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Cited by 1,589

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Stroke in China: advances and challenges in epidemiology, prevention, and management

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Wu, Simiao, Wu, Bo, Liu, Ming, Chen, Zhengming, Wang, Wenzhi, Anderson, Craig S, Sandercock, Peter, Wang, Yongjun, Huang, Yining, Cui, Liying, Pu, Chuanqiang, Jia, Jianping, Zhang, Tong, Liu, Xinfeng, Zhang, Suming, Xie, Peng, Fan, Dongsheng, Ji, Xunming, Wong, Ka-Sing Lawrence, Wang, Longde, Wu, Simiao, Wu, Bo, Liu, Ming, Chen, Zhengming, Wang, Wenzhi, Anderson, Craig S, Sandercock, Peter, Wang, Yongjun, Huang, Yining, Cui, Liying, Pu, Chuanqiang, Jia, Jianping, Zhang, Tong, Liu, Xinfeng, Zhang, Suming, Xie, Peng, Fan, Dongsheng, Ji, Xunming, Wong, Ka-Sing Lawrence, Wang, Longde, Wei, Chenchen, Wang, Yanan, Cheng, Yajun, Liu, Yunhai, Li, Xin, Dong, Qiang, Zeng, Jinsheng, Peng, Bin, Xu, Yun, Yang, Yi, Wang, Yilong, Zhao, Gang, Wang, Wei, Xu, Yuming, Yang, Qingwu, He, Zhiyi, Wang, Shaoshi, You, Chao, Gao, Ying, Zhou, Dong, He, Li, Li, Zixiao, Yang, Jie, Lei, Chunyan, Zhao, Yuhua, Liu, Junfeng, Zhang, Shuting, Tao, Wendan, Hao, Zilong, Wang, Deren, Zhang, Shihong·2019·The Lancet Neurology
DOI 10.1016/s1474-4422(18)30500-3
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Abstract

With over 2 million new cases annually, stroke is associated with the highest disability-adjusted life-years lost of any disease in China. The burden is expected to increase further as a result of population ageing, an ongoing high prevalence of risk factors (eg, hypertension), and inadequate management. Despite improved access to overall health services, the availability of specialist stroke care is variable across the country, and especially uneven in rural areas. In-hospital outcomes have improved because of a greater availability of reperfusion therapies and supportive care, but adherence to secondary prevention strategies and long-term care are inadequate. Thrombolysis and stroke units are accepted as standards of care across the world, including in China, but bleeding-risk concerns and organisational challenges hamper widespread adoption of this care in China. Despite little supporting evidence, Chinese herbal products and neuroprotective drugs are widely used, and the increased availability of neuroimaging techniques also results in overdiagnosis and overtreatment of so-called silent stroke. Future efforts should focus on providing more balanced availability of specialised stroke services across the country, enhancing evidence-based practice, and encouraging greater translational research to improve outcome of patients with stroke.

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Metadata

Authors
Wu, S., Wu, B., Liu, M., Chen, Z., Wang, W., Anderson, C. S., Sandercock, P., Wang, Y., Huang, Y., Cui, L., Pu, C., Jia, J., Zhang, T., Liu, X., Zhang, S., Xie, P., Fan, D., Ji, X., Wong, K.-S. L., Wang, L., Wu, S., Wu, B., Liu, M., Chen, Z., Wang, W., Anderson, C. S., Sandercock, P., Wang, Y., Huang, Y., Cui, L., Pu, C., Jia, J., Zhang, T., Liu, X., Zhang, S., Xie, P., Fan, D., Ji, X., Wong, K.-S. L., Wang, L., Wei, C., Wang, Y., Cheng, Y., Liu, Y., Li, X., Dong, Q., Zeng, J., Peng, B., Xu, Y., Yang, Y., Wang, Y., Zhao, G., Wang, W., Xu, Y., Yang, Q., He, Z., Wang, S., You, C., Gao, Y., Zhou, D., He, L., Li, Z., Yang, J., Lei, C., Zhao, Y., Liu, J., Zhang, S., Tao, W., Hao, Z., Wang, D., & Zhang, S.
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2019-04
Volume
18
Issue
4
Pages
394-405
ISSN
1474-4422 (ISSN-L)
DOI
10.1016/s1474-4422(18)30500-3
OpenAlex
W2921524827
Cited by
1,589
References
5
FWCI
103.83
Type
journal article
Language
en
Open access
green
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • Major International (Regional) Joint Research Project, National Natural Science Foundation of China (81620108009)
  • National Key Research and Development Program of China, Ministry of Science and Technology of China (2016YFC1300500-505)
  • Key Research and Development Program, Science and Technology Department of Sichuan Province (2017SZ0007)
  • West China Hospital, Sichuan University (ZYGD18009)
  • National Natural Science Foundation of China (81701156, 81870937, 81671146)
  • National Key Development Plan for Precision Medicine Research (2017YFC0910004)

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CoChat. (2026). Citation check: Stroke in China: advances and challenges in epidemiology, prevention, and management. https://app.cochat.ai/papers/10.1016/s1474-4422(18)30500-3
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Wu, S., Wu, B., Liu, M., Chen, Z., Wang, W., Anderson, C. S., Sandercock, P., Wang, Y., Huang, Y., Cui, L., Pu, C., Jia, J., Zhang, T., Liu, X., Zhang, S., Xie, P., Fan, D., Ji, X., Wong, K.-S. L., . . . Zhang, S. (2019). Stroke in China: advances and challenges in epidemiology, prevention, and management. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(18)30500-3

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