Cited by 523Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsNeuroprotection in Cerebral Ischemia

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The promise of minocycline in neurology

Yong, V Wee, Wells, Jennifer, Giuliani, Fabrizio, Casha, Steven, Power, Christopher, Metz, Luanne M·2004·The Lancet Neurology

DOI 10.1016/s1474-4422(04)00937-8

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Abstract

The capacity of minocycline to alleviate disease for several neurological disorders in animals is increasingly being recognised. Indeed, that one drug alone can attenuate the severity of disease in stroke, multiple sclerosis, spinal-cord injury, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis is astounding. In this review, we describe the evidence for the efficacy of minocycline in several animal models of neurological disease, discuss the mechanisms by which minocycline affects a range of neurological diseases with diverse causes, and introduce the emerging investigation of minocycline in clinical neurology. The encouraging results of minocycline in experimental neurology bode well for its therapeutic use in human neurological diseases.

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Aktaş, O., & Zipp, F. (2015) · Elsevier eBooks · doi:10.1016/b978-3-437-22083-8.00019-5
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Lemasters, J. J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.00112-3
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Guo, X. (2014) · Springer eBooks · doi:10.1007/978-4-431-54965-9_21
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(2010) · Elsevier eBooks · doi:10.1016/b978-0-444-53272-5.50005-4
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Qaid, E. Y. A., Abdullah, Z., Zakaria, R., & Long, I. (2022) · Research Square · doi:10.21203/rs.3.rs-1752755/v1
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Kim, H. B., Kim, H., Choi, S. Y., Lee, D. C., & Cho, K. J. (2023) · Medical Lasers · doi:10.25289/ml.23.036
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Biancotti, J. C., Sescleifer, A. M., Sferra, S. R., Penikis, A. B., Halbert-Elliott, K. M., Bubb, C. R., & Kunisaki, S. M. (2024) · Journal of Surgical Research · doi:10.1016/j.jss.2024.07.088
Minocycline-Induced Agranulocytosis
Jonathan, C., Gopalan, S., Arthur, P., Shanmugam, S. G., & Thomas, S. (2025) · Annals of Internal Medicine Clinical Cases · doi:10.7326/aimcc.2024.0432
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Busch, S. A. (2009) · OhioLink ETD Center (Ohio Library and Information Network)
Sustained release of estrogens from PEGylated nanoparticles for treatment of secondary spinal cord injury
Barry, J. (2013) · TigerPrints (Clemson University)

Authors: Yong, V. W., Wells, J., Giuliani, F., Casha, S., Power, C., & Metz, L. M.
Affiliations: University of Calgary (CA)
Corresponding author: Yong, V Wee
ORCID: Yong, V Wee
Giuliani, Fabrizio
Casha, Steven
Power, Christopher
Metz, Luanne M
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2004-12
Volume: 3
Issue: 12
Pages: 744-751
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(04)00937-8
OpenAlex: W2063885093
Cited by: 518
References: 64
Citations by year: 2026: 10 · 2025: 19 · 2024: 17 · 2023: 19 · 2022: 20 · 2021: 19 · 2020: 24 · 2019: 14 · 2018: 27 · 2017: 19 · 2016: 17 · 2015: 28 · 2014: 33 · 2013: 32 · 2012: 35
FWCI: 2.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: Teva Pharmaceutical Industries
Multiple Sclerosis Society of Canada
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords: minocycline, neuroprotection, stroke, multiple sclerosis, spinal cord injury, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, animal models of neurological disease, clinical trials
MeSH terms: Animals, Humans, Minocycline, Nervous System Diseases

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The promise of minocycline in neurology

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