Brca1 Controls Homology-Directed DNA Repair

The double-strand-break repair model for recombination

Szostak, J. W., Orr-Weaver, T. L., Rothstein, R. J., & Stahl, F. W. (1983) · Cell · doi:10.1016/0092-8674(83)90331-8 · Cited by 2,437

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459

XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsPreprint

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Gatekeepers and caretakers

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The Genetic Basis of Human Cancer

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

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Nine novel conserved motifs in BRCA1 identified by the chicken orthologue

Orelli, B. J., Logsdon, J. M., Jr., & Bishop, D. K. (2001) · Oncogene · doi:10.1038/sj.onc.1204485 · Cited by 40

Germline copy number variations in BRCA1‐associated ovarian cancer patients

Yoshihara, K., Tajima, A., Adachi, S., Quan, J., Sekine, M., Kase, H., Yahata, T., Inoue, I., & Tanaka, K. (2010) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20841 · Cited by 39

Unsolved mystery: the role of BRCA1 in DNA end-joining

Saha, J., & Davis, A. J. (2016) · Journal of Radiation Research · doi:10.1093/jrr/rrw032 · Cited by 38

Nick-initiated homologous recombination: Protecting the genome, one strand at a time

Vriend, L. E. M., & Krawczyk, P. M. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.12.005 · Cited by 37

TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats

Mosbach, V., Poggi, L., Viterbo, D., Charpentier, M., & Richard, G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.083 · Cited by 38

Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk

Petitalot, A., Dardillac, E., Jacquet, E., Nhiri, N., Guirouilh‐Barbat, J., Julien, P. E., Bouazzaoui, I., Bonte, D., Feunteun, J., Schnell, J. A., et al. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0357 · Cited by 38

Akt1 inhibits homologous recombination in Brca1-deficient cells by blocking the Chk1-Rad51 pathway

Jia, Y., Song, W. M., Zhang, F., Yan, J., & Yang, Q. (2012) · Oncogene · doi:10.1038/onc.2012.211 · Cited by 37

RNF168 forms a functional complex with RAD6 during the DNA damage response

Liu, C., Wang, D., Wu, J., Keller, J. A., Ma, T., & Yu, X. (2013) · Journal of Cell Science · doi:10.1242/jcs.122945 · Cited by 39

Age-dependent accumulation of recombinant cells in the mouse pancreas revealed by in situ fluorescence imaging

Wiktor‐Brown, D. M., Hendricks, C. A., Olipitz, W., & Engelward, B. P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604943103 · Cited by 38

Brief Report: Towards a dietary prevention of hereditary breast cancer

Kotsopoulos, J., & Narod, S. A. (2005) · Cancer Causes & Control · doi:10.1007/s10552-004-2593-8 · Cited by 39

Clinical Considerations in the Management of Individuals at Risk for Hereditary Breast and Ovarian Cancer

Robson, M. E. (2002) · Cancer Control · doi:10.1177/107327480200900602 · Cited by 38

Gene conversion is strongly induced in human cells by double-strand breaks and is modulated by the expression of BCL-x(L).

Wiese, C., Pierce, A. J., Gauny, S. S., Jasin, M., & Kronenberg, A. (2002) · PubMed · Cited by 37

Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity?

Papeo, G., Forte, B., Orsini, P., Perrera, C., Posteri, H., Scolaro, A., & Montagnoli, A. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770903215883 · Cited by 38

A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer

García‐Casado, Z., Romero, I., Fernández‐Serra, A., Rubio, L., Llopis, F., Garcia, A., Llombart, P., & López‐Guerrero, J. A. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-134 · Cited by 38

BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1

Dohrn, L., Salles, D. C., Siehler, S. Y., Kaufmann, J., & Wiesmüller, L. (2011) · Biochemical Journal · doi:10.1042/bj20110314 · Cited by 41

“DNA Binding Region” of BRCA1 Affects Genetic Stability through modulating the Intra-S-Phase Checkpoint

Masuda, T., Xu, X., Dimitriadis, E. K., Lahusen, T. J., & Deng, C. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.14242 · Cited by 37

Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity

Adamovich, A. I., Banerjee, T., Wingo, M., Duncan, K., Ning, J., Rodrigues, F. M., Huang, K., Lee, C., Chen, F., Ding, L., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008049 · Cited by 38

Phase 1 study of veliparib (ABT-888), a poly (ADP-ribose) polymerase inhibitor, with carboplatin and paclitaxel in advanced solid malignancies

Appleman, L. J., Beumer, J. H., Jiang, Y., Lin, Y., Ding, F., Puhalla, S., Swartz, L. K., Owonikoko, T. K., Harvey, R. D., Stoller, R. G., et al. (2019) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-019-03960-w · Cited by 39

Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase

Somyajit, K., Mishra, A., Jameei, A., & Nagaraju, G. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu211 · Cited by 38

BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II

Čabart, P., Chew, H. K., & Murphy, S. (2004) · Oncogene · doi:10.1038/sj.onc.1207684 · Cited by 37

Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells

Acharya, S. K., Kaul, Z., Gocha, A. R. S., Martinez, A. R., Harris, J. M., Parvin, J. D., & Groden, J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103819 · Cited by 40

Cyclin D1 Integrates Estrogen-Mediated DNA Damage Repair Signaling

Li, Z., Chen, K., Jiao, X., Wang, C., Willmarth, N. E., Casimiro, M. C., Li, W., Ju, X., Kim, S. H., Lisanti, M. P., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3137 · Cited by 40

Fidelity of DNA double-strand break repair in heterozygous cell lines harbouring BRCA1 missense mutations

Coupier, I., Baldeyron, C., Rousseau, A., Mosseri, V., Pagès-Berhouet, S., Caux‐Moncoutier, V., Papadopoulo, D., & Stoppa‐Lyonnet, D. (2003) · Oncogene · doi:10.1038/sj.onc.1207191 · Cited by 37

Chemie und Biologie der DNA‐Reparatur

Schärer, O. D. (2003) · Angewandte Chemie · doi:10.1002/ange.200200523 · Cited by 37

BRCA1 at a branch point

Parvin, J. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121184998 · Cited by 36

Molecular and Clinical Predictors of Improvement in Progression‐free Survival with Maintenance PARP Inhibitor Therapy in Women with Platinum‐sensitive, Recurrent Ovarian Cancer: A Meta‐analysis

Lee, C. K., Friedlander, M. L., Tjokrowidjaja, A., Ledermann, J. A., Coleman, R. L., Mirza, M. R., Matulonis, U. A., Pujade‐Lauraine, E., Bloomfield, R., Goble, S., et al. (2021) · Cancer · doi:10.1002/cncr.33517 · Cited by 36

Somatic alterations as the basis for resistance to targeted therapies

Blair, B. G., Bardelli, A., & Park, B. H. (2013) · The Journal of Pathology · doi:10.1002/path.4278 · Cited by 36

FANCJ Helicase Operates in the Fanconi Anemia DNA Repair Pathway and the Response to Replicational Stress

Wu, Y., & Brosh, R. M. (2009) · Current Molecular Medicine · doi:10.2174/156652409788167159 · Cited by 37

AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers

Guirouilh‐Barbat, J., Wilhelm, T., & López, B. S. (2010) · Oncotarget · doi:10.18632/oncotarget.203 · Cited by 38

Combination treatment using DDX3 and PARP inhibitors induces synthetic lethality in BRCA1-proficient breast cancer

van Voss, M. R. H., Brilliant, J., Vesuna, F., Bol, G. M., van der Wall, E., van Diest, P. J., & Raman, V. (2017) · Medical Oncology · doi:10.1007/s12032-017-0889-2 · Cited by 36

Rucaparib: a novel PARP inhibitor for BRCA advanced ovarian cancer

Colombo, I., Lheureux, S., & Oza, A. M. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s130809 · Cited by 36

Patients with Biallelic BRCA1/2 Inactivation Respond to Olaparib Treatment Across Histologic Tumor Types

van der Wijngaart, H., Hoes, L. R., Henegouwen, J. M. V. B., van der Velden, D. L., Zeverijn, L. J., Roepman, P., van Werkhoven, E., de Leng, W. W. J., Jansen, A. M. L., Mehra, N., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-1104 · Cited by 38

Absence of major defects in non-homologous DNA end joining in human breast cancer cell lines

Merel, P., Prieur, A., Pfeiffer, P., & Delattre, O. (2002) · Oncogene · doi:10.1038/sj.onc.1205742 · Cited by 36

BRCA1 and Transcription

Lane, T. F. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.6.843 · Cited by 36

BRCA1 and BRCA2 Tumor Suppressor Function in Meiosis

Li, Q., & Engebrecht, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.668309 · Cited by 35

The Fanconi anemia ID2 complex: Dueling saxes at the crossroads

Boisvert, R. A., & Howlett, N. G. (2014) · Cell Cycle · doi:10.4161/15384101.2014.956475 · Cited by 38

Ubiquitin and SUMO signalling in DNA repair

Thomson, T. M., & Guerra‐Rebollo, M. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380116 · Cited by 34

Barrier-to-autointegration-factor (Banf1) modulates DNA double-strand break repair pathway choice via regulation of DNA-dependent kinase (DNA-PK) activity

Burgess, J. T., Cheong, C. M., Suraweera, A., Sobanski, T., Beard, S., Dave, K. A., Rose, M., Boucher, D., Croft, L. V., Adams, M. N., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab110 · Cited by 38

Role of BRCA1 in heat shock response

Ma, Y. X., Fan, S., Xiong, J., Yuan, R., Meng, Q., Gao, M., Goldberg, I. D., Fuqua, S. A. W., Pestell, R. G., & Rosen, E. M. (2003) · Oncogene · doi:10.1038/sj.onc.1206061 · Cited by 35

DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity

Stoepker, C., Faramarz, A., Rooimans, M. A., van Mil, S. E., Balk, J. A., Velleuer, E., Ameziane, N., Riele, H. T., & de Winter, J. P. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.12.003 · Cited by 33

Checkpoint and DNA-repair proteins are associated with the cores of mammalian meiotic chromosomes

Tarsounas, M., & Møens, P. B. (2001) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(01)51004-2 · Cited by 36

SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation

Minten, E. V., Kapoor-Vazirani, P., Li, C., Zhang, H., Balakrishnan, K., & Yu, D. S. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108921 · Cited by 34

The functional impact of BRCA1 BRCT domain variants using multiplexed DNA double-strand break repair assays

Adamovich, A. I., Diabate, M., Banerjee, T., Nagy, G., Smith, N. T., Duncan, K., Mendoza, E. M., Ajo, G. P., Freitas, M. A., Starita, L. M., et al. (2022) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2022.01.019 · Cited by 36

Individual factors define the overall effects of dietary genistein exposure on breast cancer patients

Liu, R., Yu, X., Chen, X., Zhong, H., Liang, C., Xu, X., Xu, W., Cheng, Y., Wang, W., Yu, L., et al. (2019) · Nutrition Research · doi:10.1016/j.nutres.2019.03.015 · Cited by 34

BRCA2 and homologous recombination

Orelli, B. J., & Bishop, D. K. (2001) · Breast Cancer Research · doi:10.1186/bcr310 · Cited by 34

Amplifying tumour-specific replication lesions by DNA repair inhibitors – A new era in targeted cancer therapy

Helleday, T. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.02.044 · Cited by 34

The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features

Barroso, E., Pita, G., Arias, J. I., Menéndez, P. R., Zamora, P. M., Blanco, M., Benitez, J. J., & Ribas, G. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0439-5 · Cited by 33

Functional Analysis of BARD1 Missense Variants in Homology-Directed Repair of DNA Double Strand Breaks

Lee, C., Banerjee, T., Gillespie, J. L., Ceravolo, A. H., Parvinsmith, M. R., Starita, L. M., Fields, S., Toland, A. E., & Parvin, J. D. (2015) · Human Mutation · doi:10.1002/humu.22902 · Cited by 34

Overabundant FANCD2, alone and combined with NQO1, is a sensitive marker of adverse prognosis in breast cancer

Fagerholm, R., Sprott, K. M., Heikkinen, T., Bártková, J., Heikkilä, P., Aittomäki, K., Bártek, J., Weaver, D. T., BLOMQVIST, C. P., & Nevanlinna, H. A. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt290 · Cited by 37

Current Knowledge on the Pathophysiology of Fanconi Anemia: From Genes to Phenotypes

Yamashita, T., & Nakahata, T. (2001) · International Journal of Hematology · doi:10.1007/bf02982547 · Cited by 34

Spontaneous and double-strand break-induced recombination, and gene conversion tract lengths, are differentially affected by overexpression of wild-type or ATPase-defective yeast Rad54

Kim, P. M. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf413 · Cited by 34

Apoptosis regulatory protein–protein interaction demonstrates hierarchical scale-free fractal network

Nafis, S., Ponnusamy, K., Singh, R. K. B., Husain, M., & Bamezai, R. N. K. (2014) · Briefings in Bioinformatics · doi:10.1093/bib/bbu036 · Cited by 33

Cadmium disrupts the DNA damage response by destabilizing RNF168

Zhang, S., Hao, S., Qiu, Z., Wang, Y., Zhao, Y., Li, Y., Gao, W. Y., Wu, Y., Liu, C., Xu, X., et al. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110745 · Cited by 35

FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks

Nath, S., & Nagaraju, G. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008701 · Cited by 34

Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer

Zoeller, J. J., Vagodny, A., Daniëls, V. W., Taneja, K. L., Tan, B. Y., DeRose, Y. S., Fujita, M., Welm, A. L., Letai, A. G., Leverson, J. D., et al. (2020) · Breast Cancer Research · doi:10.1186/s13058-020-01374-8 · Cited by 34

Normal lymphocyte development and thymic lymphoma formation in Brca1 exon-11-deficient mice

Bachelier, R., Xu, X., Wang, X., Li, W., Naramura, M., Gu, H., & Deng, C. (2003) · Oncogene · doi:10.1038/sj.onc.1206208 · Cited by 33

NUSAP1 influences the DNA damage response by controlling BRCA1 protein levels

Kotian, S., Banerjee, T., Lockhart, A. A. K., Huang, K., Çatalyürek, Ü. V., & Parvin, J. D. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.28019 · Cited by 34

Inactivation of the Nijmegen Breakage Syndrome Gene Leads to Excess Centrosome Duplication via the ATR/BRCA1 Pathway

Shimada, M., Sagae, R., Kobayashi, J., Habu, T., & Komatsu, K. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3016 · Cited by 33

BRCA1 Suppresses Osteopontin-mediated Breast Cancer

El‐Tanani, M., Campbell, F. C., Crowe, P., Erwin, P. J., Harkin, D. P., Pharoah, P. D. P., Ponder, B. A. J., & Rudland, P. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604403200 · Cited by 33

Homologous recombination in extrachromosomal plasmid substrates is not suppressed by p53

俊輔, 鈴., 範久, 藤., 通良, 阿., Dahm-Daphi, J., & Powell, S. N. (2001) · Carcinogenesis · doi:10.1093/carcin/22.11.1757 · Cited by 33

A Functional Comparison of BRCA1 C-terminal Domains in Transcription Activation and Chromatin Remodeling

Miyake, T., Hu, Y., Yu, D. S., & Li, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007138200 · Cited by 33

Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by CezannePreprint

Wu, X. Y., Liu, S., Sagum, C. A., Chen, J., Singh, R. K., Chaturvedi, A., Horton, J. R., Kashyap, T. R., Fushman, D., Cheng, X., et al. (2019) · Genes & Development · doi:10.1101/gad.332395.119 · Cited by 35

Rb-Associated Protein 46 (RbAp46) Inhibits Transcriptional Transactivation Mediated by BRCA1

Chen, G.-C., Guan, L., Yu, J., Li, G., Kim, H.-R. C., & Wang, Z. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5003 · Cited by 32

Effects of Tumor-associated Mutations on Rad54 Functions

Smirnova, M., Komen, S. V., Sung, P., & Klein, H. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402719200 · Cited by 31

HDAC Inhibitors: A New Radiosensitizer for Non-small-cell Lung Cancer

Zhu, L., Wu, K., Ma, S., & Zhang, S. (2015) · Tumori Journal · doi:10.5301/tj.5000347 · Cited by 32

Inherited bone marrow failure syndromes in 2012

Sakaguchi, H., Nakanishi, K., & Kojima, S. (2012) · International Journal of Hematology · doi:10.1007/s12185-012-1249-9 · Cited by 32

Human papillomavirus status and the relative biological effectiveness of proton radiotherapy in head and neck cancer cells

Wang, L., Wang, X., Li, Y., Han, S., Zhu, J., Wang, X., Molkentine, D. P., Blanchard, P., Yang, Y., Zhang, R., et al. (2016) · Head & Neck · doi:10.1002/hed.24673 · Cited by 31

Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair

Isobe, S.-Y., Nagao, K., Nozaki, N., Kimurâ, H., & Obuse, C. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.056 · Cited by 31

PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation

Páhi, Z. G., Borsos, B. N., Pantazi, V., Újfaludi, Z., & Pankotai, T. (2020) · Cancers · doi:10.3390/cancers12010183 · Cited by 31

Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor

Liu, J., Adhav, R., Miao, K., Su, S. M., Mo, L., Chan, U. I., Zhang, X., Xu, J., Li, J., Shu, X., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18637-9 · Cited by 32

BRCA1 deficient mouse models to study pathogenesis and therapy of triple negative breast cancer

Díaz‐Cruz, E. S., Cabrera, M. C., Nakles, R. E., Rutstein, B. H., & Furth, P. A. (2011) · Breast Disease · doi:10.3233/bd-2010-0308 · Cited by 31

Prevalence of Germline Mutations in Genes Engaged in DNA Damage Repair by Homologous Recombination in Patients with Triple-Negative and Hereditary Non-Triple-Negative Breast Cancers

Domagała, P., Jakubowska, A., Jaworska–Bieniek, K., Białkowska, K., Durda, K., Kurlapska, A., Cybulski, C., & Lubiński, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130393 · Cited by 31

Suppression of Homologous Recombination by insulin-like growth factor-1 inhibition sensitizes cancer cells to PARP inhibitors

Amin, O., Beauchamp, M.-C., Abou-Nader, P., Laskov, I., Iqbal, S., Philip, C., Yasmeen, A., & Gotlieb, W. H. (2015) · BMC Cancer · doi:10.1186/s12885-015-1803-y · Cited by 31

BRCA1 Forms a Functional Complex with γ ‐H2AX as a Late Response to Genotoxic Stress

Krum, S. A., Dalugdugan, E. D. L. R., Miranda‐Carboni, G. A., & Lane, T. F. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/801594 · Cited by 32

PARP inhibition and synthetic lethality in ovarian cancer

Eskander, R. N., & Tewari, K. S. (2014) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2014.930662 · Cited by 31

Transcription-coupled repair of oxidative DNA damage in human cells: \nMechanisms and consequences

Tsutakawa, S. E., & Cooper, P. K. (2001) · eScholarship (California Digital Library) · Cited by 31

PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells

Węsierska‐Gądek, J., Zulehner, N., Ferk, F., Składanowski, A., Komina, O., & Maurer‐Granofszky, M. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.07.024 · Cited by 30

The frequency of cancer predisposition gene mutations in hereditary breast and ovarian cancer patients in Taiwan: From BRCA1/2 to multi-gene panels

Sung, P., Wen, K., Chen, Y., Chao, T., Tsai, Y., Tseng, L., Qiu, J.-T. T., Chao, K.-C., Wu, H.-H., Chuang, C.-M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185615 · Cited by 30

From the Magic Bullet to the Magic Target: Exploiting the Diverse Roles of DDX3X in Viral Infections and Tumorigenesis

Riva, V., & Maga, G. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0451 · Cited by 29

Homologous recombination: from model organisms to human disease.

Modesti, M., & Kanaar, R. (2001) · Genome biology · doi:10.1186/gb-2001-2-5-reviews1014 · Cited by 30

Lymphocytes of BRCA1 and BRCA2 germ-line mutation carriers, with or without breast cancer, are not abnormally sensitive to the chromosome damaging effect of moderate folate deficiency

Beetstra, S., Salisbury, C., Turner, J., Altree, M., McKinnon, R. A., Suthers, G., & Fenech, M. F. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi226 · Cited by 30

The BRCA1 E3 Ubiquitin Ligase Controls Centrosome Dynamics

Parvin, J. D., & Sankaran, S. (2006) · Cell Cycle · doi:10.4161/cc.5.17.3208 · Cited by 31

Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer

Fernandes, P. H., Saam, J. R., Peterson, J., Hughes, E., Kaldate, R., Cummings, S. A., Theisen, A. P., Chen, S., Trost, J. T., & Roa, B. B. (2014) · Cancer · doi:10.1002/cncr.28504 · Cited by 29

Common variants at theCHEK2gene locus and risk of epithelial ovarian cancer

Lawrenson, K., Iversen, E. S., Tyrer, J. P., Weber, R. P., CONCANNON, P. J., Hazelett, D. J., Li, Q., Marks, J. R., Berchuck, A., Lee, J. M., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv138 · Cited by 29

Trinucleotide repeat instability during double-strand break repair: from mechanisms to gene therapy

Mosbach, V., Poggi, L., & Richard, G. (2018) · Current Genetics · doi:10.1007/s00294-018-0865-1 · Cited by 28

Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1

Xiao, M., Guo, J., Xie, L., Yang, C., Gong, L., Wang, Z., & Cai, J. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-1369 · Cited by 29

BRCA1: a scaffold for p53 response?

Hohenstein, P., & Giles, R. H. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00193-8 · Cited by 29

Protein phosphatase 5 is necessary for ATR-mediated DNA repair

Kang, Y., Cheong, H.-M., Lee, J.-H., Song, P. I., Lee, K., Kim, S.-Y., Jun, J. Y., & You, H. J. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.005 · Cited by 31

XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations

Wang, Y., Liang, D., Spitz, M. R., Zhang, K., Dong, Q., Amos, C. I., & Wu, X. (2003) · Cancer · doi:10.1002/cncr.11692 · Cited by 29

Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation

Tarapore, P., Hanashiro, K., & Fukasawa, K. (2012) · Cell Cycle · doi:10.4161/cc.21396 · Cited by 31

BRCA1 regulates the cancer stem cell fate of breast cancer cells in the context of hypoxia and histone deacetylase inhibitors

Kim, H., Lin, Q., & Yun, Z. (2019) · Scientific Reports · doi:10.1038/s41598-019-46210-y · Cited by 29

The carboxyl-terminal of BRCA1 is required for subnuclear assembly of RAD51 after treatment with cisplatin but not ionizing radiation in human breast and ovarian cancer cells

Zhou, C., Huang, P., & Liu, J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.197 · Cited by 29

Bcr/Abl Interferes with the Fanconi Anemia/BRCA Pathway: Implications in the Chromosomal Instability of Chronic Myeloid Leukemia Cells

Valeri, A., Alonso-Ferrero, M. E., Rı́o, P., Pujol, R. M., Casado, J. A., Perez, L. N., Jacome, A., Agirre, X., Calasanz, M. J., Hanenberg, H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015525 · Cited by 27

Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites

Sherker, A., Chaudhary, N., Adam, S., Heijink, A. M., Noordermeer, S. M., Fradet‐Turcotte, A., & Durocher, D. (2021) · EMBO Reports · doi:10.15252/embr.202153679 · Cited by 31

Development of the NOGGO GIS v1 Assay, a Comprehensive Hybrid-Capture-Based NGS Assay for Therapeutic Stratification of Homologous Repair Deficiency Driven Tumors and Clinical Validation

Willing, E., Vollbrecht, C., Vössing, C., Weist, P., Schallenberg, S., Herbst, J., Schatz, S., Jóri, B., Bataillon, G., Harter, P., et al. (2023) · Cancers · doi:10.3390/cancers15133445 · Cited by 29

Expression of human BRCA1Δ17–19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response

Sevcik, J., Falk, M., Macůrek, L., Kleiblová, P., Lhota, F., Hojny, J., Štefančíková, L., Janatová, M., Bártek, J., Stribrna, J., et al. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.02.008 · Cited by 28

Multifunctional transcription factor TFII-I is an activator of BRCA1 function

Tanikawa, M., Wada‐Hiraike, O., Nakagawa, S., Shirane, A., Hiraike, H., Koyama, S., Miyamoto, Y., Sone, K., Tsuruga, T., Nagasaka, K., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.75 · Cited by 28

RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination

Baldock, R. A., Pressimone, C. A., Baird, J. M., Khodakov, A. Y., Luong, T., Grundy, M. K., Smith, C. M., Karpenshif, Y., Bratton-Palmer, D. S., Garcin, E. B., et al. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.02.008 · Cited by 28

Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1

Hinton, C. V., Fitzgerald, L. D., & Thompson, M. E. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.03.008 · Cited by 28

Caretaker Brca1: keeping the genome in the straight and narrow

Yu, V. P. C. C. (2000) · Breast Cancer Research · doi:10.1186/bcr37 · Cited by 17

Commentary Caretaker Brca1: keeping the genome in the straight and narrow

Yu, V. (2000)

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

Snouwaert, J. N., Gowen, L. C., Latour, A. M., Mohn, A. R., Xiao, A., DiBiase, L., & Koller, B. H. (1999) · Oncogene · doi:10.1038/sj.onc.1203334 · Cited by 197

BRCA1: a key player at multiple stages of homologous recombination in DNA double-strand break repair

Liu, Y., & Lu, L. (2021) · Genome Instability & Disease · doi:10.1007/s42764-021-00042-1 · Cited by 11

The Role of the BRCA1 Tumor Suppressor in DNA Double-Strand Break Repair

Zhang, J., & Powell, S. N. (2005) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0192 · Cited by 213