The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
The promise of minocycline in neurology
Abstract
The capacity of minocycline to alleviate disease for several neurological disorders in animals is increasingly being recognised. Indeed, that one drug alone can attenuate the severity of disease in stroke, multiple sclerosis, spinal-cord injury, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis is astounding. In this review, we describe the evidence for the efficacy of minocycline in several animal models of neurological disease, discuss the mechanisms by which minocycline affects a range of neurological diseases with diverse causes, and introduce the emerging investigation of minocycline in clinical neurology. The encouraging results of minocycline in experimental neurology bode well for its therapeutic use in human neurological diseases.
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“Thanks to the ability to efficiently cross the BBB, minocycline is considered neuroprotective for a variety of neurological conditions, including PD [251,252,253,254,255,256,257].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [253]
In the citing paper
“Thanks to the ability to efficiently cross the BBB, minocycline is considered neuroprotective for a variety of neurological conditions, including PD [251,252,253,254,255,256,257].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [253]
Citations
Cites
Inflammation is detrimental for neurogenesis in adult brain
Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559
Wu, D. C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D.-K., Ischiropoulos, H., & Przedborski, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01763.2002 · Cited by 1,183
Metalloproteinases in biology and pathology of the nervous system
Yong, W. V., Power, C., Forsyth, P., & Edwards, D. (2001) · Nature Reviews Neuroscience · doi:10.1038/35081571 · Cited by 1,094
Zhu, S., Stavrovskaya, I. G., Drozda, M., Kim, B. Y. S., Ona, V. O., Li, M., Sarang, S. S., Liu, A. S., Hartley, D. M., Wu, D. C., et al. (2002) · Nature · doi:10.1038/417074a · Cited by 1,069
Chen, M., Ona, V. O., Li, M., Ferrante, R. J., Fink, K., Zhu, S., Bian, J., Guo, L., Farrell, L. A., Hersch, S. M., et al. (2000) · Nature Medicine · doi:10.1038/77528 · Cited by 1,060
Yrjänheikki, J., Kauppinen, T. M., Keinänen, R., Goldsteins, G., Chan, P. H., & Koıstınaho, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13496 · Cited by 1,040
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
Yrjänheikki, J., Keinänen, R., Pellikka, M., Hökfelt, T., & Koistinaho, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15769 · Cited by 1,006
Tikka, T., Fiebich, B. L., Goldsteins, G., Keinänen, R., & Koistinaho, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02580.2001 · Cited by 958
Du, Y., Ma, Z., Lin, S., Dodel, R. C., Gao, F., Bales, K. R., Triarhou, L. C., Chernet, E., Perry, K. W., Nelson, D. L. G., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251341998 · Cited by 789
Chen, D., Endres, R. L., Erickson, C. A., Weis, K. F., McGregor, M. W., Kawaoka, Y., & Payne, L. G. (2000) · Nature Medicine · doi:10.1038/80538 · Cited by 547
Research works printed but not linked: 1
- Giuliani, 2004, Synergistic activity of minocycline and glatiramer acetate in an animal model of multiple sclerosis, Mult Scler, 9, S76
Cited by
Sorted by citations
Items 501–523 of 523
Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593178
Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593163
Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593166
Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593160
Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593169
Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593175
Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593172
Fahim, F., Lashkarian, M. F., Kakhki, F. T., Qahremani, R., Ghaffari, A., Moosavian, S. M., Jafari, M., Ebrahimabad, M., Ghasemi, M., Mahmoodi, H., et al. (2025) · medRxiv · doi:10.64898/2025.12.19.25342695
Holanda, M. C. D. S., Pereira, C. C. D. S. B., Barbosa, M. S., Costa, J. V., Afonso, R. T. L., Cardoso, M. M., Teixeira, C. E. C., Franco, E. C. S., & Gomes‐Leal, W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.14.705644
Tetracycline antibiotics: Emerging roles in neuropsychiatric disorders
Acar, A. Ş., Saday, Ö., & Erbaş, O. (2024) · Demiroglu Science University Florence Nightingale Journal of Medicine · doi:10.5606/fng.btd.2024.149
Peng, L., Chen, M., Zuo, X., Wu, X., Gong, M., Qin, Z., Sun, W., & Xu, E. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03822-2
Raymundi, A. M., Cardoso, N. C., Lourenço, G. C., Queiroz, R., Dolzan, M. D., Vitali, L., Meyer, E., Lisboa, S. F. D. S., Guimarães, F. S., Pinna, G., et al. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02434-x
Recent research progress and future directions of intracerebral hemorrhage
Liang, W., Wu, H. W., Pan, D., & Wang, Y. K. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1845566 · Cited by 1
Fan, Z., Zhao, J., Shi, R., Yao, L., Zhang, H., Yin, R., Li, W., Yu, L., Xp, Y., Jia, Y., et al. (2026) · BMC Medicine · doi:10.1186/s12916-026-05092-4
Yilmaz, S. I., Meydan, S., Eşrefoğlu, M., Mustafayev, N., Mustafayeva, L., Baki, K. B., Demirel, M., MARAL, F., & Selek, Ş. (2026) · Aesthetic Plastic Surgery · doi:10.1007/s00266-026-05976-z
Xiang, W., Yin, B., Huang, Q., Li, S., Ding, M., Feng, G., Li, R., Wang, D., Min, L., Hu, X., et al. (2026) · Journal of Environmental Sciences · doi:10.1016/j.jes.2026.105733
Yang, Q., Li, Y., Wang, L., Ai, T., Lu, Y., Zhang, M., Zhou, D., Liu, C., Ren, L., Zhou, X., et al. (2026) · EClinicalMedicine · doi:10.1016/j.eclinm.2026.104239
Luo, J. (2011) · OpenGrey (Institut de l'Information Scientifique et Technique)
da Silva, M. C. (2011) · Americanae (AECID Library)
Review of Novel Immunotherapeutic Strategies for MS
Wiendl, H., & Hohlfeld, R. (2007) · Springer eBooks · doi:10.1007/978-0-387-36003-4_14
The Effect of Different Microglial Activation States on the Survival of Retinal Ganglion Cells
Siddiqui, A. M. (2013) · MacSphere (McMaster University) · doi:10.71548/21084
Metadata
- Authors
- Yong, V. W., Wells, J., Giuliani, F., Casha, S., Power, C., & Metz, L. M.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Yong, V Wee
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2004-12
- Volume
- 3
- Issue
- 12
- Pages
- 744-751
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2063885093
- Cited by
- 518
- References
- 64
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 17 · 2023: 19 · 2022: 20 · 2021: 19 · 2020: 24 · 2019: 14 · 2018: 27 · 2017: 19 · 2016: 17 · 2015: 28 · 2014: 33 · 2013: 32 · 2012: 35
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Teva Pharmaceutical Industries
- Multiple Sclerosis Society of Canada
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- minocycline, neuroprotection, stroke, multiple sclerosis, spinal cord injury, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, animal models of neurological disease, clinical trials
- MeSH terms
- Animals, Humans, Minocycline, Nervous System Diseases
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