Cited by 548Multiple Sclerosis Research StudiesPsoriasis: Treatment and PathogenesisPolyomavirus and related diseases

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Multiple sclerosis: risk factors, prodromes, and potential causal pathways

Ramagopalan, Sreeram V, Dobson, Ruth, Meier, Ute C, Giovannoni, Gavin·2010·The Lancet Neurology

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Abstract

Multiple sclerosis (MS) is a common, complex neurological disease. The precise aetiology of MS is not yet known, although epidemiological data indicate that both genetic and environmental factors are important. The evidence that the environment acts long before MS becomes clinically evident is well established and suggests the existence of a prodromal phase for the disease. The increasing incidence of MS emphasises the need for strategies to prevent this chronic disorder, and the possibility of a prodrome indicates a window of opportunity to potentially reverse early disease processes before clinical disease becomes evident. Studying a prodrome requires techniques other than clinical observation such as monitoring endophenotypes that result from associated risk factors. However, our current knowledge of causal pathways and endophenotypes in MS is limited. Identifying and studying individuals with a high risk of developing the disease provides a powerful opportunity to understand the MS causal cascade and is highly relevant to strategies that are aimed at preventing this debilitating disease.

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Vitamin D Deficiency
Holick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720
A Randomized, Placebo-Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis
Polman, C. H., O'Connor, P. W., Havrdová, E., Hutchinson, M., Kappos, L., Miller, D. H., Phillips, J. T., LUBLIN, F. D., Giovannoni, G., Wajgt, A., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa044397 · Cited by 3,433
Multiple Sclerosis
Noseworthy, J. H., Lucchinetti, C. F., Rodriguez, M., & Weinshenker, B. G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009283431307 · Cited by 3,016
B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
Hauser, S. L., Waubant, E., Arnold, D. L., Vollmer, T., Antel, J., Fox, R. J., Bar-Or, A., Panzara, M., Sarkar, N., Agarwal, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706383 · Cited by 2,439
A Population-Based Study
Christakis, D., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., & Yapanel, U. H. (2009) · Cited by 2,290
Serum 25-Hydroxyvitamin D Levels and Risk of Multiple Sclerosis
Munger, K. L., Levin, L. I., Hollis, B. W., Howard, N. S., & Ascherio, A. (2006) · JAMA · doi:10.1001/jama.296.23.2832 · Cited by 1,899
Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis
Viglietta, V., Baecher‐Allan, C., Weiner, H. L., & Hafler, D. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031579 · Cited by 1,858
Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study
(2007) · New England Journal of Medicine · doi:10.1056/nejmoa073493 · Cited by 1,746
Sex differences in autoimmune disease
Whitacre, C. C. (2001) · Nature Immunology · doi:10.1038/ni0901-777 · Cited by 1,294
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis
Barkhof, F. (1997) · Brain · doi:10.1093/brain/120.11.2059 · Cited by 1,251
Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis
Tzartos, J. S., Friese, M. A., Craner, M. J., Palace, J. A., Newcombe, J., Esiri, M. M., & Fugger, L. H. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070690 · Cited by 1,225
Vitamin D intake and incidence of multiple sclerosis
Munger, K. L., Zhang, S. M., O’Reilly, É. J., Hernán, M. Á., Olek, M. J., Willett, W. C., & Ascherio, A. (2004) · Neurology · doi:10.1212/01.wnl.0000101723.79681.38 · Cited by 1,090
Environmental risk factors for multiple sclerosis. Part I: The role of infection
Ascherio, A., & Munger, K. L. (2007) · Annals of Neurology · doi:10.1002/ana.21117 · Cited by 1,036
Alemtuzumab vs. Interferon Beta-1a in Early Multiple Sclerosis
The CAMMS Trial Investigators (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802670 · Cited by 1,021
Multiple sclerosis: a complicated picture of autoimmunity
McFarland, H. F., & Martin, R. (2007) · Nature Immunology · doi:10.1038/ni1507 · Cited by 985
Sex ratio of multiple sclerosis in Canada: a longitudinal study
Orton, S. M., Herrera, B. M., Yee, I. M. L., Valdar, W. S. J., Ramagopalan, S. V., Sadovnick, A. D., & Ebers, G. C. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70581-6 · Cited by 922
Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis
Fisniku, L. K., Brex, P. A., Altmann, D. R., Miszkiel, K. A., Benton, C. E., Lanyon, R., Thompson, A. J., & Miller, D. H. (2008) · Brain · doi:10.1093/brain/awm329 · Cited by 897
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
International MS Genetics Consortium, De Jager, P. L., Jia, X., Wang, J., de Bakker, P. I. W., Ottoboni, L., Aggarwal, N. T., Piccio, L., Raychaudhuri, S., Tran, D., et al. (2009) · Nature Genetics · doi:10.1038/ng.401 · Cited by 800
Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors
Ascherio, A., & Munger, K. L. (2007) · Annals of Neurology · doi:10.1002/ana.21141 · Cited by 747
Temporal trends in the incidence of multiple sclerosis
Alonso, Á., & Hernán, M. Á. (2008) · Neurology · doi:10.1212/01.wnl.0000316802.35974.34 · Cited by 695
Incidental MRI anomalies suggestive of multiple sclerosis: The radiologically isolated syndrome
Okuda, D. T., Mowry, E. M., Beheshtian, A., Waubant, E., Baranzini, S. E., Goodin, D. S., Hauser, S. L., & Pelletier, D. (2009) · Neurology · doi:10.1212/01.wnl.0000335764.14513.1a · Cited by 642
Vitamin D and multiple sclerosis
Ascherio, A., Munger, K. L., & Simon, K. C. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70086-7 · Cited by 614
Regulatory CD56 bright natural killer cells mediate immunomodulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosis
Bielekova, B., Catálfamo, M., Reichert-Scrivner, S. A., Packer, A., Černá, M., Waldmann, T. A., McFarland, H. F., Henkart, P. A., & Martinꝉ, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601335103 · Cited by 597
Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis
Miller, D., Barkhof, F., Montalban, X., Thompson, A., & Filippi, M. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70071-5 · Cited by 594
Genetics of multiple sclerosis
Dyment, D. A., Ebers, G. C., & Dessa Sadovnick, A. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00663-x · Cited by 563
Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study
van der Mei, I. A. F., Ponsonby, A., Dwyer, T., Blizzard, L., Simmons, R. D., Taylor, B. V., Butzkueven, H., & Kilpatrick, T. J. (2003) · BMJ · doi:10.1136/bmj.327.7410.316 · Cited by 550
Infectious mononucleosis and risk for multiple sclerosis: A meta‐analysis
Thacker, E. L., Mirzaei, F., & Ascherio, A. (2006) · Annals of Neurology · doi:10.1002/ana.20820 · Cited by 535
Twin concordance and sibling recurrence rates in multiple sclerosis
Willer, C. J., Dyment, D. A., RISCH, N. J., Sadovnick, A. D., Ebers, G. C., & The Canadian Collaborative Study Group§§ (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1932604100 · Cited by 532
The epidemiology of multiple sclerosis
Goodin, D. S. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802973-2.00011-2 · Cited by 517
Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study
Segal, B. M., Constantinescu, C. S., Raychaudhuri, A., Kim, L., Fidelus-Gort, R., & Kasper, L. H. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70173-x · Cited by 493
The endophenotype concept in psychiatric genetics
FLINT, J., & MUNAFÒ, M. R. (2007) · Psychological Medicine · doi:10.1017/s0033291706008750 · Cited by 477
HISTOCOMPATIBILITY DETERMINANTS IN MULTIPLE SCLEROSIS, WITH SPECIAL REFERENCE TO CLINICAL COURSE
Jersild, C., Hansen, G., Svejgaard, A., Fog, T., Thomsen, M., & Dupont, B. (1973) · The Lancet · doi:10.1016/s0140-6736(73)90970-7 · Cited by 467
Timing of birth and risk of multiple sclerosis: population based study
Willer, C. J., Dyment, D. A., Sadovnick, A. D., Rothwell, P. M., Murray, T. J., & Ebers, G. C. (2004) · BMJ · doi:10.1136/bmj.38301.686030.63 · Cited by 451
Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis
Haas, J., Hug, A., Viehöver, A., Fritzsching, B., Falk, C. S., Filser, A., Vetter, T., Milkova, L., Korporal, M., Fritz, B., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200526065 · Cited by 450
Temporal Relationship Between Elevation of Epstein-Barr Virus Antibody Titers and Initial Onset of Neurological Symptoms in Multiple Sclerosis
Levin, L. I. (2005) · JAMA · doi:10.1001/jama.293.20.2496 · Cited by 446
Body size and risk of MS in two cohorts of US women
Munger, K. L., Chitnis, T., & Ascherio, A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c0d6e0 · Cited by 441
Toward constructing an endophenotype strategy for bipolar disorders
Hasler, G., Drevets, W. C., Gould, T. D., Gottesman, I. I., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.006 · Cited by 423
Isolated demyelinating syndromes: comparison of different MR imaging criteria to predict conversion to clinically definite multiple sclerosis.
Tintoré, M., Rovira, À., Martinez, M. J., Río, J., Villoslada, P., Brieva, L., Borrás, C., Grivé, E., Capellades, J., & Montalbán, X. (2000) · PubMed Central · Cited by 419
Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes.
Dalton, C., Chard, D., Davies, G., Miszkiel, K., Altmann, D., Fernando, K., Plant, G., Thompson, A., & Miller, D. H. (2004) · Brain : a journal of neurology · doi:10.1093/brain/awh126 · Cited by 385
Symptomless Cancer in Women
Powley, J. M. (1964) · The Lancet · doi:10.1016/s0140-6736(64)91052-9 · Cited by 366
Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?
Tintoré, M., Rovira, A., Río, J., Tur, C., Pelayo, R., Nos, C., Téllez, N., Perkal, H., Comabella, M., Sastre-Garriga, J., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000280576.73609.c6 · Cited by 345
Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study
Banwell, B., Krupp, L., Kennedy, J., Tellier, R., Tenembaum, S. N., Ness, J., Belman, A. L., Boiko, A., Быкова, О. В., Waubant, E. L., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70196-5 · Cited by 344
Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis
Hedström, A. K., Bäärnhielm, M., Olsson, T. P., & Alfredsson, L. S. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b59c40 · Cited by 323
Multiple sclerosis. Updated risks for relatives
Sadovnick, A. D., Baird, P. A., Ward, R. H., Optiz, J. M., & Reynolds, J. F. (1988) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320290310 · Cited by 318
Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis
Barcellos, L. F., Sawcer, S. J., Ramsay, P. P., Baranzini, S. E., Thomson, G. J., Briggs, F. B. S., Cree, B., Begovich, A. B., Villoslada, P., Montalbán, X., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl223 · Cited by 312
On the Risk of Multiple Sclerosis According to Age at Immigration to South Africa
Dean, G., & Kurtzke, J. F. (1971) · BMJ · doi:10.1136/bmj.3.5777.725 · Cited by 304
An altered immune response to Epstein-Barr virus in multiple sclerosis
Sundström, P., Juto, P., Wadell, G., Hallmans, G., Svenningsson, A., Nyström, L., Dillner, J., & Forsgren, L. (2004) · Neurology · doi:10.1212/01.wnl.0000130496.51156.d7 · Cited by 302
Cigarette Smoking and Incidence of Multiple Sclerosis
Hernán, M. Á. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.1.69 · Cited by 299
HLA-DR2 Dose Effect on Susceptibility to Multiple Sclerosis and Influence on Disease Course
Barcellos, L. F., Oksenberg, J. R., Begovich, A. B., Martin, E. R., Schmidt, S., Vittinghoff, E., Goodin, D. S., Pelletier, D., Lincoln, R., Bucher, P., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/367781 · Cited by 293
Migrant studies in multiple sclerosis
Galé, C. R., & Martyn, C. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)80008-v · Cited by 289
SOME COMMENTS ON THE RELATIONSHIP OF THE DISTRIBUTION OF MULTIPLE SCLEROSIS TO LATITUDE, SOLAR RADIATION, AND OTHER VARIABLES
Acheson, E. D., Bachrach, C. A., & Wright, F. M. (1960) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1960.tb08674.x · Cited by 278
Epidemiology of multiple sclerosis in U.S. veterans
Kurtzke, J. F., Beebe, G. W., & Norman, J. E. (1979) · Neurology · doi:10.1212/wnl.29.9_part_1.1228 · Cited by 277
Parent-of-origin effect in multiple sclerosis: observations in half-siblings
Ebers, G. C., Sadovnick, A. D., Dyment, D. A., Yee, I., Willer, C. J., & RISCH, N. J. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16304-6 · Cited by 269
Wintertime vitamin D insufficiency is common in young Canadian women, and their vitamin D intake does not prevent it
Vieth, R., Cole, D., HAWKER, G. A., Trang, H., & Rubin, L. A. (2001) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601275 · Cited by 264
Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: Results of a randomized, double-blind, placebo-controlled MR-monitored phase II trial
van Oosten, B. W., Lai, M., Hodgkinson, S. J., Barkhof, F., Miller, D., MOSELEY, I. F., Thompson, A. J., Rudge, P., McDougall, A., McLeod, J., et al. (1997) · Neurology · doi:10.1212/wnl.49.2.351 · Cited by 262
Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score
Jager, P. L. D., Chibnik, L. B., Cui, J., Reischl, J., Lehr, S., Simon, K. C., Aubin, C., Bauer, D., Heubach, J. F., Sandbrink, R., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70275-3 · Cited by 261
Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients
Jacobsen, M., Cepok, S., Quak, E., Happel, M., Gaber, R., Ziegler, A., Schock, S., Oertel, W. H., Sommer, N., & Hemmer, B. (2002) · Brain · doi:10.1093/brain/awf059 · Cited by 253
Smoking and Disease Progression in Multiple Sclerosis
Healy, B. C., Ali, E. N., Guttmann, C. R. G., Chitnis, T., Glanz, B. I., Buckle, G. J., Houtchens, M. K., Stazzone, L., Moodie, J., Berger, A. M., et al. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.122 · Cited by 245
Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance
Dyment, D. A., Herrera, B. M., Cader, M. Z., Willer, C. J., Lincoln, M. R., Sadovnick, A. D., RISCH, N. J., & Ebers, G. C. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi206 · Cited by 243
Annual incidence, prevalence, and mortality of multiple sclerosis in white South-African-born and in white immigrants to South Africa.
Dean, G. (1967) · BMJ · doi:10.1136/bmj.2.5554.724 · Cited by 236
Age–adjusted recurrence risks for relatives of patients with multiple sclerosis
Robertson, N. P., Fraser, M., Deans, J., Clayton, D. G., Walker, N., & Compston, D. A. S. (1996) · Brain · doi:10.1093/brain/119.2.449 · Cited by 234
The age-range of risk of developing multiple sclerosis: Evidence from a migrant population in Australia
Hammond, S. R. (2000) · Brain · doi:10.1093/brain/123.5.968 · Cited by 228
Epigenetics: molecular mechanisms and implications for disease
Handel, A. E., Ebers, G. C., & Ramagopalan, S. V. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.11.003 · Cited by 227
Elevated Epstein–Barr virus‐encoded nuclear antigen‐1 immune responses predict conversion to multiple sclerosis
Lünemann, J. D., Tintoré, M., Messmer, B., Strowig, T., Rovira, À., Perkal, H., Caballero, E., Münz, C., Montalbán, X., & Comabella, M. (2009) · Annals of Neurology · doi:10.1002/ana.21886 · Cited by 227
High seroprevalence of Epstein–Barr virus in children with multiple sclerosis
Pohl, D., Krone, B., Rostasy, K. M., Kahler, E., Brunner, E., Lehnert, M., Wagner, H., Gärtner, J., & Hanefeld, F. A. (2006) · Neurology · doi:10.1212/01.wnl.0000247665.94088.8d · Cited by 226
Multiple sclerosis in US veterans of the Vietnam era and later military service: race, sex, and geography
Wallin, M. T., Page, W. F., & Kurtzke, J. F. (2004) · Annals of Neurology · doi:10.1002/ana.10788 · Cited by 224
Multiple sclerosis after infectious mononucleosis.
Nielsen, T., Rostgaard, K., Nielsen, N., Koch-Henriksen, N., Haahr, S., Sørensen, P., & Hjalgrim, H. (2007) · Archives of Neurology · doi:10.1001/archneur.64.1.72 · Cited by 221
Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI
Farrell, R. A., Antony, D., Wall, G., Clark, D. A., Fisniku, L., Swanton, J. K., Khaleeli, Z., Schmierer, K., Miller, D. H., & Giovannoni, G. (2009) · Neurology · doi:10.1212/wnl.0b013e3181aa29fe · Cited by 219
Unsuspected Multiple Sclerosis
Gilbert, J. J., & Sadler, M. (1983) · Archives of Neurology · doi:10.1001/archneur.1983.04050080033003 · Cited by 215
The Causal Cascade to Multiple Sclerosis: A Model for MS Pathogenesis
Goodin, D. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004565 · Cited by 212
THE EPIDEMIOLOGY OF MULTIPLE SCLEROSIS IN THREE AUSTRALIAN CITIES: PERTH, NEWCASTLE AND HOBART
Hammond, S. R., McLeod, J. G., Millingen, K. S., Stewart‐Wynne, E. G., English, D. R., HOLLAND, J. T., & McCall, M. G. (1988) · Brain · doi:10.1093/brain/111.1.1 · Cited by 211
Multiple sclerosis among United Kingdom-born children of immigrants from the Indian subcontinent, Africa and the West Indies.
Elian, M., Nightingale, S., & Dean, G. (1990) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.10.906 · Cited by 205
Optic neuritis
Söderström, M. B., Jin, Y., Hillert, J. A., & Link, H. (1998) · Neurology · doi:10.1212/wnl.50.3.708 · Cited by 193
Risk of multiple sclerosis related to age at immigration to Israel.
Alter, M., Leibowitz, U., & Speer, J. (1966) · Archives of Neurology · doi:10.1001/archneur.1966.00470150012002 · Cited by 190
Integrating risk factors
Jager, P. L. D., Simon, K. C., Munger, K. L., Rioux, J. D., Hafler, D. A., & Ascherio, A. (2008) · Neurology · doi:10.1212/01.wnl.0000294325.63006.f8 · Cited by 179
Age at immigration to England of Asian and Caribbean immigrants and the risk of developing multiple sclerosis
Dean, G., & Elian, M. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.63.5.565 · Cited by 179
Cognitive Function in Recent-Onset Demyelinating Diseases
Lyon‐Caen, O., Jouvent, R., Hauser, S. L., Chaunu, M., Benoit, N., Widlöcher, D., & Lhermitte, F. (1986) · Archives of Neurology · doi:10.1001/archneur.1986.00520110034010 · Cited by 178
Geographic distribution of multiple sclerosis: An update with special reference to Europe and the Mediterranean region
Kurtzke, J. F. (1980) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1980.tb03006.x · Cited by 176
Pathogenic CD8+ T cells in multiple sclerosis
Friese, M. A., & Fugger, L. H. (2009) · Annals of Neurology · doi:10.1002/ana.21744 · Cited by 170
Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility
Lincoln, M. R., Ramagopalan, S. V., Chao, M. J., Herrera, B. M., DeLuca, G. C., Orton, S. M., Dyment, D. A., Sadovnick, A. D., & Ebers, G. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812664106 · Cited by 169
Multiple sclerosis: the environment and causation
Giovannoni, G., & Ebers, G. C. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32815610c2 · Cited by 169
Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis
Jilek, S., Schluep, M., Meylan, P. R., Vingerhoets, F. J. G., Guignard, L., Monney, A., Kleeberg, J., Goff, G. L., Pantaleo, G., & Pasquier, R. D. (2008) · Brain · doi:10.1093/brain/awn108 · Cited by 169
Multiple sclerosis immunology
Kasper, L. H., & Shoemaker, J. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c97c8f · Cited by 167
HLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis
Hensiek, A. E. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.2.184 · Cited by 167
Mortality from multiple sclerosis and exposure to residential and occupational solar radiation: a case-control study based on death certificates
Freedman, D. M., Dosemeci, M., & Alavanja, M. C. R. (2000) · Occupational and Environmental Medicine · doi:10.1136/oem.57.6.418 · Cited by 166
Dysfunction of natural killer cells in multiple sclerosis: a possible pathogenetic factor.
Benczur, M., Petrányl, G. G., Pálffy, G., Varga, M., Tálas, M., Kotsy, B., Földeş, I., & Hollán, S. R. (1980) · PubMed Central · Cited by 165
Pediatric multiple sclerosis
Yeh, E. A., Chitnis, T., Krupp, L., Ness, J., Chabas, D., Kuntz, N. L., & Waubant, E. L. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.158 · Cited by 155
Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia
Marrosu, M. G. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.25.2907 · Cited by 154
Smoking is a risk factor for multiple sclerosis: a metanalysis
Hawkes, C. H. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506073501 · Cited by 149
Role of return migration in the emergence of multiple sclerosis in the French West Indies
Cabre, P., Signaté, A., Olindo, S., Merle, H., Caparros-Lefebvre, D., Béra, O., & Smadja, D. (2005) · Brain · doi:10.1093/brain/awh624 · Cited by 145
Smoking is a risk factor for early conversion to clinically definite multiple sclerosis
Pauli, F. D., Reindl, M., Ehling, R., Schautzer, F., Gneiss, C., Lutterotti, A., O’Reilly, É., Munger, K. L., Deisenhammer, F., Ascherio, A., et al. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458508093679 · Cited by 141
Expansion of CD56Bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta
Saraste, M., Irjala, H., & Airas, L. M. (2007) · Neurological Sciences · doi:10.1007/s10072-007-0803-3 · Cited by 139
Potentially modifiable determinants of vitamin D status in an older population in the Netherlands: the Hoorn Study
van Dam, R. M., Snijder, M. B., Dekker, J. M., Stehouwer, C. D. A., Bouter, L. M., Heine, R. J., & Lips, P. T. A. M. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.755 · Cited by 138
Increasing prevalence and incidence of multiple sclerosis in South East Wales
Hirst, C. L., Ingram, G., Pickersgill, T. P., Swingler, R. J., Compston, D. A. S., & Robertson, N. P. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.144667 · Cited by 138
The Inheritance of Resistance Alleles in Multiple Sclerosis
Ramagopalan, S. V., Morris, A. P., Dyment, D. A., Herrera, B. M., DeLuca, G. C., Lincoln, M. R., Orton, S. M., Chao, M. J., Sadovnick, A. D., & Ebers, G. C. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030150 · Cited by 135
The regulatory role of natural killer cells in multiple sclerosis
Takahashi, K. (2004) · Brain · doi:10.1093/brain/awh219 · Cited by 133
Unexpected multiple sclerosis: follow-up of 30 patients with magnetic resonance imaging and clinical conversion profile
Lebrun‐Frénay, C., Bensa, C., Debouverie, M., Seze, J. D., Wiertlievski, S., Brochet, B., Clavelou, P., Brassat, D., Labauge, P. M., Roullet, E., et al. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.108274 · Cited by 131
Epidemiology of multiple sclerosis in US veterans
Kurtzke, J. F., Beebe, G. W., & Norman, J. E. (1985) · Neurology · doi:10.1212/wnl.35.5.672 · Cited by 128
Multiple Sclerosis in Israel
Alter, M. (1962) · Archives of Neurology · doi:10.1001/archneur.1962.04210040005001 · Cited by 126
Multiple sclerosis characteristics in A frican A merican patients in the New York State Multiple Sclerosis C onsortium
Weinstock‐Guttman, B., Jacobs, L., Brownscheidle, C. M., Baier, M. L., Rea, D. F., Apatoff, B. R., Blitz-Shabbir, K. M., Coyle, P. K., Frontera, A. T., Goodman, A. D., et al. (2003) · Multiple Sclerosis Journal · doi:10.1191/1352458503ms909oa · Cited by 125
Natural killer type 2 bias in remission of multiple sclerosis
Takahashi, K., Miyake, S., Kondo, T., Terao, K., Hatakenaka, M., Hashimoto, S., & Yamamura, T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11819 · Cited by 120
Epidemiology of Multiple Sclerosis in US Veterans
Page, W. F., Mack, T. M., Kurtzke, J. F., Murphy, F. M., & Norman, J. E. (1995) · Neuroepidemiology · doi:10.1159/000109804 · Cited by 119
Multiple sclerosis among immigrants in Greater London.
Dean, G., McLoughlin, H., Brady, R., Adelstein, A. M., & Tallett-Williams, J. (1976) · BMJ · doi:10.1136/bmj.1.6014.861 · Cited by 116
Sex and age at diagnosis are correlated with the HLA-DR2, DQ6 haplotype in multiple sclerosis
Celius, E. G., Harbo, H. F., EGELAND, T., Vartdal, F., Vandvik, B., & Spurkland, A. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00389-0 · Cited by 116
Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event
Corvol, J., Pelletier, D., Henry, R., Caillier, S., Wang, J. H., Pappas, D., Casazza, S., Okuda, D., Hauser, S., Oksenberg, J., et al. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0805065105 · Cited by 115
A clinical patho-anatomical study of clinically silent multiple sclerosis
Engell, T. (1989) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1989.tb03811.x · Cited by 114
Monoclonal antibodies in MS
Bielekova, B., & Becker, B. L. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c97ed3 · Cited by 111
Vitamin D: A Candidate for the Environmental Effect in Multiple Sclerosis – Observations from Norway
Kampman, M. T., & Brustad, M. (2008) · Neuroepidemiology · doi:10.1159/000122330 · Cited by 111
Magnetization transfer histograms in clinically isolated syndromes suggestive of multiple sclerosis.
Fernando, K., Tozer, D., Miszkiel, K., Gordon, R., Swanton, J., Dalton, C., Barker, G., Plant, G., Thompson, A., & Miller, D. H. (2005) · Brain : a journal of neurology · doi:10.1093/brain/awh654 · Cited by 111
Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor α-chain are excluded from the analysis
Michel, L., Berthelot, L., Pettré, S., Wiertlewski, S., Lefrère, F., Braudeau, C., Brouard, S., Soulillou, J., & Laplaud, D. A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35365 · Cited by 110
Effects of infectious mononucleosis and HLA-DRB1*15 in multiple sclerosis
Nielsen, T., Rostgaard, K., Askling, J., Steffensen, R., Oturai, A. B., Jersild, C., Koch‐Henriksen, N., Sørensen, P. S., & Hjalgrim, H. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458508100037 · Cited by 108
Age of puberty and the risk of multiple sclerosis: a population based study
Ramagopalan, S. V., Valdar, W. S. J., Criscuoli, M. G., DeLuca, G. C., Dyment, D. A., Orton, S. M., Yee, I. M. L., Ebers, G. C., Sadovnick, A. D., & for the Canadian Collaborative Study Group (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02431.x · Cited by 107
Differential twin concordance for multiple sclerosis by latitude of birthplace
Islam, T. S., Gauderman, W. J., Cozen, W., Hamilton, A. S., Burnett, M. E., & Mack, T. M. (2006) · Annals of Neurology · doi:10.1002/ana.20871 · Cited by 106
Predicting the Outcome of Optic Neuritis
Nilsson, P., Larsson, E., Sundgren, P. C., Perfekt, R., & Sandberg‐Wollheim, M. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0655-9 · Cited by 97
Association of Infectious Mononucleosis with Multiple Sclerosis
Ramagopalan, S. V., Valdar, W. S. J., Dyment, D. A., DeLuca, G. C., Yee, I. M. L., Giovannoni, G., Ebers, G. C., & Sadovnick, A. D. (2009) · Neuroepidemiology · doi:10.1159/000201564 · Cited by 96
Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex
Chao, M., Ramagopalan, S. V., Herrera, B. M., Lincoln, M. R., Dyment, D. A., Sadovnick, A. D., & Ebers, G. C. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn353 · Cited by 96
A role for natural killer cells in the immunopathogenesis of multiple sclerosis
Kastrukoff, L. F., Morgan, N., Zecchini, D., White, R., Petkau, A. J., Satoh, J., & Paty, D. W. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00014-9 · Cited by 94
Mental change as an early feature of multiple sclerosis
Young, A. C., Saunders, J. A., & Ponsford, J. R. (1976) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.39.10.1008 · Cited by 89
Marked differences in prevalence of multiple sclerosis between ethnic groups in Oslo, Norway
Smestad, C., Sandvik, L., Holmøy, T., Harbo, H. F., & Celius, E. G. (2007) · Journal of Neurology · doi:10.1007/s00415-007-0659-8 · Cited by 87
Multiple sclerosis among the United Kingdom-born children of immigrants from the West Indies.
Elian, M., & Dean, G. (1987) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.50.3.327 · Cited by 86
Clinical relapses of multiple sclerosis are associated with ‘novel’ valleys in natural killer cell functional activity
Kastrukoff, L. F., Lau, A. S., Wee, R., Zecchini, D., White, R., & Paty, D. W. (2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.10.001 · Cited by 86
Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells
Jager, P. L. D., Rossin, E. J., Pyne, S., Tamayo, P., Ottoboni, L., Viglietta, V., Weiner, M., Soler, D. F., Izmailova, E. S., Faron-Yowe, L., et al. (2008) · Brain · doi:10.1093/brain/awn118 · Cited by 80
Parent-of-origin effects in MS
Herrera, B. M., Ramagopalan, S. V., Lincoln, M. R., Orton, S. M., Chao, M., Sadovnick, A. D., & Ebers, G. C. (2008) · Neurology · doi:10.1212/01.wnl.0000312377.50395.00 · Cited by 73
Maternal Transmission of Multiple Sclerosis in a Dutch Population
Hoppenbrouwers, I. A., Liu, F., Aulchenko, Y. S., Ebers, G. C., Oostra, B. A., van Duijn, C. M., & Hintzen, R. Q. (2008) · Archives of Neurology · doi:10.1001/archneurol.2007.63 · Cited by 70
Imaging brain damage in first‐degree relatives of sporadic and familial multiple sclerosis
Stefano, N. D., Cocco, E. E., Lai, M., Battaglini, M., Spissu, A., Marchi, P., Floris, G., Mortilla, M., Stromillo, M. L., Paolillo, A., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20767 · Cited by 69
Multiple sclerosis among Orientals and Caucasians in Hawaii
Alter, M., Okihiro, M. M., Rowley, W., & Morris, T. (1971) · Neurology · doi:10.1212/wnl.21.2.122 · Cited by 67
Circulating natural killer cells but not cytotoxic T lymphocytes are reduced in patients with active relapsing multiple sclerosis and little clinical disability as compared to controls
Munschauer, F. E., Hartrich, L., Stewart, C. C., & Jacobs, L. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00115-9 · Cited by 66
CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis
Jilek, S., Schluep, M., Rossetti, A. O., Guignard, L., Goff, G. L., Pantaleo, G., & Pasquier, R. D. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.11.004 · Cited by 64
Multiple sclerosis in North African migrants to France
Kurtzke, J. F., Delasnerie-Lauprêtre, N., & Wallin, M. T. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1998.tb01738.x · Cited by 63
The Schizophrenia Prodrome
White, T. J. H., Anjum, A., & Schulz, S. C. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.3.376 · Cited by 62
Timing of Birth and Risk of Multiple Sclerosis in the Scottish Population
Bayes, H. K., Weir, C. J., & O’Leary, C. (2009) · European Neurology · doi:10.1159/000268163 · Cited by 60
EBNA-1 reactivity and HLA DRB1*1501 as statistically independent risk factors for multiple sclerosis: a case-control study
Sundström, P., Nyström, L., Jidell, E., & Hallmans, G. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458508092353 · Cited by 55
Seasonal fluctuation of multiple sclerosis births in Sardinia
Sotgiu, S., Pugliatti, M., Sotgiu, M. A., Fois, M. L., Arru, G., Sanna, A., & Rosati, G. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0917-6 · Cited by 54
Incidence of CSF abnormalities in siblings of multiple sclerosis patients and unrelated controls
Haghighi, S., Andersen, O., Rosengren, L., Bergström, T. B., Wahlström, J., & Nilsson, S. (2000) · Journal of Neurology · doi:10.1007/s004150070130 · Cited by 52
Natural killer cell number and activity in multiple sclerosis
Vraneš, Z., Poljaković, Z., & Marušić, M. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90222-0 · Cited by 50
Evidence of Early Childhood as the Susceptibility Period in Multiple Sclerosis: Space-Time Cluster Analysis in a Sardinian Population
Pugliatti, M., Riise, T., Sotgiu, M. A., Satta, W. M., Sotgiu, S., Pirastru, M. I., & Rosati, G. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj190 · Cited by 49
Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS
Hauser, S. L., Oksenberg, J. R., Lincoln, R., Garovoy, J., Beck, R. W., Cole, S. R., Moke, P. S., Kip, K. E., Gal, R. L., Long, D. T., et al. (2000) · Neurology · doi:10.1212/wnl.54.9.1859 · Cited by 47
Longitudinal analysis of immune cell phenotypes in early stage multiple sclerosis: distinctive patterns characterize MRI-active patients
Rinaldi, L. (2006) · Brain · doi:10.1093/brain/awl179 · Cited by 43
The influence of HLA-DR and -DQ alleles on progression to multiple sclerosis following a clinically isolated syndrome
Kelly, M. A., Cavan, D. A., Penny, M. A., Mijovic, C. H., Jenkins, D. J. A., Morrissey, S., Miller, D. H., Barnett, A. H., & Francis, D. A. (1993) · Human Immunology · doi:10.1016/0198-8859(93)90184-3 · Cited by 42
The Frequency of Multiple Sclerosis in Jewish and Arab Populations in Greater Jerusalem
Karni, A., Kahana, E., Zilber, N., Abramsky, O., Alter, M., & Karussis, D. M. (2003) · Neuroepidemiology · doi:10.1159/000067101 · Cited by 42
Multiple sclerosis
Antel, J. P., Rosenkoetter, M., Reder, A. T., Oger, J. J.-F., & Arnason, B. G. W. (1984) · Neurology · doi:10.1212/wnl.34.9.1155 · Cited by 41
HLA-DRB1 and multiple sclerosis in Malta
Dean, G., Yeo, T. W., Goris, A., Taylor, C. J., Goodman, R. S., Elian, M., Debono, A. G., Aquilina, A., Felice, A. E., Vella, M., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000284598.98525.d7 · Cited by 41
Recommended Standard of Cerebrospinal Fluid Analysis in the Diagnosis of Multiple Sclerosis: A Consensus Statement
Freedman, M. S., Thompson, E. J., Deisenhammer, F., Giovannoni, G., Grimsley, G., Keir, G., Öhman, S., Racke, M. K., Sharief, M., Sindic, C. J. M., et al. (2005) · Archives of Neurology · doi:10.1001/archneur.62.6.865 · Cited by 41
Self-citation
Parent-of-origin effect in multiple sclerosis
Ramagopalan, S. V., Yee, I. M. L., Dyment, D. A., Orton, S. M., Marrie, R. A., Sadovnick, A. D., & Ebers, G. C. (2009) · Neurology · doi:10.1212/wnl.0b013e3181af33cf · Cited by 38
Relationships between gray matter metabolic abnormalities and white matter inflammation in patients at the very early stage of MS
Duong, M., Audoin, B., Fur, Y. L., Confort-Gouny, S., Malikova, I., Soulier, E., Viout, P., Ali‐Chérif, A., Pelletier, J., Cozzone, P., et al. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0474-7 · Cited by 37
A 3-year diffusion tensor MRI study of grey matter damage progression during the earliest clinical stage of MS
Rovaris, M., Judica, E., Ceccarelli, A., Ghezzi, A., Martinelli, V., Comi, G. P., & Filippi, M. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0877-8 · Cited by 35
Enumeration of T, B and Natural Killer Peripheral Blood Cells of Patients with Multiple Sclerosis and Controls
Kreuzfelder, E., Shen, G., Bittorf, M., Scheiermann, N., Thraenhart, O., Seidel, D. U., & Grosse‐Wilde, H. (2008) · European Neurology · doi:10.1159/000116820 · Cited by 29
Natural Killer Cell Activity in Patients with Multiple Sclerosis: Interferon and Plasmapheresis
Uchida, A., Maida, E. M., Lenzhofer, R., & Micksche, M. (1982) · Immunobiology · doi:10.1016/s0171-2985(82)80003-x · Cited by 28
Characterization of CD8+ T cell repertoire in identical twins discordant and concordant for multiple sclerosis
Somma, P., Ristori, G., Battistini, L., Cannoni, S., Borsellino, G., Diamantini, A., Salvetti, M., Sorrentino, R., & Fiorillo, M. T. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0906584 · Cited by 26
Evoked potential testing in relatives of multiple sclerosis patients
Nuwer, M. R., Visscher, B. R., Packwood, J. W., & Namerow, N. S. (1985) · Annals of Neurology · doi:10.1002/ana.410180106 · Cited by 23
Natural cytotoxic activity in multiple sclerosis patients: defects in IL-2/interferon gamma-regulatory circuit.
Braakman, E., van Tunen, A., Meager, A., & Lucas, C. J. (1986) · PubMed Central · Cited by 18
MULTIPLE SCLEROSIS IN ISRAEL
Acheson, E. D. (1970) · The Lancet · doi:10.1016/s0140-6736(70)91545-x · Cited by 13
CSF analysis in suspected MS
Hintzen, R. Q., & Giovannoni, G. (2008) · Neurology · doi:10.1212/01.wnl.0000306413.29367.82 · Cited by 9
Untitled work
Khan (2000) · doi:10.1002/1531-8249(200008)48:2

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Authors: Ramagopalan, S. V., Dobson, R., Meier, U. C., & Giovannoni, G.
Affiliations: Centre for Human Genetics (GB)
Queen Mary University of London (GB)
Corresponding author: Giovannoni, Gavin
ORCID: Ramagopalan, Sreeram V
Dobson, Ruth
Meier, Ute C
Giovannoni, Gavin
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2010-07
Volume: 9
Issue: 7
Pages: 727-739
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(10)70094-6
OpenAlex: W2149134458
Cited by: 548
References: 155
Citations by year: 2026: 18 · 2025: 25 · 2024: 19 · 2023: 33 · 2022: 38 · 2021: 33 · 2020: 32 · 2019: 36 · 2018: 24 · 2017: 39 · 2016: 39 · 2015: 31 · 2014: 38 · 2013: 41 · 2012: 49
FWCI: 5.57
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Rea Charitable Trust
Medical Research Council
National Multiple Sclerosis Society
Aims2Cure
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
Keywords: multiple sclerosis, risk factors, prodromal symptoms, etiology, causal pathways, endophenotypes, genetic factors, environmental factors, disease prevention, MS incidence
MeSH terms: Disease Susceptibility, Environment, Environmental Exposure, Humans, Multiple Sclerosis, Risk Factors, Sex Factors

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Multiple sclerosis: risk factors, prodromes, and potential causal pathways

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