Cited by 730interferon and immune responsesGenomics and Chromatin DynamicsNF-κB Signaling Pathways

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Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

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Wathelet, Marc G, Lin, Charles H, Parekh, Bhavin S, Ronco, Lucienne V, Howley, Peter M, Maniatis, Tom·1998·Molecular Cell

DOI 10.1016/s1097-2765(00)80051-9

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Abstract

We have identified a virus-activated factor (VAF) that binds to a regulatory element shared by different virus-inducible genes. We provide evidence that VAF contains two members of the interferon regulatory factor (IRF) family of transcriptional activator proteins (IRF-3 and IRF-7), as well as the transcriptional coactivator proteins p300 and CBP. Remarkably, VAF, as well as recombinant IRF-3 and IRF-7 proteins, binds very weakly to the interferon-beta (IFN-beta) gene promoter in vitro. However, in virus-infected cells, both proteins are recruited to the endogenous IFN-beta promoter as part of a protein complex that includes ATF-2/c-Jun and NF-kappa B. These observations provide a unique example of the coordinate activation of multiple transcriptional activator proteins and their highly cooperative assembly into a transcriptional enhancer complex in vivo.

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Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300
Zhong, H., Voll, R. E., & Ghosh, S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80066-0 · Cited by 1,210
Transcriptional activation by recruitment
Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158
Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome
Thanos, D., & Maniatis, T. (1995) · Cell · doi:10.1016/0092-8674(95)90136-1 · Cited by 1,014
Self-citation
Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity
Hill, C. S., & Treisman, R. (1995) · Cell · doi:10.1016/0092-8674(95)90403-4 · Cited by 1,012
CREB-binding protein/p300 are transcriptional coactivators of p65
Gerritsen, M. E., Williams, A. J., Neish, A. S., Moore, S., Shi, Y., & Collins, T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2927 · Cited by 820
Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kündig, T. M., Amakawa, R., Kishihara, K., Wakeham, A., et al. (1993) · Cell · doi:10.1016/s0092-8674(05)80086-8 · Cited by 649
Analysis of Chromatin Structure byin VivoFormaldehyde Cross-Linking
Orlando, V., Strutt, H. L., & Paro, R. (1997) · Methods · doi:10.1006/meth.1996.0407 · Cited by 607
A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
Arany, Z., Newsome, D., Oldread, E., Livingston, D. M., & Eckner, R. (1995) · Nature · doi:10.1038/374081a0 · Cited by 533

Show all 40 references

Research works printed but not linked: 3

Bannister, 1995, Stimulation of c-Jun activity by CBP, Oncogene, 11, 2509
Ness, 1996, The Myb oncoprotein, Biochim. Biophys. Acta, 1288, F123
Wathelet, M.G., Clauss, I.M., Paillard, F., Content, J., and Huez, G.A. (1988b). Regulation of interferon-inducible genes by interferon, poly(rI)·poly(rC), and viruses. In The Biology of the Interferon System, Y. Kawade and S. Kobayashi, eds. (Tokyo: Kodansha Scientific Ltd.), pp. 11–17. · DOI

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Distinction between AP1 and NF-E2 factor-binding at specific chromatin regions in mammalian cells
Daftari, P., Gavva, N. R., & Shen, C.-K. J. (1999) · Oncogene · doi:10.1038/sj.onc.1202916 · Cited by 34
Limited specificity of IRF3 and ISGF3 in the transcriptional innate-immune response to double-stranded RNA
Ourthiague, D., Birnbaum, H. A., Ortenlöf, N., Vargas, J. D., Wollman, R., & Hoffmann, A. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.4a1014-483rr · Cited by 31
Mitochondrial Protein PINK1 Positively Regulates RLR Signaling
Zhou, J., Yang, R., Zhang, Z., Liu, Q., Zhang, Y., Wang, Q., & Yuan, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01069 · Cited by 33
The NF- B, p38 MAPK and STAT1 pathways differentially regulate the dsRNA-mediated innate immune responses of epidermal keratinocytes
Dai, X., Sayama, K., Tohyama, M., Shirakata, Y., Yang, L., Hirakawa, S., Tokumaru, S., & Hashimoto, K. (2008) · International Immunology · doi:10.1093/intimm/dxn048 · Cited by 33
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Matthaei, M., Budt, M., & Wolff, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056659 · Cited by 33
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Pitha, P. M. (2011) · Viruses · doi:10.3390/v3071179 · Cited by 34
Interleukin-17A Facilitates Chikungunya Virus Infection by Inhibiting IFN-α2 Expression
Neupane, B., Acharya, D., Nazneen, F., Gonzalez-Fernandez, G., Flynt, A. S., & Bai, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.588382 · Cited by 32
Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease
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The Innate Antiviral Response: New Insights Into A Continuing Story
Paun, A., & Pitha, P. M. (2006) · Advances in virus research · doi:10.1016/s0065-3527(06)69001-5 · Cited by 31
Host inhibits replication of European porcine reproductive and respiratory syndrome virus in macrophages by altering differential regulation of type-I interferon transcriptional response
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Alcantara, F. F., Tang, H., & McLachlan, A. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.9.2068 · Cited by 32
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Bergstrøm, B., Johnsen, I. B., Nguyen, T. T., Hagen, L., Slupphaug, G., Thommesen, L., & Anthonsen, M. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.084822 · Cited by 30
IRF3 function and immunological gaps in sepsis
Basak, B., & Akashi‐Takamura, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1336813 · Cited by 30
Fimbriae reprogram host gene expression – Divergent effects of P and type 1 fimbriae
Ambite, I., Butler, D. S. C., Stork, C., Grönberg-Hernández, J., Köves, B., Zdziarski, J., Pinkner, J. S., Hultgren, S. J., Dobrindt, U., Wullt, B., et al. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007671 · Cited by 29
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Liu, X., Zhang, M., Ye, C., Ruan, K., Xu, A., Gao, F., Tong, G., & Zheng, H. (2021) · Veterinary Microbiology · doi:10.1016/j.vetmic.2021.109023 · Cited by 29
Myeloid neddylation targets IRF7 and promotes host innate immunity against RNA viruses
Zhao, M., Zhang, Y., Yang, X., Jin, J., Shen, Z., Feng, X., Zou, T., Deng, L., Cheng, D., Zhang, X., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009901 · Cited by 28
Protein Kinase Cα Is Involved in Interferon Regulatory Factor 3 Activation and Type I Interferon-β Synthesis
Johnson, J., Albarani, V., Nguyen, M., Goldman, M., Willems, F., & Aksoy, E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700421200 · Cited by 29
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Mboko, W. P., Mounce, B. C., Wood, B. M., Kulinski, J. M., Corbett, J. A., & Tarakanova, V. L. (2012) · Journal of Virology · doi:10.1128/jvi.07119-11 · Cited by 30
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Ren, W., Wang, C., Wang, Q., Zhao, D., Zhao, K., Sun, D., Liu, X., Han, C., Hou, J., Li, X., et al. (2017) · Scientific Reports · doi:10.1038/srep39986 · Cited by 29
The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity
Stewart, H., Lu, Y., O’Keefe, S. M., Valpadashi, A., Cruz‐Zaragoza, L. D., Michel, H. A., Nguyen, S. K., Carnell, G., Lukhovitskaya, N. I., Milligan, R., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108080 · Cited by 28

Authors: Wathelet, M. G., Lin, C. H., Parekh, B. S., Ronco, L. V., Howley, P. M., & Maniatis, T.
Affiliations: Harvard University (US)
Corresponding author: Maniatis, Tom
ORCID: Lin, Charles H
Ronco, Lucienne V
Howley, Peter M
Maniatis, Tom
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 1998-03
Volume: 1
Issue: 4
Pages: 507-518
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/s1097-2765(00)80051-9
OpenAlex: W2095194341
Cited by: 730
References: 40
Citations by year: 2026: 6 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 23 · 2020: 11 · 2019: 22 · 2018: 10 · 2017: 16 · 2016: 24 · 2015: 20 · 2014: 25 · 2013: 24 · 2012: 23
FWCI: 13.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5617 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA50661, P01CA050661)
National Institute of Allergy and Infectious Diseases (AI20642)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: IRF3, IRF7, interferon regulatory factors, P300, CBP, NF-κB, transcriptional coactivator, virus-induced gene expression, interferon-beta promoter
MeSH terms: Animals, Base Sequence, Cell Nucleus, DNA, DNA-Binding Proteins, Enhancer Elements, Genetic, Fungal Proteins, Cricetinae, HeLa Cells, Humans, Molecular Sequence Data, Nuclear Proteins, Respirovirus Infections, Phosphorylation, Recombinant Fusion Proteins, Transcription Factors, Transcription, Genetic, Trans-Activators, Gene Expression Regulation, Viral, NF-kappa B, Leucine Zippers, CHO Cells, Interferon-beta, Cyclic AMP Response Element-Binding Protein, Respirovirus, Saccharomyces cerevisiae Proteins, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, CREB-Binding Protein, Activating Transcription Factor 2

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Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

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