Cited by 1,944Nerve injury and regenerationCell death mechanisms and regulationNeurogenesis and neuroplasticity mechanisms

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Neurotrophin signal transduction in the nervous system

Kaplan, David R, Miller, Freda D·2000·Current Opinion in Neurobiology

DOI 10.1016/s0959-4388(00)00092-1

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Abstract

Neurotrophins use two types of receptors, the Trk tyrosine kinase receptors and the p75 neurotrophin receptor (p75NTR), to regulate the growth, development, survival and repair of the nervous system. These receptors can either collaborate with or inhibit each other's actions to mediate neurotrophin effects. The development and survival of neurons is thus based upon the functional interplay of the signals generated by Trk and p75NTR. In the past two years, the signaling pathways used by these receptors, including Akt and MAPK-induced signaling via Trk, and JNK, p53, and NF-kappaB signaling via p75NTR, have been identified. In addition, a number of novel p75NTR-interacting proteins have been identified that transmit growth, survival, and apoptotic signals.

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Neuronal Cell Death: Retraction
Hagg, T. (1999) · Science · doi:10.1126/science.285.5426.337h · Cited by 13
Retracted
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216
Regulation of neuronal survival by the serine-threonine protein kinase Akt
Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., & Greenberg, M. E. (1997) · Science · doi:10.1126/science.275.5300.661 · Cited by 2,436
Self-citation
Phosphatidylinositol-3-OH kinase direct target of Ras
Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., & Downward, J. (1994) · Nature · doi:10.1038/370527a0 · Cited by 1,954
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,908
Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
Peso, L. D., González-Garcı́a, M., Page, C., Herrera, R., & Nuñez, G. (1997) · Science · doi:10.1126/science.278.5338.687 · Cited by 1,797
The PI3K‒PDK1 connection: more than just a road to PKB
Vanhaesebroeck, B., & Alessi, D. R. (2000) · Biochemical Journal · doi:10.1042/bj3460561 · Cited by 1,649

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Self-citation
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Ho, R., Eggert, A., Hishiki, T., Minturn, J. E., Ikegaki, N., Foster, P., Camoratto, A. M., Evans, A. E., & Brodeur, G. M. (2002) · PubMed · Cited by 228
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Moy, S. S., & Nadler, J. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002082 · Cited by 204
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Favalli, G. P. D. S., Li, J., Belmonte-de-Abreu, P. S., Wong, A. H. C., & Daskalakis, Z. J. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.09.022 · Cited by 207
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BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment
Novkovic, T., Mittmann, T., & Manahan‐Vaughan, D. (2014) · Hippocampus · doi:10.1002/hipo.22342 · Cited by 199
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Indo, Y. (2001) · Human Mutation · doi:10.1002/humu.1224 · Cited by 192
Rearrangements of NTRK1 gene in papillary thyroid carcinoma
Greco, A., Miranda, C., & Pierotti, M. A. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.10.009 · Cited by 192
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Isenmann, S. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(03)00027-2 · Cited by 192
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Gao, Y., Nikulina, E., Mellado, W., & Filbin, M. T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-37-11770.2003 · Cited by 192
Ligand-Induced Internalization of the p75 Neurotrophin Receptor: A Slow Route to the Signaling Endosome
Bronfman, F. C., Tcherpakov, M., Jovin, T. M., & Fainzilber, M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03209.2003 · Cited by 190
Improving peripheral nerve regeneration: From molecular mechanisms to potential therapeutic targets
Chan, K. M., Gordon, T., Zochodne, D. W., & Power, H. A. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.09.006 · Cited by 189
Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival
Chen, S., Mangé, A., Dong, L., Lehmann, S., & Schachner, M. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(02)00014-3 · Cited by 189
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Aso, E., Ozaita, A., Valdizán, E. M., Ledent, C. A., Pazos, Á., Maldonado, R. J., & Valverde, O. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05149.x · Cited by 189
Lipid rafts-protein association and the regulation of protein activity.
Lucero, H., & Robbins, P. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.03.020 · Cited by 201
Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy
Heinrich, C., Lähteinen, S., Suzuki, F., Laharie, A., Huber, S., Häussler, U., Haas, C. A., Larmet, Y., Ċastrén, E., & Depaulis, A. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.001 · Cited by 187
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BDNF overexpression increases dendrite complexity in hippocampal dentate gyrus
Tolwani, R. J., Buckmaster, P. S., Varma, S., Cosgaya, J. M., Wu, Y.-J., Suri, C., & Shooter, E. M. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00301-9 · Cited by 184
Mature neurons: equipped for survival
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Authors: Kaplan, D. R., & Miller, F. D.
Affiliations: Montreal Neurological Institute and Hospital (CA)
Corresponding author: Kaplan, David R
Miller, Freda D
ORCID: Kaplan, David R
Miller, Freda D
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2000-06
Volume: 10
Issue: 3
Pages: 381-391
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/s0959-4388(00)00092-1
OpenAlex: W2128960139
Cited by: 1,944
References: 122
Citations by year: 2026: 18 · 2025: 35 · 2024: 41 · 2023: 44 · 2022: 44 · 2021: 38 · 2020: 51 · 2019: 45 · 2018: 49 · 2017: 53 · 2016: 66 · 2015: 53 · 2014: 91 · 2013: 79 · 2012: 68
FWCI: 11.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: neurotrophins, signal transduction, Trk receptors, p75 neurotrophin receptor, neurotrophin receptor signaling, Akt signaling, MAPK signaling, JNK signaling, p53 pathway, NF-κB signaling, neuronal survival, neuronal development, apoptosis
MeSH terms: Animals, Nerve Growth Factors, Nervous System Physiological Phenomena, Neurons, Signal Transduction

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Neurotrophin signal transduction in the nervous system

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