Brca1 Controls Homology-Directed DNA Repair

The double-strand-break repair model for recombination

Szostak, J. W., Orr-Weaver, T. L., Rothstein, R. J., & Stahl, F. W. (1983) · Cell · doi:10.1016/0092-8674(83)90331-8 · Cited by 2,437

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459

XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsPreprint

Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2633 · Cited by 1,384

Gatekeepers and caretakers

Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386761a0 · Cited by 1,240

The Genetic Basis of Human Cancer

Vogelstein, B., & Kinzler, K. W. (1997) · Cited by 1,120

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,087

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

Xu, X., Ohler, Z. W., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., & Deng, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819

RAD51 Up-regulation Bypasses BRCA1 Function and Is a Common Feature of BRCA1 -Deficient Breast Tumors

Martin, R. W., Orelli, B. J., Yamazoe, M., Minn, A. J., Takeda, S., & Bishop, D. K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0290 · Cited by 177

REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps

Taglialatela, A., Leuzzi, G., Sannino, V., Cuella-Martin, R., Huang, J., Wu-Baer, F., Baer, R. J., Costanzo, V., & Ciccia, A. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.08.016 · Cited by 183

USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors

Lim, K. S., Li, H., Roberts, E. A., Gaudiano, E. F., Clairmont, C. S., Sambel, L. A., Ponnienselvan, K., Liu, J., Yang, C., Kozono, D., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.10.045 · Cited by 174

BRCA 1, a ‘complex’ protein involved in the maintenance of genomic stability

Savage, K. I., & Harkin, D. P. (2014) · FEBS Journal · doi:10.1111/febs.13150 · Cited by 183

FANCE: the link between Fanconi anaemia complex assembly and activity

Pace, P., Johnson, M., Tan, W. M., Mosedale, G., Sng, C. C. A., Hoatlin, M., de Winter, J. P., Joenje, H., Gergely, F. V., & Patel, K. J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf355 · Cited by 172

Interactive competition between homologous recombination and non-homologous end joining.

Allen, C., Halbrook, J., & Nickoloff, J. A. (2003) · PubMed · Cited by 171

Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

Kang, J., Bronson, R. T., & Xu, Y. (2002) · The EMBO Journal · doi:10.1093/emboj/21.6.1447 · Cited by 173

Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells

Konishi, H., Mohseni, M., Tamaki, A., Garay, J. P., Croessmann, S., Karnan, S., Ota, A., Wong, H. Y., Konishi, Y., Karakas, B., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110969108 · Cited by 170

PARP1-Driven Poly-ADP-Ribosylation Regulates BRCA1 Function in Homologous Recombination–Mediated DNA Repair

Hu, Y., Petit, S. A., Ficarro, S. B., Toomire, K. J., Xie, A., Lim, E., Cao, S. A., Park, E., Eck, M. J., Scully, R., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0891 · Cited by 181

Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair

Chen, X., Zhong, S., Zhu, X., Dziegielewska, B., Ellenberger, T., Wilson, G. M., MacKerell, A. D., & Tomkinson, A. E. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6636 · Cited by 173

Roles of BRCA1 in DNA damage repair: a link between development and cancer

Deng, C. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg082 · Cited by 169

Mouse models of pancreatic cancer

Herreros‐Villanueva, M. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i12.1286 · Cited by 174

Targeting the DNA repair defect of BRCA tumours

Turner, N. C., Tutt, A. N. J., & Ashworth, A. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.03.006 · Cited by 164

Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice

Xu, X., Aprelikova, O. N., Møens, P. B., Deng, C., & Furth, P. A. (2003) · Development · doi:10.1242/dev.00410 · Cited by 166

The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination

Zhao, W., Wiese, C., Kwon, Y., Hromas, R., & Sung, P. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111058 · Cited by 169

Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer

Waks, A. G., Cohen, O., Kochupurakkal, B. S., Kim, D., Dunn, C. E., Buendia, J., Wander, S. A., Helvie, K. E., Lloyd, M. R., Marini, L., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.02.008 · Cited by 163

Role of 53BP1 in the Regulation of DNA Double-Strand Break Repair Pathway Choice

Gupta, A. K. D., Hunt, C. R., Chakraborty, S., PANDITA, R. K., Yordy, J. S., Ramnarain, D. B., Horikoshi, N., & Pandita, T. K. (2013) · Radiation Research · doi:10.1667/rr13572.1 · Cited by 162

Human DNA repair genes

Ronen, A., & Glickman, B. W. (2001) · Environmental and Molecular Mutagenesis · doi:10.1002/em.1033 · Cited by 161

An analogy between the evolution of drug resistance in bacterial communities and malignant tissues

Lambert, G., Estévez-Salmerón, L., Oh, S., Liao, D., Emerson, B. M., Tlsty, T. D., & Austin, R. H. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3039 · Cited by 160

BRCA1/BARD1 Ubiquitinate Phosphorylated RNA Polymerase II

Starita, L. M., Horwitz, A. A., Keogh, M., Ishioka, C., Parvin, J. D., & Chiba, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414020200 · Cited by 156

Cdc2–cyclin B kinase activity links Crb2 and Rqh1–topoisomerase IIIPreprint

Caspari, T., Murray, J. M., & Carr, A. M. (2002) · Genes & Development · doi:10.1101/gad.221402 · Cited by 156

A BRCA1‐interacting lncRNA regulates homologous recombination

Sharma, V., Khurana, S., Kubben, N., Abdelmohsen, K., Oberdoerffer, P., Gorospe, M., & Misteli, T. (2015) · EMBO Reports · doi:10.15252/embr.201540437 · Cited by 151

BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents

Mullan, P. B., Quinn, J. E., Gilmore, P. M., McWilliams, S., Andrews, H. N., Gervin, C., McCabe, N., McKenna, S., White, P., Song, Y., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204712 · Cited by 154

Pc-G/trx-G and the SWI/SNF connection: Developmental gene regulation through chromatin remodeling

Gebuhr, T. C., Bultman, S. J., & Magnuson, T. (2000) · genesis · doi:10.1002/(sici)1526-968x(200003)26:3 · Cited by 37

MERIT40 controls BRCA1–Rap80 complex integrity and recruitment to DNA double-strand breaksPreprint

Shao, G., Patterson-Fortin, J., Messick, T. E., Feng, D., Shanbhag, N. M., Wang, Y., & Greenberg, R. A. (2009) · Genes & Development · doi:10.1101/gad.1739609 · Cited by 153

Resveratrol Prevents Epigenetic Silencing of BRCA-1 by the Aromatic Hydrocarbon Receptor in Human Breast Cancer Cells ,

Papoutsis, A. J., Lamore, S. D., Wondrak, G. T., Selmin, O. I., & Romagnolo, D. F. (2010) · Journal of Nutrition · doi:10.3945/jn.110.123422 · Cited by 153

Fanconi Anemia FANCG Protein in Mitigating Radiation- and Enzyme-Induced DNA Double-Strand Breaks by Homologous Recombination in Vertebrate Cells

Yamamoto, K., Ishiai, M., Matsushita, N., Arakawa, H., Lamerdin, J. E., Buerstedde, J.-M., Tanimoto, M., Harada, M., Thompson, L. H., & Takata, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5421-5430.2003 · Cited by 151

BRCA1 Facilitates Microhomology-mediated End Joining of DNA Double Strand Breaks

Zhong, Q., Chen, C., Chen, P., & Lee, W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200748200 · Cited by 155

Homologous DNA recombination in vertebrate cells

Sonoda, E., Takata, M., Yamashita, Y. M., Morrison, C. G., & Takeda, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111006398 · Cited by 151

Somatic Mosaicism in the Human Genome

Freed, D. N., Stevens, E. L., & Pevsner, J. (2014) · Genes · doi:10.3390/genes5041064 · Cited by 156

p300 Modulates the BRCA1 inhibition of estrogen receptor activity.

Fan, S., Ma, Y. X., Wang, C., Yuan, R., Meng, Q., Wang, J., Erdos, M. R., Goldberg, I. D., Webb, P., Kushner, P. J., et al. (2002) · PubMed · Cited by 148

Is homologous recombination really an error-free process?

Guirouilh‐Barbat, J., Lambert, S., Bertrand, P., & López, B. S. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00175 · Cited by 161

Histone Ubiquitination Associates with BRCA1-Dependent DNA Damage Response

Wu, J., Huen, M. S. Y., Lu, L., Lin, Y., Dou, Y., Ljungman, M. E., Chen, J., & Yu, X. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01302-08 · Cited by 152

The association of BRCA1 and BRCA2 mutations with prostate cancer risk, frequency, and mortality: A meta‐analysis

Oh, M., Alkhushaym, N., Fallatah, S., Althagafi, A. A., Aljadeed, R., Alsowaida, Y. S., Jeter, J., Martin, J. R., Babiker, H. M., McBride, A., et al. (2019) · The Prostate · doi:10.1002/pros.23795 · Cited by 151

BRCA1/BARD1 Orthologs Required for DNA Repair in Caenorhabditis elegans

Boulton, S. J., Martin, J. S., Polanowska, J., HILL, D. E., Gartner, A., & Vidal, M. (2004) · Current Biology · doi:10.1016/j.cub.2003.11.029 · Cited by 146

A conserved pathway to activate BRCA1‐dependent ubiquitylation at DNA damage sites

Polanowska, J., Martin, J. S., García‐Muse, T., Petalcorin, M. I. R., & Boulton, S. J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601102 · Cited by 147

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

Ekumi, K. M., Paculová, H., Lenasi, T., Pospíchalová, V., Bösken, C. A., Rybaříková, J., Bryja, V., Geyer, M., Blažek, D., & Barborič, M. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv101 · Cited by 145

Human Genome and Diseases:¶Double-strand breaks and translocations in cancer

Elliott, B., & Jasin, M. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8429-3 · Cited by 146

Complexity of genome sequencing and reporting: Next generation sequencing (NGS) technologies and implementation of precision medicine in real life

Morganti, S., Tarantino, P., Ferraro, E., D’Amico, P., Viale, G., Trapani, D., Duso, B. A., & Curigliano, G. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.11.008 · Cited by 151

ATP Hydrolysis by Mammalian RAD51 Has a Key Role during Homology-directed DNA Repair

Stark, J. M., Hu, P., Pierce, A. J., Moynahan, M. E., Ellis, N. A., & Jasin, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112132200 · Cited by 144

Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

Joukov, V., Chen, J., Fox, E. A., Green, J. B. A., & Livingston, D. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211427098 · Cited by 146

A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants

Bouwman, P., van der Gulden, H., van der Heijden, I., Drost, R., Klijn, C. N., Prasetyanti, P., Pieterse, M., Wientjens, E., Seibler, J., Hogervorst, F. B. L., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0094 · Cited by 140

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

Heijink, A. M., Talens, F., Jae, L. T., van Gijn, S. E., Fehrmann, R. S. N., Brummelkamp, T. R., & van Vugt, M. A. T. M. (2019) · Nature Communications · doi:10.1038/s41467-018-07927-y · Cited by 140

BRCA1 and BRCA2 Gene Mutations and Colorectal Cancer Risk: Systematic Review and Meta-analysis

Oh, M., McBride, A., Yun, S., Bhattacharjee, S., Slack, M. K., Martin, J. R., Jeter, J., & Abraham, I. L. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy148 · Cited by 140

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA -deficient cells to PARP inhibitors

Fugger, K., Bajrami, I., dos Santos, M. S., Young, S. J., Kunzelmann, S., Kelly, G. P., Hewitt, G., Patel, H., Goldstone, R. J., Carell, T., et al. (2021) · Science · doi:10.1126/science.abb4542 · Cited by 141

Death and more: DNA damage response pathways in the nematode C. elegans

Stergiou, L., & Hengartner, M. O. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401340 · Cited by 140

Role for the BRCA1 C-terminal Repeats (BRCT) Protein 53BP1 in Maintaining Genomic Stability

Morales, J. C., Xia, Z., Lu, T., Aldrich, M. B., Wang, B., Rosales, C., Kellems, R. E., Hittelman, W. N., Elledge, S. J., & Carpenter, P. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212484200 · Cited by 142

Mechanisms of BRCA1–BARD1 nucleosome recognition and ubiquitylation

Hu, Q., Botuyan, M. V., Zhao, D., Cui, G., Mer, E., & Mer, G. (2021) · Nature · doi:10.1038/s41586-021-03716-8 · Cited by 139

BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability

Skórski, T. (2002) · Oncogene · doi:10.1038/sj.onc.1206087 · Cited by 136

Oncogenic tyrosine kinases and the dna-damage response

Skórski, T. (2002) · Nature reviews. Cancer · doi:10.1038/nrc799 · Cited by 136

Loss of Bard1, the Heterodimeric Partner of the Brca1 Tumor Suppressor, Results in Early Embryonic Lethality and Chromosomal Instability

McCarthy, E. E., Celebi, J. T., Baer, R. J., & Ludwig, T. E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.14.5056-5063.2003 · Cited by 140

Chromosomal breakage syndromes and the BRCA1 genome surveillance complex

Futaki, M., & Liu, J. M. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02178-5 · Cited by 135

Cellular responses to ionizing radiation damage

Li, L., Story, M. D., & Legerski, R. J. (2001) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(00)01524-8 · Cited by 134

Advanced pancreatic adenocarcinoma: a review of current treatment strategies and developing therapies

Teague, A. S., Lim, K., & Wang‐Gillam, A. (2015) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758834014564775 · Cited by 135

Molecular subtypes and precision treatment of triple-negative breast cancer

Zhao, S., Zuo, W., Shao, Z., & Jiang, Y. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.03.194 · Cited by 140

Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin

Oca, R. M. D., Andreassen, P. R., Margossian, S. P., Gregory, R. C., Taniguchi, T., Wang, X., Houghtaling, S. R., Grompe, M., & D’Andrea, A. D. (2004) · Blood · doi:10.1182/blood-2003-11-3997 · Cited by 134

Secondary mutations of BRCA1/2 and drug resistance

Dhillon, K. K., Swisher, E. M., & Taniguchi, T. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01840.x · Cited by 135

Biochemical mechanism of DSB end resection and its regulation

Daley, J. M., Niu, H., Miller, A. S., & Sung, P. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.04.015 · Cited by 141

Regulation of antioxidants in cancer

Hecht, F., Zocchi, M., Alimohammadi, F., & Harris, I. S. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.11.001 · Cited by 138

AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51

Plo, I., Laulier, C., Gauthier, L., Lebrun, F., Calvo, F. M., & López, B. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0861 · Cited by 132

Analysis of the DNA Substrate Specificity of the Human BACH1 HelicaseAssociated with BreastCancer

Gupta, R., Sharma, S., Sommers, J. A., Jin, Z., Cantor, S. B., & Brosh, R. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501995200 · Cited by 131

The multiple roles of the Mre11 complex for meiotic recombination

Borde, V. (2007) · Chromosome Research · doi:10.1007/s10577-007-1147-9 · Cited by 141

ATR Affecting Cell Radiosensitivity Is Dependent on Homologous Recombination Repair but Independent of Nonhomologous End Joining

Wang, H., Wang, H., Powell, S. N., Iliakis, G., & Wang, Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1289 · Cited by 130

Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair

Park, J.-Y., Singh, T. R., Nassar, N., Zhang, F., Freund, M., Hanenberg, H., Meetei, A. R., & Andreassen, P. R. (2014) · Oncogene · doi:10.1038/onc.2013.421 · Cited by 130

MicroRNA-182-5p targets a network of genes involved in DNA repair

Krishnan, K., Steptoe, A. L., Martin, H. C., Wani, S., Nones, K., Waddell, N., Mariasegaram, M., Simpson, P. T., Lakhani, S. R., Gabrielli, B. G., et al. (2012) · RNA · doi:10.1261/rna.034926.112 · Cited by 131

Caretaker tumour suppressor genes that defend genome integrity

Levitt, N. C., & Hickson, I. D. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02298-0 · Cited by 138

Hereditary breast cancer

Robson, M. E., Boyd, J. A., Borgen, P. I., & Cody, H. S. (2001) · Current Problems in Surgery · doi:10.1016/s0011-3840(01)70035-4 · Cited by 133

Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1.

Wu, G., Jiang, X., Lee, W., & Chen, P. (2003) · PubMed · Cited by 128

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

Reid, L. J., Shakya, R., Modi, A. P., Lokshin, M., Cheng, J., Jasin, M., Baer, R. J., & Ludwig, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811203106 · Cited by 131

Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.

Zhong, Q., Boyer, T., Chen, P., & Lee, W. (2002) · PubMed · Cited by 128

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Osório, A., Milne, R. L., Kuchenbaecker, K. B., Vaclová, T., Pita, G., Alonso, R., Peterlongo, P., Blanco, I., de la Hoya, M., Duran, M., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004256 · Cited by 132

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adducts

Aparicio, T., Baer, R. J., Gottesman, M. E., & Gautier, J. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201504005 · Cited by 128

BRCA1/BRCA2Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies

Lee, A., Moon, B.-I., & Kim, T. H. (2019) · Annals of Laboratory Medicine · doi:10.3343/alm.2020.40.2.114 · Cited by 127

MiR-96 Downregulates REV1 and RAD51 to Promote Cellular Sensitivity to Cisplatin and PARP Inhibition

Wang, Y., Huang, J., Calses, P. C., Kemp, C. J., & Taniguchi, T. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0103 · Cited by 127

Characterization of mammalian RAD51 double strand break repair using non‐lethal dominant‐negative forms

Lambert, S., & López, B. S. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.3090 · Cited by 125

Epigenetic Inactivation of the Chromosomal Stability Control Genes BRCA1, BRCA2, and XRCC5 in Non–Small Cell Lung Cancer

Lee, M.-N., Tseng, R., Hsu, H., Chen, J.-Y., Tzao, C., Ho, W. L., & Wang, Y. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2694 · Cited by 124

Biological determinants of radioresistance and their remediation in pancreatic cancer

Seshacharyulu, P., Baine, M. J., Souchek, J. J., Menning, M., Kaur, S., Yan, Y., Ouellette, M. M., Jain, M., Lin, C. H., & Batra, S. K. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.02.003 · Cited by 127

Early events in the mammalian response to DNA double-strand breaks

Riches, L. C., Lynch, A. M., & Gooderham, N. J. (2008) · Mutagenesis · doi:10.1093/mutage/gen039 · Cited by 124

Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.

Wang, H., Guan, J., Wang, H., Perrault, A. R., Wang, Y., & Iliakis, G. E. (2001) · PubMed · Cited by 123

Ubiquitination and Proteasomal Degradation of the BRCA1 Tumor Suppressor Is Regulated during Cell Cycle Progression

Choudhury, A. D., Xu, H., & Baer, R. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403646200 · Cited by 126

Ubiquitin and breast cancer

Ohta, T., & Fukuda, M. (2004) · Oncogene · doi:10.1038/sj.onc.1207371 · Cited by 123

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

Shakya, R., Szabolcs, M. J., McCarthy, E. E., Ospina, E., Basso, K., Nandula, S. V., Murty, V. V., Baer, R. J., & Ludwig, T. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711032105 · Cited by 125

A role for human homologous recombination factors in suppressing microhomology-mediated end joining

Ahrabi, S., Sarkar, S., Pfister, S. X., Pirovano, G., Higgins, G. S., Porter, A. C. G., & Humphrey, T. C. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw326 · Cited by 127

DNA damage and cell cycle checkpoints in hyperoxic lung injury: braking to facilitate repair

O’Reilly, M. A. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.2.l291 · Cited by 122

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

Watkins, J. A., Weekes, D. B., Shah, V., Gazińska, P., Joshi, S. P., Sidhu, B., Gillett, C., Pinder, S. E., Vanoli, F., Jasin, M., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-1092 · Cited by 120

BRCA1 Is Required for Postreplication Repair after UV-Induced DNA Damage

Pathania, S., Nguyen, J., Hill, S. J., Scully, R., Adelmant, G., Marto, J. A., Feunteun, J., & Livingston, D. M. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.09.002 · Cited by 125

Identification of Breast Tumor Mutations in BRCA1 That Abolish Its Function in Homologous DNA Recombination

Ransburgh, D. J. R., Chiba, N., Ishioka, C., Toland, A. E., & Parvin, J. D. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2850 · Cited by 120

A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer

Rafii, S. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.12.1433 · Cited by 120

RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer

Somyajit, K., Subramanya, S., & Nagaraju, G. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq210 · Cited by 122

Roles of BRCA1 in centrosome duplication

Deng, C. (2002) · Oncogene · doi:10.1038/sj.onc.1205713 · Cited by 120

Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection

Kakarougkas, A., Ismail, A., Katsuki, Y., Freire, R., Shibata, A., & Jeggo, P. A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt802 · Cited by 121

Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

Wang, H., Zeng, Z., Bui, T. A., DiBiase, S. J., Qin, W., Xia, F., Powell, S. N., & Iliakis, G. E. (2001) · PubMed · Cited by 119

RAD51 localization and activation following DNA damage

Tarsounas, M., Davies, A. A., & West, S. C. (2004) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2003.1368 · Cited by 119

Double-strand breaks and tumorigenesis

Pierce, A. J., Stark, J. M., Araujo, F. D., Moynahan, M. E., Berwick, M., & Jasin, M. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)82296-0 · Cited by 119

Links between genome integrity and BRCA1 tumor suppression

Covington, M. L., & Greenberg, R. A. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.06.007 · Cited by 119

Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins

McIlwraith, M. J., Dyck, E. V., Masson, J., Stasiak, A. Z., Stasiak, A., & West, S. C. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4180 · Cited by 121

MDC1 interacts with Rad51 and facilitates homologous recombination

Zhang, J., Ma, Z., Treszezamsky, A. D., & Powell, S. N. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb991 · Cited by 121

RAD51, genomic stability, and tumorigenesis

Richardson, C. A. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.08.009 · Cited by 118

Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1

Hussain, S. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg266 · Cited by 117

Therapeutic resistance of pancreatic cancer: Roadmap to its reversal

Yu, S., Zhang, C., & Xie, K. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188461 · Cited by 119

Caretaker Brca1: keeping the genome in the straight and narrow

Yu, V. P. C. C. (2000) · Breast Cancer Research · doi:10.1186/bcr37 · Cited by 17

Commentary Caretaker Brca1: keeping the genome in the straight and narrow

Yu, V. (2000)

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

Snouwaert, J. N., Gowen, L. C., Latour, A. M., Mohn, A. R., Xiao, A., DiBiase, L., & Koller, B. H. (1999) · Oncogene · doi:10.1038/sj.onc.1203334 · Cited by 197

BRCA1: a key player at multiple stages of homologous recombination in DNA double-strand break repair

Liu, Y., & Lu, L. (2021) · Genome Instability & Disease · doi:10.1007/s42764-021-00042-1 · Cited by 11

The Role of the BRCA1 Tumor Suppressor in DNA Double-Strand Break Repair

Zhang, J., & Powell, S. N. (2005) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0192 · Cited by 213