Habenula: crossroad between the basal ganglia and the limbic system
Open accessAbstract
There is a growing awareness that emotion, motivation, and reward values are important determinants of our behavior. The habenula is uniquely positioned both anatomically and functionally to participate in the circuit mediating some forms of emotive decision making. In the last few years there has been a surge of interest in this structure, especially the lateral habenula (LHb). The new studies suggest that the LHb plays a pivotal role in controlling motor and cognitive behaviors by influencing the activity of dopamine and serotonin neurons. Further, dysfunctions of the LHb have also been implicated in psychiatric disorders, such as depression, schizophrenia, and drug-induced psychosis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The LHb is a source of anti-reward signals that influences reward-related DA neuron activity.
“Studies conducted in recent years have identified the LHb as a source of anti-reward signals that plays an important role in determining the reward-related activity of DA neurons [18, 30, 68–70].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [70]
LHb neurons increase their activity when adverse outcomes occur or are predicted and provide disynaptic inhibitory input to VTA DANs.
“LHb neurons increase their activity when adverse outcomes occur or are predicted and provide a disynaptic inhibitory (-GABAergic) input to VTA DANs.125,126”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [126]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564 · see citing works
By Carrot or by Stick: Cognitive Reinforcement Learning in Parkinsonism
Frank, M. J., Seeberger, L. C., & O'Reilly, R. C. (2004) · Science · doi:10.1126/science.1102941 · Cited by 1,964 · see citing works
Midbrain dopamine neurons encode a quantitative reward prediction error signal
Bayer, H. M., & Glimcher, P. W. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.020 · Cited by 1,304 · see citing works
Lateral habenula as a source of negative reward signals in dopamine neurons
Matsumoto, M., & Hikosaka, O. (2007) · Nature · doi:10.1038/nature05860 · Cited by 1,292 · see citing works
Self-citationEfferent connections of the habenular nuclei in the rat
Herkenham, M. A., & Nauta, W. J. H. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901870103 · Cited by 855 · see citing works
Comparative vertebrate neuroanatomy: evolution and adaptation
(1996) · Choice Reviews Online · doi:10.5860/choice.34-0925 · Cited by 800 · see citing works
Herkenham, M. A., & Nauta, W. J. H. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901730107 · Cited by 798 · see citing works
The short-latency dopamine signal: a role in discovering novel actions?
Redgrave, P., & Gurney, K. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn2022 · Cited by 762 · see citing works
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models
Kreitzer, A. C., & Malenka, R. C. (2007) · Nature · doi:10.1038/nature05506 · Cited by 735 · see citing works
Comparative Vertebrate Neuroanatomy: Evolution and Adaptation
Butler, A. B., & Hodos, W. (2005) · doi:10.1002/0471733849 · Cited by 640 · see citing works
Sutherland, R. J. (1982) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(82)90003-3 · Cited by 537 · see citing works
Dopamine-dependent plasticity of corticostriatal synapses
Reynolds, J. N. J., & Wickens, J. R. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00045-x · Cited by 528 · see citing works
Ullsperger, M., & von Cramon, D. Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04308.2003 · Cited by 484 · see citing works
Christoph, G., Leonzio, R., & Wilcox, K. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-03-00613.1986 · Cited by 418 · see citing works
Physiological Evidence for Habenula as Major Link Between Forebrain and Midbrain Raphe
Wang, R. Y., & Aghajanian, G. K. (1977) · Science · doi:10.1126/science.194312 · Cited by 411 · see citing works
Ji, H., & Shepard, P. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0958-07.2007 · Cited by 388 · see citing works
Self-citationBasal ganglia orient eyes to reward
Hikosaka, O., Nakamura, K., & Nakahara, H. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00458.2005 · Cited by 377 · see citing works
Self-citationCovariation of activity in habenula and dorsal raphe nuclei following tryptophan depletion
Morris, J. S., Smith, K. A., Cowen, P. J., Friston, K. J., & Dolan, R. J. (1999) · NeuroImage · doi:10.1006/nimg.1999.0455 · Cited by 288 · see citing works
Reversal learning in Parkinson's disease depends on medication status and outcome valence
Cools, R., Altamirano, L. J., & D’Esposito, M. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.03.030 · Cited by 286 · see citing works
Lecourtier, L., & Kelly, P. H. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.01.004 · Cited by 283 · see citing works
Self-citationAsymmetry in the epithalamus of vertebrates
Concha, M. L., & Wilson, S. W. (2001) · Journal of Anatomy · doi:10.1046/j.1469-7580.2001.19910063.x · Cited by 279 · see citing works
Cassel, J., & Jeltsch‐David, H. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00241-a · Cited by 257 · see citing works
Deep brain stimulation of the lateral habenula in treatment resistant major depression
Sartorius, A., & Henn, F. A. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.03.021 · Cited by 251 · see citing works
Reward-Dependent Modulation of Neuronal Activity in the Primate Dorsal Raphe Nucleus
Nakamura, K., Matsumoto, M., & Hikosaka, O. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0021-08.2008 · Cited by 243 · see citing works
Self-citationYang, L.-M., Hu, B., Xia, Y.-H., Zhang, B.-L., & Zhao, H. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.10.022 · Cited by 236 · see citing works
Caldecott-Hazard, S., Mazziotta, J. C., & Phelps, M. E. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-01951.1988 · Cited by 194 · see citing works
Role of Dopamine in the Primate Caudate Nucleus in Reward Modulation of Saccades
Nakamura, K., & Hikosaka, O. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4853-05.2006 · Cited by 179 · see citing works
Self-citationNishikawa, T., Fage, D., & Scatton, B. (1986) · Brain Research · doi:10.1016/0006-8993(86)90347-1 · Cited by 166 · see citing works
Araki, M., McGeer, P. L., & Kimura, H. (1988) · Brain Research · doi:10.1016/0006-8993(88)91410-2 · Cited by 163 · see citing works
Habenula lesions cause impaired cognitive performance in rats: implications for schizophrenia
Lecourtier, L., Neijt, H. C., & Kelly, P. H. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03356.x · Cited by 158 · see citing works
Self-citationBasal Ganglia Mechanisms of Reward‐Oriented Eye Movement
Hikosaka, O. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1390.012 · Cited by 155 · see citing works
Self-citationHabenular and interpeduncularis nuclei: shared components in multiple-function networks.
Klemm, W. R. (2004) · PubMed · Cited by 153 · see citing works
The Lateral Habenula:No Longer Neglected
Geisler, S., & Trimble, M. (2008) · CNS Spectrums · doi:10.1017/s1092852900016710 · Cited by 149 · see citing works
Tronel, S., & Sara, S. J. (2002) · Learning & Memory · doi:10.1101/lm.47802 · Cited by 147 · see citing works
Shepard, D. S., Holcomb, H. H., & Gold, J. M. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj083 · Cited by 140 · see citing works
Brain Systems Underlying Susceptibility to Helplessness and Depression
Shumake, J., & Gonzalez-Lima, F. (2003) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582303259057 · Cited by 135 · see citing works
Lisoprawski, A., Herve, D., Blanc, G., Glowinski, J., & Tassin, J. P. (1980) · Brain Research · doi:10.1016/0006-8993(80)90135-3 · Cited by 130 · see citing works
Lecourtier, L., Oranburg, T. D., & Moghaddam, B. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06130.x · Cited by 125 · see citing works
Self-citationBeurrier, C., & Malenka, R. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05817.2002 · Cited by 102 · see citing works
Bilateral Lesions of the Habenula Induce Attentional Disturbances in Rats
Lecourtier, L., & Kelly, P. H. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300595 · Cited by 94 · see citing works
Self-citationThe Wisconsin Card Sorting impairment in schizophrenia is evident in the first four trials
Prentice, K. J., Gold, J. M., & Buchanan, R. W. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2007.07.015 · Cited by 92 · see citing works
Ellison, G. (2002) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00020-2 · Cited by 92 · see citing works
Potential surgical targets for deep brain stimulation in treatment-resistant depression
Hauptman, J. S., DeSalles, A. A. F., Espinoza, R. T., Sedrak, M. F., & Ishida, W. (2008) · Neurosurgical FOCUS · doi:10.3171/foc/2008/25/7/e3 · Cited by 86 · see citing works
Gruber, C., Kahl, A., Lebenheim, L., Kowski, A. B., Dittgen, A., & Veh, R. W. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.09.016 · Cited by 85 · see citing works
Reisine, T., Soubrié, P., Artaud, F., & Glowinski, J. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-08-01062.1982 · Cited by 80 · see citing works
Dougherty, K. D., & Milner, T. A. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990428)407:1 · Cited by 76 · see citing works
Relevance of the Habenular Complex to Neuropsychiatry: A Review and Hypothesis
Sandyk, R. (1991) · International Journal of Neuroscience · doi:10.3109/00207459108990738 · Cited by 70 · see citing works
Heldt, S. A., & Ressler, K. J. (2006) · Brain Research · doi:10.1016/j.brainres.2005.12.053 · Cited by 65 · see citing works
Water maze training in aged rats: effects on brain metabolic capacity and behavior
Villarreal, J., Gonzalez-Lima, F., Berndt, J. D., & Barea-Rodrı́guez, E. J. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02545-3 · Cited by 53 · see citing works
A water-maze discrimination learning deficit in the rat following lesion of the habenula
Thornton, E. W., & Davies, C. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90324-h · Cited by 46 · see citing works
Hunt, M. J., Kessal, K., & Garcia, R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3800-04.2005 · Cited by 40 · see citing works
Park, M. R. (1987) · Brain Research Bulletin · doi:10.1016/0361-9230(87)90075-x · Cited by 40 · see citing works
Koenig, J., Cosquer, B., & Cassel, J. (2007) · Hippocampus · doi:10.1002/hipo.20368 · Cited by 38 · see citing works
Habenula lesions alter synaptic plasticity within the fimbria–accumbens pathway in the rat
Lecourtier, L., Deschaux, O., Arnaud, C., Chessel, A., Kelly, P. H., & Garcia, R. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.018 · Cited by 27 · see citing works
Self-citationThe effect of bilateral kainic acid-induced lateral habenula lesions on dopamine-mediated behaviors
Carvey, P. M., Kao, L. C., & Klawans, H. L. (1987) · Brain Research · doi:10.1016/0006-8993(87)90759-1 · Cited by 20 · see citing works
Hikosaka, O. (2007) · Scholarpedia · doi:10.4249/scholarpedia.2703 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The neurobiology of anhedonia and other reward-related deficits
Der-Avakian, A., & Markou, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.005 · Cited by 1,130 · see citing works
Light as a central modulator of circadian rhythms, sleep and affect
LeGates, T. A., Fernandez, D. C., & Hattar, S. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3743 · Cited by 1,001 · see citing works
Cortico-Basal Ganglia Reward Network: Microcircuitry
Sesack, S. R., & Grace, A. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.93 · Cited by 985 · see citing works
Self-citationJhou, T. C., Fields, H. L., Baxter, M. G., Saper, C. B., & Holland, P. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.001 · Cited by 696 · see citing works
Sartorius, A., Kiening, K. L., Kirsch, P., von Gall, C. C., Haberkorn, U., Unterberg, A. W., Henn, F. A., & Meyer-Lindenberg, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.027 · Cited by 611 · see citing works
Addiction circuitry in the human brain
Volkow, N. D., Wang, G.-J., Fowler, J. S., & Tomasi, D. (2012) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134625 · Cited by 592 · see citing works
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works
Tripp, G., & Wickens, J. R. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.026 · Cited by 492 · see citing works
Serotonin and dopamine: unifying affective, activational, and decision functions.
Cools, R., Nakamura, K., & Daw, N. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.121 · Cited by 464 · see citing works
Reward processing by the lateral habenula in normal and depressive behaviors
Proulx, C. D., Hikosaka, O., & Malinow, R. (2014) · Nature Neuroscience · doi:10.1038/nn.3779 · Cited by 461 · see citing works
Self-citationNicotine addiction and nicotinic receptors: lessons from genetically modified mice
Changeux, J.-P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2849 · Cited by 453 · see citing works
βCaMKII in Lateral Habenula Mediates Core Symptoms of Depression
Li, K., Zhou, T., Liao, L., Yang, Z., Wong, C., Henn, F., Malinow, R., Yates, J. R., & Hu, H. (2013) · Science · doi:10.1126/science.1240729 · Cited by 411 · see citing works
Toward a neurobiology of delusions
Corlett, P. R., Taylor, J. R., Wang, X.-J., Fletcher, P. C., & Krystal, J. H. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.06.007 · Cited by 394 · see citing works
A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy
Huang, L., Xi, Y., Peng, Y., Yang, Y., Huang, X., Fu, Y., Tao, Q., Xiao, J., Yuan, T., An, K., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.037 · Cited by 300 · see citing works
Lateral habenula in the pathophysiology of depression
Yang, Y., Wang, H., Hu, J., & Hu, H. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.024 · Cited by 254 · see citing works
Cerniauskas, I., Winterer, J., de Jong, J. W., Lukacsovich, D., Yang, H., Khan, F., Peck, J. R., Obayashi, S. K., Lilascharoen, V., Lim, B. K., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.005 · Cited by 187 · see citing works
Cellular Circadian Clocks in Mood Disorders
McCarthy, M. J., & Welsh, D. K. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412456367 · Cited by 203 · see citing works
Ranft, K., Dobrowolny, H., Krell, D., Bielau, H., Bogerts, B., & Bernstein, H.-G. (2010) · Psychological Medicine · doi:10.1017/s0033291709990821 · Cited by 183 · see citing works
Translating the habenula-from rodents to humans
Boulos, L.-J., Darcq, E., & Kieffer, B. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.003 · Cited by 164 · see citing works
Transcriptional and spatial resolution of cell types in the mammalian habenula
Hashikawa, Y., Hashikawa, K., Rossi, M. A., Basiri, M. L., Liu, Y., Johnston, N. L., Ahmad, O. R., & Stuber, G. D. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.011 · Cited by 167 · see citing works
The role of the habenula in drug addiction
Velasquez, K. M., Molfese, D. L., & Salas, R. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00174 · Cited by 155 · see citing works
Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset
Zheng, Z., Guo, C., Li, M., Yang, L., Liu, P., Zhang, X., Liu, Y., Guo, X., Cao, S., Dong, Y., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.011 · Cited by 142 · see citing works
Winter, C., Vollmayr, B., Djodari-Irani, A., Klein, J., & Sartorius, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.07.034 · Cited by 145 · see citing works
Lanzenberger, R., Kranz, G. S., Haeusler, D., Akimova, E., Savli, M., Hahn, A., Mitterhauser, M., Spindelegger, C., Philippe, C., Fink, M., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.07.023 · Cited by 139 · see citing works
Overriding Phasic Dopamine Signals Redirects Action Selection during Risk/Reward Decision Making
Stopper, C. M., Tse, M. T. L., Montes, D. R., Wiedman, C. R., & Floresco, S. B. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.033 · Cited by 136 · see citing works
Vasopressin innervation of the mouse ( <i>Mus musculus</i> ) brain and spinal cord
Rood, B. D., & De Vries, G. J. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22635 · Cited by 134 · see citing works
Left Habenula Mediates Light-Preference Behavior in Zebrafish via an Asymmetrical Visual Pathway
Zhang, B.-B., Yao, Y.-Y., Zhang, H.-F., Kawakami, K., & Du, J.-L. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.011 · Cited by 115 · see citing works
The Effects of Tryptophan Depletion on Neural Responses to Emotional Words in Remitted Depression
Roiser, J. P., Levy, J., Fromm, S. J., Nugent, A. C., Talagala, S. L., Hasler, G., Henn, F. A., Sahakian, B. J., & Drevets, W. C. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.002 · Cited by 123 · see citing works
Rood, B. D., Stott, R. T., You, S., Smith, C. J. W., Woodbury, M. E., & De Vries, G. J. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23288 · Cited by 120 · see citing works
Metzger, C. D. (2010) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2010.00138 · Cited by 114 · see citing works
Progress in understanding mood disorders: optogenetic dissection of neural circuits
Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98 · see citing works
Moreines, J. L., Owrutsky, Z. L., & Grace, A. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.249 · Cited by 93 · see citing works
Flexibility and adaptation of the neural substrate that supports maternal behavior in mammals
Olazábal, D. E., Pereira, M., Agrati, D., Ferreira, A., Fleming, A. S., González-Mariscal, G., Lévy, F., Lucion, A. B., Morrell, J. I., Numan, M., et al. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.004 · Cited by 97 · see citing works
Poller, W. C., Madai, V. I., Bernard, R., Laube, G., & Veh, R. W. (2013) · Brain Research · doi:10.1016/j.brainres.2013.01.029 · Cited by 77 · see citing works
Brown, R. M., Short, J. L., & Lawrence, A. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015889 · Cited by 69 · see citing works
Mechanistic insights into nicotine withdrawal
Paolini, M., & De Biasi, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.075 · Cited by 66 · see citing works
Synaptic and circuit functions of multitransmitter neurons in the mammalian brain
Wallace, M. L., & Sabatini, B. L. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.003 · Cited by 59 · see citing works
Lee, M., Yoon, J., Song, H., Lee, B., Lam, D. T., Yoon, J., Baek, K., Clevers, H., & Jeong, Y. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.02.010 · Cited by 48 · see citing works
Mallika, C., Guo, Q., & Li, J. Y. H. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.08.010 · Cited by 43 · see citing works
A habenula-insular circuit encodes the willingness to act
Khalighinejad, N., Garrett, N., Priestley, L., Lockwood, P., & Rushworth, M. F. S. (2021) · Nature Communications · doi:10.1038/s41467-021-26569-1 · Cited by 32 · see citing works
McGinty, V. B., Hayden, B. Y., Heilbronner, S. R., Dumont, E. C., Graves, S. M., Mirrione, M. M., du Hoffmann, J., Sartor, G. C., España, R. A., Millan, E. Z., et al. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.036 · Cited by 36 · see citing works
A translational perspective on the anti-anhedonic effect of ketamine and its neural underpinnings
Pulcu, E., Guinea, C., Cowen, P. J., Murphy, S. E., & Harmer, C. J. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01183-1 · Cited by 35 · see citing works
Vavers, E., Zvejniece, L., & Dambrova, M. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106771 · Cited by 30 · see citing works
- Authors
- Hikosaka, O., Sesack, S. R., Lecourtier, L., & Shepard, P. D.
- Affiliations
- National Institutes of Health (US)
- University of Pittsburgh (US)
- Centre National de la Recherche Scientifique (FR)
- University of Maryland, Baltimore (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-11-12
- Volume
- 28
- Issue
- 46
- Pages
- 11825-11829
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2613689
- OpenAlex
- W1992654377
- Cited by
- 432
- References
- 56
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 28 · 2023: 27 · 2022: 28 · 2021: 28 · 2020: 31 · 2019: 19 · 2018: 15 · 2017: 22 · 2016: 32 · 2015: 19 · 2014: 28 · 2013: 39 · 2012: 19
- FWCI
- 10.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- National Institutes of Health
- U.S. Public Health Service
- National Institute of Mental Health (MH067937, R01MH067937, MH-072647, R24MH072647, R37MH048404, R37-MH48404)
- National Eye Institute (Z01EY000415)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- habenula, lateral habenula, basal ganglia, limbic system, emotions, motivation, reward, dopaminergic neurons, serotonergic neurons, depression, schizophrenia, drug-induced psychosis
- MeSH terms
- Animals, Basal Ganglia, Brain Stem, Cognition, Emotions, Humans, Limbic System, Neural Pathways, Synaptic Transmission, Psychomotor Performance, Biogenic Monoamines, Habenula
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
