Cited by 183Genomics and Chromatin DynamicsHemoglobinopathies and Related DisordersHemoglobin structure and function

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The β-Globin LCR Is Not Necessary for an Open Chromatin Structure or Developmentally Regulated Transcription of the Native Mouse β-Globin Locus

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Epner, Elliot, Reik, Andreas, Cimbora, Daniel, Telling, Agnes, Bender, M.A, Fiering, Steve, Enver, Tariq, Martin, David I.K, Kennedy, Marion, Keller, Gordon, Groudine, Mark·1998·Molecular Cell

DOI 10.1016/s1097-2765(00)80144-6

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Abstract

The murine beta-globin locus control region (LCR) was deleted from its native chromosomal location. The approximately 25 kb deletion eliminates all sequences and structures homologous to those defined as the human LCR. In differentiated ES cells and erythroleukemia cells containing the LCR-deleted chromosome, DNasel sensitivity of the beta-globin domain is established and maintained, developmental regulation of the locus is intact, and beta-like globin RNA levels are reduced 5%-25% of normal. Thus, in the native murine beta-globin locus, the LCR is necessary for normal levels of transcription, but other elements are sufficient to establish the open chromatin structure, transcription, and developmental specificity of the locus. These findings suggest a contributory rather than dominant function for the LCR in its native location.

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Authors: Epner, E., Reik, A., Cimbora, D., Telling, A., Bender, M. A., Fiering, S., Enver, T., Martin, D. I. K., Kennedy, M., Keller, G., & Groudine, M.
Affiliations: Fred Hutch Cancer Center (US)
National Jewish Health (US)
University of Washington (US)
Corresponding author: Groudine, Mark
ORCID: Cimbora, Daniel
Enver, Tariq
Keller, Gordon
Groudine, Mark
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 1998-10
Volume: 2
Issue: 4
Pages: 447-455
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/s1097-2765(00)80144-6
OpenAlex: W2070298061
Cited by: 183
References: 60
Citations by year: 2025: 2 · 2023: 2 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 1
FWCI: 8.97
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 923 d)
Locations: Molecular Cell (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: National Institutes of Health (5p30hd028834-10)
National Heart, Lung, and Blood Institute (HL 48834)
National Institute of Diabetes and Digestive and Kidney Diseases (DK52854)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30 HD28834)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords: beta-globin locus control region, beta-globin gene expression, DNase I sensitivity, embryonic stem cells, erythroleukemia cells, chromatin accessibility
MeSH terms: Animals, Chromatin, Deoxyribonucleases, Leukemia, Erythroblastic, Acute, Globins, Humans, Phenotype, Protein Conformation, Tumor Cells, Cultured, Transcriptional Activation, Gene Expression, Gene Deletion, Protein Structure, Tertiary, Mice

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The β-Globin LCR Is Not Necessary for an Open Chromatin Structure or Developmentally Regulated Transcription of the Native Mouse β-Globin Locus

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