Cited by 730interferon and immune responsesGenomics and Chromatin DynamicsNF-κB Signaling Pathways

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Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

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Wathelet, Marc G, Lin, Charles H, Parekh, Bhavin S, Ronco, Lucienne V, Howley, Peter M, Maniatis, Tom·1998·Molecular Cell

DOI 10.1016/s1097-2765(00)80051-9

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Abstract

We have identified a virus-activated factor (VAF) that binds to a regulatory element shared by different virus-inducible genes. We provide evidence that VAF contains two members of the interferon regulatory factor (IRF) family of transcriptional activator proteins (IRF-3 and IRF-7), as well as the transcriptional coactivator proteins p300 and CBP. Remarkably, VAF, as well as recombinant IRF-3 and IRF-7 proteins, binds very weakly to the interferon-beta (IFN-beta) gene promoter in vitro. However, in virus-infected cells, both proteins are recruited to the endogenous IFN-beta promoter as part of a protein complex that includes ATF-2/c-Jun and NF-kappa B. These observations provide a unique example of the coordinate activation of multiple transcriptional activator proteins and their highly cooperative assembly into a transcriptional enhancer complex in vivo.

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Authors: Wathelet, M. G., Lin, C. H., Parekh, B. S., Ronco, L. V., Howley, P. M., & Maniatis, T.
Affiliations: Harvard University (US)
Corresponding author: Maniatis, Tom
ORCID: Lin, Charles H
Ronco, Lucienne V
Howley, Peter M
Maniatis, Tom
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 1998-03
Volume: 1
Issue: 4
Pages: 507-518
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/s1097-2765(00)80051-9
OpenAlex: W2095194341
Cited by: 730
References: 40
Citations by year: 2026: 6 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 23 · 2020: 11 · 2019: 22 · 2018: 10 · 2017: 16 · 2016: 24 · 2015: 20 · 2014: 25 · 2013: 24 · 2012: 23
FWCI: 13.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5617 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA50661, P01CA050661)
National Institute of Allergy and Infectious Diseases (AI20642)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: IRF3, IRF7, interferon regulatory factors, P300, CBP, NF-κB, transcriptional coactivator, virus-induced gene expression, interferon-beta promoter
MeSH terms: Animals, Base Sequence, Cell Nucleus, DNA, DNA-Binding Proteins, Enhancer Elements, Genetic, Fungal Proteins, Cricetinae, HeLa Cells, Humans, Molecular Sequence Data, Nuclear Proteins, Respirovirus Infections, Phosphorylation, Recombinant Fusion Proteins, Transcription Factors, Transcription, Genetic, Trans-Activators, Gene Expression Regulation, Viral, NF-kappa B, Leucine Zippers, CHO Cells, Interferon-beta, Cyclic AMP Response Element-Binding Protein, Respirovirus, Saccharomyces cerevisiae Proteins, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, CREB-Binding Protein, Activating Transcription Factor 2

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Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

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