Cited by 1,062Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes and associated disordersDiabetes Management and Research

Diabetes: a 21st century challenge

Zimmet, Paul Z, Magliano, Dianna J, Herman, William H, Shaw, Jonathan E·2014·The Lancet Diabetes & Endocrinology

Abstract

The number of people with diabetes worldwide has more than doubled during the past 20 years. One of the most worrying features of this rapid increase is the emergence of type 2 diabetes in children, adolescents, and young adults. Although the role of traditional risk factors for type 2 diabetes (eg, genetic, lifestyle, and behavioural risk factors) has been given attention, recent research has focused on identifying the contributions of epigenetic mechanisms and the effect of the intrauterine environment. Epidemiological data predict an inexorable and unsustainable increase in global health expenditure attributable to diabetes, so disease prevention should be given high priority. An integrated approach is needed to prevent type 2 diabetes, taking into account its many origins and heterogeneity. Thus, research needs to be directed at improved understanding of the potential role of determinants such as the maternal environment and other early life factors, as well as changing trends in global demography, to help shape disease prevention programmes.

Integrity signals

Registry

Crossref · 10.1016/s2213-8587(13)70112-8

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82 of 82 references verified0 citation errors · 0 not checkable

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  • The escalating global epidemics of CVD and T2DM and dramatic changes in societies over recent decades are pivotal in the pathogenesis of obesity, T2DM and CVD.

    “We see this scenario as pivotal in the pathogenesis of obesity, T2DM and CVD and in the light of the modern epidemics of NCDs 8, 55.”

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Authors
Zimmet, P. Z., Magliano, D. J., Herman, W. H., & Shaw, J. E.
Affiliations
  • Baker Heart and Diabetes Institute (AU)
  • University of Michigan (US)
Corresponding author
Zimmet, Paul Z
Venue
The Lancet Diabetes & Endocrinology
Publisher
Elsevier BV
Published
2014-01
Volume
2
Issue
1
Pages
56-64
ISSN
2213-8587 (ISSN-L)
OpenAlex
W2112463249
Cited by
1,062
References
82
Citations by year
2026: 38 · 2025: 106 · 2024: 123 · 2023: 97 · 2022: 122 · 2021: 108 · 2020: 95 · 2019: 93 · 2018: 85 · 2017: 69 · 2016: 56 · 2015: 45 · 2014: 22 · 2013: 2
FWCI
6.12
Type
journal article
Language
en
Open access
closed
Locations
  • The Lancet Diabetes & Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Health and Medical Research Council fellowship (586623)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK092926)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
type 2 diabetes, diabetes prevalence, childhood obesity, epigenetics, intrauterine environment, maternal environment, early life factors, diabetes prevention, health care costs, global demography, risk factors
MeSH terms
Diabetes Mellitus, Type 2, Health Promotion, Humans, Risk Factors, Global Health, Prevalence, Health Care Costs, History, 21st Century

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