Evidence for structural abnormalities of the human habenular complex in affective disorders but not in schizophrenia

Ranft, K.; Dobrowolny, H.; Krell, D.; Bielau, H.; Bogerts, B.; Bernstein, H.-G.

doi:10.1017/s0033291709990821

Cited by 183Treatment of Major DepressionSchizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Evidence for structural abnormalities of the human habenular complex in affective disorders but not in schizophrenia

Ranft, K., Dobrowolny, H., Krell, D., Bielau, H., Bogerts, B., Bernstein, H.-G.·2010·Psychological Medicine

DOI 10.1017/s0033291709990821

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Abstract

BACKGROUND: The habenular complex is composed of important relay nuclei linking the limbic forebrain to the midbrain and brain stem nuclei. Based on clinical observations, experiments with animals and theoretical considerations, it has been speculated that this brain area might be involved in psychiatric diseases (i.e. schizophrenia and depression). However, evidence in favour of this hypothesis is still lacking because the human habenular complex has rarely been studied with regard to mental illness. METHOD: We examined habenular volumes in post-mortem brains of 17 schizophrenia patients, 14 patients with depression (six patients with major depression and eight patients with bipolar depression) and 13 matched controls. We further determined the neuronal density, cell number and cell area of the medial habenular nuclei of the same cohorts using a counting box and a computer-assisted instrument. RESULTS: Significantly reduced habenular volumes of the medial and lateral habenula were estimated in depressive patients in comparison to normal controls and schizophrenia patients. We also found a reduction in neuronal cell number and cell area in depressive patients for the right side compared to controls and schizophrenia patients. No such changes were seen in schizophrenia. CONCLUSIONS: Our anatomical data argue against prominent structural alterations of the habenular nuclei in schizophrenia but demonstrate robust alterations in depressive patients. We are currently applying immunohistochemical markers to better characterize neuronal subpopulations of this brain region in schizophrenia and depression.

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Authors: Ranft, K., Dobrowolny, H., Krell, D., Bielau, H., Bogerts, B., & Bernstein, H.-G.
Affiliations: Otto-von-Guericke-Universität Magdeburg (DE)
Corresponding author: Bernstein, H.-G.
ORCID: Dobrowolny, H.
Bernstein, H.-G.
Venue: Psychological Medicine
Publisher: Cambridge University Press (CUP)
Published: 2009-08-12
Volume: 40
Issue: 4
Pages: 557-567
ISSN: 0033-2917 (ISSN-L)
1469-8978
DOI: 10.1017/s0033291709990821
OpenAlex: W2116663570
Cited by: 183
References: 82
Citations by year: 2026: 5 · 2025: 6 · 2024: 17 · 2023: 8 · 2022: 14 · 2021: 12 · 2020: 6 · 2019: 12 · 2018: 14 · 2017: 21 · 2016: 11 · 2015: 15 · 2014: 9 · 2013: 11 · 2012: 8
FWCI: 5.05
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Psychological Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: habenula, schizophrenia, depression, bipolar depression, medial habenula, lateral habenula, neuronal density, cell size, postmortem brain, mood disorders, limbic system
MeSH terms: Adult, Aged, Cell Count, Female, Humans, Male, Middle Aged, Nerve Net, Schizophrenia, Severity of Illness Index, Habenula, Mood Disorders, Diagnostic and Statistical Manual of Mental Disorders

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Evidence for structural abnormalities of the human habenular complex in affective disorders but not in schizophrenia

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