The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Neurotrophin signal transduction in the nervous system
Abstract
Neurotrophins use two types of receptors, the Trk tyrosine kinase receptors and the p75 neurotrophin receptor (p75NTR), to regulate the growth, development, survival and repair of the nervous system. These receptors can either collaborate with or inhibit each other's actions to mediate neurotrophin effects. The development and survival of neurons is thus based upon the functional interplay of the signals generated by Trk and p75NTR. In the past two years, the signaling pathways used by these receptors, including Akt and MAPK-induced signaling via Trk, and JNK, p53, and NF-kappaB signaling via p75NTR, have been identified. In addition, a number of novel p75NTR-interacting proteins have been identified that transmit growth, survival, and apoptotic signals.
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Claims the paper makes
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Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It regulates many different cellular processes involved in the development and maintenance of normal brain function by binding and activating the TrkB, a member of the larger family of Trk receptors.”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [86]
In the citing paper
“BDNF signals through the tropomycin receptor kinase B (TrkB) and the low affinity p75 neurotrophin receptor (p75NTR).”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [86]
In the citing paper
“Both proBDNF and mBDNF are active, eliciting opposing effects via the p75 neurotrophin receptor (p75NTR), a member of the tumor necrosis factor (TNF) receptor family and TrkB receptor, respectively.”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [86]
In the citing paper
“mBDNF binds with the high-affinity TrkB receptor, the receptor dimerizes, and the intracellular tyrosine residues are autophosphorylated [86].”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [86]
In the citing paper
“where it is implicated in plasticity mechanisms hypothesized to underlie learning6.”
From Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease (2009) · cites this paper as [6]
In the citing paper
“Deficiencies in canonical signaling through Erk–mitogen-activated protein kinase kinase, but not Akt, would be predicted in a model of cell dysfunction but not death6; our findings in aged rats are consistent with this prediction, as BDNF ameliorates age-related deficiencies in Erk without detectably perturbing Akt.”
From Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease (2009) · cites this paper as [6]
Citations
Cites
1 retracted
Neuronal Cell Death: Retraction
Hagg, T. (1999) · Science · doi:10.1126/science.285.5426.337h · Cited by 13
RetractedAkt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216
Regulation of neuronal survival by the serine-threonine protein kinase Akt
Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., & Greenberg, M. E. (1997) · Science · doi:10.1126/science.275.5300.661 · Cited by 2,436
Self-citationPhosphatidylinositol-3-OH kinase direct target of Ras
Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., & Downward, J. (1994) · Nature · doi:10.1038/370527a0 · Cited by 1,954
Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,908
Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
Peso, L. D., González-Garcı́a, M., Page, C., Herrera, R., & Nuñez, G. (1997) · Science · doi:10.1126/science.278.5338.687 · Cited by 1,797
The PI3K‒PDK1 connection: more than just a road to PKB
Vanhaesebroeck, B., & Alessi, D. R. (2000) · Biochemical Journal · doi:10.1042/bj3460561 · Cited by 1,649
Cited by
Sorted by citations
Items 1,001–1,001 of 1,001
Identification and Characterization of Compounds That Potentiate NT-3-Mediated Trk Receptor Activity
Lewis, M. A., Hunihan, L., Franco, D., Robertson, B., Palmer, J., Laurent, D. R. S., Balasubramanian, B. N., Li, Y., & Westphal, R. S. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.020255 · Cited by 21
Metadata
- Authors
- Kaplan, D. R., & Miller, F. D.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- Corresponding author
- Kaplan, David R
- Miller, Freda D
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 10
- Issue
- 3
- Pages
- 381-391
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2128960139
- Cited by
- 1,944
- References
- 122
- Citations by year
- 2026: 18 · 2025: 35 · 2024: 41 · 2023: 44 · 2022: 44 · 2021: 38 · 2020: 51 · 2019: 45 · 2018: 49 · 2017: 53 · 2016: 66 · 2015: 53 · 2014: 91 · 2013: 79 · 2012: 68
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- neurotrophins, signal transduction, Trk receptors, p75 neurotrophin receptor, neurotrophin receptor signaling, Akt signaling, MAPK signaling, JNK signaling, p53 pathway, NF-κB signaling, neuronal survival, neuronal development, apoptosis
- MeSH terms
- Animals, Nerve Growth Factors, Nervous System Physiological Phenomena, Neurons, Signal Transduction
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