CoChat
Sign Up
Cited by 158Nutritional Studies and DietFolate and B Vitamins ResearchPhytochemicals and Antioxidant Activities

Plasma C-reactive protein and homocysteine concentrations are related to frequent fruit and vegetable intake in Hispanic and non-Hispanic white elders

Open access
Gao, Xiang, Bermudez, Odilia I., Tucker, Katherine L.·2004·The Journal of Nutrition
DOI 10.1093/jn/134.4.913
Open this paper in CoChat — free accountOpen PDF

Abstract

Elevated C-reactive protein (CRP) and plasma total homocysteine (Hcy) were recently identified as risk factors for cardiovascular disease. However, few studies have related fruit and vegetable consumption to these markers of inflammation and B vitamin deficiency, particularly in the Hispanic population. We examined the relation of fruit and vegetable intake with plasma CRP and Hcy concentrations in a cross-sectional study. Subjects were 445 Hispanic elders and 154 neighborhood-based non-Hispanic white elders living in Massachusetts. Diet was assessed with a FFQ designed for this population. There were significant inverse dose-response associations between fruit and vegetable intake and plasma CRP (P for trend = 0.010) and Hcy (P for trend = 0.033) concentrations, after adjustment for potential confounders. The prevalence of high plasma CRP (> 10 mg/L), and high Hcy (>10.4 micromol/L for women and >11.4 micromol/L for men), was significantly greater among subjects in the lowest quartile of fruit and vegetable consumption relative to those in the highest quartile, 17.9 vs. 9.1% and 58.7 vs. 44.4%, respectively. With each additional serving of fruit and vegetable intake, adjusted odd ratios for high plasma CRP and Hcy were 0.79 (95% CI: 0.65 to 0.97) and 0.83 (95% CI: 0.72 to 0.96), respectively. Greater frequency of fruit and vegetable intake was associated with significantly lower plasma CRP and Hcy concentrations. Because both of these metabolites are known risk factors for CVD, these findings contribute to the evidence that a higher intake of fruit and vegetables may reduce the risk of CVD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/jn/134.4.913

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Consumption of a Western diet rich in Maillard reaction products correlates with impaired glucose metabolism, insulin resistance, and increased risk of cardiovascular and renal disease associated with metabolic syndrome and related conditions.

    “In fact, consumption of a Western diet rich in these products was found to correlate with impaired glucose metabolism, insulin resistance and increased risk of cardiovascular and renal disease associated with the metabolic syndrome and related conditions (449,450) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [450]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Gao, X., Bermudez, O. I., & Tucker, K. L.
Affiliations
Tufts University (US)
Corresponding author
Tucker, Katherine L.
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2004-04
Volume
134
Issue
4
Pages
913-918
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/134.4.913
OpenAlex
W2116211264
Cited by
158
References
62
Citations by year
2025: 1 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 11 · 2020: 3 · 2019: 7 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 10 · 2014: 10 · 2013: 13 · 2012: 10
FWCI
10.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Agriculture
  • National Institutes of Health (5r01ag010425-05)
  • National Institute on Aging (AG-10425-05)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
C-reactive protein, homocysteine, fruit and vegetable intake, dietary intake, inflammation, vitamin B deficiency, cardiovascular risk, Hispanic elders, older adults, cardiovascular risk factors
MeSH terms
Aged, Aging, C-Reactive Protein, Diet, Female, Fruit, Hispanic or Latino, Homocysteine, Humans, Male, Massachusetts, Vegetables, Odds Ratio

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review