Cited by 1,944Nerve injury and regenerationCell death mechanisms and regulationNeurogenesis and neuroplasticity mechanisms

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Neurotrophin signal transduction in the nervous system

Kaplan, David R, Miller, Freda D·2000·Current Opinion in Neurobiology

DOI 10.1016/s0959-4388(00)00092-1

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Abstract

Neurotrophins use two types of receptors, the Trk tyrosine kinase receptors and the p75 neurotrophin receptor (p75NTR), to regulate the growth, development, survival and repair of the nervous system. These receptors can either collaborate with or inhibit each other's actions to mediate neurotrophin effects. The development and survival of neurons is thus based upon the functional interplay of the signals generated by Trk and p75NTR. In the past two years, the signaling pathways used by these receptors, including Akt and MAPK-induced signaling via Trk, and JNK, p53, and NF-kappaB signaling via p75NTR, have been identified. In addition, a number of novel p75NTR-interacting proteins have been identified that transmit growth, survival, and apoptotic signals.

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Authors: Kaplan, D. R., & Miller, F. D.
Affiliations: Montreal Neurological Institute and Hospital (CA)
Corresponding author: Kaplan, David R
Miller, Freda D
ORCID: Kaplan, David R
Miller, Freda D
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2000-06
Volume: 10
Issue: 3
Pages: 381-391
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/s0959-4388(00)00092-1
OpenAlex: W2128960139
Cited by: 1,944
References: 122
Citations by year: 2026: 18 · 2025: 35 · 2024: 41 · 2023: 44 · 2022: 44 · 2021: 38 · 2020: 51 · 2019: 45 · 2018: 49 · 2017: 53 · 2016: 66 · 2015: 53 · 2014: 91 · 2013: 79 · 2012: 68
FWCI: 11.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: neurotrophins, signal transduction, Trk receptors, p75 neurotrophin receptor, neurotrophin receptor signaling, Akt signaling, MAPK signaling, JNK signaling, p53 pathway, NF-κB signaling, neuronal survival, neuronal development, apoptosis
MeSH terms: Animals, Nerve Growth Factors, Nervous System Physiological Phenomena, Neurons, Signal Transduction

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Neurotrophin signal transduction in the nervous system

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