Brca1 Controls Homology-Directed DNA Repair

The double-strand-break repair model for recombination

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Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

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XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsPreprint

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Gatekeepers and caretakers

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The Genetic Basis of Human Cancer

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

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The role of BRCA1 in transcriptional regulation and cell cycle control

Mullan, P. B., Quinn, J. E., & Harkin, D. P. (2006) · Oncogene · doi:10.1038/sj.onc.1209872 · Cited by 322

Centrosome amplification, chromosome instability and cancer development

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Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer

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Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial Treatments, and New Developments

Yip, H. Y. K., & Papa, A. (2021) · Cells · doi:10.3390/cells10030659 · Cited by 341

Chromosomal aberrations: formation, identification and distribution

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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

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Pathway choice in DNA double strand break repair: observations of a balancing act

Brandsma, I., & van Gent, D. C. (2012) · Genome Integrity · doi:10.1186/2041-9414-3-9 · Cited by 335

PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2

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DNA Strand Break Repair and Human Genetic Disease

McKinnon, P. J., & Caldecott, K. W. (2007) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115648 · Cited by 321

Manipulating the mammalian genome by homologous recombination

Vásquez, K. M., Marburger, K., Intödy, Z., & Wilson, J. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111009698 · Cited by 310

BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome

Ganesan, S., Silver, D. P., Greenberg, R. A., Avni, D., Drapkin, R., Miron, A., Mok, S. C., Randrianarison-Huetz, V., Brodie, S. G., Salstrom, J. L., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01052-8 · Cited by 306

Massively Parallel Functional Analysis of BRCA1 RING Domain Variants

Starita, L. M., Young, D. L., Islam, M. M., Kitzman, J. O., Gullingsrud, J., Hause, R. J., Fowler, D. M., Parvin, J. D., Shendure, J., & Fields, S. (2015) · Genetics · doi:10.1534/genetics.115.175802 · Cited by 300

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

Cao, L., Li, W., Kim, S., Brodie, S. G., & Deng, C.-X. (2003) · Genes & Development · doi:10.1101/gad.1050003 · Cited by 293

Cellular functions of the BRCA tumour-suppressor proteins

Boulton, S. J. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340633 · Cited by 299

Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition

Johnson, N., Li, Y., Walton, Z. E., Cheng, K. A., Li, D., Rodig, S. J., Moreau, L. A., Unitt, C., Bronson, R. T., Thomas, H. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2377 · Cited by 293

Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2

Venkitaraman, A. R. (2014) · Science · doi:10.1126/science.1252230 · Cited by 300

Targeted therapy for cancer using PARP inhibitors

Lord, C. J., & Ashworth, A. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.06.016 · Cited by 288

DNA DSB repair pathway choice: an orchestrated handover mechanism

Kakarougkas, A., & Jeggo, P. A. (2013) · British Journal of Radiology · doi:10.1259/bjr.20130685 · Cited by 301

Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double‐strand breaks

Potts, P. R., Porteus, M. H., & Yu, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601218 · Cited by 282

Direct DNA binding by Brca1

Paull, T. T., Cortez, D., Bowers, B., Elledge, S. J., & Gellert, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111125998 · Cited by 282

Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2

Oza, A. M., Tinker, A. V., Oaknin, A., Shapira‐Frommer, R., McNeish, I. A., Swisher, E. M., Ray-Coquard, I. L., Bell‐McGuinn, K. M., Coleman, R. L., O’Malley, D. M., et al. (2017) · Gynecologic Oncology · doi:10.1016/j.ygyno.2017.08.022 · Cited by 286

Regulation of BRCC, a Holoenzyme Complex Containing BRCA1 and BRCA2, by a Signalosome-like Subunit and Its Role in DNA Repair

Dong, Y., Hakimi, M., Chen, X., Kumaraswamy, E., Cooch, N. S., Godwin, A. K., & Shiekhattar, R. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00424-6 · Cited by 279

DNA Damage Response Genes and the Development of Cancer Metastasis

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Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency

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BRCA Genes: The Role in Genome Stability, Cancer Stemness and Therapy Resistance

Gorodetska, I., Kozeretska, I. A., & Dubrovska, A. (2019) · Journal of Cancer · doi:10.7150/jca.30410 · Cited by 302

Interaction of FANCD2 and NBS1 in the DNA damage response

Nakanishi, K., Taniguchi, T., Ranganathan, V., New, H. V., Moreau, L. A., Stotsky, M., Mathew, C. G., Kastan, M. B., Weaver, D. T., & D’Andrea, A. D. (2002) · Nature Cell Biology · doi:10.1038/ncb879 · Cited by 275

Development of a Functional Assay for Homologous Recombination Status in Primary Cultures of Epithelial Ovarian Tumor and Correlation with Sensitivity to Poly(ADP-Ribose) Polymerase Inhibitors

Mukhopadhyay, A., Elattar, A., Cerbinskaite, A., Wilkinson, S. J., Drew, Y., Kyle, S., Los, G., Hostomský, Z., Edmondson, R. J., & Curtin, N. J. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2758 · Cited by 271

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

Morris, J. R., & Solomon, E. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh095 · Cited by 282

BRCA1 gene in breast cancer

Rosen, E. M., Fan, S., Pestell, R. G., & Goldberg, I. D. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10257 · Cited by 279

Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response

Reinhardt, H. C., & Yaffe, M. B. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3640 · Cited by 269

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

Xia, F., Taghian, D. G., DeFrank, J. S., Zeng, Z., Willers, H., Iliakis, G. E., & Powell, S. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151253498 · Cited by 263

BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance

Drost, R., Bouwman, P., Rottenberg, S., Boon, U., Schut, E., Klarenbeek, S., Klijn, C. N., van der Heijden, I., van der Gulden, H. M. L., Wientjens, E., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.11.014 · Cited by 266

Mediator function of the human Rad51B–Rad51C complex in Rad51/RPA-catalyzed DNA strand exchangePreprint

Sigurðsson, S., Komen, S. V., Bussen, W., Schild, D., Albala, J. S., & Sung, P. (2001) · Genes & Development · doi:10.1101/gad.935501 · Cited by 257

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

Baer, R. J. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00269-6 · Cited by 263

Elevated levels of Rad51 recombination protein in tumor cells.

Raderschall, E., Stout, K., Freier, S., Suckow, V., Schweiger, S., & Haaf, T. (2002) · PubMed · Cited by 257

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

Cruz-García, A., López-Saavedra, A., & Huertas, P. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.076 · Cited by 273

ATM, a central controller of cellular responses to DNA damage

Khanna, K. K., Lavin, M. F., Jackson, S. P., & Mulhern, T. D. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400874 · Cited by 260

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

Clapperton, J. A., Manke, I. A., Lowery, D. M., Ho, T., Haire, L. F., Yaffe, M. B., & Smerdon, S. J. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb775 · Cited by 244

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

Evers, B., & Jonkers, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209871 · Cited by 264

Double-strand breaks and tumorigenesis

Pierce, A. J., Stark, J. M., Araujo, F. D., Moynahan, M. E., Berwick, M., & Jasin, M. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02149-3 · Cited by 269

A subset of ATM‐ and ATR‐dependent phosphorylation events requires the BRCA1 protein

Foray, N., Marot, D., Gabriel, A., Randrianarison-Huetz, V., Carr, A. M., Perricaudet, M., Ashworth, A., & Jeggo, P. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg274 · Cited by 266

Role for ATM in DNA damage-induced phosphorylation of BRCA1.

Gatei, M. H., Scott, S. P., Filippovitch, I., Soronika, N., Lavin, M. F., Weber, B. L., & Khanna, K. K. (2000) · PubMed · Cited by 245

Genomic integrity and the repair of double-strand DNA breaks

Pastink, A., Eeken, J. C. J., & Lohman, P. H. M. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00167-1 · Cited by 247

Homologous and non‐homologous recombination differentially affect DNA damage repair in mice

Essers, J., STEEG, H. V., de Wit, J., Swagemakers, S. M. A., Vermeij, M., Hoeijmakers, J. H. J., & Kanaar, R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.7.1703 · Cited by 247

Next Generation Sequencing (NGS): A Revolutionary Technology in Pharmacogenomics and Personalized Medicine in Cancer

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BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

Shakya, R., Reid, L. J., Reczek, C. R., Cole, F., Egli, D., Lin, C.-S., deRooij, D. G., Hirsch, S., Ravi, K., Hicks, J. B., et al. (2011) · Science · doi:10.1126/science.1209909 · Cited by 244

A Phase I–II Study of the Oral PARP Inhibitor Rucaparib in Patients with Germline BRCA1/2 -Mutated Ovarian Carcinoma or Other Solid Tumors

Kristeleit, R. S., Shapiro, G. I., Burris, H. A., Oza, A. M., LoRusso, P. M., Patel, M. R., Domchek, S. M., Balmañà, J., Drew, Y., Chen, L.-M., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2796 · Cited by 248

The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

Smeenk, G., Wiegant, W. W., Vrolijk, H., Solari, A. P., Pastink, A., & van Attikum, H. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201001048 · Cited by 243

Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes

Tongelen, A. V., Loriot, A. E., & Smet, C. D. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.03.029 · Cited by 247

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

Cantor, S., Drapkin, R., Zhang, F., Lin, Y., Han, J., Pamidi, S., & Livingston, D. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308717101 · Cited by 240

Applying Synthetic Lethality for the Selective Targeting of Cancer

McLornan, D. P., List, A. F., & Mufti, G. J. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1407390 · Cited by 246

Functions of BRCA1 and BRCA2 in the biological response to DNA damage

Venkitaraman, A. R. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.20.3591 · Cited by 237

The role of BRCA1 in DNA damage response

Wu, J., Lu, L.-Y., & Yu, X. (2010) · Protein & Cell · doi:10.1007/s13238-010-0010-5 · Cited by 235

The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair

Starita, L. M. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00042-5 · Cited by 238

A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

van Vugt, M. A. T. M., Gardino, A. K., Linding, R., Ostheimer, G. J., Reinhardt, H. C., Ong, S.-E., Tan, C. S. H., Miao, H., Keezer, S. M., Li, J., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000287 · Cited by 236

Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: An NRG Oncology/Gynecologic Oncology Group Study

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RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear fociPreprint

Hu, Y., Scully, R., Sobhian, B., Xie, A., Shestakova, E. A., & Livingston, D. M. (2011) · Genes & Development · doi:10.1101/gad.2011011 · Cited by 244

Coupled Homologous and Nonhomologous Repair of a Double-Strand Break Preserves Genomic Integrity in Mammalian Cells

Richardson, C. A., & Jasin, M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.9068-9075.2000 · Cited by 233

Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation

Griffin, C. S., Simpson, P. J., Wilson, C. R., & Thacker, J. (2000) · Nature Cell Biology · doi:10.1038/35036399 · Cited by 232

Sequence-Specific Transcriptional Corepressor Function for BRCA1 through a Novel Zinc Finger Protein, ZBRK1

Zheng, L., Pan, H., Li, S., Flesken‐Nikitin, A., Chen, P., Boyer, T., & Lee, W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00075-7 · Cited by 232

The ubiquitous role of ubiquitin in the DNA damage response

Al-Hakim, A., Escribano‐Diaz, C., Landry, M.-C., O’Donnell, L., Panier, S., Szilard, R. K., & Durocher, D. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.011 · Cited by 240

The democratization of gene editing: Insights from site-specific cleavage and double-strand break repair

Jasin, M., & Haber, J. E. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.001 · Cited by 229

BRCA1/2 testing: therapeutic implications for breast cancer management

Tung, N., & Garber, J. E. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0127-5 · Cited by 228

Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis

Woods, N. (2002) · Blood · doi:10.1182/blood-2002-07-2238 · Cited by 220

Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structurePreprint

Joo, W. S., Jeffrey, P. D., Cantor, S. B., Finnin, M. S., Livingston, D. M., & Pavletich, N. P. (2002) · Genes & Development · doi:10.1101/gad.959202 · Cited by 219

The BARD1-CstF-50 Interaction Links mRNA 3′ End Formation to DNA Damage and Tumor Suppression

Kleiman, F. E., & Manley, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00270-7 · Cited by 215

The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers

Paul, A. (2014) · Frontiers in bioscience · doi:10.2741/4230 · Cited by 224

BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor

Zheng, L., Annab, L., Afshari, C., Lee, W.-H., & Boyer, T. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.171174298 · Cited by 241

The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair

Bridge, W. L., Vandenberg, C. J., Franklin, R., & Hiom, K. J. (2005) · Nature Genetics · doi:10.1038/ng1627 · Cited by 209

Control of Sister Chromatid Recombination by Histone H2AX

Xie, A., Puget, N., Shim, I., Odate, S., Jarzyna, I., Bassing, C. H., Alt, F. W., & Scully, R. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.12.007 · Cited by 211

The Role of the BRCA1 Tumor Suppressor in DNA Double-Strand Break Repair

Zhang, J., & Powell, S. N. (2005) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0192 · Cited by 213

BRCA1 mRNA Expression Levels Predict for Overall Survival in Ovarian Cancer after Chemotherapy

Quinn, J. E., James, C. R., Stewart, G. E., Mulligan, J. M., White, P., Chang, G. K. F., Mullan, P. B., Johnston, P. G., Wilson, R. H., & Harkin, D. P. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1083 · Cited by 207

Effects of BRCA1 - and BRCA2 -Related Mutations on Ovarian and Breast Cancer Survival: A Meta-analysis

Zhong, Q., Peng, H., Zhao, X., Zhang, L., & Hwang, W. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1816 · Cited by 209

BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations

Ye, Q., Hu, Y.-F., Zhong, H.-J., Nye, A. C., Belmont, A. S., & Li, R. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200108049 · Cited by 204

BRCA2-dependent and independent formation of RAD51 nuclear foci

Tarsounas, M., Davies, D. C., & West, S. C. (2003) · Oncogene · doi:10.1038/sj.onc.1206263 · Cited by 214

Platinum response characteristics of patients with pancreatic ductal adenocarcinoma and a germline BRCA1, BRCA2 or PALB2 mutation

Wattenberg, M. M., Asch, D., Yu, S., O'Dwyer, P. J., Domchek, S. M., Nathanson, K. L., Rosen, M. A., Beatty, G. L., Siegelman, E. S., & Reiss, K. A. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0582-7 · Cited by 211

Linking the Cellular Functions ofBRCAGenes to Cancer Pathogenesis and Treatment

Venkitaraman, A. R. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.3.121806.151422 · Cited by 201

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

Kais, Z., Rondinelli, B., Holmes, A. L., O’Leary, C., Kozono, D., D’Andrea, A. D., & Ceccaldi, R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.031 · Cited by 208

Tracing the network connecting brca and fanconi anaemia proteins

Venkitaraman, A. R. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1321 · Cited by 202

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

Snouwaert, J. N., Gowen, L. C., Latour, A. M., Mohn, A. R., Xiao, A., DiBiase, L., & Koller, B. H. (1999) · Oncogene · doi:10.1038/sj.onc.1203334 · Cited by 197

Exploiting the DNA Repair Defect in BRCA Mutant Cells in the Design of New Therapeutic Strategies for CancerPreprint

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Regulatory ubiquitylation in response to DNA double-strand breaks

Panier, S., & Durocher, D. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.01.013 · Cited by 203

Regulation of DNA repair in hypoxic cancer cells

Bindra, R. S., Crosby, M. E., & Glazer, P. M. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9061-3 · Cited by 194

Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer

Morlando, M., & Fatica, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020570 · Cited by 197

BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells.

Page, F. L., Randrianarison-Huetz, V., Marot, D., Cabannes, J., Perricaudet, M., Feunteun, J., & Sarasin, A. R. (2000) · PubMed · Cited by 190

DNA replication-dependent nuclear dynamics of the Mre11 complex.

Mirzoeva, O. K., & Petrini, J. H. J. (2003) · PubMed · Cited by 188

Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function

Chi, P., Komen, S. V., Sehorn, M. G., Sigurðsson, S., & Sung, P. (2006) · DNA repair · doi:10.1016/j.dnarep.2005.11.005 · Cited by 197

miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13

Zhang, P., Wang, L., Rodriguez‐Aguayo, C., Yuan, Y., Debeb, B. G., Chen, D., Sun, Y., You, M. J., Liu, Y., Dean, D. C., et al. (2014) · Nature Communications · doi:10.1038/ncomms6671 · Cited by 188

Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice

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Lessons learned from BRCA1 and BRCA2

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