The promise of minocycline in neurology

Inflammation is detrimental for neurogenesis in adult brain

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Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

Wu, D. C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D.-K., Ischiropoulos, H., & Przedborski, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01763.2002 · Cited by 1,183

Metalloproteinases in biology and pathology of the nervous system

Yong, W. V., Power, C., Forsyth, P., & Edwards, D. (2001) · Nature Reviews Neuroscience · doi:10.1038/35081571 · Cited by 1,094

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

Zhu, S., Stavrovskaya, I. G., Drozda, M., Kim, B. Y. S., Ona, V. O., Li, M., Sarang, S. S., Liu, A. S., Hartley, D. M., Wu, D. C., et al. (2002) · Nature · doi:10.1038/417074a · Cited by 1,069

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

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A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

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Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

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Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia

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Minocycline Prevents Nigrostriatal Dopaminergic Neurodegeneration in the MPTP Model of Parkinson’s Disease

Du, Y., Ma, Z., Lin, S., Dodel, R. C., Gao, F., Bales, K. R., Triarhou, L. C., Chernet, E., Perry, K. W., Nelson, D. L. G., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251341998 · Cited by 789

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

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Inflammation in Acute Ischemic Stroke and its Relevance to Stroke Critical Care

Emsley, H. C. A., Smith, C. J., Tyrrell, P. J., & Hopkins, S. J. (2007) · Neurocritical Care · doi:10.1007/s12028-007-9035-x · Cited by 95

Minocycline Synergizes with N-Acetylcysteine and Improves Cognition and Memory Following Traumatic Brain Injury in Rats

Baki, S. G. A., Schwab, B., Haber, M., Fenton, A. A., & Bergold, P. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012490 · Cited by 94

Preventive Antibiotics for Infections in Acute Stroke

van de Beek, D., Wijdicks, E. F. M., Vermeij, F. H., de Haan, R. J., Prins, J. M., Spanjaard, L., Dippel, D. W. J., & Nederkoorn, P. J. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.176 · Cited by 93

A New Face for Old Antibiotics: Tetracyclines in Treatment of Amyloidoses

Stoilova, T., Colombo, L., Forloni, G., Tagliavini, F., & Salmona, M. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400161p · Cited by 97

Involvement of pro- and antinociceptive factors in minocycline analgesia in rat neuropathic pain model

Rojewska, E., Popiołek-Barczyk, K., Jurga, A. M., Makuch, W., Przewłocka, B., & Mika, J. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.09.020 · Cited by 92

Acute microglia ablation induces neurodegeneration in the somatosensory system

Rubino, S. J., Mayo, L., Wimmer, I., Siedler, V., Brunner, F., Hametner, S., Madi, A., Lanser, A., Moreira, T., Donnelly, D., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05929-4 · Cited by 91

Phenotypic dysregulation of microglial activation in young offspring rats with maternal sleep deprivation-induced cognitive impairment

Zhao, Q., Xie, X., Fan, Y., Zhang, J., Jiang, W. I., Wu, X., Yan, S., Chen, Y., Peng, C. Y., & You, Z. (2015) · Scientific Reports · doi:10.1038/srep09513 · Cited by 92

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases

Dhib-Jalbut, S. S., Arnold, D. L., Cleveland, D. W., Fisher, M., Friedlander, R. M., Mouradian, M. M., Przedborski, S., Trapp, B. D., Wyss‐Coray, T., & Yong, V. W. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.03.027 · Cited by 91

The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment

Varesi, A., Campagnoli, L. I. M., Fahmideh, F., Pierella, E., Romeo, M., Ricevuti, G., Nicoletta, M., Chirumbolo, S., & Pascale, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012289 · Cited by 88

Minocycline Modulates Neuroinflammation Independently of Its Antimicrobial Activity in Staphylococcus aureus-Induced Brain Abscess

Kielian, T., Esen, N., Liu, S., Phulwani, N. K., Syed, M., Phillips, N., Nishina, K. A., Cheung, A. L., Schwartzman, J. D., & Ruhe, J. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070231 · Cited by 88

Therapy of MS

Vosoughi, R., & Freedman, M. S. (2010) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2010.03.010 · Cited by 92

North Central Cancer Treatment Group/Alliance trial N08CA—the use of glutathione for prevention of paclitaxel/carboplatin‐induced peripheral neuropathy: A phase 3 randomized, double‐blind, placebo‐controlled study

Leal, A. D., Qin, R., Atherton, P. J., Haluska, P., Behrens, R. J., Tiber, C. H., Watanaboonyakhet, P., Weiss, M., Adams, P. T., Dockter, T., et al. (2014) · Cancer · doi:10.1002/cncr.28654 · Cited by 86

The efficacy of a glial inhibitor, minocycline, for preventing persistent pain after lumbar discectomy: A randomized, double-blind, controlled study

Martinez, V., Székély, B., Lemarié, J. C., Martin, F., Gentili, M. E., Ammar, S. B., Lepeintre, J.-F., de Loubresse, C. G., CHAUVIN, M., Bouhassira, D., et al. (2013) · Pain · doi:10.1016/j.pain.2013.03.028 · Cited by 84

Genetic findings in Parkinson’s disease and translation into treatment: a leading role for mitochondria?

Bogaerts, V., Theuns, J., & Broeckhoven, C. V. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00342.x · Cited by 91

Major depressive disorder as a neuro-immune disorder: Origin, mechanisms, and therapeutic opportunities

Réus, G. Z., Manosso, L. M., Quevedo, J., & Carvalho, A. F. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105425 · Cited by 94

Combination Therapy With Interferon Beta-1a and Doxycycline in Multiple Sclerosis

Minagar, A., Alexander, J. S., Schwendimann, R. N., Kelley, R. E., Gonzalez‐Toledo, E., Jimenez, J. J., Mauro, L., Jy, W., & Smith, S. J. (2007) · Archives of Neurology · doi:10.1001/archneurol.2007.41 · Cited by 84

Emerging Role of Immunity in Cerebral Small Vessel Disease

Fu, Y., & Yan, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00067 · Cited by 80

Dose–response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation.

Lee, C. Z., Yao, J. S., Huang, Y., Zhai, W., Liu, W., Guglielmo, B. J., Lin, E., Yang, G.-Y., & Young, W. L. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600268 · Cited by 78

Minocycline inhibits the growth of glioma by inducing autophagy

Liu, W., Lin, C.-H., Hsiao, M., & Gean, P. (2011) · Autophagy · doi:10.4161/auto.7.2.14043 · Cited by 78

Methamphetamine induced neurotoxic diseases, molecular mechanism, and current treatment strategies

Shrestha, P., Katila, N., Lee, S., Seo, J. H., Jeong, J., & Yook, S. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113591 · Cited by 91

Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice

Jiang, Y., Liu, Y., Zhu, C., Ma, X., Ma, L., Zhou, L., Huang, Q., Lei, C., Pi, R., & Chen, X. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.03.003 · Cited by 75

The prospects of minocycline in multiple sclerosis.

Chen, X.-H., Ma, X.-M., Jiang, Y., Pi, R., Liu, Y.-Y., & Ma, L.-L. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.04.006 · Cited by 75

Differential neuroprotective effects of a minocycline-based drug cocktail in transient and permanent focal cerebral ischemia

Weng, Y. C., & Križ, J. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2006.12.003 · Cited by 77

Minocycline protects against lipopolysaccharide-induced cognitive impairment in mice

Hou, Y., Xie, G., Liu, X., Li, G., Jia, C., Xu, J., & Wang, B. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4169-6 · Cited by 76

Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome

Camara-Lemarroy, C. R., Metz, L. M., & Yong, V. W. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i37.4217 · Cited by 77

Effects of Minocycline Plus Tissue Plasminogen Activator Combination Therapy After Focal Embolic Stroke in Type 1 Diabetic Rats

Fan, X., Lo, E. H., & Wang, X. (2013) · Stroke · doi:10.1161/strokeaha.111.000309 · Cited by 75

Early post-stressor intervention with minocycline, a second-generation tetracycline, attenuates post-traumatic stress response in an animal model of PTSD

Levkovitz, Y., Fenchel, D., Kaplan, Z., Zohar, J., & Cohen, H. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.11.012 · Cited by 75

Potential Neuroimmune Interaction in Chronic Pain: A Review on Immune Cells in Peripheral and Central Sensitization

Yang, J.-X., Wang, H., Chen, J.-Z., Li, H., Hu, J.-C., Yu, A.-A., Wen, J., Chen, S., Lai, W.-D., Wang, S., et al. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.946846 · Cited by 82

Reduced neurogenesis after suppressed inflammation by minocycline in transient cerebral ischemia in rat

Kim, B. J., Kim, M., Park, J., Lee, S., Kim, Y. J., Ryu, S., Kim, Y. H., & Yoon, B. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.12.025 · Cited by 73

Pilot Study of Minocycline in Relapsing-Remitting Multiple Sclerosis

Zhang, Y., Metz, L. M., Yong, V. W., Bell, R. B., Yeung, M., Patry, D. G., & Mitchell, J. R. (2008) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100008611 · Cited by 72

Improving Outcomes of Neuroprotection by Minocycline

Xue, M., Mikliaeva, E. I., Casha, S., Zygun, D., Demchuk, A. M., & Yong, V. W. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090361 · Cited by 71

The Significance of Matrix Metalloproteinases in the Immunopathogenesis and Treatment of Multiple Sclerosis

Mirshafiey, A., Asghari, B., Ghalamfarsa, G., Jadidi‐Niaragh, F., & Azizi, G. (2014) · Sultan Qaboos University medical journal · doi:10.12816/0003332 · Cited by 73

Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain

Zhang, L., Shirayama, Y., Shimizu, E., Iyo, M., & Hashimoto, K. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.05.047 · Cited by 71

Modulation of microglial activation enhances neuroprotection and functional recovery derived from bone marrow mononuclear cell transplantation after cortical ischemia

Franco, E. C. S., Cardoso, M. M., Gouvêia, A., Pereira, A., & Gomes‐Leal, W. (2012) · Neuroscience Research · doi:10.1016/j.neures.2012.03.006 · Cited by 71

Minocycline Inhibition of Monocyte Activation Correlates with Neuronal Protection in SIV NeuroAIDS

Campbell, J. H., Burdo, T. H., Autissier, P., Bombardier, J. P., Westmoreland, S. V., Soulas, C., González, R. G., Ratai, E., & Williams, K. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018688 · Cited by 71

Effective combination of minocycline and interferon-β in a model of multiple sclerosis

Giuliani, F., Fu, S. A., Metz, L. M., & Yong, V. W. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.04.020 · Cited by 71

Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy

Marchezan, J., Winkler dos Santos, E. G. A., Deckmann, I., & Riesgo, R. D. S. (2018) · Neuroimmunomodulation · doi:10.1159/000492225 · Cited by 70

Angelman syndrome: a journey through the brain

Maranga, C., Fernandes, T. G., Bekman, E., & da Rocha, S. T. (2020) · FEBS Journal · doi:10.1111/febs.15258 · Cited by 78

Minocycline, an antibiotic with inhibitory effect on microglial activation, attenuates the maintenance and reinstatement of methamphetamine-seeking behavior in rat

Attarzadeh-Yazdi, G., Arezoomandan, R., & Haghparast, A. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.04.008 · Cited by 70

Abrogated Inflammatory Response Promotes Neurogenesis in a Murine Model of Japanese Encephalitis

Das, S., Dutta, K., Kumawat, K. L., Ghoshal, A., Adhya, D., & Basu, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017225 · Cited by 65

Toward the development of rational therapies in multiple sclerosis: what is on the horizon?

Hemmer, B., & Hartung, H. (2007) · Annals of Neurology · doi:10.1002/ana.21289 · Cited by 70

Randomized trial of minocycline in the treatment of HIV-associated cognitive impairment

Nakasujja, N., Miyahara, S., Evans, S., Lee, A., Musisi, S., Katabira, E., Robertson, K., Ronald, A., Clifford, D. B., & Sacktor, N. (2013) · Neurology · doi:10.1212/wnl.0b013e31827b9121 · Cited by 67

Inflammatory and structural biomarkers in acute traumatic spinal cord injury

Kwon, B. K., Casha, S., Hurlbert, R. J., & Yong, V. W. (2010) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.068 · Cited by 68

Cardiac Uptake of Minocycline and Mechanisms for In Vivo Cardioprotection

Romero‐Perez, D., Fricovsky, E. S., Yamasaki, K. G., Griffin, M. O., Barraza-Hidalgo, M., DILLMANN, W. H., & Villarreal, F. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.06.028 · Cited by 69

Reduced PBR/TSPO Expression After Minocycline Treatment in a Rat Model of Focal Cerebral Ischemia: A PET Study Using [18F]DPA-714

Martín, A., Boisgard, R., Kassiou, M., Dollé, F., & Tavitian, B. (2010) · Molecular Imaging and Biology · doi:10.1007/s11307-010-0324-y · Cited by 68

Matrix Metalloproteinases in Neuropathic Pain and Migraine: Friends, Enemies, and Therapeutic Targets

Lakhan, S. E., & Avramut, M. (2012) · Pain Research and Treatment · doi:10.1155/2012/952906 · Cited by 67

Minocycline Preserves the Integrity and Permeability of BBB by Altering the Activity of DKK1–Wnt Signaling in ICH Model

Wang, G., Li, Z., Li, S., Ren, J., Suresh, V., Xu, D., Zang, W., Liu, X., Li, W., Wang, H., et al. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.06.038 · Cited by 67

The Neuroimmunology of Schizophrenia

Annya, M., Smyth, Stephen, M., & Lawrie, S. M. (2013) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2013.11.3.107 · Cited by 68

Disease-Modifying Agents for Multiple Sclerosis

Menge, T., Weber, M. S., Hemmer, B., Kieseier, B. C., von Büdingen, H. ‐., Warnke, C., Zamvil, S. S., Boster, A. L., Khan, O., Hartung, H. P., et al. (2008) · Drugs · doi:10.2165/0003495-200868170-00004 · Cited by 66

Protective Effects of Minocycline on the Reduction of Dopamine Transporters in the Striatum After Administration of Methamphetamine: A Positron Emission Tomography Study in Conscious Monkeys

Hashimoto, K., Tsukada, H., Nishiyama, S., Fukumoto, D., Kakiuchi, T., & Iyo, M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.019 · Cited by 65

Nitric Oxide Protects against Infection-Induced Neuroinflammation by Preserving the Stability of the Blood-Brain Barrier

Olivera, G. C., Ren, X., Vodnala, S. K., Lu, J., Coppo, L., Leepiyasakulchai, C., Holmgren, A., Kristensson, K., & Rottenberg, M. E. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005442 · Cited by 67

Hydrogels as delivery systems for spinal cord injury regeneration

Silva, D., Sousa, R. A., & Salgado, A. J. (2021) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100093 · Cited by 66

Promoting repair in multiple sclerosis: problems and prospects

Lubetzki, C., Williams, A., & Stankoff, B. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000169739.83793.e0 · Cited by 63

Targeting MMPs in Acute and Chronic Neurological Conditions

Yong, V. W., Agrawal, S. M., & Stirling, D. P. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.07.005 · Cited by 64

Tetracyclines Modify Translation By Targeting Key Human rRNA Substructures

Mortison, J. D., Schenone, M., Myers, J. A., Zhang, Z., Chen, L., Ciarlo, C., Comer, E., Natchiar, S. K., Carr, S. A., Klaholz, B. P., et al. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2018.09.010 · Cited by 62

Increases in β-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-κB pathway activation

Cai, Z., Zhao, Y., Yao, S., & Zhao, B. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70504-7 · Cited by 62

Reformulating Pro-Oxidant Microglia in Neurodegeneration

García‐Revilla, J., Alonso-Bellido, I. M., Burguillos, M. Á., Herrera, A. J., Espinosa‐Oliva, A. M., Ruiz, R., Cruz-Hernández, L., García-Domínguez, I., Roca-Ceballos, M. A., Santiago, M., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101719 · Cited by 66

Amyotrophic lateral sclerosis: recent advances and future therapies

Nirmalananthan, N., & Greensmith, L. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000187248.21103.c5 · Cited by 60

An open-label pilot trial of minocycline in children as a treatment for Angelman syndrome

Grieco, J. C., Ciarlone, S. L., Gieron-Korthals, M. A., Schoenberg, M. R., Smith, A., Philpot, R. M., Heussler, H., Banko, J. L., & Weeber, E. J. (2014) · BMC Neurology · doi:10.1186/s12883-014-0232-x · Cited by 60

Minocycline alleviates beta-amyloid protein and tau pathology via restraining neuroinflammation induced by diabetic metabolic disorder

Cai, Z., Yan, & Wang (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s46536 · Cited by 61

Anti-inflammatory Actions of Adjunctive Tetracyclines and Other Agents in Periodontitis and Associated Comorbidities

Tilakaratne, A., & Soory, M. (2014) · The Open Dentistry Journal · doi:10.2174/1874210601408010109 · Cited by 59

A pilot open-label trial of minocycline in patients with autism and regressive features

Pardo, C. A., Buckley, A., Thurm, A., Lee, L.-C., Azhagiri, A., Neville, D. M., & Swedo, S. E. (2013) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-5-9 · Cited by 58

Remote Neurodegeneration: Multiple Actors for One Play

Viscomi, M. T., & Molinari, M. (2014) · Molecular Neurobiology · doi:10.1007/s12035-013-8629-x · Cited by 59

Clinical and Experimental Advances in Regeneration of Spinal Cord Injury

Hyun, J. K., & Kim, H. (2010) · Journal of Tissue Engineering · doi:10.4061/2010/650857 · Cited by 61

A pilot study of minocycline for the prevention of paclitaxel-associated neuropathy: ACCRU study RU221408I

Pachman, D. R., Dockter, T., Zekan, P. J., Fruth, B. F., Ruddy, K. J., Ta, L. E., Lafky, J. M., Dentchev, T., Le-Lindqwister, N. A., Sikov, W. M., et al. (2017) · Supportive Care in Cancer · doi:10.1007/s00520-017-3760-2 · Cited by 58

Adjunct Treatments for Schizophrenia and Bipolar Disorder: What to Try When You Are Out of Ideas

Torrey, E. F., & Davis, J. M. (2011) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.5.4.5 · Cited by 56

Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegeneration

Cheng, S., Hou, J., Zhang, C., Xu, C., Wang, L., Zou, X., Yu, H., Shi, Y. S., Yin, Z., & Chen, G. (2015) · Scientific Reports · doi:10.1038/srep10535 · Cited by 59

Minocycline Prevents Osmotic Demyelination Syndrome by Inhibiting the Activation of Microglia

Suzuki, H., Sugimura, Y., Iwama, S., Suzuki, H., Ozaki, N., Nagasaki, H., Arima, H., Sawada, M., & Oiso, Y. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010040438 · Cited by 56

Matrix metalloproteinases in intracerebral hemorrhage

Xue, M., & Yong, V. W. (2008) · Neurological Research · doi:10.1179/174313208x341102 · Cited by 58

Oculopharyngeal muscular dystrophy - an under-diagnosed disorder?

Plasilov, M., & Müller, H. (2005) · Swiss Medical Weekly · doi:10.4414/smw.2005.11221 · Cited by 55

Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment and Microglia Activation after Motor Cortex Excitotoxic Injury

Santos, A. G., Santos, D. S., Santos, I. R., Lima, R. R., Pereira, A., de Moura, L. S., de Carvalho, R. N., Lameira, O. A., & Gomes‐Leal, W. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/918174 · Cited by 54

Beyond the lesion site: minocycline augments inflammation and anxiety-like behavior following SCI in rats through action on the gut microbiota

Schmidt, E. K. A., Raposo, P. J. F., Espin, A. T., Fenrich, K. K., & Fouad, K. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02123-0 · Cited by 53

Early-Stage Inflammation and Experimental Therapy in Transgenic Models of the Alzheimer-Like Amyloid Pathology

Cuello, A. C., Ferretti, M. T., León, W., Iulita, M. F., Melis, T., Ducatenzeiler, A., Bruno, M. A., & Canneva, F. (2010) · Neurodegenerative Diseases · doi:10.1159/000285514 · Cited by 54

Reduction of microglial activity in a model of multiple sclerosis by dipyridamole

Sloka, S., Metz, L. M., Hader, W., Starreveld, Y., & Yong, V. W. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-89 · Cited by 53

Minocycline Treatment Inhibits Lipid Peroxidation, Preserves Spinal Cord Ultrastructure, and Improves Functional Outcome After Traumatic Spinal Cord Injury in the Rat

Sönmez, E., Kabataş, S., Özen, Ö., Karabay, G., Türkoğlu, S., Öğüş, E., Yılmaz, C., Caner, H., & Altınörs, N. (2013) · Spine · doi:10.1097/brs.0b013e3182895587 · Cited by 53

Endogenous and synthetic MMP inhibitors in CNS physiopathology.

Baranger, K., Rivera, S., Liechti, F. D., Grandgirard, D., Bigas, J., Seco, J., Tarrago, T., Leib, S. L., & Khrestchatisky, M. (2014) · Progress in Brain Research · doi:10.1016/b978-0-444-63486-3.00014-1 · Cited by 52

Efficacy of Minocycline in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Rodent and Clinical Studies

Sheng, Z., Liu, Y., Li, H., Zheng, W., Xia, B., Zhang, X., Yong, V. W., & Xue, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01103 · Cited by 53

Minocycline mitigates motor impairments and cortical neuronal loss induced by focal ischemia in rats chronically exposed to ethanol during adolescence

de Oliveira, G. B., Fontes-Júnior, E. A., de Carvalho, S., da Silva, J. B., Fernandes, L. M. P., Oliveira, M. C. S. P., Prediger, R. D., Gomes‐Leal, W., Lima, R. R., & Maia, C. D. S. F. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.005 · Cited by 52

Inhibition of p53 Transcriptional Activity: A Potential Target for Future Development of Therapeutic Strategies for Primary Demyelination

Li, J., Ghiani, C. A., Kim, J. Y., Liu, A., Sandoval, J., deVellis, J., & Casaccia‐Bonnefil, P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0184-08.2008 · Cited by 53

PEG Minocycline-Liposomes Ameliorate CNS Autoimmune Disease

Hu, W., Metselaar, J. M., Ben, L.-H., Cravens, P. D., Singh, M. P., Frohman, E. M., Eagar, T. N., Racke, M. K., Kieseier, B. C., & Stüve, O. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004151 · Cited by 50

Early microglial inhibition preemptively mitigates chronic pain development after experimental spinal cord injury.

Tan, A. M., Zhao, P., Waxman, S. G., & Hains, B. C. (2009) · PubMed · Cited by 50

Antibiotic Use and Risk of Multiple Sclerosis

Alonso, Á., Jick, S. S., Jick, H., & Hernán, M. Á. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj123 · Cited by 50

Minocycline treatment reduces white matter damage after excitotoxic striatal injury

Guimarães, J. S., Freire, M. A. M., Lima, R. R., Diniz, C. W. P., Pereira, A., & Gomes‐Leal, W. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.007 · Cited by 49

Antinociceptive evaluation of ceftriaxone and minocycline alone and in combination in a neuropathic pain model in rat

Amin, B., Hajhashemi, V., Hosseinzadeh, H., & Abnous, K. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.07.058 · Cited by 48

Minocycline Reduces the Severity of Autonomic Dysreflexia after Experimental Spinal Cord Injury

Squair, J. W., Ruiz, I., Phillips, A. A., Zheng, M. M. Z., Sarafis, Z. K., Sachdeva, R., Gopaul, R., Liu, J., Tetzlaff, W., West, C. R., et al. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.5703 · Cited by 52

Attenuation of oxidative stress, inflammation and apoptosis by minocycline prevents retrovirus-induced neurodegeneration in mice

Kuang, X., Scofield, V. L., Yan, M., Stoica, G., Liu, N., & Wong, P. K. Y. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.007 · Cited by 47

Treatment trials in progressive MS—current challenges and future directions

Koch, M. W., Cutter, G., Stys, P. K., Yong, V. W., & Metz, L. M. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.148 · Cited by 46

Immunopathogenesis of Multiple Sclerosis

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Transport and Metabolism at Blood–Brain Interfaces and in Neural Cells: Relevance to Bilirubin-Induced Encephalopathy

Gazzin, S., Strazielle, N., Tiribelli, C., & Ghersi‐Egea, J. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00089 · Cited by 45

Alarm or curse? The pain of neuroinflammation

Saab, C. Y., Waxman, S. G., & Hains, B. C. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.04.002 · Cited by 46

Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline

Månsson, R., Hansson, M. J., Morota, S., Uchino, H., Ekdahl, C. T., & Elmér, E. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.09.008 · Cited by 46

Neuroprotection of minocycline by inhibition of extracellular matrix metalloproteinase inducer expression following intracerebral hemorrhage in mice

Liu, Y., Li, Z., Khan, S., Zhang, R., Wei, R., Zhang, Y., Xue, M., & Yong, V. W. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136297 · Cited by 45

Profile of minocycline and its potential in the treatment of schizophrenia

Zhang, L., & Zhao, J. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s64236 · Cited by 45

Investigational drugs for the treatment of spinal cord injury: review of preclinical studies and evaluation of clinical trials from Phase I to II

Nagoshi, N., & Fehlings, M. G. (2015) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2015.1009629 · Cited by 45

Minocycline protects developing brain against ethanol-induced damage

Wang, X., Zhang, K., Yang, F., Ren, Z., Xu, M., Frank, J. A., Ke, Z., & Luo, J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.019 · Cited by 47

Emergent Prophylactic, Reparative and Restorative Brain Interventions for Infants Born Preterm With Cerebral Palsy

Finch‐Edmondson, M., Morgan, C., Hunt, R. W., & Novak, I. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00015 · Cited by 47

β‐Hydroxybutyric acid attenuates heat stress‐induced neuroinflammation via inhibiting TLR4/p38 MAPK and NF‐κB pathways in the hippocampus

Huang, J., Chai, X., Wu, Y., Hou, Y., Li, C., Xue, Y., Pan, J., Zhao, Y., Su, A., Zhu, X., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101469rr · Cited by 46

Minocycline blocks traumatic brain injury-induced alcohol consumption and nucleus accumbens inflammation in adolescent male mice

Karelina, K., Nicholson, S., & Weil, Z. M. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.01.012 · Cited by 44

Therapy with Minocycline Aggravates Experimental Rabies in Mice

Jackson, A. C., Scott, C. A., Owen, J., Weli, S. C., & Rossiter, J. P. (2007) · Journal of Virology · doi:10.1128/jvi.00323-07 · Cited by 44

Beneficial Effects of Minocycline and Botulinum Toxin–Induced Constraint Physical Therapy Following Experimental Traumatic Brain Injury

Lam, T. I., Bingham, D., Chang, T. J., Lee, C. C., Shi, J., Wang, D., Massa, S. M., Swanson, R. A., & Liu, J. (2013) · Neurorehabilitation and neural repair · doi:10.1177/1545968313491003 · Cited by 43

NEUROLOGICAL REVIEW ONLINE FIRST Prospects for

Neuroprotection, M., Plane, J. M., Shen, P. Y., David, P., Pleasure, E., & Deng, M. W. (2014)

The Potential of Minocycline for Neuroprotection in Human Neurologic Disease

Zemke, D., & Majid, A. (2004) · Clinical Neuropharmacology · doi:10.1097/01.wnf.0000150867.98887.3e · Cited by 125

Minocycline in neurological diseases

Bandini, F. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)00998-1 · Cited by 7

Minocycline in neurological diseases ? Authors' reply

METZ, L., & YONG, V. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70005-3

The Disease Ameliorating Effects of Minocycline in Neurologic Disorders

Kapoor, S. N. (2013) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2012.10.024