Brca1 Controls Homology-Directed DNA Repair

The double-strand-break repair model for recombination

Szostak, J. W., Orr-Weaver, T. L., Rothstein, R. J., & Stahl, F. W. (1983) · Cell · doi:10.1016/0092-8674(83)90331-8 · Cited by 2,437

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459

XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsPreprint

Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2633 · Cited by 1,384

Gatekeepers and caretakers

Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386761a0 · Cited by 1,240

The Genetic Basis of Human Cancer

Vogelstein, B., & Kinzler, K. W. (1997) · Cited by 1,120

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,087

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

Xu, X., Ohler, Z. W., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., & Deng, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819

Weighted Frequent Gene Co-expression Network Mining to Identify Genes Involved in Genome Stability

Zhang, J., Lü, K., Xiang, Y., Islam, M. M., Kotian, S., Kais, Z., Lee, C., Arora, M., Liu, H.-W., Parvin, J. D., et al. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002656 · Cited by 76

A role for Brca1 in chromosome end maintenance

McPherson, J. P., Hande, M. P., Poonepalli, A., Lemmers, B., Matysiak‐Zablocki, E., Migon, E., Shehabeldin, A., Porras, A., Karásková, J., Vukovic, B., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl002 · Cited by 79

Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks, nicks and paired nicks

Vriend, L. E. M., Prakash, R., Chen, C.-C., Vanoli, F., Cavallo, F., Zhang, Y., Jasin, M., & Krawczyk, P. M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw179 · Cited by 77

Role of BRCAgene dysfunction in breast and ovarian cancer predisposition

Scully, R. (2000) · Breast Cancer Research · doi:10.1186/bcr76 · Cited by 78

Missed therapeutic and prevention opportunities in women with BRCA‐mutated epithelial ovarian cancer and their families due to low referral rates for genetic counseling and BRCA testing: A review of the literature

Hoskins, P. J., & Gotlieb, W. H. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21408 · Cited by 77

A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours

Wilson, R. H., Evans, T. J., Middleton, M. R., Molife, L. R., Spicer, J. F., Dieras, V. C., Roxburgh, P., Giordano, H., Jaw‐Tsai, S., Goble, S. M., et al. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.36 · Cited by 78

Homologous Recombination Assay for Interstrand Cross-Link Repair

Nakanishi, K., Cavallo, F., Brunet, E., & Jasin, M. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-129-1_16 · Cited by 76

Yeast Recombination Factor Rdh54 Functionally Interacts with the Rad51 Recombinase and Catalyzes Rad51 Removal from DNA

Chi, P., Kwon, Y., Seong, C., Epshtein, A., Lam, I., Sung, P., & Klein, H. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602983200 · Cited by 77

Mediators of Homologous DNA PairingPreprint

Zelensky, A. N., Kanaar, R., & Wyman, C. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016451 · Cited by 81

The emerging role of Polycomb repressors in the response to DNA damage

Vissers, J. H. A., van Lohuizen, M., & Citterio, E. (2012) · Journal of Cell Science · doi:10.1242/jcs.107375 · Cited by 81

Suppression of retroviral infection by the RAD52 DNA repair protein

Lau, A., Kanaar, R., Jackson, S. P., & O’Connor, M. J. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600348 · Cited by 76

Platinum chemotherapy for BRCA1-related breast cancer: do we need more evidence?

Turner, N. C., & Tutt, A. N. J. (2012) · Breast Cancer Research · doi:10.1186/bcr3332 · Cited by 76

Homologous Recombination and Its Role in Carcinogenesis

Bishop, A. J. R., & Schiestl, R. H. (2002) · BioMed Research International · doi:10.1155/s1110724302204052 · Cited by 77

RNF20–RNF40: A ubiquitin‐driven link between gene expression and the DNA damage response

Shiloh, Y., Shema, E., Moyal, L., & Oren, M. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.07.034 · Cited by 77

Homologous recombination as a mechanism of carcinogenesis

Bishop, A. J. R., & Schiestl, R. H. (2001) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(01)00018-x · Cited by 76

LncRNAs in DNA damage response and repair in cancer cells

Su, M., Wang, H., Wang, W., Wang, Y., Ouyang, L., Chen, P., Xia, L., Cao, D., & Liao, Q. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy022 · Cited by 72

Identification of DBC1 as a transcriptional repressor for BRCA1

Hiraike, H., Wada‐Hiraike, O., Nakagawa, S., Koyama, S., Miyamoto, Y., Sone, K., Tanikawa, M., Tsuruga, T., Nagasaka, K., Matsumoto, Y., et al. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605577 · Cited by 74

BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids

Chandramouly, G., Kwok, A., Huang, B., Willis, N. A., Xie, A., & Scully, R. (2013) · Nature Communications · doi:10.1038/ncomms3404 · Cited by 70

Ubiquitin C-Terminal Hydrolase L1 in Tumorigenesis

Hurst-Kennedy, J., Chin, L., & Li, L. (2012) · Biochemistry Research International · doi:10.1155/2012/123706 · Cited by 71

The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting

Severson, T., Wolf, D. M., Yau, C. S. F., Peeters, J. K., Wehkam, D., Schouten, P. C., Chin, S., Majewski, I. J., Michaut, M., Bosma, A. R., et al. (2017) · Breast Cancer Research · doi:10.1186/s13058-017-0861-2 · Cited by 77

The role of DNA damage response proteins at telomeres—an “integrative” model

Slijepčević, P. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.038 · Cited by 73

Revisiting DNA damage repair, p53-mediated apoptosis and cisplatin sensitivity in germ cell tumors

Cavallo, F., Feldman, D. R., & Barchi, M. (2013) · The International Journal of Developmental Biology · doi:10.1387/ijdb.130135mb · Cited by 72

Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations

Chang, S., Biswas, K., Martin, B. K., Stauffer, S., & Sharan, S. K. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39836 · Cited by 72

Sorafenib potentiates irradiation effect in hepatocellular carcinoma in vitro and in vivo

Wen, Y., Gu, K., Yu, Z., Yuan, D., He, M., Ma, N., Lai, S., Zhao, J., Ren, Z., Zhang, X., et al. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.10.024 · Cited by 72

Regulation of the Fanconi anemia pathway by monoubiquitination

Gregory, R. C., Taniguchi, T., & D’Andrea, A. D. (2002) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(02)00102-5 · Cited by 72

OUP accepted manuscript

Chen, Y., Zhang, H., Xu, Z., Tang, H., Geng, A., Cai, B., Su, T., Shi, J., Jiang, C., Tian, X., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz592 · Cited by 75

Genome maintenance and transcription integrity in aging and disease

Wolters, S., & Schumacher, B. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00019 · Cited by 73

Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasion

Akhmedov, A. T. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.16.3022 · Cited by 71

Association between DNA Damage Response and Repair Genes and Risk of Invasive Serous Ovarian Cancer

Schildkraut, J. M., Iversen, E. S., Wilson, M. A., Clyde, M. A., Moorman, P. G., Weber, R. P., Whitaker, R. S., Bentley, R. C., Marks, J. R., & Berchuck, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010061 · Cited by 70

Skin cancer risk inBRCA1/2mutation carriers

Gumaste, P. V., Penn, L. A., Cymerman, R. M., Kirchhoff, T., Polsky, D., & McLellan, B. N. (2014) · British Journal of Dermatology · doi:10.1111/bjd.13626 · Cited by 69

Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair

Xiao, M., Cai, J., Cai, L., Jia, J., Xie, L., Zhu, Y., Huang, B., Jin, D., & Wang, Z. (2017) · Journal of Ovarian Research · doi:10.1186/s13048-017-0321-8 · Cited by 69

DNA polymerase stalling, sister chromatid recombination and the BRCA genes

Scully, R., Puget, N., & Vlasáková, K. (2000) · Oncogene · doi:10.1038/sj.onc.1203971 · Cited by 68

Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer

Caponio, V. C. A., Troiano, G., Adipietro, I., Zhurakivska, K., Arena, C., Mangieri, D., Mascitti, M., Cirillo, N., & Muzio, L. L. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0984-6 · Cited by 68

Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers

Baeyens, A., Thierens, H., Claes, K., Poppe, B. G., Ridder, L. D., & Vral, A. (2004) · International Journal of Radiation Biology · doi:10.1080/09553000400017937 · Cited by 68

The secret life of Bcl-2: Apoptosis-independent inhibition of DNA repair by Bcl-2 family members

Laulier, C., & López, B. S. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.05.002 · Cited by 70

BRCA1 in the DNA damage response and at telomeres

Rosen, E. M. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00085 · Cited by 68

BRCA1‐like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential

Severson, T., Peeters, J. K., Majewski, I. J., Michaut, M., Bosma, A. R., Schouten, P. C., Chin, S., Pereira, B., Goldgraben, M. A., Bismeijer, T., et al. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.04.011 · Cited by 67

A Novel Human Rad54 Homologue, Rad54B, Associates with Rad51

Tanaka, K., Hiramoto, T., Fukuda, T., & Miyagawa, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910306199 · Cited by 67

Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20

Oliveira, D. V. N. P., Kato, A., Nakamura, K., Ikura, T., Okada, M., Kobayashi, J., Yanagihara, H., Saito, Y., Tauchi, H., & Komatsu, K. (2013) · Journal of Cell Science · doi:10.1242/jcs.135855 · Cited by 73

Cancer, DNA Repair Mechanisms, and Resistance to Chemotherapy

Fojo, T. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.19.1434 · Cited by 67

Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin

Jacquemont, C. F., Simon, J. A., D’Andrea, A. D., & Taniguchi, T. (2012) · Molecular Cancer · doi:10.1186/1476-4598-11-26 · Cited by 69

Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network

Greenberg, R. A. (2008) · Chromosoma · doi:10.1007/s00412-008-0154-8 · Cited by 69

Functional Cross-talk among Rad51, Rad54, and Replication Protein A in Heteroduplex DNA Joint Formation

Komen, S. V., Petukhova, G. D., Sigurðsson, S., & Sung, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205864200 · Cited by 65

Ionizing radiation-induced foci formation of mammalian Rad51 and Rad54 depends on the Rad51 paralogs, but not on Rad52

van Veelen, L. R., Essers, J., van de Rakt, M. W. M. M., Odijk, H., Pastink, A., Zdzienicka, M. Z., Paulusma, C. C., & Kanaar, R. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.01.020 · Cited by 64

Role of homologous recombination in DNA interstrand crosslink repair

Hinz, J. M. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20577 · Cited by 68

BRCA1 Physically and Functionally Interacts with ATF1

Houvras, Y. J., Benezra, M., Zhang, H., Manfredi, J. J., Weber, B. L., & Licht, J. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002539200 · Cited by 66

The DNA double-strand break response pathway: becoming more BRCAish than ever

Ting, N. S. Y., & Lee, W. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.026 · Cited by 67

BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining

Kamp, J. A., van Schendel, R., Dilweg, I. W., & Tijsterman, M. (2020) · Nature Communications · doi:10.1038/s41467-020-17455-3 · Cited by 65

BRCA1 Mutations in Cancer: Coordinating Deficiencies in Homologous Recombination with Tumorigenesis

Krais, J. J., & Johnson, N. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-1830 · Cited by 66

The role of BRCA1 in non-homologous end-joining

Bau, D., Mau, Y.-C., & Shen, C. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.08.003 · Cited by 65

Breast Cancer Genes and DNA Repair

Venkitaraman, A. R. (1999) · Science · doi:10.1126/science.286.5442.1100 · Cited by 65

Collaboration of Brca1 and Chk2 in tumorigenesisPreprint

McPherson, J. P., Lemmers, B., Hirao, A., Hakem, A., Abraham, J., Migon, E., Matysiak‐Zablocki, E., Tamblyn, L., Sanchez-Sweatman, O. H., Khokha, R., et al. (2004) · Genes & Development · doi:10.1101/gad.1192704 · Cited by 67

DNA repair mechanisms protect our genome from carcinogenesis

Moraes, M. C. S. (2012) · Frontiers in Bioscience · doi:10.2741/3992 · Cited by 64

DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination

Chakraborty, P., & Hiom, K. J. (2021) · Nature Communications · doi:10.1038/s41467-021-24341-z · Cited by 67

The Biphasic Effect of Flavonoids on Oxidative Stress and Cell Proliferation in Breast Cancer Cells

Xi, X., Wang, J., Qin, Y., You, Y., Huang, W., & Zhan, J. (2022) · Antioxidants · doi:10.3390/antiox11040622 · Cited by 64

Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53

Süße, S., Janz, C., Janus, F., Deppert, W., & Wiesmüller, L. (2000) · Oncogene · doi:10.1038/sj.onc.1203809 · Cited by 64

Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function

Nikkilä, J., Coleman, K. A., Morrissey, D., Pylkäs, K., Erkko, H., Messick, T. E., Karppinen, S.-M., Amelina, A., Winqvist, R., & Greenberg, R. A. (2009) · Oncogene · doi:10.1038/onc.2009.33 · Cited by 63

BRCA Gene Structure and Function in Tumor Suppression

Murphy, C. G., & Moynahan, M. E. (2010) · The Cancer Journal · doi:10.1097/ppo.0b013e3181cf0204 · Cited by 63

Inhibiting homologous recombination decreases extrachromosomal amplification but has no effect on intrachromosomal amplification in methotrexate‐resistant colon cancer cells

Cai, M., Zhang, H., Hou, L., Gao, W., Song, Y., Cui, X., Li, C., Guan, R., Ma, J., Wang, X., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31781 · Cited by 62

P5 eHealth: An Agenda for the Health Technologies of the Future

Pravettoni, G., & Triberti, S. (2019) · Springer eBooks · doi:10.1007/978-3-030-27994-3 · Cited by 63

The ?portrait? of hereditary breast cancer

Lacroix, M., & Leclercq, G. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-004-2172-4 · Cited by 62

BRCA1 Regulates the Interferon γ-mediated Apoptotic Response

Andrews, H. N., Mullan, P. B., McWilliams, S., Šebelová, Š., Quinn, J. E., Gilmore, P. M., McCabe, N., Pace, A. J., Koller, B. H., Johnston, P. G., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201316200 · Cited by 62

TP53 mutation patterns in breast cancers: searching for clues of environmental carcinogenesis

Olivier, M., & Hainaut, P. L. (2001) · Seminars in Cancer Biology · doi:10.1006/scbi.2001.0390 · Cited by 62

BRCA1 DNA-Binding Activity Is Stimulated by BARD1

Simons, A. M., Horwitz, A. A., Starita, L. M., Griffin, K., Williams, R. S., Glover, J. N. M., & Parvin, J. D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3296 · Cited by 63

Targeting abnormal DNA double strand break repair in cancer

Rassool, F. V., & Tomkinson, A. E. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0493-5 · Cited by 62

The CDK1 inhibitor RO3306 improves the response of BRCA-proficient breast cancer cells to PARP inhibition

XIA, Q., Cai, Y., Peng, R., Wu, G., Shi, Y., & Jiang, W. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2240 · Cited by 62

Independence of R/M/N Focus Formation and the Presence of Intact BRCA1

Wu, X. (2000) · Science · doi:10.1126/science.289.5476.11a · Cited by 61

Targeting the FANCJ–BRCA1 interaction promotes a switch from recombination to polη-dependent bypass

Xie, J., Litman, R., Wang, S., Peng, M., Guillemette, S., Rooney, T., & Cantor, S. B. (2010) · Oncogene · doi:10.1038/onc.2010.18 · Cited by 60

PRMT2 and RORγ Expression Are Associated With Breast Cancer Survival Outcomes

Oh, T. G., Bailey, P. J., Dray, E. V., Smith, A. G., Goode, J. M., Eriksson, N. A., Funder, J. W., Fuller, P. J., Simpson, E. R., Tilley, W. D., et al. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1403 · Cited by 61

Involvement of DNA-PK and ATM in Radiation- and Heat-induced DNA Damage Recognition and Apoptotic Cell Death

Tomita, M. (2010) · Journal of Radiation Research · doi:10.1269/jrr.10039 · Cited by 61

Tumor formation in Brca1 conditional mutant mice

Deng, C. (2002) · Environmental and Molecular Mutagenesis · doi:10.1002/em.10069 · Cited by 60

H2AX post-translational modifications in the ionizing radiation response and homologous recombination

Xie, A., Odate, S., Chandramouly, G., & Scully, R. A. (2010) · Cell Cycle · doi:10.4161/cc.9.17.12884 · Cited by 59

Regulation of Ionizing Radiation-induced Rad52 Nuclear Foci Formation by c-Abl-mediated Phosphorylation

Kitao, H., & Yuan, Z.-M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208151200 · Cited by 58

Cells of origin of ovarian cancer: ovarian surface epithelium or fallopian tube?

Klotz, D. M., & Wimberger, P. (2017) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4529-z · Cited by 59

Retrospective Survival Analysis of Patients With Advanced Pancreatic Ductal Adenocarcinoma and Germline BRCA or PALB2 Mutations

Reiss, K. A., Yu, S., Judy, R., Symecko, H., Nathanson, K. L., & Domchek, S. M. (2018) · JCO Precision Oncology · doi:10.1200/po.17.00152 · Cited by 61

BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance

Wang, Y., Bernhardy, A. J., Nacson, J., Krais, J. J., Tan, Y., Nicolas, É., Radke, M. R., Handorf, E., Llop‐Guevara, A., Balmañà, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13530-6 · Cited by 60

A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage

Hohenstein, P., Kielman, M. F., Breukel, C., Bennett, L. M., Wiseman, R. W., Krimpenfort, P., Cornelisse, C. J., van Ommen, G. B., Devilee, P., & Fodde, R. (2001) · Oncogene · doi:10.1038/sj.onc.1204363 · Cited by 58

Dual role of CDKs in DNA repair: To be, or not to be

Yata, K., & Esashi, F. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.09.002 · Cited by 62

Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis

Yeung, B. H. Y., Kwan, B. W. Y., He, Q., Lee, A. S., Liu, J., & Wong, A. S. T. (2008) · Oncogene · doi:10.1038/onc.2008.290 · Cited by 58

Curcumin activates DNA repair pathway in bone marrow to improve carboplatin-induced myelosuppression

Chen, X., Wang, J., Fu, Z., Zhu, B., Wang, J., Guan, S., & Hua, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-16436-9 · Cited by 58

Optimizing Phylogenomics with Rapidly Evolving Long Exons: Comparison with Anchored Hybrid Enrichment and Ultraconserved Elements

Karin, B. R., Gamble, T., & Jackman, T. R. (2019) · Molecular Biology and Evolution · doi:10.1093/molbev/msz263 · Cited by 61

BRCA1 Mutational Complementation Induces Synthetic Viability

Nacson, J., Marcantonio, D. D., Wang, Y., Bernhardy, A. J., Clausen, E., Hua, X., Cai, K. Q., Martı́nez, E., Feng, W., Callén, E., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.04.006 · Cited by 53

Association of p53 and MSH2 with recombinative repair complexes during S phase

Zink, D., Mayr, C., Janz, C., & Wiesmüller, L. (2002) · Oncogene · doi:10.1038/sj.onc.1205614 · Cited by 56

BRCA1-Ku80 Protein Interaction Enhances End-joining Fidelity of Chromosomal Double-strand Breaks in the G1 Phase of the Cell Cycle

Jiang, G., Plo, I., Wang, T., Rahman, M. A., Cho, J. H., Yang, E. S.-H., López, B. S., & Xia, F. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.412650 · Cited by 57

Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development

Yoshitomi, Y., Ikeda, T., Saito-Takatsuji, H., & Yonekura, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062804 · Cited by 56

Functional differences among BRCA1 missense mutations in the control of centrosome duplication

Kais, Z., Chiba, N., Ishioka, C., & Parvin, J. D. (2011) · Oncogene · doi:10.1038/onc.2011.271 · Cited by 57

BRCA1 and Its Network of Interacting Partners

Christou, C. M., & Kyriacou, K. C. (2013) · Biology · doi:10.3390/biology2010040 · Cited by 58

Risk of colorectal cancer associated with BRCA1 and/or BRCA2 mutation carriers: systematic review and meta-analysis

Cullinane, C. M., Creavin, B., O’Connell, E., Kelly, L., O’Sullivan, M. J., Corrigan, M. A., & Redmond, H. P. (2020) · British journal of surgery · doi:10.1002/bjs.11603 · Cited by 57

Brief Report: Human Pluripotent Stem Cell Models of Fanconi Anemia Deficiency Reveal an Important Role for Fanconi Anemia Proteins in Cellular Reprogramming and Survival of Hematopoietic Progenitors

Yung, S., Tilgner, K., Ledran, M. H., Habibollah, S., Neganova, I. E., Singhapol, C., Saretzki, G. C., Stojković, M., Armstrong, L., Przyborski, S. A., et al. (2012) · Stem Cells · doi:10.1002/stem.1308 · Cited by 56

Structural Requirements for the BARD1 Tumor Suppressor in Chromosomal Stability and Homology-directed DNA Repair

Reyngold, M., Nandula, S. V., Modi, A. P., Wang, S., Jasin, M., Murty, V. V. V. S., Ludwig, T., & Baer, R. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705198200 · Cited by 56

The DNA-damage response: new molecular insights and new approaches to cancer therapy

Jackson, S. P. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370483 · Cited by 59

BRCA1 and p53: compensatory roles in DNA repair

Hartman, A., & Ford, J. M. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0477-0 · Cited by 62

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

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PARP Inhibitors in Breast and Ovarian Cancer

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BRCA1 Mutation: A Predictive Marker for Radiation Therapy?

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KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair

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Functional assays for BRCA1 and BRCA2

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Distinct implications of different BRCA mutations: efficacy of cytotoxic chemotherapy, PARP inhibition and clinical outcome in ovarian cancer

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The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers.

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Cell Cycle Checkpoint Control Mechanisms That Can Be Disrupted in Cancer

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Caretaker Brca1: keeping the genome in the straight and narrow

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Commentary Caretaker Brca1: keeping the genome in the straight and narrow

Yu, V. (2000)

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

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BRCA1: a key player at multiple stages of homologous recombination in DNA double-strand break repair

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The Role of the BRCA1 Tumor Suppressor in DNA Double-Strand Break Repair

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