Cited by 1,245DNA Repair MechanismsBRCA gene mutations in cancerPARP inhibition in cancer therapy

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Brca1 Controls Homology-Directed DNA Repair

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Moynahan, Mary Ellen, Chiu, Joanne W, Koller, Beverly H, Jasin, Maria·1999·Molecular Cell

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Abstract

Germline mutations in BRCA1 confer a high risk of breast and ovarian tumors. The role of BRCA1 in tumor suppression is not yet understood, but both transcription and repair functions have been ascribed. Evidence that BRCA1 is involved in DNA repair stems from its association with RAD51, a homolog of the yeast protein involved in the repair of DNA double-strand breaks (DSBs) by homologous recombination. We report here that Brca1-deficient mouse embryonic stem cells have impaired repair of chromosomal DSBs by homologous recombination. The relative frequencies of homologous and nonhomologous DNA integration and DSB repair were also altered. The results demonstrate a caretaker role for BRCA1 in preserving genomic integrity by promoting homologous recombination and limiting mutagenic nonhomologous repair processes.

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Crossref · 10.1016/s1097-2765(00)80202-6

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Retracted
RETRACTED: Growth Retardation, DNA Repair Defects, and Lack of Spermatogenesis in BRCA1-Deficient Mice
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Retracted
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Authors: Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
University of North Carolina at Chapel Hill (US)
Corresponding author: Jasin, Maria
ORCID: Moynahan, Mary Ellen
Koller, Beverly H
Jasin, Maria
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 1999-10
Volume: 4
Issue: 4
Pages: 511-518
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/s1097-2765(00)80202-6
OpenAlex: W2059365987
Cited by: 1,245
References: 60
Citations by year: 2026: 27 · 2025: 18 · 2024: 22 · 2023: 35 · 2022: 21 · 2021: 42 · 2020: 47 · 2019: 48 · 2018: 53 · 2017: 47 · 2016: 47 · 2015: 45 · 2014: 55 · 2013: 58 · 2012: 47
FWCI: 22.97
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 923 d)
Locations: Molecular Cell (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: National Institutes of Health
National Cancer Institute (1P50CA68425, P50CA068425)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: BRCA1, homologous recombination, homology-directed repair, DNA double-strand break repair, RAD51, non-homologous end joining, genome stability, tumor suppression, mouse embryonic stem cells, germline mutations, breast and ovarian cancer
MeSH terms: Animals, Arabinofuranosyluracil, Cell Line, Chromosomes, DNA Damage, DNA Repair, DNA-Binding Proteins, Mutation, Proto-Oncogene Proteins, Recombination, Genetic, Stem Cells, Thymidine Kinase, Transfection, Retinoblastoma Protein, Mice, Knockout, Gene Targeting, BRCA1 Protein, Rad51 Recombinase, Mice

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Brca1 Controls Homology-Directed DNA Repair

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