Cited by 1,944Nerve injury and regenerationCell death mechanisms and regulationNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.

Neurotrophin signal transduction in the nervous system

Kaplan, David R, Miller, Freda D·2000·Current Opinion in Neurobiology

DOI 10.1016/s0959-4388(00)00092-1

Open this paper in CoChat — free account

Abstract

Neurotrophins use two types of receptors, the Trk tyrosine kinase receptors and the p75 neurotrophin receptor (p75NTR), to regulate the growth, development, survival and repair of the nervous system. These receptors can either collaborate with or inhibit each other's actions to mediate neurotrophin effects. The development and survival of neurons is thus based upon the functional interplay of the signals generated by Trk and p75NTR. In the past two years, the signaling pathways used by these receptors, including Akt and MAPK-induced signaling via Trk, and JNK, p53, and NF-kappaB signaling via p75NTR, have been identified. In addition, a number of novel p75NTR-interacting proteins have been identified that transmit growth, survival, and apoptotic signals.

Integrity signals

Registry

Crossref · 10.1016/s0959-4388(00)00092-1

Cites

123 of 123 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Neuronal Cell Death: Retraction
Hagg, T. (1999) · Science · doi:10.1126/science.285.5426.337h · Cited by 13
Retracted
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216
Regulation of neuronal survival by the serine-threonine protein kinase Akt
Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., & Greenberg, M. E. (1997) · Science · doi:10.1126/science.275.5300.661 · Cited by 2,436
Self-citation
Phosphatidylinositol-3-OH kinase direct target of Ras
Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., & Downward, J. (1994) · Nature · doi:10.1038/370527a0 · Cited by 1,954
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,908
Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
Peso, L. D., González-Garcı́a, M., Page, C., Herrera, R., & Nuñez, G. (1997) · Science · doi:10.1126/science.278.5338.687 · Cited by 1,797
The PI3K‒PDK1 connection: more than just a road to PKB
Vanhaesebroeck, B., & Alessi, D. R. (2000) · Biochemical Journal · doi:10.1042/bj3460561 · Cited by 1,649

Show all 122 references

Sorted by citations

Items 401–500 of 1,001

SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
Marsh, H. N., Dubreuil, C., Quevedo, C., Lee, A. F., Majdan, M., Walsh, G. S., Hausdorff, S. F., Said, F. A., Zoueva, O., Kozlowski, M., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200309036 · Cited by 94
Self-citation
Cholesterol Loss Enhances TrkB Signaling in Hippocampal Neurons Aging in Vitro
Martín, M. G., Perga, S., Trovò, L., Rasola, A., Holm, P. C., Rantamäki, T., Harkany, T., Ċastrén, E., Chiara, F., & Dotti, C. G. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0897 · Cited by 103
Seizure-Suppressant and Neuroprotective Effects of Encapsulated BDNF-Producing Cells in a Rat Model of Temporal Lobe Epilepsy
Falcicchia, C., Paolone, G., Emerich, D. F., Lovisari, F., Bell, W. J., Fradet, T., Wahlberg, L. U., & Simonato, M. (2018) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2018.03.001 · Cited by 94
Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7 cells
Nguyen, T. L., Kim, C. K., Cho, J.-H., Lee, K.-H., & Ahn, J. (2010) · Experimental & Molecular Medicine · doi:10.3858/emm.2010.42.8.060 · Cited by 95
Neurotrophin Receptor-interacting Mage Homologue Is an Inducible Inhibitor of Apoptosis Protein-interacting Protein That Augments Cell Death
Jordan, B. W. M., Dinev, D., Mellay, V. L., Troppmair, J., Götz, R., Wixler, L., Sendtner, M., Ludwig, S., & Rapp, U. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100171200 · Cited by 93
The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC
Fayard, B., Loeffler, S., Weis, J., Vögelin, E., & Krüttgen, A. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20432 · Cited by 93
Therapeutic Potentials of BDNF/TrkB in Breast Cancer; Current Status and Perspectives
Tajbakhsh, A., Mokhtari‐Zaer, A., Rezaee, M., Afzaljavan, F., Rivandi, M., Hassanian, S. M., Ferns, G. A., Pasdar, A., & Avan, A. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25943 · Cited by 93
ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic Activity in Response to Reductions in TrkA Receptor Levels
Ioannou, M. S., & Fahnestock, M. L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030599 · Cited by 93
High-affinity TrkA and p75 neurotrophin receptor complexes: A twisted affair
Conroy, J. N., & Coulson, E. J. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101568 · Cited by 93
AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3‐kinase‐dependent activation in extracellular signal‐regulated kinase to upregulate BDNF gene expression
Wu, X., Zhu, D., Jiang, X., Okagaki, P., Mearow, K. M., Zhu, G., McCall, S. A., Banaudha, K. K., Lipsky, R. H., & Marini, A. M. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02526.x · Cited by 92
Estrogen and female reproductive tract innervation: Cellular and molecular mechanisms of autonomic neuroplasticity
Brauer, M. M., & Smith, P. G. (2014) · Autonomic Neuroscience · doi:10.1016/j.autneu.2014.11.009 · Cited by 92
Calmodulin Mediates Brain-derived Neurotrophic Factor Cell Survival Signaling Upstream of Akt Kinase in Embryonic Neocortical Neurons
Cheng, A., Wang, S., Yang, D., Xiao, R.-P., & Mattson, M. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207232200 · Cited by 92
Neurotrophin p75 Receptor Is Involved in Neuronal Damage by Prion Peptide-(106–126)
Bianca, V. D., Rossi, F., Armato, U., Prà, I. D., Costantini, C., Perini, G., Politi, V., & Valle, G. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107454200 · Cited by 92
Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy
Shinoda, S., Schindler, C. K., Meller, R., So, N. K., Araki, T., Yamamoto, A., Lan, J., Taki, W., Simon, R. P., & Henshall, D. C. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419971 · Cited by 92
Minocycline promotes posthemorrhagic neurogenesis via M2 microglia polarization via upregulation of the TrkB/BDNF pathway in rats
Miao, H., Li, R., Han, C., Lu, X., & Zhang, H. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00234.2018 · Cited by 91
cAMP promotes neurite outgrowth and extension through protein kinase A but independently of Erk activation in cultured rat motoneurons
Aglah, C., Gordon, T., & de Chaves, E. I. P. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.04.005 · Cited by 91
Hippocampal ProNGF Signaling Pathways and β-Amyloid Levels in Mild Cognitive Impairment and Alzheimer Disease
Mufson, E. J., He, B., Nadeem, M., Perez, S. E., Counts, S., Leurgans, S. E., Fritz, J. J., Lah, J. J., Ginsberg, S. D., Wuu, J., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318272caab · Cited by 90
The role of neurotrophic factors in autism
Nickl‐Jockschat, T., & Michel, T. M. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.103 · Cited by 96
IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo
Perrelet, D., Ferri, A., Liston, P., Muzzin, P., Korneluk, R. G., & Kato, A. (2002) · Nature Cell Biology · doi:10.1038/ncb751 · Cited by 91
The Herpes Simplex Virus Type 2 R1 Protein Kinase (ICP10 PK) Functions as a Dominant Regulator of Apoptosis in Hippocampal Neurons Involving Activation of the ERK Survival Pathway and Upregulation of the Antiapoptotic Protein Bag-1
Perkins, D. J., Pereira, E. F. R., & Aurelian, L. (2002) · Journal of Virology · doi:10.1128/jvi.77.2.1292-1305.2003 · Cited by 91
Nerve Growth Factor Modulates the Activation Status and Fast Axonal Transport of ERK 1/2 in Adult Nociceptive Neurones
Averill, S., Delcroix, J., Michael, G. J., Tomlinson, D. R., Fernyhough, P., & Priestley, J. V. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1015 · Cited by 90
Neurotrophic regulation of retinal ganglion cell synaptic connectivity: from axons and dendrites to synapses
Cohen‐Cory, S., & Lom, B. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041883sc · Cited by 87
BDNF Therapeutic Mechanisms in Neuropsychiatric Disorders
Bazzari, A. H., & Bazzari, F. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158417 · Cited by 98
Brawn for Brains: The Role of MEF2 Proteins in the Developing Nervous System
Shalizi, A., & Bonni, A. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)69009-6 · Cited by 86
FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling
Zheng, W., Kar, S., & Quirion, R. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2002.00783.x · Cited by 96
7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis
Korkmaz, O. T., Aytan, N., Carreras, I., Choi, J., Kowall, N. W., Jenkins, B. G., & Dedeoglu, A. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.02.058 · Cited by 90
Combined effect of nerve growth factor and brain-derived neurotrophic factor on neuronal differentiation of neural stem cells and the potential molecular mechanisms
Liu, F., Xuan, A., Chen, Y., ZHANG, J., Xu, L., Yan, Q., & Long, D. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2393 · Cited by 89
Nerve growth factor regulates substance P in adult sensory neurons through both TrkA and p75 receptors
Skoff, A. M., & Adler, J. E. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.10.006 · Cited by 88
Neuritin Mediates Nerve Growth Factor–Induced Axonal Regeneration and Is Deficient in Experimental Diabetic Neuropathy
Karamoysoyli, E., Burnand, R. C., Tomlinson, D. R., & Gardiner, N. J. (2007) · Diabetes · doi:10.2337/db07-0895 · Cited by 89
Brain-derived neurotrophic factor can act as a pronecrotic factor through transcriptional and translational activation of NADPH oxidase
Kim, S. H., Won, S. J., Sohn, S., Kwon, H. J., Lee, J. Y., Park, J.-H., & Gwag, B. J. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112131 · Cited by 90
Long-Lasting Rescue of Age-Associated Deficits in Cognition and the CNS Cholinergic Phenotype by a Partial Agonist Peptidomimetic Ligand of TrkA
Bruno, M. A., Clarke, P. B. S., Seltzer, A. M., Quirion, R., Burgess, K., Cuello, A. C., & Saragovi, H. U. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1508-04.2004 · Cited by 89
NGF-dependent neurons and neurobiology of emotions and feelings: Lessons from congenital insensitivity to pain with anhidrosis
Indo, Y. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.01.013 · Cited by 90
Growth and guidance cues for regenerating axons: Where have they gone?
Koeberle, P. D., & Bähr, M. (2004) · Journal of Neurobiology · doi:10.1002/neu.10345 · Cited by 88
Trypanosoma cruzi trans - sialidase: A potent and specific survival factor for human Schwann cells by means of phosphatidylinositol 3-kinase/Akt signaling
Chuenkova, M. V., Furnari, F. B., Cavenee, W. K., & Pereira, M. E. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161298398 · Cited by 88
Brain-Derived Neurotrophic Factor (BDNF) Acts Primarily via the JAK/STAT Pathway to Promote Neurite Growth in the Major Pelvic Ganglion of the Rat: Part 2
Lin, G., Bella, A. J., Lue, T. F., & Lin, C. (2006) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00292.x · Cited by 88
Modulation of neurogenesis via neurotrophic factors in acupuncture treatments for neurological diseases
Shin, H. K., Lee, S., & Choi, B. T. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.04.029 · Cited by 87
Human ProNGF: biological effects and binding profiles at TrkA, P75 NTR and sortilin
Clewes, O., Fahey, M. S., Tyler, S. J., Watson, J. J., Seok, H., Catania, C., Cho, K., Dawbarn, D., & Allen, S. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05698.x · Cited by 87
Neurotrophin production in brain pericytes during hypoxia: A role of pericytes for neuroprotection
Ishitsuka, K., Ago, T., Arimura, K., Nakamura, K., Tokami, H., Makihara, N., Kuroda, J., Kamouchi, M., & Kitazono, T. (2012) · Microvascular Research · doi:10.1016/j.mvr.2012.02.009 · Cited by 89
Brain-derived neurotrophic factor amplifies neurotransmitter responses and promotes synaptic communication in the enteric nervous system
Boesmans, W., Gomes, P. M., Janssens, J., Tack, J. F., & Berghe, P. V. (2007) · Gut · doi:10.1136/gut.2007.131839 · Cited by 87
Pan-Neurotrophin Receptor p75 Contributes to Neuronal Hyperreactivity and Airway Inflammation in a Murine Model of Experimental Asthma
Kerzel, S., Päth, G., Nockher, W. A., Quarcoo, D., Raap, U., Groneberg, D. A., Dinh, Q. T., Fischer, A., Braun, A. C., & Renz, H. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.4811 · Cited by 87
Synaptogenesis in the CNS: An Odyssey from Wiring Together to Firing Together
Munno, D. W., & Syed, N. I. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.045062 · Cited by 86
Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neuronsPreprint
Postigo, A. A., Calella, A. M., Fritzsch, B., Knipper, M., Katz, D. M., Eilers, A., Schimmang, T., Lewin, G. R., Klein, R., & Minichiello, L. (2002) · Genes & Development · doi:10.1101/gad.217902 · Cited by 86
Involvement of Brain-Derived Neurotrophic Factor in Late-Life Depression
Dwivedi, Y. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.10.026 · Cited by 86
Combination therapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: Is more better?
Kline, A. E., Leary, J. B., Radabaugh, H. L., B, J. P. C. A., & Bondi, C. O. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.05.002 · Cited by 89
A Positive Role of the PI3-K/Akt Signaling Pathway in PC12 Cell Differentiation
Kim, Y., Seger, R., V., S. B. C., Hwang, S., & Yoo, Y. S. (2004) · Molecules and Cells · doi:10.1016/s1016-8478(23)13124-4 · Cited by 85
Brain‐derived neurotrophic factor induces proliferation of human airway smooth muscle cells
Aravamudan, B., Thompson, M., Pabelick, C. M., & Prakash, Y. S. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01356.x · Cited by 85
Differential effects of neurotrophins on neuronal survival and axonal regeneration after spinal cord injury in adult rats
Novikova, L. N., Novikov, L. N., & Kellerth, J. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10381 · Cited by 85
Protein trafficking mechanisms associated with neurite outgrowth and polarized sorting in neurons
Tang, B. L. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00674.x · Cited by 85
Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases
Numakawa, T., & Kajihara, R. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1247422 · Cited by 90
Formation and Evolution of the Chordate Neurotrophin and Trk Receptor Genes
Hallböök, F., Wilson, K., Thorndyke, M. C., & Olinski, R. P. (2006) · Brain Behavior and Evolution · doi:10.1159/000094083 · Cited by 85
Apoptosis in the mature and developing olfactory neuroepithelium
Cowan, C. M., & Roskams, A. J. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10150 · Cited by 84
Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation
Emdal, K. B., Pedersen, A.-K., Bekker‐Jensen, D. B., Tsafou, K. P., Horn, H., Lindner, S., Schulte, J. H., Eggert, A., Jensen, L. J., Francavilla, C., et al. (2015) · Science Signaling · doi:10.1126/scisignal.2005769 · Cited by 82
Neurotrophins in the Regulation of Cellular Survival and Death
Ceni, C., Unsain, N., Zeinieh, M. P., & Barker, P. A. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-45106-5_8 · Cited by 81
Role of Megakaryoblastic Acute Leukemia-1 in ERK1/2-Dependent Stimulation of Serum Response Factor-Driven Transcription by BDNF or Increased Synaptic Activity
Kalita, K. B., Kharebava, G., Zheng, J., & Hetman, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2644-06.2006 · Cited by 83
Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways
Lorber, B., Howe, M. L., Benowitz, L. I., & Irwin, N. (2009) · Nature Neuroscience · doi:10.1038/nn.2414 · Cited by 83
Sorting of Internalized Neurotrophins into an Endocytic Transcytosis Pathway via the Golgi System: Ultrastructural Analysis in Retinal Ganglion Cells
Butowt, R., & von Bartheld, C. S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-22-08915.2001 · Cited by 83
Dual role for p75NTR signaling in survival and cell death: Can intracellular mediators provide an explanation?
Mamidipudi, V., & Wooten, M. W. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10244 · Cited by 84
Brain-derived neurotrophic factor induces matrix metalloproteinase 9 expression in neurons via the serum response factor/c-Fos pathway
Kuzniewska, B., Rejmak, E., Malik, A. R., Jaworski, J., Kaczmarek, L., & Kalita, K. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00008-13 · Cited by 82
Activation of Rac1 by phosphatidylinositol 3‐kinase in vivo: role in activation of mitogen‐activated protein kinase (MAPK) pathways and retinoic acid‐induced neuronal differentiation of SH‐SY5Y cells
Pan, J., Kao, Y., Joshi, S., Jeetendran, S., DiPette, D., & Singh, U. S. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03106.x · Cited by 94
Gene therapy for retinal ganglion cell neuroprotection in glaucoma
Wilson, A. M., & Polo, A. D. (2011) · Gene Therapy · doi:10.1038/gt.2011.142 · Cited by 81
Green tea polyphenol (–)‐epigallocatechin‐3‐gallate promotes the rapid protein kinase C‐ and proteasome‐mediated degradation of Bad: implications for neuroprotection
Kalfon, L., Youdim, M. B. H., & Mandel, S. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04265.x · Cited by 82
Reduced neuroplasticity in aged rats: a role for the neurotrophin brain-derived neurotrophic factor
Calabrese, F., Guidotti, G., Racagni, G., & Riva, M. A. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.014 · Cited by 82
Neutralization of Nerve Growth Factor Induces Plasticity of ATP-Sensitive P2X3Receptors of Nociceptive Trigeminal Ganglion Neurons
D’Arco, M., Giniatullin, R. A., Simonetti, M., Fabbro, A., Nair, A., Nistri, A., & Fabbretti, E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0713-07.2007 · Cited by 83
Proneurotrophins, Seizures, and Neuronal Apoptosis
Friedman, W. (2010) · The Neuroscientist · doi:10.1177/1073858409349903 · Cited by 82
Conventional and Functional Proteomics Using Large Format Two-Dimensional Gel Electrophoresis 24 Hours after Controlled Cortical Impact in Postnatal Day 17 Rats
Jenkins, L. W., Peters, G., Dixon, C. E., Zhang, X., Clark, R. S. B., Skinner, J. C., Marion, D. W., Adelson, P. D., & Kochanek, P. M. (2002) · Journal of Neurotrauma · doi:10.1089/08977150260139101 · Cited by 81
Activation of the specific neurotrophin receptors TrkA, TrkB and TrkC influences the function of eosinophils
Noga, O., Englmann, C., Hanf, G., Grützkau, A., Guhl, S., & Kunkel, G. (2002) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2745.2002.01442.x · Cited by 82
PolyADP-Ribosylation Is Involved in Neurotrophic Activity
Visochek, L., Steingart, R. A., Vulih-Shultzman, I., Klein, R., Priel, E., Gozes, I., & Cohen‐Armon, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0333-05.2005 · Cited by 82
Altered Expression and Activation of the Nerve Growth Factor Receptors TrkA and p75 Provide the First Evidence of Tumor Progression to Effusion in Breast Carcinoma
Davidson, B., Reich, R., Lazarovici, P., Flørenes, V. A., Nielsen, S. M., & Nesland, J. M. (2004) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000010704.17479.8a · Cited by 81
Mitogen‐activated protein kinase pathway mediates effects of brain‐derived neurotrophic factor on differentiation of basal forebrain oligodendrocytes
Du, Y., Lercher, L. D., Zhou, R., & Dreyfus, C. F. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21080 · Cited by 81
Nerve growth factor in treatment and pathogenesis of Alzheimer's disease
Williams, B. J., Eriksdotter, M., & Granholm, A. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.09.001 · Cited by 81
Use of Genetically Modified Mesenchymal Stem Cells to Treat Neurodegenerative Diseases
Wyse, R. D., Dunbar, G. L., & Rossignol, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15021719 · Cited by 81
TNF-α/TNFR1 Signaling Is Required for the Development and Function of Primary Nociceptors
Wheeler, M. A., Heffner, D. L., Kim, S., Espy, S. M., Spano, A., Cleland, C. L., & Deppmann, C. D. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.009 · Cited by 84
Individual and Combined Effects of TrkA and p75NTR Nerve Growth Factor Receptors
Lad, S. P., Peterson, D. A., Bradshaw, R. A., & Neet, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212270200 · Cited by 80
Plenty of calcification: imaging characterization of polymorphous low-grade neuroepithelial tumor of the young
Johnson, D. R., Giannini, C., Jenkins, R. B., Kim, D. K., & Kaufmann, T. J. (2019) · Neuroradiology · doi:10.1007/s00234-019-02269-y · Cited by 79
A review of dorsal root ganglia and primary sensory neuron plasticity mediating inflammatory and chronic neuropathic pain
Jang, K., & Garraway, S. M. (2024) · Neurobiology of Pain · doi:10.1016/j.ynpai.2024.100151 · Cited by 83
Identification of a Switch in Neurotrophin Signaling by Selective Tyrosine Phosphorylation
Arévalo, J. C., Pereira, D. B., Yano, H., Teng, K. K., & Chao, M. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504163200 · Cited by 85
A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling
Rajagopal, R., & Chao, M. V. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.06.002 · Cited by 79
Low Concentration of BDNF in the Acute Phase of Ischemic Stroke as a Factor in Poor Prognosis in Terms of Functional Status of Patients
Lasek‐Bal, A., Jędrzejowska–Szypułka, H., Różycka, J., Bal, W., Holecki, M. T., Duława, J., & Lewin‐Kowalik, J. (2015) · Medical Science Monitor · doi:10.12659/msm.895358 · Cited by 80
The Role of Neurotrophic Factors, Apoptosis-Related Proteins, and Endogenous Antioxidants in the Differential Temporal Vulnerability of Neonatal Cerebellum to Ethanol
Heaton, M. B., Moore, D. B., Paiva, M., Madorsky, I., Mayer, J., & Shaw, G. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2003.tb04402.x · Cited by 79
Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor
Hartmann, M., Brigadski, T., Erdmann, K. S., Holtmann, B., Sendtner, M., Narz, F., & Leßmann, V. (2004) · Journal of Cell Science · doi:10.1242/jcs.01511 · Cited by 78
Dendritic changes in visual pathways in glaucoma and other neurodegenerative conditions
Liu, M., Duggan, J., Salt, T. E., & Cordeiro, M. F. (2011) · Experimental Eye Research · doi:10.1016/j.exer.2011.01.014 · Cited by 78
Neuropathological and Behavioral Consequences of Adeno-Associated Viral Vector-Mediated Continuous Intrastriatal Neurotrophin Delivery in a Focal Ischemia Model in Rats
Andsberg, G., Kokaia, Z., Klein, R. L., Muzyczka, N., Lindvall, O., & Mandel, R. J. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0456 · Cited by 80
The coupling of a trkB tyrosine residue to LTP
Ernfors, P., & Bramham, C. R. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00064-x · Cited by 78
Inhibition of Protein Kinase C Prevents Purkinje Cell Death But Does Not Affect Axonal Regeneration
Ghoumari, A. M., Wehrlé, R., Zeeuw, C. I. D., Sotelo, C., & Dusart, I. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03531.2002 · Cited by 77
The concerted signaling of ERK1/2 and JNKs is essential for PC12 cell neuritogenesis and converges at the level of target proteins
Waetzig, V., & Herdegen, T. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00126-x · Cited by 76
Src and FAK are key early signalling intermediates required for neurite growth in NGF-responsive adult DRG neurons
Tucker, B. A., Rahimtula, M., & Mearow, K. M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.10.014 · Cited by 77
The memory-enhancing effects of Euphoria longan fruit extract in mice
Park, S. J., Park, D. H., Kim, D. H., Lee, S., Yoon, B. H., Jung, W. Y., Lee, K., Cheong, J. H., & Ryu, J. H. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.01.001 · Cited by 77
Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas
Schulte, J. H., Schramm, A. R., Klein‐Hitpaß, L., Klenk, M., Wessels, H., Hauffa, B. P., Eils, J., Eils, R., Brodeur, G. M., Schweigerer, L., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1208000 · Cited by 77
O-Methylated Metabolite of 7,8-Dihydroxyflavone Activates TrkB Receptor and Displays Antidepressant Activity
Liu, X., Qi, Q., Xiao, G., Li, J., Luo, H. R., & Ye, K. (2013) · Pharmacology · doi:10.1159/000346920 · Cited by 75
BDNF-, IGF-1- and GDNF-Secreting Human Neural Progenitor Cells Rescue Amyloid β-Induced Toxicity in Cultured Rat Septal Neurons
Kitiyanant, N., Kitiyanant, Y., Svendsen, C. N., & Thangnipon, W. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0592-1 · Cited by 76
Protection with estradiol in developmental models of apoptotic neurodegeneration
Asimiadou, S., Bittigau, P., Felderhoff‐Mueser, U., Manthey, D., Sifringer, M., Pesditschek, S., Dzietko, M., Kaindl, A. M., Pytel, M., Studniarczyk, D., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20553 · Cited by 75
ROS Produced by NOX2 Controls In Vitro Development of Cerebellar Granule Neurons Development
Olguín‐Albuerne, M., & Morán, J. (2015) · ASN NEURO · doi:10.1177/1759091415578712 · Cited by 78
Genomic Fusions in Pigmented Spindle Cell Nevus of Reed
VandenBoom, T. G., Quan, V. L., Zhang, B., Garfield, E. M., Kong, B. Y., Isales, M. C., Panah, E., Igartua, C., Taxter, T., Beaubier, N. T., et al. (2018) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000001074 · Cited by 76
Neuroprotection of immortalized hippocampal neurones by brain‐derived neurotrophic factor and Raf‐1 protein kinase: role of extracellular signal‐regulated protein kinase and phosphatidylinositol 3‐kinase
Rößler, O. G., Giehl, K. M., & Thiel, G. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02255.x · Cited by 77
Nerve Growth Factor Induces Proliferation and Aggressiveness in Prostate Cancer Cells
Donato, M. D., Cernera, G., Migliaccio, A., & Castoria, G. (2019) · Cancers · doi:10.3390/cancers11060784 · Cited by 73
Testing NTRK testing: Wet‐lab and in silico comparison of RNA‐based targeted sequencing assays
Pfarr, N., Kirchner, M., Lehmann, U., Leichsenring, J., Merkelbach‐Bruse, S., Glade, J., Hummel, M., Stögbauer, F., Lehmann, A., Trautmann, M., et al. (2019) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22819 · Cited by 74
TrkB Truncated Isoform Receptors as Transducers and Determinants of BDNF Functions
Tessarollo, L., & Yanpallewar, S. U. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.847572 · Cited by 85
Genetically modified mesenchymal stem cells (MSCs) promote axonal regeneration and prevent hypersensitivity after spinal cord injury
Kumagai, G., Tsoulfas, P., Toh, S., McNiece, I., Bramlett, H. M., & Dietrich, W. D. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.06.028 · Cited by 75
The Role of Rab Proteins in Neuronal Cells and in the Trafficking of Neurotrophin Receptors
Bucci, C., Alifano, P., & Cogli, L. (2014) · Membranes · doi:10.3390/membranes4040642 · Cited by 77
MiR-133b Promotes Neurite Outgrowth by Targeting RhoA Expression
Lu, X. C., Zheng, J. Y., Tang, L. J., Huang, B. S., Li, K., Tao, Y., Yu, W., Zhu, R. L., Li, S., & Li, L. X. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000369692 · Cited by 75

Authors: Kaplan, D. R., & Miller, F. D.
Affiliations: Montreal Neurological Institute and Hospital (CA)
Corresponding author: Kaplan, David R
Miller, Freda D
ORCID: Kaplan, David R
Miller, Freda D
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2000-06
Volume: 10
Issue: 3
Pages: 381-391
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/s0959-4388(00)00092-1
OpenAlex: W2128960139
Cited by: 1,944
References: 122
Citations by year: 2026: 18 · 2025: 35 · 2024: 41 · 2023: 44 · 2022: 44 · 2021: 38 · 2020: 51 · 2019: 45 · 2018: 49 · 2017: 53 · 2016: 66 · 2015: 53 · 2014: 91 · 2013: 79 · 2012: 68
FWCI: 11.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: neurotrophins, signal transduction, Trk receptors, p75 neurotrophin receptor, neurotrophin receptor signaling, Akt signaling, MAPK signaling, JNK signaling, p53 pathway, NF-κB signaling, neuronal survival, neuronal development, apoptosis
MeSH terms: Animals, Nerve Growth Factors, Nervous System Physiological Phenomena, Neurons, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neurotrophin signal transduction in the nervous system

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks