Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease

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Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

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Mild cognitive impairment as a diagnostic entity

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Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease

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The amyloid hypothesis of Alzheimer's disease at 25 years

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A perivascular origin for mesenchymal stem cells in multiple human organs

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Second consensus statement on the diagnosis of multiple system atrophy

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National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

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Diagnostic Criteria for Parkinson Disease

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Neuroinflammation in Parkinson’s disease: A target for neuroprotection?

Hirsch, E. C., & Hunot, S. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70062-6 · Cited by 1,984 · see citing works

How neuroinflammation contributes to neurodegeneration

Ransohoff, R. M. (2016) · Science · doi:10.1126/science.aag2590 · Cited by 1,967 · see citing works

Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT)

Bourin, P., Bunnell, B. A., Casteilla, L., Dominici, M., Katz, A. J., March, K. L., Redl, H., Rubin, J. P., Yoshimura, K., & Gimble, J. M. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2013.02.006 · Cited by 1,890 · see citing works

Concise review: MSC-derived exosomes for cell-free therapy

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Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia

Boillée, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A., Kassiotis, G., Kollias, G., & Cleveland, D. W. (2006) · Science · doi:10.1126/science.1123511 · Cited by 1,623 · see citing works

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

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Transfer of mitochondria from astrocytes to neurons after stroke

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Alzheimer's Disease and Parkinson's Disease

Nussbaum, R. L., & Ellis, C. E. (2003) · New England Journal of Medicine · doi:10.1056/nejm2003ra020003 · Cited by 1,351 · see citing works

100 years of Lewy pathology

Goedert, M., Spillantini, M. G., Del Tredici, K., & Braak, H. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.242 · Cited by 1,190 · see citing works

Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial

Panés, J., García‐Olmo, D., Assche, G. V., Colombel, J., Reinisch, W., Baumgart, D. C., Dignass, A. U., Nachury, M., Ferrante, M., Kazemi-Shirazi, L., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31203-x · Cited by 1,094 · see citing works

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

Wyss-Coray, T., & Rogers, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006346 · Cited by 975 · see citing works

Neuropathological assessment of Parkinson’s disease: refining the diagnostic criteria

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A Clinicopathologic Study of 100 Cases of Parkinson's Disease

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Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

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Mesenchymal stem cells avoid allogeneic rejection

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Innate immunity in Alzheimer's disease

Heneka, M. T., Golenbock, D. T., & Latz, E. (2015) · Nature Immunology · doi:10.1038/ni.3102 · Cited by 902 · see citing works

A Long-Term Follow-Up Study of Intravenous Autologous Mesenchymal Stem Cell Transplantation in Patients With Ischemic Stroke

Lee, J. S., Hong, J. M., Moon, G. J., Lee, P. H., Ahn, Y. H., & Bang, O. Y. (2010) · Stem Cells · doi:10.1002/stem.430 · Cited by 775 · see citing works

Idiopathic hyposmia as a preclinical sign of Parkinson's disease

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Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

Moreira, P. I., Carvalho, C., Zhu, X., Smith, M. A., & Perry, G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.10.006 · Cited by 734 · see citing works

Human Umbilical Cord Matrix Stem Cells: Preliminary Characterization and Effect of Transplantation in a Rodent Model of Parkinson's Disease

Weiss, M. L., Medicetty, S., Bledsoe, A. R., Rachakatla, R. S., Choi, M. S. K., Merchav, S., Luo, Y., Rao, M. S., Velagaleti, G. V. N., & Troyer, D. L. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0330 · Cited by 694 · see citing works

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

Philips, T., & Robberecht, W. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70015-1 · Cited by 646 · see citing works

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

Connick, P., Kolappan, M., Crawley, C. R., Webber, D. J., Patani, R., Michell, A. W., Du, M., Luan, S., Altmann, D. R., Thompson, A. J., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70305-2 · Cited by 607 · see citing works

Cascading network failure across the Alzheimer’s disease spectrum

Jones, D. T., Knopman, D. S., Gunter, J. L., Graff‐Radford, J., Vemuri, P., Boeve, B. F., Petersen, R. C., Weiner, M. W., & Jack, C. R. (2015) · Brain · doi:10.1093/brain/awv338 · Cited by 532 · see citing works

MSC-Based Product Characterization for Clinical Trials: An FDA Perspective

Mendicino, M., Bailey, A. M., Wonnacott, K., Puri, R. K., & Bauer, S. R. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.01.013 · Cited by 500 · see citing works

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS

Storkebaum, E., Lambrechts, D., Dewerchin, M. A., Moreno-Murciano, P., Appelmans, S., Oh, H., Damme, P. V., Rutten, B. P. F., Man, W. Y., Mol, M. D., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1360 · Cited by 495 · see citing works

Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke

Honmou, O., Houkin, K., Matsunaga, T., Niitsu, Y., Ishiai, S., Onodera, R., Waxman, S. G., & Kocsis, J. D. (2011) · Brain · doi:10.1093/brain/awr063 · Cited by 493 · see citing works

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

Butovsky, O., Siddiqui, S., Gabriely, G., Lanser, A. J., Dake, B., Murugaiyan, G., Doykan, C. E., Wu, P. M., Gali, R. R., Iyer, L. K., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62636 · Cited by 481 · see citing works

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

Beers, D. R., Henkel-Tigges, J., Zhao, W., Wang, J., & Appel, S. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807419105 · Cited by 468 · see citing works

Parkinson's--Divergent Causes, Convergent Mechanisms

Greenamyre, J. T., & Hastings, T. G. (2004) · Science · doi:10.1126/science.1098966 · Cited by 453 · see citing works

A controlled trial of recombinant methionyl human BDNF in ALS

The BDNF Study Group (Phase III) (1999) · Neurology · doi:10.1212/wnl.52.7.1427 · Cited by 453 · see citing works

Neuroplasticity Failure in Alzheimer's Disease

Mesulam, M.-M. (1999) · Neuron · doi:10.1016/s0896-6273(00)81109-5 · Cited by 449 · see citing works

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

Beers, D. R., Henkel-Tigges, J., Zhao, W., Wang, J., Huang, A., Wen, S., Liao, B., & Appel, S. H. (2011) · Brain · doi:10.1093/brain/awr074 · Cited by 427 · see citing works

The Occurrence of Depression in Parkinson's Disease

Tandberg, E. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550020087019 · Cited by 413 · see citing works

Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy

Glenn, J. D. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i5.526 · Cited by 406 · see citing works

Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's disease

Venkataramana, N. K., Kumar, S. K. V., Balaraju, S., Radhakrishnan, R. C., Bansal, A., Dixit, A., Rao, D. K., Das, M., Jan, M., Gupta, P. K., et al. (2009) · Translational research · doi:10.1016/j.trsl.2009.07.006 · Cited by 403 · see citing works

Clinical Outcomes of Transplanted Modified Bone Marrow–Derived Mesenchymal Stem Cells in Stroke

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Arrest of Motor Neuron Disease in wobbler Mice Cotreated with CNTF and BDNF

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Aggregates from mutant and wild‐type α‐synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β‐sheet and amyloid‐like filaments

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Targeting mi<scp>R</scp>‐155 restores abnormal microglia and attenuates disease in <scp>SOD</scp>1 mice

Butovsky, O., Jedrychowski, M. P., Cialic, R., Krasemann, S., Murugaiyan, G., Fanek, Z., Greco, D. J., Wu, P. M., Doykan, C. E., Kiner, O., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24304 · Cited by 358 · see citing works

Lost in translation: Treatment trials in the SOD1 mouse and in human ALS

Benatar, M. G. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.015 · Cited by 352 · see citing works

The role of α-synuclein in Parkinson's disease: insights from animal models

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A placebo‐controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis

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Alzheimer’s disease, dementia, and stem cell therapy

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Natural history of multiple system atrophy in the USA: a prospective cohort study

Low, P. A., Reich, S. G., Jankovic, J. J., Shults, C. W., Stern, M. B., Novák, P., Tanner, C. M., Gilman, S., Marshall, F. J., Wooten, F. G., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00058-7 · Cited by 337 · see citing works

Autophagy and Alzheimer’s Disease

Li, Q., Liu, Y., & Sun, M. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0386-8 · Cited by 331 · see citing works

Clinicopathologic and¹¹C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer’s disease spectrum

Murray, M. E., Lowe, V. J., Graff-Radford, N. R., Liesinger, A. M., Cannon, A., Przybelski, S. A., Rawal, B., Parisi, J. E., Petersen, R. C., Kantarci, K., et al. (2015) · Brain · doi:10.1093/brain/awv050 · Cited by 324 · see citing works

Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)

Zhang, R., Miller, R. G., Gascon, R., Champion, S., Katz, J., Lancero, M., Narvaez, A., Honrada, R., Ruvalcaba, D., & McGrath, M. S. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.09.017 · Cited by 319 · see citing works

Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis

Engelhardt, J. I., Tajti, J., & Appel, S. H. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540010026013 · Cited by 318 · see citing works

Amyotrophic Lateral Sclerosis: An Update for 2018

Oskarsson, B., Gendron, T. F., & Staff, N. P. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.04.007 · Cited by 315 · see citing works

Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis

Vercelli, A., Mereuta, O., Garbossa, D., Muraca, G., Mareschi, K., Rustichelli, D., Ferrero, I., Mazzini, L., Madon, E., & Fagioli, F. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.016 · Cited by 310 · see citing works

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis

Petrou, P., Gothelf, Y., Argov, Z., Gotkine, M., Levy, Y. S., Kassis, I., Vaknin‐Dembinsky, A., Ben‐Hur, T., Offen, D., Abramsky, O., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2015.4321 · Cited by 304 · see citing works

A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis

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Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical Neurons

Zhang, Y., Chopp, M., Liu, X., Katakowski, M., Wang, X., Tian, X., Wu, D., & Zhang, Z. G. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9851-0 · Cited by 302 · see citing works

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

Zhao, W., Beers, D. R., & Appel, S. H. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9489-x · Cited by 298 · see citing works

Widespread Alterations of α-Synuclein in Multiple System Atrophy

Dickson, D. W., Liu, W.-K., Hardy, J., Farrer, M. J., Mehta, N. D., Uitti, R. J., Mark, M. H., Zimmerman, T., Golbe, L. I., Sage, J., et al. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65226-1 · Cited by 298 · see citing works

MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells

Eirin, A., Riester, S. M., Zhu, X. Y., Tang, H. R., Evans, J. M., O’Brien, D. R., van Wijnen, A. J., & Lerman, L. O. (2014) · Gene · doi:10.1016/j.gene.2014.08.041 · Cited by 293 · see citing works

Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation

Ohta, M., Suzuki, Y., Noda, T., Ejiri, Y., Dezawa, M., Kataoka, K., Chou, H., Ishikawa, N., Matsumoto, N., Iwashita, Y., et al. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.01.021 · Cited by 292 · see citing works

Clear up this stem-cell mess

Sipp, D., Robey, P. G., & Turner, L. G. (2018) · Nature · doi:10.1038/d41586-018-06756-9 · Cited by 286 · see citing works

Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation

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Intracerebral transplantation of bone marrow stromal cells in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

Li, Y., Chen, J., Wang, L., Zhang, L., Lü, M., & Chopp, M. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02384-9 · Cited by 271 · see citing works

Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti‐inflammatory action

Kim, Y., Park, H., Lee, G., Bang, O. Y., Ahn, Y. H., Joe, E.-H., Kim, H. O., & Lee, P. H. (2008) · Glia · doi:10.1002/glia.20731 · Cited by 251 · see citing works

Subcutaneous IGF-1 is not beneficial in 2-year ALS trial

Sorenson, E. J., Windbank, A. J., Mandrekar, J. N., Bamlet, W. R., Appel, S. H., Armon, C., Barkhaus, P. E., Bosch, P., Boylan, K., David, W. S., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000335970.78664.36 · Cited by 244 · see citing works

Expanding the spectrum of neuronal pathology in multiple system atrophy

Cykowski, M. D., Coon, E. A., Powell, S. Z., Jenkins, S. M., Benarroch, E. E., Low, P. A., Schmeichel, A. M., & Parisi, J. E. (2015) · Brain · doi:10.1093/brain/awv114 · Cited by 241 · see citing works

A randomized trial of mesenchymal stem cells in multiple system atrophy

Lee, P. H., Lee, J. E., Kim, H., Song, S., Lee, H. S., Nam, H. S., Cheong, J., Jeong, Y., Park, H., Kim, D. J., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23612 · Cited by 233 · see citing works

IgG Reactivity in the Spinal Cord and Motor Cortex in Amyotrophic Lateral Sclerosis

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Autologous Mesenchymal Stem Cell Therapy Delays the Progression of Neurological Deficits in Patients With Multiple System Atrophy

Lee, P. H., Kim, J., Bang, O., Ahn, Y., Joo, I., & Huh, K. H. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100386 · Cited by 217 · see citing works

Microglial activation mediates neurodegeneration related to oligodendroglial α‐synucleinopathy: Implications for multiple system atrophy

Stefanova, N., Reindl, M., Neumann, M., Kahle, P. J., Poewe, W. H., & Wenning, G. K. (2007) · Movement Disorders · doi:10.1002/mds.21671 · Cited by 217 · see citing works

Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes

Nakano, M. H., Nagaishi, K., Konari, N., Saito, Y., Chikenji, T., Mizue, Y., & Fujimiya, M. (2016) · Scientific Reports · doi:10.1038/srep24805 · Cited by 211 · see citing works

Mesenchymal stem cell-derived exosomes from different sources selectively promote neuritic outgrowth

Lopez‐Verrilli, M. A., Caviedes, A., Cabrera, A. J. H., Sandoval, S., Wyneken, Ú., & Khoury, M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.061 · Cited by 208 · see citing works

Mesenchymal stromal cell transplantation in amyotrophic lateral sclerosis: a long-term safety study

Mazzini, L., Mareschi, K., Ferrero, I., Miglioretti, M., Stecco, A., Servo, S., Carriero, A., Monaco, F., & Fagioli, F. (2011) · Cytotherapy · doi:10.3109/14653249.2011.613929 · Cited by 205 · see citing works

Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and Animal Behavior in a Rat Model of Parkinson's Disease

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Effect of Bone Marrow Stromal Cells in Parkinson's Disease Rodent Model: A Meta-Analysis

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Artemisin and human endometrial-derived stem cells improve cognitive function and synaptic plasticity in a rat model of Alzheimer disease and diabetes

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Alzheimer’s Disease Treated with Autologous and Allogeneic TelomerasePositive Stem Cells

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Adipose mesenchymal stem cells-derived extracellular vesicles exert their preferential action in damaged central sites of SOD1 mice rather than peripherally

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