A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of Msi1 mRNA
Open accessAbstract
Post-transcriptional regulation exerted by neural-specific RNA-binding proteins plays a pivotal role in the development and maintenance of the nervous system. Neural ELAV proteins are key inducers of neuronal differentiation through the stabilization and/or translational enhancement of target transcripts bearing the AU-rich elements (AREs), whereas Musashi-1 maintains the stem cell proliferation state by acting as a translational repressor. Since the gene encoding Musashi-1 (Msi1) contains a conserved ARE in its 3′ untranslated region, we focused on the possibility of a mechanistic relationship between ELAV proteins and Musashi-1 in cell fate commitment. Colocalization of neural ELAV proteins with Musashi-1 clearly shows that ELAV proteins are expressed at early stages of neural commitment, whereas interaction studies demonstrate that neural ELAV proteins exert an ARE-dependent binding activity on the Msi1 mRNA. This binding activity has functional effects, since the ELAV protein family member HuD is able to stabilize the Msi1 ARE-containing mRNA in a sequence-dependent way in a deadenylation/degradation assay. Furthermore activation of the neural ELAV proteins by phorbol esters in human SH-SY5Y cells is associated with an increase of Musashi-1 protein content in the cytoskeleton. We propose that ELAV RNA-binding proteins exert an important post-transcriptional control on Musashi-1 expression in the transition from proliferation to neural differentiation of stem/progenitor cells.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HuD binds and regulates several mRNAs encoding proteins with important functions in neuronal differentiation, including cell cycle arrest (p21cip1/waf1), neuroblast proliferation (MSI-1), neuron migration (MARCKS), neurite extension (GAP-43, Tau, AChE), synapse formation (NOVA-1), and neuronal growth and survival (NGF, BDNF, NT-3).
“In addition to these transcripts, HuD has been shown to bind and regulate several other mRNAs in vitro and in vivo, many of which encode proteins with important functions in neuronal differentiation such as cell cycle arrest (p21cip1/waf1) (Joseph et al. 1998), neuroblast proliferation (MSI-1) (Ratti et al. 2006), neuron migration (MARCKS) (Wein et al. 2003), neurite extension ([GAP-43] [Chung et”
From Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction (2013) · cites this paper as Ratti et al. 2006
The indexed copy contains a repository title indicating ELAV-related stabilization of Msi1 mRNA, but no article passage establishing that HuD binds or regulates it, or linking MSI-1 to neuroblast proliferation. Searches for HuD and Msi1 regulation returned only repository metadata and a PDF listing, not the paper’s substantive text. The other listed transcripts are attributed to separate citations in the citing sentence. (LLM, conf=0.72)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Shaw, G. D., & Kamen, R. (1986) · Cell · doi:10.1016/0092-8674(86)90341-7 · Cited by 3,946 · see citing works
AU-rich elements: characterization and importance in mRNA degradation
Chen, C.-Y. A., & Shyu, A.-B. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89102-1 · Cited by 1,948 · see citing works
Neurogenesis in Adult Subventricular Zone
Álvarez-Buylla, A., & García‐Verdugo, J. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00629.2002 · Cited by 1,467 · see citing works
Milestones of neuronal development in the adult hippocampus
Kempermann, G., Jessberger, S., Steiner, B., & Kronenberg, G. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.013 · Cited by 1,411 · see citing works
Qian, X., Shen, Q., Goderie, S. K., He, W., Capela, A., Davis, A. A., & Temple, S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00086-6 · Cited by 860 · see citing works
The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis
Kee, N., Sivalingam, S., Boonstra, R., & Wojtowicz, J. M. (2002) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(02)00007-9 · Cited by 775 · see citing works
Hitoshi, S., Alexson, T. O., Tropepe, V., Donoviel, D. B., Elia, A., Nye, J. S., Conlon, R. A., Mak, T. W., Bernstein, A., & van der Kooy, D. (2002) · Genes & Development · doi:10.1101/gad.975202 · Cited by 690 · see citing works
Nestin expression ? a property of multi-lineage progenitor cells?
Wiese, C., Rolletschek, A., Kania, G., Błyszczuk, P., Tarasov, K. V., Tarasova, Y. S., Wersto, R. P., Boheler, K. R., & Wobus, A. M. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4144-6 · Cited by 616 · see citing works
Szabo, A., Dalmau, J., Manley, G., Rosenfeld, M., Wong, E., Henson, J., Posner, J. B., & Furneaux, H. M. (1991) · Cell · doi:10.1016/0092-8674(91)90184-z · Cited by 553 · see citing works
Mouse-Musashi-1, a Neural RNA-Binding Protein Highly Enriched in the Mammalian CNS Stem Cell
Sakakibara, S., Imai, T., Hamaguchi, K., Okabe, M., Aruga, J., Nakajima, K., Yasutomi, D., Nagata, T., Kurihara, Y., Uesugi, S., et al. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0130 · Cited by 526 · see citing works
Gritti, A., Frolichsthal, P., Galli, R., Parati, E. A., Cova, L., Pagano, S., Bjornson, C. R. R., & Vescovi, A. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-09-03287.1999 · Cited by 523 · see citing works
Self-citationMaslov, A. Y., Barone, T. A., Plunkett, R. J., & Pruitt, S. C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4608-03.2004 · Cited by 522 · see citing works
Musashi1: An Evolutionally Conserved Marker for CNS Progenitor Cells Including Neural Stem Cells
Kaneko, Y., Sakakibara, S., Imai, T., Suzuki, A., Nakamura, Y., Sawamoto, K., Ogawa, Y., Toyama, Y., Miyata, T., & Okano, H. (2000) · Developmental Neuroscience · doi:10.1159/000017435 · Cited by 519 · see citing works
Sfold web server for statistical folding and rational design of nucleic acids
Ding, Y.-B., Chan, C. Y., & Lawrence, C. E. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh449 · Cited by 519 · see citing works
Robinow, S., & White, K. (1991) · Journal of Neurobiology · doi:10.1002/neu.480220503 · Cited by 507 · see citing works
Hu neuronal proteins are expressed in proliferating neurogenic cells
Marusich, M. F., Furneaux, H. M., Henion, P. D., & Weston, J. A. (1994) · Journal of Neurobiology · doi:10.1002/neu.480250206 · Cited by 485 · see citing works
Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis
Zhong, W., Feder, J. N., Jiang, M., Jan, L. Y., & Jan, Y. N. (1996) · Neuron · doi:10.1016/s0896-6273(00)80279-2 · Cited by 478 · see citing works
The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
Schaeffer, C., Bardoni, B., Mandel, J., Ehresmann, B., Ehresmann, C., & Moine, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4803 · Cited by 471 · see citing works
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs
Lal, A., Mazan‐Mamczarz, K., Kawai, T., Yang, X., Martindale, J. L., & Gorospe, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600305 · Cited by 461 · see citing works
Imai, T., Tokunaga, A., Yoshida, T., Hashimoto, M., Mikoshiba, K., Weinmaster, G., Nakafuku, M., & Okano, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.3888-3900.2001 · Cited by 454 · see citing works
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation
Mazan-Mamczarz, K., Galbán, S., de Silanes, I. L., Martindale, J. L., Atasoy, U., Keene, J. D., & Gorospe, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432104100 · Cited by 445 · see citing works
Bakheet, T. M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.1.246 · Cited by 399 · see citing works
Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase.
Chu, E., Koeller, D. M., Casey, J. L., Drake, J. C., Chabner, B. A., Elwood, P. C., Zinn, S., & Allegra, C. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.8977 · Cited by 382 · see citing works
A Hierarchy of Hu RNA Binding Proteins in Developing and Adult Neurons
Okano, H. J., & Darnell, R. B. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03024.1997 · Cited by 379 · see citing works
Galli, R., Gritti, A., Bonfanti, L., & Vescovi, A. L. (2003) · Circulation Research · doi:10.1161/01.res.0000065580.02404.f4 · Cited by 370 · see citing works
Nakamura, M., Okano, H., Blendy, J. A., & Montell, C. (1994) · Neuron · doi:10.1016/0896-6273(94)90460-x · Cited by 359 · see citing works
Levine, T., Gao, F., King, P. H., Andrews, L. G., & Keene, J. D. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3494 · Cited by 356 · see citing works
Musashi: a translational regulator of cell fate
Okano, H., Imai, T., & Okabe, M. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.7.1355 · Cited by 345 · see citing works
Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres
Suslov, O. N., Kukekov, V. G., Ignatova, T. N., & Steindler, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212525299 · Cited by 339 · see citing works
Post‐transcriptional regulation of gene expression by degradation of messenger RNAs
Bevilacqua, A., Ceriani, M. C., Capaccioli, S., & Nicolin, A. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10272 · Cited by 316 · see citing works
Chakrabarti, S. K., James, J. C., & Mirmira, R. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111857200 · Cited by 284 · see citing works
Tenenbaum, S. A. (2002) · Methods · doi:10.1016/s1046-2023(02)00022-1 · Cited by 269 · see citing works
Lakshmipathy, U., & Verfaillie, C. M. (2004) · Blood Reviews · doi:10.1016/j.blre.2004.03.001 · Cited by 264 · see citing works
Neurosphere and neurosphere-forming cells: morphological and ultrastructural characterization
Bez, A., Corsini, E., Curti, D., Biggiogera, M., Colombo, A., Nicosia, R. F., Pagano, S., & Parati, E. A. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.061 · Cited by 261 · see citing works
Sakakibara, S., Nakamura, Y., Satoh, H., & Okano, H. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08091.2001 · Cited by 260 · see citing works
Akamatsu, W., Okano, H. J., Osumi, N., Inoue, T., Nakamura, S., Sakakibara, S., Miura, M., Matsuo, N., Darnell, R. B., & Okano, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9885 · Cited by 256 · see citing works
Sakakibara, S., & Okano, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08300.1997 · Cited by 251 · see citing works
Ford, L. P., Watson, J., Keene, J. D., & Wilusz, J. (1999) · Genes & Development · doi:10.1101/gad.13.2.188 · Cited by 243 · see citing works
Sequential expression and role of Hu RNA-binding proteins during neurogenesis
Wakamatsu, Y., & Weston, J. A. (1997) · Development · doi:10.1242/dev.124.17.3449 · Cited by 240 · see citing works
Antic, D., & Keene, J. D. (1997) · The American Journal of Human Genetics · doi:10.1086/514866 · Cited by 231 · see citing works
Keene, J. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111145598 · Cited by 230 · see citing works
Roegiers, F., & Jan, Y. N. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.02.010 · Cited by 223 · see citing works
The RNA-binding protein HuD regulates neuronal cell identity and maturation
Akamatsu, W., Fujihara, H., Mitsuhashi, T., Yano, M., Shibata, S., Hayakawa, Y., Okano, H. J., Sakakibara, S.-I., Takano, H., Takano, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407523102 · Cited by 222 · see citing works
Barami, K., Iversen, K., Furneaux, H., & Goldman, S. A. (1995) · Journal of Neurobiology · doi:10.1002/neu.480280108 · Cited by 209 · see citing works
Antic, D., Lu, N., & Keene, J. D. (1999) · Genes & Development · doi:10.1101/gad.13.4.449 · Cited by 202 · see citing works
Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals
Cayouette, M., & RAFF, M. C. (2002) · Nature Neuroscience · doi:10.1038/nn1202-1265 · Cited by 195 · see citing works
Role of HuD and other RNA‐binding proteins in neural development and plasticity
Perrone‐Bizzozero, N. I., & Bolognani, F. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10175 · Cited by 186 · see citing works
Battelli, C., Nikopoulos, G. N., Mitchell, J., & Verdi, J. M. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.09.003 · Cited by 176 · see citing works
Pascale, A., Gusev, P. A., Amadio, M., Dottorini, T., Govoni, S., Alkon, D. L., & Quattrone, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307674100 · Cited by 174 · see citing works
Self-citationThe Wnt/β-Catenin→Pitx2 Pathway Controls the Turnover of Pitx2 and Other Unstable mRNAs
Briata, P., Ilengo, C., Corte, G., Moroni, C., Rosenfeld, M. G., Chen, C., & Gherzi, R. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00407-6 · Cited by 163 · see citing works
Expression of the neural RNA‐binding protein Musashi1 in human gliomas
Toda, M., Iizuka, Y., Yu, W., Imai, T., Ikeda, E., Yoshida, K., Kawase, T., Kawakami, Y., Okano, H., & Uyemura, K. (2001) · Glia · doi:10.1002/glia.1034 · Cited by 162 · see citing works
Gao, F., Carson, C. C., Levine, T., & Keene, J. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11207 · Cited by 156 · see citing works
Chung, S., Eckrich, M., Perrone-Bizzozero, N., Kohn, D. T., & Furneaux, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6593 · Cited by 142 · see citing works
Aranda-Abreu, G. E., Behar, L., Chung, S., Furneaux, H., & Ginzburg, I. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06907.1999 · Cited by 142 · see citing works
Quattrone, A., Pascale, A., Nogues, X., Zhao, W., Gusev, P., Pacini, A., & Alkon, D. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191388398 · Cited by 137 · see citing works
Self-citationKanemura, Y., Yamasaki, M., Mori, K., Fujikawa, H., Hayashi, H., Nakano, A., Matsumoto, T., Tamura, K., Arita, N., Sakakibara, S., et al. (2001) · Differentiation · doi:10.1046/j.1432-0436.2001.680208.x · Cited by 134 · see citing works
Yano, M., Okano, H. J., & Okano, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411119200 · Cited by 130 · see citing works
Neuronal ELAV proteins enhance mRNA stability by a PKCα-dependent pathway
Pascale, A., Amadio, M., Scapagnini, G., Lanni, C., Racchi, M., Provenzani, A., Govoni, S., Alkon, D. L., & Quattrone, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504702102 · Cited by 129 · see citing works
Self-citationJoseph, B., Orlian, M., & Furneaux, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20511 · Cited by 127 · see citing works
Kasashima, K., Terashima, K., Yamamoto, K., Sakashita, E., & Sakamoto, H. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00292.x · Cited by 120 · see citing works
A Hypothesis About the Role of Adult Neurogenesis in Hippocampal Function
Schinder, A. F., & Gage, F. H. (2004) · Physiology · doi:10.1152/physiol.00012.2004 · Cited by 108 · see citing works
Abe, R., Sakashita, E., Yamamoto, K. I., & Sakamoto, H. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.24.4895 · Cited by 99 · see citing works
Pascale, A., Fortino, I., Govoni, S. M., Trabucchi, M., Wetsel, W. C., & Battaini, F. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67062471.x · Cited by 86 · see citing works
Self-citationIrwin, N. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.6.1281 · Cited by 86 · see citing works
Disguising adult neural stem cells
Morshead, C. M., & van der Kooy, D. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.01.008 · Cited by 81 · see citing works
Neural Stem Cells in the Adult Nervous System
Bottai, D., Fiocco, R., Gelain, F., Filippis, L. D., Galli, R., Gritti, A., & Vescovi, L. A. (2003) · Stem Cells and Development · doi:10.1089/15258160360732687 · Cited by 79 · see citing works
Bolognani, F., Merhege, M. A., Twiss, J., & Perrone-Bizzozero, N. I. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.08.074 · Cited by 68 · see citing works
Anin VitroSystem Using HeLa Cytoplasmic Extracts That Reproduces Regulated mRNA Stability
Ford, L. P., & Wilusz, J. (1999) · Methods · doi:10.1006/meth.1998.0703 · Cited by 60 · see citing works
Evolutionary conservation of the AU-rich 3'untranslated region of messenger RNA.
Asson–Batres, M. A., Spurgeon, S. L., Diaz, J., DeLoughery, T. G., & Bagby, G. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1318 · Cited by 55 · see citing works
Samson, M.-L. (1998) · Genetics · doi:10.1093/genetics/150.2.723 · Cited by 51 · see citing works
Protein kinase C: its role in activity-dependent Purkinje cell dendritic development and plasticity
Metzger, F., & Kapfhammer, J. P. (2003) · The Cerebellum · doi:10.1080/14734220309419 · Cited by 50 · see citing works
Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia
Yagita, Y., Kitagawa, K., Sasaki, T., Miyata, T., Okano, H., Hori, M., & Matsumoto, M. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10342 · Cited by 50 · see citing works
Kohn, D. T., Tsai, K.-C., Cansino, V. V., Neve, R. L., & Perrone‐Bizzozero, N. I. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00239-o · Cited by 45 · see citing works
Cuadrado, A., García‐Fernández, L., Imai, T., Okano, H., & Múñoz, A. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1131 · Cited by 43 · see citing works
Regulation of nestin expression after cortical ablation in adult rat brain
Douen, A. G., Li, D., Vanance, S., Munger, R., Hogan, M. J., Thompson, C. S., & Hakim, A. M. (2004) · Brain Research · doi:10.1016/j.brainres.2003.08.070 · Cited by 37 · see citing works
Esdar, C., Oehrlein, S. A., Reinhardt, S., Maelicke, A., & Herget, T. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00455.x · Cited by 33 · see citing works
Stem Cell Therapy for Neurodegenerative Diseases: The Issue of Transdifferentiation
Cova, L., Ratti, A., Volta, M., Fogh, I., Cardin, V., Corbo, M., & Silani, V. (2004) · Stem Cells and Development · doi:10.1089/154732804773099326 · Cited by 30 · see citing works
Self-citationCuadrado, A., Navarro‐Yubero, C., Furneaux, H., & Muñoz, A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01877.x · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R. P., Horvat, V., Volk, B., & Kempermann, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008809 · Cited by 650 · see citing works
“stabilized mRNA in neuronal maintenance [34].”
Sharova, L. V., Sharov, A. A., Nedorezov, T., Piao, Y., Shaik, N., & Ko, M. S. H. (2009) · DNA Research · doi:10.1093/dnares/dsn030 · Cited by 591 · see citing works
“Expression of a wide variety of transcripts is controlled by changes in mRNA stability during neuronal development.(18,19) During muscle differentiation mRNA half-lives for muscle-specific genes—myogenin and myoD—have been shown to be the highest during differentiation, but declines when differentiation is completed.”
BackgroundSathyan, P., Golden, H. B., & Miranda, R. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1269-07.2007 · Cited by 245 · see citing works
“In contrast to Jag-1, the brain-specific RNA binding protein ELAVL2, a presumptive target of miR-335, -153, and -9, promotes neuronal maturation by binding to the 3 untranslated regions of mRNAs to suppress non-neuronal fates and promote neuronal identity (Akamatsu et al., 1999, 2005; Yano et al., 2005; Ratti et al.,…”
BackgroundRegulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
de Morrée, A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00568-6 · Cited by 243 · see citing works
RNA–protein interactions and control of mRNA stability in neurons
Bolognani, F., & Perrone‐Bizzozero, N. I. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21473 · Cited by 196 · see citing works
“Neuronal Hu proteins also have an indirect role in neural stem cell differentiation; they stabilize the mRNA of another RNA-binding protein, Musashi I (Ratti et al., 2006), which functions as a translational repressor.”
BackgroundDefining a neuron: neuronal ELAV proteins
Pascale, A., Amadio, M., & Quattrone, A. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7017-y · Cited by 158 · see citing works
Self-citationCova, L., Armentero, M., Zennaro, E., Calzarossa, C., Bossolasco, P., Busca, G. A., Deliliers, G. L., Polli, E. E., Nappi, G., Silani, V., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.041 · Cited by 152 · see citing works
Self-citationBlandini, F., Cova, L., Armentero, M., Zennaro, E., Levandis, G., Bossolasco, P., Calzarossa, C., Mellone, M., Busca, G. A., Deliliers, G. L., et al. (2010) · Cell Transplantation · doi:10.3727/096368909x479839 · Cited by 142 · see citing works
Self-citationBronicki, L. M., & Jasmin, B. J. (2013) · RNA · doi:10.1261/rna.039164.113 · Cited by 126 · see citing works
“In addition to these transcripts, HuD has been shown to bind and regulate several othermRNAs invitroand invivo,manyofwhich encode proteinswith important functions inneuronal differentiation such as cell cycle ar- rest (p21cip1/waf1) (Joseph et al. 1998), neuroblast proliferation (MSI-1) (Ratti et al. 2006), neuron mig…”
BackgroundInfluentialRegulation of mRNA transport, localization and translation in the nervous system of mammals (Review)
Liegro, C. M. D., Schiera, G., & Liegro, I. D. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1629 · Cited by 112 · see citing works
“This would allow the stem/progenitor cell to continue to divide even after Msi1 transcriptional inactivation (118).”
Musashi Signaling in Stem Cells and Cancer
Fox, R. G., Park, F. D., Koechlein, C. S., Kritzik, M. R., & Reya, T. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125446 · Cited by 115 · see citing works
“Neural ELAV family RNA-binding proteins stabilize Msi1 mRNA by binding to an AU-rich element in its 3′-UTR in CNS neural stem/progenitor cells and glioblastoma cells (Ratti 2006, Vo et al. 2012a).”
Notch3 and the Notch3‐upregulated RNA‐binding protein HuD regulate Ikaros alternative splicing
Bellavia, D., Mecarozzi, M., Campese, A. F., Grazioli, P., Talora, C., Frati, L., Gulino, A., & Screpanti, I. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601626 · Cited by 80 · see citing works
“…alternative The EMBO Journal VOL 26 | NO 6 | 2007 &2007 European Molecular Biology Organization1676 splicing and translation to modulation of mRNA transport and stability (Levine et al, 1993; Mobarak et al, 2000; Lisbin et al, 2001; Deschenes-Furry et al, 2003; Ratti et al, 2006; Zhu et al, 2006).”
Vo, D. T., Abdelmohsen, K., Martindale, J. L., Qiao, M., Tominaga, K., Burton, T. L., Gelfond, J. A. L., Brenner, A. J., Patel, V., Trageser, D., et al. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0208 · Cited by 72 · see citing works
“In normal stem cells, one study identified the HuD RBP as a potential posttranscriptional regulator of Musashi1 expression, aiding neural stem cells in the transition toward differentiation (20).”
BackgroundContext-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulation.
MacNicol, M. C., Cragle, C. E., & MacNicol, A. M. (2011) · Cell Cycle · doi:10.4161/cc.10.1.14388 · Cited by 70 · see citing works
ELAV proteins along evolution: Back to the nucleus?
Colombrita, C., Silani, V., & Ratti, A. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.02.003 · Cited by 69 · see citing works
“…ARE sequences in the 3′ UTR of specific target transcripts was described to increase the half-life of these mRNAs and also to enhance their translation (Antic et al., 1999; Aranda-Abreu et al., 1999; Cuadrado et al., 2002; Jain et al., 1997; Mobarak et al., 2000; Ratti et al., 2006, 2008).”
BackgroundSelf-citationRatti, A., Fallini, C., Colombrita, C., Pascale, A., Laforenza, U., Quattrone, A., & Silani, V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706082200 · Cited by 66 · see citing works
Self-citationTebaldi, T., Zuccotti, P., Peroni, D., Köhn, M., Gasperini, L., Potrich, V., Bonazza, V., Dudnakova, T., Rossi, A., Sanguinetti, G., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.032 · Cited by 59 · see citing works
Self-citationmiR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis
Loffreda, A., Nizzardo, M., Arosio, A., Ruepp, M., Calogero, R., Volinia, S., Galasso, M., Bendotti, C., Ferrarese, C., Lunetta, C., et al. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101803 · Cited by 58 · see citing works
MiR-330-3p inhibits gastric cancer progression through targeting MSI1.
Guan, A., Wang, H., Li, X., Xie, H., Wang, R., Zhu, Y., & Li, R. (2016) · PubMed Central · Cited by 58 · see citing works
Interplay between Posttranscriptional and Posttranslational Interactions of RNA-Binding Proteins
Mittal, N., Scherrer, T., Gerber, A. P., & Janga, S. C. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.03.064 · Cited by 52 · see citing works
SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution
Maraschi, A., Gumina, V., Dragotto, J., Colombrita, C., Mompeán, M., Buratti, E., Silani, V., Feligioni, M., & Ratti, A. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02505-8 · Cited by 50 · see citing works
“UV-CLIP was performed as previously described [48].”
Self-citationMusashi1: A stem cell marker no longer in search of a function
Glazer, R. I., Wang, X., Yuan, H., & Yin, Y. (2008) · Cell Cycle · doi:10.4161/cc.7.17.6522 · Cited by 47 · see citing works
D'Autréaux, F., Margolis, K. G., Roberts, J., Stevanovic, K., Mawe, G., Li, Z., Karamooz, N., Ahuja, A., Morikawa, Y., Cserjesi, P., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.059 · Cited by 47 · see citing works
Vicario, A., Colliva, A., Ratti, A., Davidovic, L., Baj, G., Gricman, Ł., Colombrita, C., Pallavicini, A., Jones, K. R., Bardoni, B., et al. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00062 · Cited by 44 · see citing works
“The CLIP (cross-linking and immunoprecipitation) assay for ELAV was performed as previously described by Ratti et al. (2006) and for FMRP was carried out using brains lysates from wild type (WT) and Fmr1-KO mice as described by Davidovic et al. (2011).”
MethodSelf-citationDeBoer, E., Kraushar, M. L., Hart, R. P., & Rašin, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.05.042 · Cited by 45 · see citing works
“Interestingly, HuD stabilizes Musashi mRNA, and this effect may be critical in the transition from stem cell proliferation to neural differentiation (Ratti et al., 2006).”
BackgroundAdult neurogenesis with 5-HT expression in lesioned goldfish spinal cord
Takeda, A., Nakano, M., Goris, R. C., & Funakoshi, K. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.059 · Cited by 45 · see citing works
Zheng, D., Chen, C. A., & Shyu, A. (2011) · RNA · doi:10.1261/rna.2789611 · Cited by 44 · see citing works
“…presumed function(s) Reference HUD ELAVL4 Mouse HuD Binds to and stabilizes some AU-rich element (ARE)–containing mRNAs Beckel-Mitchener et al. 2002; Ratti et al. 2006 PCBP1 HNRPE1 Transcription activation; splicing; mRNA stabilization; cap-dependent mRNA translational inhibition; IRES-driven…”
BackgroundPilotte, J., Cunningham, B. A., Edelman, G. M., & Vanderklish, P. W. (2008) · Brain Research · doi:10.1016/j.brainres.2008.12.050 · Cited by 42 · see citing works
Emerging Roles of RNA-Binding Proteins in Neurodevelopment
Parra, A. S., & Johnston, C. A. (2022) · Journal of Developmental Biology · doi:10.3390/jdb10020023 · Cited by 41 · see citing works
Downregulation of Msi1 suppresses the growth of human colon cancer by targeting p21cip1
GAO, C., HAN, C., Yu, Q., Guan, Y., Li, N., Zhou, J., Tian, Y., & Zhang, Y. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2749 · Cited by 39 · see citing works
RNA–Binding Protein HuD as a Versatile Factor in Neuronal and Non–Neuronal Systems
Jung, M., & Lee, E. K. (2021) · Biology · doi:10.3390/biology10050361 · Cited by 39 · see citing works
“In addition to targets found in neuronal tissues, HuD promotes stabilization of target mRNAs also expressed in other tissues, such as p21 [83], Ca2+/Calmodulin–dependent protein kinase II α (CaMKIIα) [84], and musashi 1 (MSI1) [85].”
BackgroundFunction and regulation of the mammalian Musashi mRNA translational regulator
MacNicol, A. M., Wilczynska, A., & MacNicol, M. C. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360528 · Cited by 39 · see citing works
Embryonic development of the nervous system in the planarian Schmidtea polychroa
Monjo, F., & Romero, R. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.10.021 · Cited by 39 · see citing works
Spatiotemporal development of the embryonic nervous system of Saccoglossus kowalevskii
Cunningham, D. D., & Casey, E. S. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.12.001 · Cited by 36 · see citing works
HuD Interacts with Bdnf mRNA and Is Essential for Activity-Induced BDNF Synthesis in Dendrites
Vanevski, F., & Xu, B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117264 · Cited by 35 · see citing works
“The neuronal ELAV (nELAV) family of RNA-binding proteins (RBPs), consisting of HuB, HuC and HuD, has been previously demonstrated to interact with several mRNAs to regulate their expression [21,25,26], and putative binding sites for these proteins are present within the long Bdnf 3' UTR, making them potential candidat…”
BackgroundMethodYano, M., Hayakawa‐Yano, Y., & Okano, H. (2016) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2016.01.002 · Cited by 33 · see citing works
“Moreover, some reports present evidence that nElavl proteins stabilize other neural RNABP transcripts, such as Msi1 and a neuron-specific splicing factor, Nova1 (Ratti et al., 2006, 2008).”
BackgroundCarrillo‐Baltodano, A. M., Boyle, M. J., Rice, M. E., & Meyer, N. P. (2019) · Journal of Morphology · doi:10.1002/jmor.21054 · Cited by 33 · see citing works
The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye.
Raji, B., Dansault, A., Leemput, J., de la Houssaye, G., Vieira, V., Kobetz, A., Arbogast, L., Masson, C., Ménasche, M., & Abitbol, M. M. (2007) · PubMed · Cited by 33 · see citing works
Wutikeli, H., Xie, T., Xiong, W., & Shen, Y. (2025) · RNA Biology · doi:10.1080/15476286.2025.2471133 · Cited by 31 · see citing works
“%) among them [20–24].”
RNA-binding protein signaling in adult neurogenesis
Chan, J. N.-M., Sánchez-Vidaña, D. I., Anoopkumar‐Dukie, S., Li, Y., & Wui-Man, L. B. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.982549 · Cited by 31 · see citing works
“Overexpression of Msi1 is an indicator of the proliferation state (Ratti et al., 2006).”
BackgroundInfluentialThe Stemness Gene Mex3A Is a Key Regulator of Neuroblast Proliferation During Neurogenesis
Naef, V., Sarlo, M. D., Testa, G., Corsinovi, D., Azzarelli, R., Borello, U., & Ori, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.549533 · Cited by 30 · see citing works
“Msi-1 maintains stem cell proliferation state by acting as a translational repressor (Ratti et al., 2006).”
BackgroundmRNA stability control: a clandestine force in normal and malignant hematopoiesis
Steinman, R. A. (2007) · Leukemia · doi:10.1038/sj.leu.2404656 · Cited by 30 · see citing works
Emerging Roles for the RNA-Binding Protein HuD (ELAVL4) in Nervous System Diseases
Silvestri, B., Mochi, M., Garone, M. G., & Rosa, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314606 · Cited by 28 · see citing works
Sekii, K., Salvenmoser, W., Katrien De Mulder, A., Schärer, L., & Ladurner, P. (2009) · BMC Developmental Biology · doi:10.1186/1471-213x-9-62 · Cited by 25 · see citing works
“Elav family genes have been mainly described to be involved in neural processes, such as the transition between proliferation and differentiation, maturation, maintenance of neurons, and learning [20,26,32-34] ([35].”
BackgroundmiR-410 controls adult SVZ neurogenesis by targeting neurogenic genes
Tsan, Y.-C., Morell, M. H., & O’Shea, K. S. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.07.003 · Cited by 26 · see citing works
Moncini, S., Bevilacqua, A., Venturin, M., Fallini, C., Ratti, A., Nicolin, A., & Riva, P. (2007) · BMC Molecular Biology · doi:10.1186/1471-2199-8-111 · Cited by 25 · see citing works
“Among these proteins, the neuronal specific nELAV RBPs, HuB, HuC and HuD, play a key role in the induction of neuronal differentiation [49-51] and have a stabilizing effect on several transcripts containing AREs in their 3'-UTR [52,53].”
BackgroundMethodSelf-citationThe Role of circRNAs in Human Papillomavirus (HPV)-Associated Cancers
Bonelli, P., Borrelli, A., Tuccillo, F. M., Buonaguro, F. M., & Tornesello, M. L. (2021) · Cancers · doi:10.3390/cancers13051173 · Cited by 23 · see citing works
Evidence for neurogenesis in the medial cortex of the leopard gecko, Eublepharis macularius
McDonald, R. P., & Vickaryous, M. K. (2018) · Scientific Reports · doi:10.1038/s41598-018-27880-6 · Cited by 23 · see citing works
The Musashi family RNA-binding proteins in stem cells
Horisawa, K., Imai, T., Okano, H., & Yanagawa, H. (2010) · BioMolecular Concepts · doi:10.1515/bmc.2010.005 · Cited by 23 · see citing works
“To find target RNAs of Msi1 in mammals, a SELEX analysis was performed, as had been done in Drosophila, and the results revealed that the mouse Msi1 protein binds specifically to RNAs that possess a (G/A)UnAGU wns1–3x sequence (19).”
BackgroundInfluentialExpression of Musashi-1 During Osteogenic Differentiation of Oral MSC: An In Vitro Study
Padial‐Molina, M., de Buitrago, J. G., Sainz-Urruela, R., Abril‐García, D., Anderson, P. O., O’Valle, F., & Galindo‐Moreno, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092171 · Cited by 21 · see citing works
“As m-numb is silenced by MSI1, the Notch pathway continues to maintain the neuronal stem cell self-renewal state [5,6].”
BackgroundDiverse Roles of PUF Proteins in Germline Stem and Progenitor Cell Development in C. elegans
Wang, X., & Voronina, E. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00029 · Cited by 19 · see citing works
Characterization of mRNA-Cytoskeleton Interactions In Situ Using FMTRIP and Proximity Ligation
Jung, J., Lifland, A. W., Alonas, E. J., Zurla, C., & Santangelo, P. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074598 · Cited by 19 · see citing works
“stem cell differentiation [46-48], and cancer pathophysiology”
Gumina, V., Colombrita, C., Fallini, C., Bossolasco, P., Maraschi, A., Landers, J. E., Silani, V., & Ratti, A. (2019) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.194413 · Cited by 18 · see citing works
“UV-CLIP experiments were performed as previously described [27].”
MethodSelf-citationJanga, S. C. (2012) · Briefings in Functional Genomics · doi:10.1093/bfgp/els046 · Cited by 17 · see citing works
“They have been shown to be involved in the regulation of several biological processes such as embryo development and stem cell differentiation [15–17], T-cell activation [18], angiogenesis [19], etc.”
BackgroundOhtsuka, T., Yano, M., & Okano, H. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.103 · Cited by 16 · see citing works
Ogawa, Y., Yamaguchi, J., Yano, M., Uchiyama, Y., & Okano, H. J. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.03.008 · Cited by 16 · see citing works
“For example, Msi1 negatively regulates the translation of target mRNAs, which accordingly induces neuronal differentiation, but these mRNAs are positively regulated by nElavl (Ratti, 2006).”
BackgroundMusashi and Plasticity of Xenopus and Axolotl Spinal Cord Ependymal Cells
Chernoff, E. A. G., Sato, K., Salfity, H., Sarria, D. A., & Belecky‐Adams, T. L. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00045 · Cited by 14 · see citing works
Post-transcriptional mechanisms controlling neurogenesis and direct neuronal reprogramming
Papadimitriou, E., & Thomaidou, D. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.390976 · Cited by 13 · see citing works
“This stabilization is considered to be a time-restricted event aiming at prolonging MSI1 activity in proliferating NSPCs preparing to exit the cell cycle even after the Msi1 transcriptional inactivation (Ratti et al., 2006).”
BackgroundPKC Activation Counteracts ADAM10 Deficit in HuD-Silenced Neuroblastoma Cells
Marchesi, N., Amadio, M., Colombrita, C., Govoni, S. M., Ratti, A., & Pascale, A. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160299 · Cited by 12 · see citing works
“…substrate (MARCKS) [16]; transcription factors such as N-myc [17] and c-myc [18]; cellular signaling regulators such as neuroserpin [19], p21waf1 [20], vascular endothelial growth factor (VEGF) [21], acetylcholinesterase (AChE) [22], and other neuronal RBP such as Msi-1 [23] and Nova1 [24].”
Self-citationTranslational Control during Mammalian Neocortex Development and Postembryonic Neuronal Function
Oliveira, N. C. M., Lins, É. M., Massirer, K. B., & Bengtson, M. H. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.09.006 · Cited by 11 · see citing works
Zuccotti, P., Colombrita, C., Moncini, S., Barbieri, A., Lunghi, M., Gelfi, C., Palma, S. D., Nicolin, A., Ratti, A., Venturin, M., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.04.018 · Cited by 11 · see citing works
Self-citationMustăciosu, C. C., Banciu, A., Rusu, C. M., Banciu, D. D., Savu, D., Radu, M., & Radu, B. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081965 · Cited by 11 · see citing works
Expression patterns of chick Musashi-1 in the developing nervous system
Wilson, J. M., Sato, K., Chernoff, E. A. G., & Belecky‐Adams, T. L. (2007) · Gene Expression Patterns · doi:10.1016/j.modgep.2007.04.001 · Cited by 10 · see citing works
ELAV–GAP43 pathway activation following combined exposure to cocaine and stress
Pascale, A., Amadio, M., Caffino, L., Racagni, G., Govoni, S. M., & Fumagalli, F. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2152-9 · Cited by 9 · see citing works
“Subcellular fractioning (cytosol and cytoskeleton) from rat hippocampi was performed as described (Ratti et al. 2006).”
MethodSelf-citationJia, S., Yu, L., Wang, L., & Peng, L. (2024) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2024.106548 · Cited by 11 · see citing works
Gumina, V., Onesto, E., Colombrita, C., Maraschi, A., Silani, V., & Ratti, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235866 · Cited by 9 · see citing works
“UV-crosslinking was performed using HEK293T protein lysates (200 μg) transfected with human Flag-TDP-43 and 32P-radiolabeled riboprobes, as previously described [46].”
MethodSelf-citationYu, T., Lan, S., Wu, B., Pan, Q.-H., Shi, L., Huang, K., Lin, Y., & Chen, Q. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1441-9 · Cited by 9 · see citing works
Post‐transcriptional regulation of gene expression in neural stem cells
Kim, D. (2016) · Cell Biochemistry and Function · doi:10.1002/cbf.3181 · Cited by 7 · see citing works
“There is a conserved ARE in the 3′UTR of Musashi1 mRNA, and the interaction between HuD protein and Musashi1 mRNA is relevant in cell fate commitment.(34) Another Hu protein, HuR, is involved in the spatiotemporal regulation of translation.”
BackgroundInfluentialMusashi Proteins in Neural Stem/Progenitor Cells
Horisawa, K., & Yanagaw, H. (2012) · InTech eBooks · doi:10.5772/31033 · Cited by 7 · see citing works
“On the other hand, Ratti et al. (2006) reported post-transcriptional regulation of Msi1 mRNA by embryonic lethal abnormal vision (ELAV), an RNA-binding protein of Drosophila (Ratti et al., 2006).”
BackgroundRNA binding protein HuD and microRNA-203a cooperatively regulate insulinoma-associated 1 mRNA
Kim, C., Ahn, S., & Lee, E. K. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.030 · Cited by 6 · see citing works
Influence of bacterial components on the developmental programming of enteric neurons
Popov, J., Bandura, J., Markovic, F., Borojevic, R., Anipindi, V. C., Pai, N., & Ratcliffe, E. M. (2020) · Physiological Reports · doi:10.14814/phy2.14611 · Cited by 5 · see citing works
“Hu proteins have been shown to affect neuronal differentiation (Akamatsu et al., 2005; Ratti et al., 2006; Sakakibara & Okano, 1997), with the further suggestion that HuD might commence its expression in proliferative neuronal progenitor cells and then become a driver of cell cycle exit (Akamatsu et al.”
BackgroundSAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA
Forcella, P., Ifflander, N., Rolando, C., Balta, E.-A., Lampada, A., Giachino, C., Mukhtar, T., Bock, T., & Taylor, V. (2024) · eLife · doi:10.7554/elife.74940 · Cited by 5 · see citing works
Nahas, G. R., Sherman, L. S., Sinha, G., El-Far, M. H., Petryna, A., Munoz, S. M., Silverio, K. A., Shaker, M., Neopane, P., Mariotti, V., et al. (2023) · Aging · doi:10.18632/aging.204620 · Cited by 4 · see citing works
The ADAR Family in Amphioxus: RNA Editing and Conserved Orthologous Site Predictions
Zawisza-Álvarez, M., Pérez-Calles, C., Gattoni, G., García‐Fernàndez, J., Benito‐Gutiérrez, È., & Herrera-Úbeda, C. (2020) · Genes · doi:10.3390/genes11121440 · Cited by 5 · see citing works
“Both genes have established roles during neurogenesis: Elav is a well-known pan-neural marker [35] and was active in early stages of neural commitment [36,37], while Prox1 is a homeobox gene involved in many developmental processes, including neural progenitor differentiation and exit from the cell cycle [29,38,39].”
BackgroundHuD regulates apoptosis in N2a cells by regulating Msi2 expression
Gaikwad, N., Sarwade, R. D., Halder, S., Agarwal, G., & Seshadri, V. (2024) · PLoS ONE · doi:10.1371/journal.pone.0315535 · Cited by 3 · see citing works
Gitau, J., Macharia, R. W., Mwangi, K. W., Ongeso, N., & Murungi, E. K. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18175 · Cited by 3 · see citing works
“It is a member of the Musashi family of RNA-binding proteins, which are known for their crucial role in the post-transcriptional regulation of gene expression [25,26], modulating the processing, localization, and translation of RNA molecules [27].”
Research Advances in the Biological Functions of RBM3
Feiyu, L. (2025) · International journal of anesthesia and clinical medicine. · doi:10.11648/j.ijacm.20251302.13 · Cited by 1 · see citing works
Regulation and expression of elrD1 and elrD2 transcripts during early Xenopus laevis development
Nassar, F. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.093050fn · Cited by 1 · see citing works
Dalui, S., Chatterjee, S., Sinha, P., & Bhattacharyya, A. (2020) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2020.104680 · Cited by 1 · see citing works
The neuronal RNA binding protein HuB as a potential tumor suppressor in glioblastoma
Tarter, M. (2013) · doi:10.15168/11572_368942 · Cited by 1 · see citing works
Sekii, K. (2014) · edoc (University of Basel) · doi:10.5451/unibas-006258323
Byers, S. W., Pishvaian, M. J., Mishra, L., & Glazer, R. I. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511605536.010
Wang, X. (2020) · The Mathematics Enthusiast
ELAVL Proteins, miRNA Fate, and Extracellular RNA Communication in Brain Aging and Neurodegeneration
Mukherjee, K., & Bhattacharyya, S. N. (2026) · Cells · doi:10.3390/cells15181649
“HuD stabilizes mRNAs such as p21 [51], CaMKII α [52], and MSI1 [53] in non-brain and brain tissues.”
Role of a Novel microRNA in Adult Neurogenesis.
Tsan, Y.-C. (2014) · Deep Blue (University of Michigan)
- Authors
- Ratti, A., Fallini, C., Cova, L., Fantozzi, R., Calzarossa, C., Zennaro, E., Pascale, A., Quattrone, A., & Silani, V.
- Affiliations
- University of Milan (IT)
- University of Pavia (IT)
- University of Florence (IT)
- Corresponding author
- Ratti, Antonia
- ORCID
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2006-04-01
- Volume
- 119
- Issue
- 7
- Pages
- 1442-1452
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2151805828
- Cited by
- 86
- References
- 78
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 8 · 2019: 6 · 2018: 5 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 3
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Musashi-1, AU-rich elements, post-transcriptional regulation, neural stem cells, neuronal differentiation, HUD, protein synthesis inhibition, 3' untranslated region, phorbol ester, SH-SY5Y cells, lineage commitment, stem/progenitor cells
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Brain, Cells, Cultured, Immunohistochemistry, Mice, Inbred Strains, Models, Biological, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Precipitin Tests, RNA, Messenger, Sequence Homology, Nucleic Acid, Stem Cells, RNA-Binding Proteins, Sequence Homology, Amino Acid, Reverse Transcriptase Polymerase Chain Reaction, RNA Stability, Mice, ELAV Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
