Yan, S., & Yan, Q. (2005) · Brain Research · doi:10.1016/j.brainres.2005.02.017 · Cited by 74
The Doublecortin Gene Family and Disorders of Neuronal Structure
Dijkmans, T. F., van Hooijdonk, L. A., Fitzsimons, C. P., & Vreugdenhil, E. (2010) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/187152410790780118 · Cited by 74
Extracellular signal‐regulated kinase 1/2 mediates survival, but not axon regeneration, of adult injured central nervous system neurons in vivo
Pernet, V., Hauswirth, W. W., & Polo, A. D. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03002.x · Cited by 76
Increased IL-1β in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase
Maher, F. O., Martin, D. S. D., & Lynch, M. A. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.007 · Cited by 73
Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes
Xu, W., Yao, X., Zhao, F., Zhao, H., Cheng, Z., Yang, W., Cui, R., Xu, S., & Li, B. (2020) · Neural Plasticity · doi:10.1155/2020/8861903 · Cited by 75
Pathophysiology of Acute Ischaemic Stroke: An Analysis of Common Signalling Mechanisms and Identification of New Molecular Targets
Mitsios, N., Gaffney, J. J., Kumar, P., Krupiński, J., Kumar, S., & SLEVIN, M. A. (2006) · Pathobiology · doi:10.1159/000096017 · Cited by 75
Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma.
Yang, W. Q., Senger, D. L., Muzik, H., Shi, Z. Q., Johnson, D., Brasher, P. M. A., Rewcastle, N. B., Hamilton, M. G., Rutka, J., Wolff, J. E. A., et al. (2003) · PubMed · Cited by 73
Herpes Simplex Virus Type 1-Induced Encephalitis has an Apoptotic Component Associated with Activation of c-Jun N-Terminal Kinase
Perkins, D., Gyure, K. A., Pereira, E. F. R., & Aurelian, L. (2003) · Journal of NeuroVirology · doi:10.1080/13550280390173427 · Cited by 71
Increased processing of APLP2 and APP with concomitant formation of APP intracellular domains in BDNF and retinoic acid‐differentiated human neuroblastoma cells
Holback, S., Adlerz, L., & Iverfeldt, K. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03440.x · Cited by 72
Drug discovery and the human kinome: Recent trends
Eglen, R. M., & Reisine, T. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.007 · Cited by 80
Role of Heat Shock Proteins During Polyglutamine Neurodegeneration: Mechanisms and Hypothesis
Wyttenbach, A. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:1-2:069 · Cited by 74
Neonatal Exposure to Estradiol Valerate Programs Ovarian Sympathetic Innervation and Follicular Development in the Adult Rat1
Sotomayor‐Zárate, R., Dorfman, M. D., Paredes, A., & Lara, H. E. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.063974 · Cited by 72
Effects of Electroconvulsive Therapy and Repetitive Transcranial Magnetic Stimulation on Serum Brain-Derived Neurotrophic Factor Levels in Patients with Depression
Gedge, L., Beaudoin, A., Lazowski, L., du Toit, R., Jokic, R., & Milev, R. V. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00012 · Cited by 78
Upregulation of Bradykinin B2 Receptor Expression by Neurotrophic Factors and Nerve Injury in Mouse Sensory Neurons
Lee, Y.-J., Zachrisson, O., Tonge, D. A., & McNaughton, P. A. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1073 · Cited by 72
N-methyl-D-aspartate and TrkB receptors protect neurons against glutamate excitotoxicity through an extracellular signal-regulated kinase pathway
Zhu, D., Wu, X., Strauss, K. I., Lipsky, R. H., Qureshi, Z., Terhakopian, A., Novelli, A., Banaudha, K. K., & Marini, A. M. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20422 · Cited by 72
p75 neurotrophin receptor is required for constitutive and NGF‐induced survival signalling in PC12 cells and rat hippocampal neurones
Bui, N. T., König, H., Culmsee, C., Bauerbach, E., Poppe, M., Krieglstein, J., & Prehn, J. H. M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00841.x · Cited by 72
A Novel Role For Serum Response Factor in Neuronal Survival
Chang, S., Poser, S., & Xia, Z. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4868-03.2004 · Cited by 72
Apoptotic PC12 Cells Exposing Phosphatidylserine Promote the Production of Anti-Inflammatory and Neuroprotective Molecules by Microglial Cells
Simone, R. D., Ajmone‐Cat, M. A., Tirassa, P., & Minghetti, L. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.2.208 · Cited by 72
Presence and Localization of Neurotrophins and Neurotrophin Receptors in Rat Lacrimal Gland
Ghinelli, E., Johansson, J. K., Ríos, J. D., Chen, L.-L., Zoukhri, D., Hodges, R. R., & Dartt, D. A. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0037 · Cited by 71
Alterations in IGF-I, BDNF and NT-3 levels following experimental brain trauma and the effect of IGF-I administration.
Kazanis, I., Giannakopoulou, M., Philippidis, H., & Stylianopoulou, F. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2003.12.004 · Cited by 70
The role of neurotrophins in the pathophysiology of allergic rhinitis
Raap, U., & Braunstahl, G. (2010) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e328334f5de · Cited by 69
An HDAC-dependent epigenetic mechanism that enhances the efficacy of the antidepressant drug fluoxetine
Schmauss, C. (2015) · Scientific Reports · doi:10.1038/srep08171 · Cited by 70
An Infant With Primary Tooth Loss and Palmar Hyperkeratosis: A Novel Mutation in the NTRK1 Gene Causing Congenital Insensitivity to Pain With Anhidrosis
Bonkowsky, J. L., Johnson, J. E., Carey, J. C., Smith, A. G., & Swoboda, K. J. (2003) · PEDIATRICS · doi:10.1542/peds.112.3.e237 · Cited by 71
A Novel Role for p75NTR in Subplate Growth Cone Complexity and Visual Thalamocortical Innervation
McQuillen, P. S., DeFreitas, M. F., Zada, G., & Shatz, C. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03580.2002 · Cited by 70
Local Injection of Lenti–BDNF at the Lesion Site Promotes M2 Macrophage Polarization and Inhibits Inflammatory Response After Spinal Cord Injury in Mice
Ji, X., Dang, Y., Gao, H., Wang, Z., Gao, M., Yang, Y., Zhang, H., & Xu, R. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0182-x · Cited by 70
Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2)
Zhai, H., Nakade, K., Oda, M., Mitsumoto, Y., Akagi, M., Sakùrai, J., & Fukuyama, Y. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.04.035 · Cited by 70
Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain
Spulber, S. D., Mateos, L., Oprica, M., Cedazo-Mı́nguez, Á., Bartfai, T., Winblad, B. G., & Schultzberg, M. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.01.010 · Cited by 70
Palmitoylation of the C-terminal fragment of p75NTR regulates death signaling and is required for subsequent cleavage by γ-secretase
Underwood, C. K., Reid, K., May, L. M., Bartlett, P. F., & Coulson, E. J. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.10.005 · Cited by 78
Protein-tyrosine Phosphatase (PTP) Wedge Domain Peptides
Xie, Y., Massa, S. M., Craig, S., Major, D. L., Yang, T., Tisi, M. A., Derevyanny, V. D., Runge, W. O., Mehta, B., Moore, L. A., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603131200 · Cited by 70
Green tea polyphenol (−)-epigallocatechin-3-gallate protects rat PC12 cells from apoptosis induced by serum withdrawal
Mandel, S. A., Reznichenko, L., Amit, T., & Youdim, M. B. H. (2003) · Neurotoxicity Research · doi:10.1007/bf03033171 · Cited by 70
A Novel p75 Neurotrophin Receptor-Related Protein, NRH2, Regulates Nerve Growth Factor Binding to the TrkA Receptor
Murray, S. S., Pérez, P., Lee, R., Hempstead, B. L., & Chao, M. V. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3960-03.2004 · Cited by 70
PRKACB is downregulated in non-small cell lung cancer and exogenous PRKACB inhibits proliferation and invasion of LTEP-A2 cells
CHEN, Y., Gao, Y., TIAN, Y., & Tian, D. (2013) · Oncology Letters · doi:10.3892/ol.2013.1294 · Cited by 69
Cognitive Rehabilitation Improves Ischemic Stroke-Induced Cognitive Impairment: Role of Growth Factors
Farokhi-Sisakht, F., Farhoudi, M., Sadigh‐Eteghad, S., Mahmoudi, J., & Mohaddes, G. (2019) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2019.07.015 · Cited by 69
Brain‐derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons
Kim, J. H., Roberts, D. S., Hu, Y., Lau, G. C., Brooks‐Kayal, A. R., Farb, D. H., & Russek, S. J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07555.x · Cited by 71
Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA trafficking
Saxena, S., Howe, C. L., Cosgaya, J. M., Steiner, P., Hirling, H., Chan, J. R., Weis, J., & Krüttgen, A. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.11.011 · Cited by 69
p75 neurotrophin receptor functions as a survival receptor in brain‐metastatic melanoma cells
Marchetti, D., Aucoin, R., Blust, J., Murry, B. P., & Greiter‐Wilke, A. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10649 · Cited by 70
The GDNF family members neurturin, artemin and persephin promote the morphological differentiation of cultured ventral mesencephalic dopaminergic neurons
Zihlmann, K. B., Ducray, A., Schaller, B., Huber, A. W., Krebs, S. H., Andres, R. H., Seiler, R. W., Meyer, M., & Widmer, H. R. (2004) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.10.012 · Cited by 69
Selective decline of neurotrophin and neurotrophin receptor genes within CA1 pyramidal neurons and hippocampus proper: Correlation with cognitive performance and neuropathology in mild cognitive impairment and Alzheimer's disease
Ginsberg, S. D., Malek‐Ahmadi, M. H., Alldred, M. J., Che, S., Elarova, I., Chen, Y., Jeanneteau, F. D., Kranz, T. M., Chao, M. V., Counts, S., et al. (2017) · Hippocampus · doi:10.1002/hipo.22802 · Cited by 69
Sensing life: regulation of sensory neuron survival by neurotrophins
Kirstein, M., & Fariñas, I. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/pl00012506 · Cited by 69
Ternary complex with Trk, p75, and an ankyrin‐rich membrane spanning protein
Chang, M., Arévalo, J. C., & Chao, M. V. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20262 · Cited by 70
Gene expression profile in human prostate LNCaP cancer cells by (−) epigallocatechin-3-gallate
Wang, S. I., & Mukhtar, H. (2002) · Cancer Letters · doi:10.1016/s0304-3835(02)00065-4 · Cited by 69
Ultrastructural evidence for a pre‐ and postsynaptic localization of full‐length trkB receptors in substantia gelatinosa (lamina II) of rat and mouse spinal cord
Salio, C., Lossi, L., Ferrini, F., & Merighi, A. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04392.x · Cited by 68
Impaired TrkB-mediated ERK1/2 Activation in Huntington Disease Knock-in Striatal Cells Involves Reduced p52/p46 Shc Expression
Ginés, S., Paoletti, P., & Alberch, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.084202 · Cited by 68
Triggering neurotrophic factor actions through adenosine A2A receptor activation: implications for neuroprotection
Sebastião, A. M., & Ribeiro, J. A. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00157.x · Cited by 68
BDNF and its TrkB receptor in human fracture healing
Kilián, O., Hartmann, S., Dongowski, N., Karnati, S., Baumgart‐Vogt, E., Härtel, F. V., Noll, T., Schnettler, R., & Lips, K. S. (2014) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2014.06.001 · Cited by 70
Engineered BDNF producing cells as a potential treatment for neurologic disease
Deng, P., Anderson, J. D., Yu, A. S., Annett, G., Fink, K. D., & Nolta, J. A. (2016) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2016.1183641 · Cited by 70
Novel role of sphingosine kinase 1 as a mediator of neurotrophin‐3 action in oligodendrocyte progenitors
Saini, H. S., Coelho, R. P., Goparaju, S. K., Jolly, P. S., Maceyka, M. W., Spiegel, S., & Sato‐Bigbee, C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03451.x · Cited by 68
The p75NTR tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells
Khwaja, F. S., Tabassum, A., Allen, J., & Djakiew, D. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.073 · Cited by 67
Aminoglycoside-Induced Degeneration of Adult Spiral Ganglion Neurons Involves Differential Modulation of Tyrosine Kinase B and p75 Neurotrophin Receptor Signaling
Tan, J., & Shepherd, R. K. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060122 · Cited by 67
The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology
Canu, N., Amadoro, G., Triaca, V., Latina, V., Sposato, V., Corsetti, V., Severini, C., Ciotti, M. T., & Calissano, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061319 · Cited by 70
Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target
Cook, P. J., Thomas, R., Kannan, R., León, E., Drilon, A. E. D. C., Rosenblum, M. K., Scaltriti, M., Benezra, R., & Ventura, A. (2017) · Nature Communications · doi:10.1038/ncomms15987 · Cited by 67
Mechanisms of neurotrophin receptor vesicular transport
Yano, H., & Chao, M. V. (2003) · Journal of Neurobiology · doi:10.1002/neu.10321 · Cited by 66
Epidermal growth factor, neurotrophins and the metastatic cascade in prostate cancer
Montano, X., & Djamgoz, M. B. A. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.088 · Cited by 67
Neuroprotection and neurorestoration as experimental therapeutics for Parkinson's disease
Francardo, V., Schmitz, Y., Sulzer, D. L., & Cenci, M. A. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.10.001 · Cited by 66
Evidence That ΔNp73 Promotes Neuronal Survival by p53-Dependent and p53-Independent Mechanisms
Lee, A. F., Ho, D. K., Zanassi, P., Walsh, G. S., Kaplan, D. R., & Miller, F. D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1588-04.2004 · Cited by 66
Self-citation
BDNF contributes to both rapid and homeostatic alterations in AMPA receptor surface expression in nucleus accumbens medium spiny neurons
Reimers, J. M., Loweth, J. A., & Wolf, M. E. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12422 · Cited by 68
Activation of protein kinase B/Akt signaling pathway contributes to mechanical hypersensitivity induced by capsaicin
Sun, R.-Q., Tu, Y., Yan, J.-Y., & Willis, W. D. (2005) · Pain · doi:10.1016/j.pain.2005.10.017 · Cited by 66
Ablation of TrkA function in the immune system causes B cell abnormalities
Coppola, V., Barrick, C. A., Southon, E. A., Celeste, A., Wang, K., Chen, B., Haddad, E., Yin, J. L., Nussenzweig, A., Subramaniam, A., et al. (2004) · Development · doi:10.1242/dev.01383 · Cited by 66
The NGF Metabolic Pathway in the CNS and its Dysregulation in Down Syndrome and Alzheimer's Disease
Iulita, M. F., & Cuello, A. C. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150921100030 · Cited by 69
Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease
Sreenivasmurthy, S. G., Liu, J., Song, J., Yang, C., Malampati, S., Wang, Z., Huang, Y., & Li, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020272 · Cited by 67
The neurobiological hypothesis of neurotrophins in the pathophysiology of schizophrenia: A meta-analysis
Rodrígues-Amorím, D., Baltanás, T. R., Bessa, J. M., Sousa, N., Vallejo-Curto, M. D. C., Rodríguez-Jamardo, C., Heras, M. E. D. L., Díaz, R., Agís‐Balboa, R. C., Olivares, J. M., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.09.007 · Cited by 66
Ca2+-dependent Regulation of TrkB Expression in Neurons
Kingsbury, T. J., Murray, P. D., Bambrick, L. L., & Krueger, B. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303082200 · Cited by 66
Characterization and use of the NSC-34 cell line for study of neurotrophin receptor trafficking
Matusica, D., Fenech, M. P., Rogers, M., & Rush, R. A. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21507 · Cited by 67
Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents
Nie, S., Yan, X., Chen, G., Ma, K., Han, C., Guo, Z., Zhang, Z., Ye, K., & Cao, X. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.016 · Cited by 65
Sphingolipids in apoptosis, survival and regeneration in the nervous system
de Chaves, E. I. P. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.09.018 · Cited by 66
Activation of protein kinase B/Akt in the periphery contributes to pain behavior induced by capsaicin in rats
Sun, R., Yan, J., & Willis, W. D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.084 · Cited by 65
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic amp-responsive transcription factor in the rat hippocampus
Blanquet, P., Mariani, J., & Derer, P. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00963-6 · Cited by 65
Electroacupuncture regulates TRPM7 expression through the trkA/PI3K pathway after cerebral ischemia–reperfusion in rats
Zhao, L., Wang, Y., Sun, N., Liu, X., Li, L., & Shi, J. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.08.034 · Cited by 65
Calorie restriction and stroke
Manzanero, S., Gelderblom, M., Magnus, T. U., & Arumugam, T. V. (2011) · Experimental & Translational Stroke Medicine · doi:10.1186/2040-7378-3-8 · Cited by 65
CD40 signaling and Alzheimer's disease pathogenesis
Town, T., Tan, J., & MULLAN, M. J. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00044-4 · Cited by 61
Is neurotrophin-3 (NT-3): a potential therapeutic target for depression and anxiety?
de Miranda, A. S., de Barros, J. L. V. M., & Teixeira, A. L. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1846720 · Cited by 67
Region-Specific Involvement of BDNF Secretion and Synthesis in Conditioned Taste Aversion Memory Formation
Ma, L., Wang, D., Zhang, T.-Y., Yu, H. J., Wang, Y., Huang, S., Lee, F. S., & Chen, Z.-Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5348-10.2011 · Cited by 66
Nerve growth factor involvement in the visual system: implications in allergic and neurodegenerative diseases
Micera, A., Lambìase, A., Aloe, L., Bonini, S., Levi‐Schaffer, F., & Bonini, S. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.09.003 · Cited by 64
Neuroprotective effects of Nigella sativa extract on cell death in hippocampal neurons following experimental global cerebral ischemia-reperfusion injury in rats
Hobbenaghi, R., Javanbakht, J., Sadeghzadeh, S., Kheradmand, D., Abdi, F. S., Moghaddam, M. H. J., Mohammadiyan, M., Khadivar, F., & Mollaei, Y. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.11.019 · Cited by 64
Propofol-Induced Changes in Neurotrophic Signaling in the Developing Nervous System In Vivo
Popić, J., Pešić, V., Milanović, D., Todorovic, S. T., Kanazir, S., Jevtović‐Todorović, V., & Ruždijić, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034396 · Cited by 62
Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3
Middlemas, A. B. (2003) · Brain · doi:10.1093/brain/awg150 · Cited by 63
Neuroimmunologic and Neurotrophic Interactions in Autism Spectrum Disorders: Relationship to Neuroinflammation
Ohja, K., Gozal, E., Fahnestock, M. L., Cai, L., Cai, J., Freedman, J. H., Switala, A., El-Baz, A. S., & Barnes, G. N. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8488-8 · Cited by 66
Neurotrophin effects on intracellular Ca2+and force in airway smooth muscle
Prakash, Y. S., Iyanoye, A., Ay, B., Mantilla, C. B., & Pabelick, C. M. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00501.2005 · Cited by 64
Modulation of p75NTR‐dependent motor neuron death by a small non‐peptidyl mimetic of the neurotrophin loop 1 domain
Pehar, M., Cassina, P., Vargas, M. R., Xie, Y., Beckman, J. S., Massa, S. M., Longo, F. M., & Barbeito, L. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05040.x · Cited by 67
Apigenin Ameliorates Scopolamine-Induced Cognitive Dysfunction and Neuronal Damage in Mice
Kim, Y., Kim, J.-H., He, M., Lee, A., & Cho, E. J. (2021) · Molecules · doi:10.3390/molecules26175192 · Cited by 63
Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia
Cramer, T. L. M., Gill, R., Thirouin, Z. S., Vaas, M., Sampath, S., Martineau, F. S., Noya, S. B., Panzanelli, P., Sudharshan, T. J. J., Colameo, D., et al. (2022) · Science Advances · doi:10.1126/sciadv.abj0112 · Cited by 64
Protective effect of herpes simplex virus-mediated neurotrophin gene transfer in cisplatin neuropathy
Chattopadhyay, M. (2004) · Brain · doi:10.1093/brain/awh103 · Cited by 63
Regulation of TrkB cell surface expression—a mechanism for modulation of neuronal responsiveness to brain-derived neurotrophic factor
Andreska, T., Lüningschrör, P., & Sendtner, M. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03224-7 · Cited by 73
Growth, Survival and Migration: The Trk to Cancer
Rubin, J. B., & Segal, R. A. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48158-8_1 · Cited by 62
Effects of ethanol on neurotrophic factors, apoptosis-related proteins, endogenous antioxidants, and reactive oxygen species in neonatal striatum: relationship to periods of vulnerability
Heaton, M. B., Paiva, M., Madorsky, I., Mayer, J., & Moore, D. B. (2003) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00610-7 · Cited by 62
C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons
Gil, C., CHAIB-OUKADOUR, I., & Aguilera, J. (2003) · Biochemical Journal · doi:10.1042/bj20030333 · Cited by 62
Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from HO-induced neuronal death
Onyango, I. G., TUTTLE, J., & BENNETTJR, J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.02.009 · Cited by 62
Nerve Growth Factor (NGF) Promotes Angiogenesis in the Quail Chorioallantoic Membrane
Lazarovici, P., Gazit, A., Staniszewska, I., Marcinkiewicz, C., & Lelkes, P. I. (2006) · Endothelium · doi:10.1080/10623320600669053 · Cited by 62

Authors: Kaplan, D. R., & Miller, F. D.
Affiliations: Montreal Neurological Institute and Hospital (CA)
Corresponding author: Kaplan, David R
Miller, Freda D
ORCID: Kaplan, David R
Miller, Freda D
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2000-06
Volume: 10
Issue: 3
Pages: 381-391
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/s0959-4388(00)00092-1
OpenAlex: W2128960139
Cited by: 1,944
References: 122
Citations by year: 2026: 18 · 2025: 35 · 2024: 41 · 2023: 44 · 2022: 44 · 2021: 38 · 2020: 51 · 2019: 45 · 2018: 49 · 2017: 53 · 2016: 66 · 2015: 53 · 2014: 91 · 2013: 79 · 2012: 68
FWCI: 11.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: neurotrophins, signal transduction, Trk receptors, p75 neurotrophin receptor, neurotrophin receptor signaling, Akt signaling, MAPK signaling, JNK signaling, p53 pathway, NF-κB signaling, neuronal survival, neuronal development, apoptosis
MeSH terms: Animals, Nerve Growth Factors, Nervous System Physiological Phenomena, Neurons, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neurotrophin signal transduction in the nervous system

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks