Signal transduction by tumor necrosis factor and its relatives

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

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Two tumour necrosis factor receptors: structure and function

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Free radicals and antioxidants in normal physiological functions and human disease

Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269

Inflammation and metabolic disorders

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Free radicals, metals and antioxidants in oxidative stress-induced cancer

Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680

Signalling pathways of the TNF superfamily: a double-edged sword

Aggarwal, B. B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1184 · Cited by 2,793

Macrophages, inflammation, and insulin resistance

Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738

NF-κB at the crossroads of life and death

Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709

Chronic Inflammation in Obesity and the Metabolic Syndrome

Monteiro, R., & Azevedo, I. (2010) · Mediators of Inflammation · doi:10.1155/2010/289645 · Cited by 1,186

Regulation of ferritin genes and protein

Torti, F. M., & Torti, S. V. (2002) · Blood · doi:10.1182/blood.v99.10.3505 · Cited by 1,173

Differential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-α

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IRS proteins and the common path to diabetes

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The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression

De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898

Evidence for a cytokine model of cognitive function

McAfoose, J., & Baune, B. T. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.005 · Cited by 760

Neurotrophin Signaling Through the P75 Neurotrophin Receptor

Roux, P. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00016-3 · Cited by 717

Inhibition of JNK activation through NF-κB target genes

Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., & Lin, A. (2001) · Nature · doi:10.1038/35104568 · Cited by 721

Adipocytokines in Obesity and Metabolic Disease

Cao, H. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0339 · Cited by 705

IL-6 signal transduction and its physiological roles: the signal orchestration model

Kamimura, D., Ishihara, K., & Hirano, T. (2003) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/s10254-003-0012-2 · Cited by 673

Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages

Ghisletti, S., Barozzi, I., Mietton, F., Polletti, S., De Santa, F., Venturini, E., Gregory, L., Lonie, L., Chew, A., Wei, C.-L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.008 · Cited by 666

Cell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis

Mussbacher, M., Salzmann, M., Brostjan, C., Hoesel, B., Schoergenhofer, C., Datler, H., Hohensinner, P., Basílio, J., Petzelbauer, P., Assinger, A., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00085 · Cited by 596

Redox Regulation of NF-κB Activation: Distinct Redox Regulation Between the Cytoplasm and the Nucleus

Kabe, Y., Ando, K., Hirao, S., Yoshida, M., & Handa, H. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.395 · Cited by 585

Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1

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Tumor Necrosis Factor-α, Interleukin-1β, and Interferon-γ Stimulate γ-Secretase-mediated Cleavage of Amyloid Precursor Protein through a JNK-dependent MAPK Pathway

Liao, Y.-F., Wang, B.-J., Cheng, H.-T., Kuo, L.-H., & Wolfe, M. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402034200 · Cited by 389

The dual role of the neuroinflammatory response after ischemic stroke: Modulatory effects of hypothermia

Ceulemans, A.-G., Zgavc, T., Kooijman, R., Hachimi-Idrissi, S., Sarre, S., & Michotte, Y. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-74 · Cited by 351

The many faces of p75NTR

Hempstead, B. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00321-5 · Cited by 321

Neuroplastic changes in depression: A role for the immune system

Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319

Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases

Beck, I. M. E., Vanden Berghe, W., Vermeulen, L., Yamamoto, K. R., Haegeman, G., & De Bosscher, K. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0013 · Cited by 298

Depressive-like behavior induced by tumor necrosis factor-α in mice

Kaster, M. P., Gadotti, V. M., Calixto, J. B., Santos, A. R. S., & Rodrigues, A. L. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.018 · Cited by 294

Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses

Choi, C., & Benveniste, E. N. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2003.08.007 · Cited by 270

Neuroinflammation: An Integrating Overview of Reactive‐Neuroimmune Cell Interactions in Health and Disease

Kölliker-Frers, R., Udovin, L., Otero-Losada, M., Kobiec, T., Herrera, M. I., Palacios, J., Razzitte, G., & Capani, F. (2021) · Mediators of Inflammation · doi:10.1155/2021/9999146 · Cited by 258

IκB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

Ruocco, M. G., Maeda, S., Park, J. M., Lawrence, T., Hsu, L.-C., Cao, Y., Schett, G., Wagner, E. F., & Karin, M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042081 · Cited by 252

TNF-alpha contributes to spinal cord synaptic plasticity and inflammatory pain: Distinct role of TNF receptor subtypes 1 and 2

Zhang, L., Berta, T., Xu, Z.-Z., Liu, T., Park, J. Y., & Ji, R.-R. (2011) · Pain · doi:10.1016/j.pain.2010.11.014 · Cited by 248

Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis

Yang, J., Hu, S., Bian, Y., Yao, J., Wang, D., Liu, X., Guo, Z., Zhang, S., & Peng, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.789948 · Cited by 244

Tumor Necrosis Factor (TNF) α Increases Collagen Accumulation and Proliferation in Intestinal Myofibroblasts via TNF Receptor 2

Theiss, A. L., Simmons, J. G., Jobin, C., & Lund, P. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505291200 · Cited by 233

Biologics for targeting inflammatory cytokines, clinical uses, and limitations

Rider, P., Carmi, Y., & Cohen, I. (2016) · International Journal of Cell Biology · doi:10.1155/2016/9259646 · Cited by 226

Pathways of matrix metalloproteinase induction in heart failure: Bioactive molecules and transcriptional regulation

DESCHAMPS, A., & SPINALE, F. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.10.004 · Cited by 189

Tumor Necrosis Factor-α Inhibits Endothelial Nitric-oxide Synthase Gene Promoter Activity in Bovine Aortic Endothelial Cells

Anderson, H. D. I., Rahmutula, D., & Gardner, D. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309552200 · Cited by 186

Assessment of tumor necrosis factor alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients

Monk, J. P., Phillips, G., Waite, R., Kuhn, J., Schaaf, L. J., Otterson, G. A., Guttridge, D., Rhoades, C., Shah, M., Criswell, T., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.2838 · Cited by 179

Tumor Necrosis Factor-α Causes Accumulation of a Ubiquitinated Form of Hypoxia Inducible Factor-1α through a Nuclear Factor-κB-Dependent Pathway

Zhou, J., Schmid, T., & Brüne, B. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-09-0598 · Cited by 177

Zinc Triggers Microglial Activation

Kauppinen, T. M., Higashi, Y., Suh, S. W., Escartin, C., Nagasawa, K., & Swanson, R. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1236-08.2008 · Cited by 174

Experimental Design in Systems Biology, Based on Parameter Sensitivity Analysis Using a Monte Carlo Method: A Case Study for the TNFα-Mediated NF-κ B Signal Transduction Pathway

Cho, K.-H., Shin, S.-Y., Kolch, W., & Wolkenhauer, O. (2003) · SIMULATION · doi:10.1177/0037549703040943 · Cited by 172

Oligodendroglial alterations and the role of microglia in white matter injury: relevance to schizophrenia

Chew, L.-J., Fusar-Poli, P., & Schmitz, T. (2013) · Developmental Neuroscience · doi:10.1159/000346157 · Cited by 154

Signaling pathways weigh in on decisions to make or break skeletal muscle

Guttridge, D. C. (2004) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/01.mco.0000134364.61406.26 · Cited by 149

Thymosin beta 4 suppression of corneal NFκB: A potential anti-inflammatory pathway

Sosne, G., Qiu, P., Christopherson, P. L., & Wheater, M. K. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2006.12.004 · Cited by 139

Glioblastomas Induce T-Lymphocyte Death by Two Distinct Pathways Involving Gangliosides and CD70

Chahlavi, A., Rayman, P., Richmond, A. L., Biswas, K., Zhang, R., Vogelbaum, M., Tannenbaum, C., Barnett, G., & Finke, J. H. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4395 · Cited by 141

Molecular basis of the cell specificity of cytokine action

Ishihara, K., & Hirano, T. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00321-x · Cited by 122

Anandamide Inhibits Nuclear Factor-κB Activation through a Cannabinoid Receptor-Independent Pathway

Sancho, R., Calzado, M. A., Di Marzo, V., Appendino, G., & Muñoz, E. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.2.429 · Cited by 120

JNK signaling is the shared pathway linking neuroinflammation, blood-brain barrier disruption and oligodendroglial apoptosis in the white matter injury of the immature brain

Wang, L.-W., Tu, Y.-F., Huang, C.-C., & Ho, C.-J. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-175 · Cited by 119

Low Levels of Tumor Necrosis Factor α Increase Tumor Growth by Inducing an Endothelial Phenotype of Monocytes Recruited to the Tumor Site

Li, B., Vincent, A., Cates, J., Brantley-Sieders, D. M., Polk, D. B., & Young, P. P. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1565 · Cited by 115

Untitled work

(2002) · PubMed · Cited by 79

Tumor Necrosis Factor-α Regulates Steroidogenesis, Apoptosis, and Cell Viability in the Human Adrenocortical Cell Line NCI-H295R

Mikhaylova, I. V., Kuulasmaa, T., Jääskeläinen, J., & Voutilainen, R. (2007) · Endocrinology · doi:10.1210/en.2006-0726 · Cited by 66

Lymphotoxin β Receptor (LtβR): Dual Roles in Demyelination and Remyelination and Successful Therapeutic Intervention Using LtβR–Ig Protein

Plant, S. R., Iocca, H. A., Wang, Y., Thrash, J. C., O'Connor, B. P., Arnett, H. A., Fu, Y.-X., Carson, M. J., & Ting, J. P.-Y. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1307-07.2007 · Cited by 51

The role of tumor necrosis factor-alpha in stress-induced worsening of cerebral ischemia in rats

Caso, J. R., Lizasoain, I., Lorenzo, P., Moro, M. A., & Leza, J. C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.009 · Cited by 45

Skeletal Muscle Atrophy Is Attenuated in Tumor-Bearing Mice under Chemotherapy by Treatment with Fish Oil and Selenium

Wang, H., Li, T.-L., Hsia, S., Su, I.-L., Chan, Y.-L., & Wu, C.-J. (2015) · Oncotarget · doi:10.18632/oncotarget.3483 · Cited by 39

Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions

Zhang, C., Jiang, H., Wang, P., Liu, H., & Sun, X. (2017) · Scientific Reports · doi:10.1038/srep44708 · Cited by 37

Apoptosis in primary lymphoid organs with aging

Sainz, R. M., Mayo, J. C., Reiter, R. J., Tan, D. X., & Rodriguez, C. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10414 · Cited by 32

Tele-yoga in the management of ankylosing spondylitis amidst COVID pandemic: A prospective randomized controlled trial

Singh, J., Metri, K., Tekur, P., Mohanty, S., Singh, A., & Raghuram, N. (2023) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2022.101672 · Cited by 30

TNF-α promotes cell survival through stimulation of K+ channel and NFκB activity in corneal epithelial cells

Wang, L., Reinach, P., & Lu, L. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.08.020 · Cited by 27

Transient inhibition of NF-κB signaling enhances ex vivo propagation of human hematopoietic stem cells

Talkhoncheh, M. S., Subramaniam, A., Magnusson, M., Kumar, P., Larsson, J., & Baudet, A. (2018) · Haematologica · doi:10.3324/haematol.2018.188466 · Cited by 9