Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease
Open accessAbstract
Inflammation and endothelial activation are associated with an increased risk of CVD and epidemiological evidence suggests an association between levels of markers of inflammation or endothelial activation and the intake of fruit. Also, vitamin E, a fat-soluble antioxidant, has anti-inflammatory properties. We performed a randomised 2 x 2 factorial, crossover trial to determine the effect of orange and blackcurrant juice (500 ml/d) and vitamin E (15 mg RRR-alpha-tocopherol/d) supplementation on markers of inflammation and endothelial activation in forty-eight patients with peripheral arterial disease. Patients were randomly allocated to two dietary supplements from the four possible combinations of juice and vitamin E: juice+vitamin E; juice+placebo; reference beverage (sugar drink)+vitamin E; and reference beverage+placebo. The supplementations were given for 28 d, separated by a 4-week wash-out period. Analysis of main effects showed that juice decreased C-reactive protein (CRP) by 11% and fibrinogen by 3% while the reference drink increased CRP by 13% and fibrinogen by 2% (P<0.008 and P<0.002, respectively). No significant differences were measured for IL-6 and the endothelial activation markers von Willebrand factor, tissue-plasminogen activator and plasmin activator inhibitor-1. Vitamin E supplementation had no significant effects on the various markers. We observed no significant interaction between juice and vitamin E. In this study, orange and blackcurrant juice reduced markers of inflammation, but not markers of endothelial activation, in patients with peripheral arterial disease, relative to sugar drinks.
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Ageing is accompanied by a low-grade chronic inflammatory state, shown by 2- to 4-fold increases in serum levels of several inflammatory mediators in older persons.
“Ageing is accompanied by a low-grade, chronic inflammatory state clearly shown by 2-to 4-fold increases in serum levels of several inflammatory mediators in older persons (173) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [173]
Successful ageing without co-morbidities is also associated with chronic low-grade inflammation.
“Interestingly, however, successful ageing (ageing without co-morbidities) has also been associated with chronic low-grade inflammation (173) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [173]
Inflammatory mediators influence pathological processes or act as sensitive markers of subclinical disorders in the elderly.
“This indicates that these inflammatory mediators influence pathological processes or act as very sensitive markers of subclinical disorders in the elderly (173) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [173]
Higher iron intake, especially haem iron, and higher iron status are associated with increased risk of type 2 diabetes, atherosclerosis and coronary heart disease, although the literature is not fully consistent.
“There is some epidemiological evidence that higher Fe intake, particularly that of haem Fe, and higher Fe status are associated with increased risk of type 2 diabetes, atherosclerosis and CHD (702 -714) , although not all of the literature is consistent.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [709]
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Dietary factors and low-grade inflammation in relation to overweight and obesity
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- Authors
- Dalgård, C., Nielsen, F., Morrow, J. D., Enghusen-Poulsen, H., Jonung, T., Hørder, M., & de Maat, M. P. M.
- Affiliations
- University of Southern Denmark (DK)
- Vanderbilt University Medical Center (US)
- Hospital South West Jutland (DK)
- Corresponding author
- Dalgård, Christine
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008-05-28
- Volume
- 101
- Issue
- 2
- Pages
- 263-269
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2160635501
- Cited by
- 78
- References
- 50
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 6 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 12 · 2012: 6
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Funders
- Syddansk Universitet
- National Institutes of Health (GM 15431, CA 77839)
- Klinisk Institut, Syddansk Universitet
- National Cancer Institute (CA77839, P01CA077839)
- National Institute of General Medical Sciences (GM 15431)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 48831, R01DK048831)
- National Center for Research Resources (RR00095)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- orange juice, blackcurrant juice, vitamin E supplementation, peripheral arterial disease, inflammation, endothelial activation, C-reactive protein, fibrinogen, interleukin-6, von Willebrand factor, tissue plasminogen activator, fruit juice, cardiovascular risk
- MeSH terms
- Antioxidants, Beverages, C-Reactive Protein, Female, Fibrinogen, Humans, Male, Middle Aged, Vitamin E, von Willebrand Factor, Biomarkers, Interleukin-6, Multivariate Analysis, Peripheral Vascular Diseases, Oxidative Stress, Statistics, Nonparametric, Dietary Supplements, Ribes, Citrus sinensis
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