The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo
Open accessAbstract
We have identified a virus-activated factor (VAF) that binds to a regulatory element shared by different virus-inducible genes. We provide evidence that VAF contains two members of the interferon regulatory factor (IRF) family of transcriptional activator proteins (IRF-3 and IRF-7), as well as the transcriptional coactivator proteins p300 and CBP. Remarkably, VAF, as well as recombinant IRF-3 and IRF-7 proteins, binds very weakly to the interferon-beta (IFN-beta) gene promoter in vitro. However, in virus-infected cells, both proteins are recruited to the endogenous IFN-beta promoter as part of a protein complex that includes ATF-2/c-Jun and NF-kappa B. These observations provide a unique example of the coordinate activation of multiple transcriptional activator proteins and their highly cooperative assembly into a transcriptional enhancer complex in vivo.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Therefore, such residues may play a more general role in IRF-containing complexes, including those involving IRF-3”
From Assembly requirements of PU.1–Pip (IRF‐4) activator complexes: inhibiting function in vivo using fused dimers (1999) · cites this paper as Wathelet et al., 1998
Citations
Cites
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
Zhong, H., Voll, R. E., & Ghosh, S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80066-0 · Cited by 1,210
Transcriptional activation by recruitment
Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158
Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome
Thanos, D., & Maniatis, T. (1995) · Cell · doi:10.1016/0092-8674(95)90136-1 · Cited by 1,014
Self-citationTranscriptional Regulation by Extracellular signals: Mechanisms and Specificity
Hill, C. S., & Treisman, R. (1995) · Cell · doi:10.1016/0092-8674(95)90403-4 · Cited by 1,012
CREB-binding protein/p300 are transcriptional coactivators of p65
Gerritsen, M. E., Williams, A. J., Neish, A. S., Moore, S., Shi, Y., & Collins, T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2927 · Cited by 820
Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kündig, T. M., Amakawa, R., Kishihara, K., Wakeham, A., et al. (1993) · Cell · doi:10.1016/s0092-8674(05)80086-8 · Cited by 649
Analysis of Chromatin Structure byin VivoFormaldehyde Cross-Linking
Orlando, V., Strutt, H. L., & Paro, R. (1997) · Methods · doi:10.1006/meth.1996.0407 · Cited by 607
A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
Arany, Z., Newsome, D., Oldread, E., Livingston, D. M., & Eckner, R. (1995) · Nature · doi:10.1038/374081a0 · Cited by 533
Research works printed but not linked: 3
- Bannister, 1995, Stimulation of c-Jun activity by CBP, Oncogene, 11, 2509
- Ness, 1996, The Myb oncoprotein, Biochim. Biophys. Acta, 1288, F123
- Wathelet, M.G., Clauss, I.M., Paillard, F., Content, J., and Huez, G.A. (1988b). Regulation of interferon-inducible genes by interferon, poly(rI)·poly(rC), and viruses. In The Biology of the Interferon System, Y. Kawade and S. Kobayashi, eds. (Tokyo: Kodansha Scientific Ltd.), pp. 11–17. · DOI
Cited by
Sorted by citations
Items 101–200 of 729
Balaji, S., Babu, M. M., Iyer, L. M., Luscombe, N. M., & Aravind, L. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.04.029 · Cited by 254
Barchet, W., Cella, M., Odermatt, B., Asselin‐Paturel, C., Colonna, M., & Kalinke, U. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011666 · Cited by 252
PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteinsPreprint
Ren, B., Chee, K. J., Kim, T. H., & Maniatis, T. (1999) · Genes & Development · doi:10.1101/gad.13.1.125 · Cited by 252
Self-citationBarnes, B. J., Kellum, M. J., Field, A. E., & Pitha, P. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5721-5740.2002 · Cited by 251
Varga, Z. T., Ramos, I., Hai, R., Schmolke, M., García‐Sastre, A., Fernández-Sesma, A., & Palese, P. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002067 · Cited by 246
Triggering the Interferon Response: The Role of IRF-3 Transcription Factor
Hiscott, J. B., Pitha, P. M., Génin, P., Nguyen, H., Heylbroeck, C., Mamane, Y., Algarté-Génin, M., & Lin, R. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099314360 · Cited by 244
Holzinger, D., Jorns, C., Stertz, S., Boisson‐Dupuis, S., Thimme, R., Weidmann, M., Casanova, J., Haller, O., & Kochs, G. (2007) · Journal of Virology · doi:10.1128/jvi.00546-06 · Cited by 241
Zhu, F. X., King, S. M., Smith, E., Levy, D. E., & Yuan, Y. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082420599 · Cited by 241
Multiple Regulatory Domains Control IRF-7 Activity in Response to Virus Infection
Lin, R., Mamane, Y., & Hiscott, J. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002814200 · Cited by 241
Transcriptional Coregulators in Development
Mannervik, M., Nibu, Y., Zhang, H., & Levine, M. (1999) · Science · doi:10.1126/science.284.5414.606 · Cited by 242
The role of Toll-like receptors in the host response to viruses
Bowie, A., & Haga, I. R. (2005) · Molecular Immunology · doi:10.1016/j.molimm.2004.11.007 · Cited by 249
Convergence of the NF-κB and IRF pathways in the regulation of the innate antiviral response
Hiscott, J. B. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.06.002 · Cited by 239
Initial and innate responses to viral infections — pattern setting in immunity or disease
Biron, C. A. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)80066-6 · Cited by 239
Chang, T.-H., Liao, C., & Lin, Y. (2005) · Microbes and Infection · doi:10.1016/j.micinf.2005.06.014 · Cited by 235
Smith, E., Marié, I., Prakash, A., García‐Sastre, A., & Levy, D. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008717200 · Cited by 224
Global and Distinct Targets of IRF-5 and IRF-7 during Innate Response to Viral Infection
Barnes, B. J., Richards, J. O., Mancl, M. E., Hanash, S., Beretta, L., & Pitha, P. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400726200 · Cited by 223
Fujii, Y., Shimizu, T., Kusumoto, M., Kyogoku, Y., Taniguchi, T., & Hakoshima, T. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5028 · Cited by 223
Yu, Y., & Hayward, G. S. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.027 · Cited by 221
Distinct TLR- and NLR-Mediated Transcriptional Responses to an Intracellular Pathogen
Leber, J. H., Crimmins, G. T., Raghavan, S., Meyer-Morse, N., Cox, J. S., & Portnoy, D. A. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040006 · Cited by 226
Bunyamwera Bunyavirus Nonstructural Protein NSs Counteracts the Induction of Alpha/Beta Interferon
Weber, F., Bridgen, A., Fazakerley, J. K., Streitenfeld, H., Kessler, N., Randall, R. E., & Elliott, R. M. (2002) · Journal of Virology · doi:10.1128/jvi.76.16.7949-7955.2002 · Cited by 221
Prantner, D., Perkins, D. J., Lai, W., Williams, M. S., Sharma, S., Fitzgerald, K. A., & Vogel, S. N. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.382986 · Cited by 225
Innate immune recognition of DNA: A recent history
Dempsey, A., & Bowie, A. (2015) · Virology · doi:10.1016/j.virol.2015.03.013 · Cited by 229
A SAP30 Complex Inhibits IFN-β Expression in Rift Valley Fever Virus Infected Cells
May, N. L., Mansuroglu, Z., Léger, P., Josse, T., Blot, G., Billecocq, A., Flick, R., Jacob, Y., Bonnefoy, E., & Bouloy, M. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040013 · Cited by 219
Role of DNA–PK in the cellular response to DNA double-strand breaks
Burma, S., & Chen, D. J. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.021 · Cited by 223
Génin, P., Algarté-Génin, M., Roof, P., Lin, R., & Hiscott, J. B. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.10.5352 · Cited by 216
Roles of interferon-regulatory factors in T-helper-cell differentiation
Lohoff, M. D., & Mak, T. W. (2005) · Nature reviews. Immunology · doi:10.1038/nri1552 · Cited by 223
Inverse Interference: How Viruses Fight the Interferon System
Weber, F., Kochs, G., & Haller, O. (2004) · Viral Immunology · doi:10.1089/vim.2004.17.498 · Cited by 212
Servant, M. J., Grandvaux, N., tenOever, B. R., Duguay, D., Lin, R., & Hiscott, J. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209851200 · Cited by 217
The interferon antiviral response: from viral invasion to evasion
Grandvaux, N., tenOever, B. R., Servant, M. J., & Hiscott, J. B. (2002) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200206000-00008 · Cited by 216
Burýšek, L., Yeow, W.-S., Lubyová, B., Kellum, M. J., Schafer, S. L., Huang, Y. Q., & Pitha, P. M. (1999) · Journal of Virology · doi:10.1128/jvi.73.9.7334-7342.1999 · Cited by 212
Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation
Qin, B. Y., Liu, C., Lam, S. S., Srinath, H., Delston, R. B., Correia, J. J., Derynck, R., & Lin, K. F. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb1002 · Cited by 214
Chang, H.-M., Paulson, M. S., Holko, M., Rice, C. M., Williams, B. R. G., Marié, I., & Levy, D. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400567101 · Cited by 229
Mori, M., Yoneyama, M., Ito, T., Takahashi, K., Inagaki, F., & Fujita, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310616200 · Cited by 212
Lin, R., Génin, P., Mamane, Y., Sgarbanti, M., Battistini, A., Harrington, W. J., Barber, G. N., & Hiscott, J. B. (2001) · Oncogene · doi:10.1038/sj.onc.1204163 · Cited by 212
Shaw, M. L., Cardenas, W. B., Zamarin, D., Palese, P., & Basler, C. F. (2005) · Journal of Virology · doi:10.1128/jvi.79.10.6078-6088.2005 · Cited by 209
Kumar, K. P., McBride, K. M., Weaver, B. K., Dingwall, C., & Reich, N. C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4159-4168.2000 · Cited by 212
Brass, A. L., Zhu, A. Q., & Singh, H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.4.977 · Cited by 204
Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells
Ludwig, S., Pleschka, S., Planz, O., & Wolff, T. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00678.x · Cited by 207
Sendai Virus C Proteins Counteract the Interferon-Mediated Induction of an Antiviral State
Garcin, D., Latorre, P., & Kolakofsky, D. (1999) · Journal of Virology · doi:10.1128/jvi.73.8.6559-6565.1999 · Cited by 204
Okamoto, Y., Folco, E. J. E., Minami, M., Wara, A. K., Feinberg, M. W., Sukhova, G. K., Colvin, R. A., Kihara, S., Funahashi, T., Luster, A. D., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.164988 · Cited by 208
Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1
DeFilippis, V. R., Alvarado, D. M., Sali, T. M., Rothenburg, S., & Früh, K. (2009) · Journal of Virology · doi:10.1128/jvi.01748-09 · Cited by 204
Stockinger, S., Reutterer, B., Schaljo, B., Schellack, C., Brunner, S., Materna, T., Yamamoto, M., Akira, S., Taniguchi, T., Murray, P. J., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.12.7416 · Cited by 198
Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication
Collins, S. E., Noyce, R. S., & Mossman, K. L. (2004) · Journal of Virology · doi:10.1128/jvi.78.4.1706-1717.2004 · Cited by 198
Herpes Simplex Virus 1 Has Multiple Mechanisms for Blocking Virus-Induced Interferon Production
Melroe, G. T., DeLuca, N. A., & Knipe, D. M. (2004) · Journal of Virology · doi:10.1128/jvi.78.16.8411-8420.2004 · Cited by 197
NOD2 and inflammation: current insights
Negroni, A., Pierdomenico, M., Cucchiara, S., & Stronati, L. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s137606 · Cited by 197
Abate, D. A., Watanabe, S., & Mocarski, E. S. (2004) · Journal of Virology · doi:10.1128/jvi.78.20.10995-11006.2004 · Cited by 197
Kotenko, S. V. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.07.007 · Cited by 204
Interplay between interferon and other cytokine systems in bone metabolism
Takayanagi, H., Sato, K., Takaoka, A., & Taniguchi, T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00337.x · Cited by 192
Servant, M. J., tenOever, B. R., Page, C. L., Conti, L., Gessani, S., Julkunen, I., Lin, R., & Hiscott, J. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007790200 · Cited by 192
The Interferon Regulatory Factor Family in Host Defense: Mechanism of Action
Ozato, K., Tailor, P. B., & Kubota, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700003200 · Cited by 191
The V Proteins of Simian Virus 5 and Other Paramyxoviruses Inhibit Induction of Interferon-β
Poole, E. L., He, B., Lamb, R. A., Randall, R. E., & Goodbourn, S. (2002) · Virology · doi:10.1006/viro.2002.1737 · Cited by 191
Yoshikawa, T., Hill, T. E., Yoshikawa, N., Popov, V. L., Galindo, C. L., Garner, H. R., Peters, C. J., & Tseng, C.-T. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008729 · Cited by 187
Johnsen, I. B., Nguyen, T. T., Ringdal, M., Tryggestad, A. M. A., Bakke, O., Lien, E., Espevik, T., & Anthonsen, M. W. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601222 · Cited by 192
Cytomegalovirus Immune Evasion
Powers, C., DeFilippis, V. R., Malouli, D., & Früh, K. (2008) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-77349-8_19 · Cited by 187
Gene Induction Pathways Mediated by Distinct IRFs during Viral Infection
Nakaya, T., Sato, M., Hata, N., Asagiri, M., Suemori, H., Noguchi, S., Tanaka, N., & Taniguchi, T. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4913 · Cited by 186
He, B., Paterson, R. G., Stock, N., Durbin, J. E., Durbin, R. K., Goodbourn, S., Randall, R. E., & Lamb, R. A. (2002) · Virology · doi:10.1006/viro.2002.1738 · Cited by 183
Ludwig, S., Wang, X., Ehrhardt, C., Zheng, H., Donelan, N. R., Planz, O., Pleschka, S., García‐Sastre, A., Heins, G., & Wolff, T. (2002) · Journal of Virology · doi:10.1128/jvi.76.21.11166-11171.2002 · Cited by 180
Eidson, K. M., Hobbs, W. E., Manning, B. J., Carlson, P. E., & DeLuca, N. A. (2002) · Journal of Virology · doi:10.1128/jvi.76.5.2180-2191.2002 · Cited by 180
Interferon Regulatory Factor 3 Is Regulated by a Dual Phosphorylation-dependent Switch
Panne, D., McWhirter, S. M., Maniatis, T., & Harrison, S. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703019200 · Cited by 178
Self-citationSmith, J., Turner, M., Delay, M., Klenk, E. I., Sowders, D. P., & Colbert, R. (2008) · European Journal of Immunology · doi:10.1002/eji.200737882 · Cited by 168
Xiang, Y., CONDIT, R. C., Vijaysri, S., Jacobs, B. L., Williams, B. R. G., & Silverman, R. H. (2002) · Journal of Virology · doi:10.1128/jvi.76.10.5251-5259.2002 · Cited by 177
Lubyová, B., & Pitha, P. M. (2000) · Journal of Virology · doi:10.1128/jvi.74.17.8194-8201.2000 · Cited by 174
The role of HMG I(Y) in the assembly and function of the IFN‐β enhanceosome
Yie, J., Merika, M., Munshi, N., Chen, G., & Thanos, D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.3074 · Cited by 175
Bossert, B., Marozin, S., & Conzelmann, K. (2003) · Journal of Virology · doi:10.1128/jvi.77.16.8661-8668.2003 · Cited by 178
The Interferon System and Vaccinia Virus Evasion Mechanisms
Perdiguero, B., & Estéban, M. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2009.0073 · Cited by 178
Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon
Deonarain, R., Alcamı́, A., Alexiou, M. V., Dallman, M. J., Gewert, D. R., & Porter, A. C. G. (2000) · Journal of Virology · doi:10.1128/jvi.74.7.3404-3409.2000 · Cited by 171
Daffis, S., Samuel, M. A., Suthar, M. S., Keller, B. C., Gale, M., & Diamond, M. (2008) · Journal of Virology · doi:10.1128/jvi.00918-08 · Cited by 168
Recognition of the Measles Virus Nucleocapsid as a Mechanism of IRF-3 Activation
tenOever, B. R., Servant, M. J., Grandvaux, N., Lin, R., & Hiscott, J. B. (2002) · Journal of Virology · doi:10.1128/jvi.76.8.3659-3669.2002 · Cited by 170
Crystal structure of ATF‐2/c‐Jun and IRF‐3 bound to the interferon‐β enhancer
Panne, D., Maniatis, T., & Harrison, S. (2004) · EMBO Journal · doi:10.1038/sj.emboj.7600453 · Cited by 182
Self-citationHIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation
Okumura, A., Alce, T., Lubyová, B., Ezelle, H. J., Strebel, K., & Pitha, P. M. (2007) · Virology · doi:10.1016/j.virol.2007.10.042 · Cited by 167
Recent advances in understanding viral evasion of type I interferon
Taylor, K. E., & Mossman, K. L. (2012) · Immunology · doi:10.1111/imm.12038 · Cited by 167
Review: Enhancement and Diversification of IFN Induction by IRF-7-Mediated Positive Feedback
Levy, D. E., Marié, I., Smith, E., & Prakash, A. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452692 · Cited by 166
Induction of the Human Protein P56 by Interferon, Double-Stranded RNA, or Virus Infection
Guo, J., Peters, K. L., & Sen, G. C. (2000) · Virology · doi:10.1006/viro.1999.0135 · Cited by 166
Ludwig, S., Ehrhardt, C., Neumeier, E., Kracht, M., Rapp, U. R., & Pleschka, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009902200 · Cited by 165
Signaling crosstalk between RANKL and interferons in osteoclast differentiation.
Takayanagi, H., Kim, S., & Taniguchi, T. (2002) · Arthritis Research · doi:10.1186/ar581 · Cited by 166
Graff, J. W., Ettayebi, K., & Hardy, M. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000280 · Cited by 162
Regulation of the Promoter Activity of Interferon Regulatory Factor-7 Gene
Lu, R., Au, W.-C., Yeow, W.-S., Hageman, N. S., & Pitha, P. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005288200 · Cited by 162
The IRF-3 Transcription Factor Mediates Sendai Virus-Induced Apoptosis
Heylbroeck, C., Balachandran, S., Servant, M. J., DeLuca, C., Barber, G. N., Lin, R., & Hiscott, J. B. (2000) · Journal of Virology · doi:10.1128/jvi.74.8.3781-3792.2000 · Cited by 162
Sato, M., Taniguchi, T., & Tanaka, N. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00032-0 · Cited by 166
Egli, A., Santer, D. M., O’Shea, D., Tyrrell, D. L., & Houghton, M. (2014) · Emerging Microbes & Infections · doi:10.1038/emi.2014.51 · Cited by 166
Sun, B., Robertsen, B., Wang, Z., & Liu, B. (2008) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2008.10.001 · Cited by 161
Stimulus-Specific Assembly of Enhancer Complexes on the Tumor Necrosis Factor Alpha Gene Promoter
Falvo, J. V., Uglialoro, A. M., Brinkman, B. M. N., Merika, M., Parekh, B. S., Tsai, E. Y., King, H. C., Morielli, A. D., Peralta, E. G., Maniatis, T., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2239-2247.2000 · Cited by 160
Self-citationHui, K. P. Y., Lee, S. M. Y., Cheung, C. Y., Ng, I. H. Y., Poon, L. L. M., Guan, Y., Ip, N. Y., Lau, A. S. Y., & Peiris, M. J. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.1088 · Cited by 159
Review: Control of IRF-3 Activation by Phosphorylation
Yoneyama, M., Suhara, W., & Fujita, T. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452674 · Cited by 158
SIKE is an IKKε/TBK1‐associated suppressor of TLR3‐ and virus‐triggered IRF‐3 activation pathways
Huang, J., Liu, T., Xu, L., Chen, D., Zhai, Z., & Shu, H. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600863 · Cited by 155
Xing, J., Ni, L., Wang, S., Wang, K., Lin, R., & Zheng, C. (2013) · Journal of Virology · doi:10.1128/jvi.01440-13 · Cited by 150
Histone Deacetylase Inhibitors Affect Dendritic Cell Differentiation and Immunogenicity
Nencioni, A., Beck, J., Werth, D., Grünebach, F., Patrone, F., Ballestrero, A., & Brossart, P. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2903 · Cited by 149
Karr, J. P., Ferrie, J. J., Tjian, R., & Darzacq, X. (2021) · Genes & Development · doi:10.1101/gad.349160.121 · Cited by 155
Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3
Zhang, M., Tian, Y., Wang, R., Gao, D., Zhang, Y., Diao, F., Chen, D., Zhai, Z., & Shu, H. (2008) · Cell Research · doi:10.1038/cr.2008.277 · Cited by 144
Marié, I., Smith, E., Prakash, A., & Levy, D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8803-8814.2000 · Cited by 161
Multiple signaling pathways leading to the activation of interferon regulatory factor 3
Servant, M. J., Grandvaux, N., & Hiscott, J. B. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01165-6 · Cited by 148
Preston, C. M., Harman, A. N., & Nicholl, M. J. (2001) · Journal of Virology · doi:10.1128/jvi.75.19.8909-8916.2001 · Cited by 146
Melroe, G. T., Silva, L., Schaffer, P. A., & Knipe, D. M. (2006) · Virology · doi:10.1016/j.virol.2006.10.028 · Cited by 145
Inhibition of p300 Histone Acetyltransferase by Viral Interferon Regulatory Factor
Li, M., Damania, B., Alvarez, X., Ogryzko, V., Ozato, K., & Jung, J. U. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8254-8263.2000 · Cited by 142
White, L. K., Sali, T. M., Alvarado, D. M., Gatti, E., Pierre, P., Streblow, D. N., & DeFilippis, V. R. (2010) · Journal of Virology · doi:10.1128/jvi.00767-10 · Cited by 144
RIG-I family RNA helicases: Cytoplasmic sensor for antiviral innate immunity
Yoneyama, M., & Fujita, T. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.06.023 · Cited by 144
REUL Is a Novel E3 Ubiquitin Ligase and Stimulator of Retinoic-Acid-Inducible Gene-I
Gao, D., Yang, Y., Wang, R., Zhou, X., Diao, F., Li, M., Zhai, Z., Jiang, Z., & Chen, D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005760 · Cited by 141
Viruses know it all: new insights into IFN networks
Hengel, H., Koszinowski, U. H., & Conzelmann, K. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.05.004 · Cited by 141
Tumor suppressor IRF‐1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL
Clarke, N., Jimenez-Lara, A. M., Voltz, E., & Gronemeyer, H. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600302 · Cited by 146
Epstein-Barr Virus BGLF4 Kinase Suppresses the Interferon Regulatory Factor 3 Signaling Pathway
Wang, J.-T., Doong, S.-L., Teng, S., Lee, C., Tsai, C.-H. A., & Chen, M. (2008) · Journal of Virology · doi:10.1128/jvi.01099-08 · Cited by 140
Metadata
- Authors
- Wathelet, M. G., Lin, C. H., Parekh, B. S., Ronco, L. V., Howley, P. M., & Maniatis, T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Maniatis, Tom
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 1
- Issue
- 4
- Pages
- 507-518
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2095194341
- Cited by
- 730
- References
- 40
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 23 · 2020: 11 · 2019: 22 · 2018: 10 · 2017: 16 · 2016: 24 · 2015: 20 · 2014: 25 · 2013: 24 · 2012: 23
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA50661, P01CA050661)
- National Institute of Allergy and Infectious Diseases (AI20642)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- IRF3, IRF7, interferon regulatory factors, P300, CBP, NF-κB, transcriptional coactivator, virus-induced gene expression, interferon-beta promoter
- MeSH terms
- Animals, Base Sequence, Cell Nucleus, DNA, DNA-Binding Proteins, Enhancer Elements, Genetic, Fungal Proteins, Cricetinae, HeLa Cells, Humans, Molecular Sequence Data, Nuclear Proteins, Respirovirus Infections, Phosphorylation, Recombinant Fusion Proteins, Transcription Factors, Transcription, Genetic, Trans-Activators, Gene Expression Regulation, Viral, NF-kappa B, Leucine Zippers, CHO Cells, Interferon-beta, Cyclic AMP Response Element-Binding Protein, Respirovirus, Saccharomyces cerevisiae Proteins, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, CREB-Binding Protein, Activating Transcription Factor 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review