The place of dopamine in the cortico-basal ganglia circuit

Haber, S.N.

doi:10.1016/j.neuroscience.2014.10.008

Cited by 371Neurotransmitter Receptor Influence on BehaviorNeurological disorders and treatmentsNeural and Behavioral Psychology Studies

The place of dopamine in the cortico-basal ganglia circuit

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Haber, S.N.·2014·Neuroscience

DOI 10.1016/j.neuroscience.2014.10.008PMC PMC5484174

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Abstract

The midbrain dopamine (DA) neurons play a central role in developing appropriate goal-directed behaviors, including the motivation and cognition to develop appropriate actions to obtain a specific outcome. Indeed, subpopulations of DA neurons have been associated with these different functions: the mesolimbic, mesocortical, and nigrostriatal pathways. The mesolimbic and nigrostriatal pathways are an integral part of the basal ganglia through its reciprocal connections to the ventral and dorsal striatum respectively. This chapter reviews the connections of the midbrain DA cells and their role in integrating information across limbic, cognitive and motor functions. Emphasis is placed on the interface between these functional domains within the striatum through corticostriatal connections, through the striato-nigro-striatal connection, and through the lateral habenula projection to the midbrain.

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The striatum is functionally connected to the threat detection system.
“The striatum is functionally connected to the threat detection system (Haber, 2014).”
From The effects of psychosocial stress on dopaminergic function and the acute stress response (2019) · cites this paper as Haber, 2014

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Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · cited 1× · see citing works
“Indeed, subpopulations of DA neurons have been associated with these different functions: the mesolimbic, mesocortical, and nigrostriatal pathways, respectively (Wullner et al., 1994; Sawaguchi, 1995; Goldman-Rakic, 1998; Wise, 2004).”
Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works
Getting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574 · see citing works
Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.
Alexander, G. E., Crutcher, M. D., & DeLong, M. R. (1990) · PubMed · Cited by 2,422 · see citing works
From motivation to action: Functional interface between the limbic system and the motor system
MOGENSON, G., JONES, D., & YIM, C. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90018-0 · Cited by 2,331 · see citing works
Chapter 6 Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions
(1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62678-3 · Cited by 1,961 · see citing works
Verteilung Von Noradrenalin Und Dopamin (3-Hydroxytyramin) Im Gehirn Des Menschen Und Ihr Verhalten Bei Erkrankungen Des Extrapyramidalen Systems
Ehringer, H., & Hornykiewicz, O. (1960) · Journal of Molecular Medicine · doi:10.1007/bf01485901 · Cited by 1,875 · see citing works
Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum
Haber, S. N., Fudge, J. L., & McFarland, N. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02369.2000 · Cited by 1,610 · see citing works
Self-citation
Lateral habenula as a source of negative reward signals in dopamine neurons
Matsumoto, M., & Hikosaka, O. (2007) · Nature · doi:10.1038/nature05860 · Cited by 1,292 · see citing works
Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Childress, A.-R., Jayne, M., Ma, Y., & Wong, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1544-06.2006 · Cited by 1,164 · see citing works
Longitudinal topography and interdigitation of corticostriatal projections in the rhesus monkey
Selemon, L. D., & Goldman-Rakic, P. S. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-03-00776.1985 · Cited by 1,074 · see citing works
Motivational control of goal-directed action
Dickinson, A., & Balleine, B. (1994) · Animal Learning & Behavior · doi:10.3758/bf03199951 · Cited by 995 · see citing works
Cytoarchitecture of the Human Brain Stem.
Boyd, J. D. (1955) · Archives of Ophthalmology · doi:10.1001/archopht.1955.00930010774037 · Cited by 897 · see citing works
Efferent connections of the habenular nuclei in the rat
Herkenham, M. A., & Nauta, W. J. H. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901870103 · Cited by 855 · see citing works
Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops
Tanaka, S. C., Doya, K., Okada, G., Ueda, K., Okamoto, Y., & Yamawaki, S. (2004) · Nature Neuroscience · doi:10.1038/nn1279 · Cited by 779 · see citing works
Bilateral projections from precentral motor cortex to the putamen and other parts of the basal ganglia. An autoradiographic study inMacaca fascicularis
Künzle, H. (1975) · Brain Research · doi:10.1016/0006-8993(75)90384-4 · Cited by 714 · see citing works
Different time courses of learning-related activity in the prefrontal cortex and striatum.
Pasupathy, A., & Miller, E. K. (2005) · Nature · doi:10.1038/nature03287 · Cited by 712 · see citing works
Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum
Belin, D., & Everitt, B. J. (2008) · Neuron · doi:10.1016/j.neuron.2007.12.019 · Cited by 697 · see citing works
The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses.
Jhou, T. C., Fields, H. L., Baxter, M. G., Saper, C. B., & Holland, P. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.001 · Cited by 696 · see citing works
Reward-related cortical inputs define a large striatal region in primates that interface with associative cortical connections, providing a substrate for incentive-based learning.
Haber, S. N., Kim, K.-S., Mailly, P., & Calzavara, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0271-06.2006 · Cited by 686 · see citing works
Self-citation
The basal ganglia: learning new tricks and loving it
Graybiel, A. M. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.10.006 · Cited by 650 · see citing works
Cortico-striate projections in the rhesus monkey: The organization of certain cortico-caudate connections
Yeterian, E. H., & Hoesen, G. W. V. (1978) · Brain Research · doi:10.1016/0006-8993(78)90059-8 · Cited by 641 · see citing works
Distinct basal ganglia territories are engaged in early and advanced motor sequence learning
Lehéricy, S., Benali, H., Van de Moortele, P.-F., Pélégrini-Issac, M., Waechter, T., Ugurbil, K., & Doyon, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502762102 · Cited by 634 · see citing works
Remission of major depression under deep brain stimulation of the lateral habenula in a therapy-refractory patient
Sartorius, A., Kiening, K. L., Kirsch, P., von Gall, C. C., Haberkorn, U., Unterberg, A. W., Henn, F. A., & Meyer-Lindenberg, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.027 · Cited by 611 · see citing works
The orbital and medial prefrontal circuit through the primate basal ganglia
Haber, S., Kunishio, K., Mizobuchi, M., & Lynd-Balta, E. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-07-04851.1995 · Cited by 605 · see citing works
Self-citation
An Autoradiographic Analysis of the Efferent Connections from Premotor and Adjacent Prefrontal Regions (Areas 6 and 9) in Macaca fascicularis; pp. 185–209
Künzle, H. (2008) · Brain Behavior and Evolution · doi:10.1159/000123779 · Cited by 559 · see citing works
Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction
Belin, D., Jonkman, S., Dickinson, A., Robbins, T. W., & Everitt, B. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.027 · Cited by 520 · see citing works
Error Monitoring Using External Feedback: Specific Roles of the Habenular Complex, the Reward System, and the Cingulate Motor Area Revealed by Functional Magnetic Resonance Imaging
Ullsperger, M., & von Cramon, D. Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04308.2003 · Cited by 484 · see citing works
Efferent connections of the ventral pallidum: Evidence of a dual striato pallidofugal pathway
Haber, S. N., Groenewegen, H. J., Grove, E. A., & Nauta, W. J. H. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902350304 · Cited by 432 · see citing works
Self-citation
Stimulation of the lateral habenula inhibits dopamine-containing neurons in the substantia nigra and ventral tegmental area of the rat
Christoph, G., Leonzio, R., & Wilcox, K. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-03-00613.1986 · Cited by 418 · see citing works
Distribution of dopaminergic receptors in the primate cerebral cortex: Quantitative autoradiographic analysis using [3H]raclopride, [3H]spiperone and [3H]SCH23390
Lidow, M. S., Goldman-Rakic, P. S., Gallager, D. W., & Rakic, P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90003-7 · Cited by 394 · see citing works
The Cortical Dopamine System: Role in Memory and Cognition
Goldman, P. S. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60846-7 · Cited by 393 · see citing works
Negative Reward Signals from the Lateral Habenula to Dopamine Neurons Are Mediated by Rostromedial Tegmental Nucleus in Primates
Hong, S., Jhou, T. C., Smith, M., Saleem, K. S., & Hikosaka, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1384-11.2011 · Cited by 390 · see citing works
Lateral Habenula Stimulation Inhibits Rat Midbrain Dopamine Neurons through a GABAA Receptor-Mediated Mechanism
Ji, H., & Shepard, P. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0958-07.2007 · Cited by 388 · see citing works
The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique
Bunney, B. S., & Aghajanian, G. K. (1976) · Brain Research · doi:10.1016/0006-8993(76)90751-4 · Cited by 378 · see citing works
Brainstem innervation of prefrontal and anterior cingulate cortex in the rhesus monkey revealed by retrograde transport of HRP
Porrino, L. J., & Goldman, P. S. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902050107 · Cited by 363 · see citing works
The globus pallidus sends reward-related signals to the lateral habenula
Hong, S., & Hikosaka, O. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.035 · Cited by 346 · see citing works
Insular Cortical Projections to Functional Regions of the Striatum Correlate with Cortical Cytoarchitectonic Organization in the Primate
Chikama, M., McFarland, N. R., Amaral, D. G., & Haber, S. N. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-24-09686.1997 · Cited by 341 · see citing works
Self-citation
The distribution of tyrosine hydroxylase-immunoreactive fibers in primate neocortex is widespread but regionally specific
Lewis, D., Campbell, M., Foote, S., Goldstein, M., & Morrison, J. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-01-00279.1987 · Cited by 325 · see citing works
Pedunculopontine nucleus in the squirrel monkey: Projections to the basal ganglia as revealed by anterograde tract‐tracing methods
Lavoie, B. A., & Parent, A. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903440204 · Cited by 321 · see citing works
Comparative neurobiology of the basal ganglia
Parent, A. (1986) · Cited by 308 · see citing works
Cytoarchitecture of the Human Brain Stem
Bandler, R. J. (1983) · Pathology · doi:10.1016/s0031-3025(16)37288-9 · Cited by 300 · see citing works
Biochemistry and pharmacology of the basal ganglia
Yahr, M. D. (1965) · International Journal of Neuropharmacology · doi:10.1016/0028-3908(65)90018-3 · Cited by 294 · see citing works
Topographic organization of the ventral striatal efferent projections in the rhesus monkey: An anterograde tracing study
Haber, S. N., Lynd‐Balta, E., Klein, C. M., & Groenewegen, H. J. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902930210 · Cited by 291 · see citing works
Self-citation
Primate cingulostriatal projection: Limbic striatal versus sensorimotor striatal input
Kunishio, K., & Haber, S. N. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903500302 · Cited by 290 · see citing works
Self-citation
The Olfactory Cortex and the Ventral Striatum
Heimer, L. (1978) · Springer eBooks · doi:10.1007/978-1-4757-0716-8_7 · Cited by 283 · see citing works
Differential activation of the caudate nucleus in primates performing spatial and nonspatial working memory tasks
Levy, R., Friedman, H. R., Davachi, L., & Goldman-Rakic, P. S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03870.1997 · Cited by 279 · see citing works
Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains
Porrino, L. J., Lyons, D., Smith, H. R., Daunais, J. B., & Nader, M. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5578-03.2004 · Cited by 276 · see citing works
Influence of Expectation of Different Rewards on Behavior-Related Neuronal Activity in the Striatum
Hassani, O. K., Cromwell, H. C., & Schultz, W. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.6.2477 · Cited by 257 · see citing works
Glutamatergic axons from the lateral habenula mainly terminate on GABAergic neurons of the ventral midbrain
Brinschwitz, K., Dittgen, A., Madai, V. I., Lommel, R., Geisler, S., & Veh, R. W. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.050 · Cited by 240 · see citing works
The organization of midbrain projections to the striatum in the primate: sensorimotor-related striatum versus ventral striatum
Lynd-Balta, E., & Haber, S. N. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90182-1 · Cited by 233 · see citing works
Self-citation
The subcortical afferents to caudate nucleus and putamen in primate: A fluorescence retrograde double labeling study
Parent, A., Mackey, A., & Bellefeuille, L. D. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90104-5 · Cited by 233 · see citing works
The Neural Network Underlying Incentive-Based Learning: Implications for Interpreting Circuit Disruptions in Psychiatric Disorders
Haber, S. N., & Behrens, T. E. J. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.031 · Cited by 230 · see citing works
Self-citation
Amygdaloid projections to ventromedial striatal subterritories in the primate
Fudge, J. L., Kunishio, K., Walsh, P., Richard, C., & Haber, S. N. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00546-2 · Cited by 226 · see citing works
Self-citation
Corticostriatal Interactions during Learning, Memory Processing, and Decision Making
Pennartz, C. M. A., Berke, J. D., Graybiel, A. M., Ito, R., Lansink, C. S., van der Meer, M., Redish, A. D., Smith, K. S., & Voorn, P. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3177-09.2009 · Cited by 213 · see citing works
Region‐specific distribution of catecholamine afferents in primate cerebral cortex: A fluorescence histochemical analysis
Levitt, P., RAKIC, P. T., & Goldman‐Rakic, P. S. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902270105 · Cited by 191 · see citing works
Subsets of midbrain dopaminergic neurons in monkeys are distinguished by different levels of mRNA for the dopamine transporter: Comparison with the mRNA for the D2 receptor, tyrosine hydroxylase and calbindin immunoreactivity
Haber, S. N., Ryoo, H., Cox, C., & Lu, W. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903620308 · Cited by 188 · see citing works
Self-citation
The organization of the descending ventral pallidal projections in the monkey
Haber, S., Lynd-Balta, E., & Mitchell, S. (1993) · The Journal of comparative neurology · doi:10.1002/cne.903290108 · Cited by 184 · see citing works
Self-citation
Evidence for structural abnormalities of the human habenular complex in affective disorders but not in schizophrenia
Ranft, K., Dobrowolny, H., Krell, D., Bielau, H., Bogerts, B., & Bernstein, H.-G. (2010) · Psychological Medicine · doi:10.1017/s0033291709990821 · Cited by 183 · see citing works
A Pallidus-Habenula-Dopamine Pathway Signals Inferred Stimulus Values
Bromberg-Martin, E. S., Matsumoto, M., Hong, S., & Hikosaka, O. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00158.2010 · Cited by 182 · see citing works
Habenula Volume in Bipolar Disorder and Major Depressive Disorder: A High-Resolution Magnetic Resonance Imaging Study
Savitz, J. B., Nugent, A. C., Bogers, W., Roiser, J. P., Bain, E., Neumeister, A., Zarate, C. A., Manji, H. K., Cannon, D. M., Marrett, S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.027 · Cited by 182 · see citing works
Topography and collateralization of the dopaminergic projections to motor and lateral prefrontal cortex in owl monkeys
Gaspar, P., Stepniewska, I., & Kaas, J. H. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903250102 · Cited by 180 · see citing works
Estimates of projection overlap and zones of convergence within frontal-striatal circuits
Averbeck, B. B., Lehman, J., Jacobson, M., & Haber, S. N. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5806-12.2014 · Cited by 179 · see citing works
Self-citation
The ventral pallidal projection to the mediodorsal thalamus: a study with fluorescent retrograde tracers and immunohistofluorescence
Young, W. S., Alheid, G., & Heimer, L. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-06-01626.1984 · Cited by 179 · see citing works
The effects of cocaine: A shifting target over the course of addiction
Porrino, L. J., Smith, H. R., Nader, M. A., & Beveridge, T. J. R. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.040 · Cited by 178 · see citing works
Relationship between the corticostriatal terminals from areas 9 and 46, and those from area 8A, dorsal and rostral premotor cortex and area 24c: an anatomical substrate for cognition to action
Calzavara, R., Mailly, P., & Haber, S. N. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05825.x · Cited by 170 · see citing works
Self-citation
Parallel processing in the basal ganglia: up to a point
Percheron, G., & Filion, M. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90020-u · Cited by 168 · see citing works
Dopaminergic neurons expressing calbindin in normal and parkinsonian monkeys
Lavoie, B. A., & Parent, A. (1991) · Neuroreport · doi:10.1097/00001756-199110000-00012 · Cited by 165 · see citing works
Monoamine Innervation of Cerebral Cortex and a Theory of the Role of Monoamines in Cerebral Cortex and Basal Ganglia
Fallon, J. H., & Loughlin, S. E. (1932) · Cerebral cortex · doi:10.1007/978-1-4615-6616-8_2 · Cited by 165 · see citing works
The efferent projections of the medial prefrontal cortex in the squirrel monkey (Saimiri sciureus)
Leichnetz, G. R., & Astruc, J. A. (1976) · Brain Research · doi:10.1016/0006-8993(76)90027-5 · Cited by 164 · see citing works
Primate striatonigral projections: A comparison of the sensorimotor‐related striatum and the ventral striatum
Lynd‐Balta, E., & Haber, S. N. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903450407 · Cited by 164 · see citing works
Self-citation
The efferent projections of the rat lateral habenular nucleus revealed by the PHA-L anterograde tracing method
Araki, M., McGeer, P. L., & Kimura, H. (1988) · Brain Research · doi:10.1016/0006-8993(88)91410-2 · Cited by 163 · see citing works
Reward-Modulated Motor Information in Identified Striatum Neurons
Isomura, Y., Takekawa, T., Harukuni, R., Handa, T., Aizawa, H., Takada, M., & Fukai, T. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0381-13.2013 · Cited by 162 · see citing works
Signals in Human Striatum Are Appropriate for Policy Update Rather than Value Prediction
Li, J., & Daw, N. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6316-10.2011 · Cited by 149 · see citing works
Comparative anatomy of the ventromedial mesencephalic tegmentum in the rat, cat, monkey and human
Halliday, G. M., & Törk, I. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902520402 · Cited by 147 · see citing works
Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression
Winter, C., Vollmayr, B., Djodari-Irani, A., Klein, J., & Sartorius, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.07.034 · Cited by 145 · see citing works
Electrical stimulation of the lateral habenula produces enduring inhibitory effect on cocaine seeking behavior
Friedman, A., Lax, E., Dikshtein, Y., Abraham, L., Flaumenhaft, Y., Sudai, E., Ben‐Tzion, M., Ami-Ad, L., Yaka, R., & Yadid, G. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.06.008 · Cited by 145 · see citing works
Comparative morphology of the substantia nigra and ventral tegmental area in the monkey, cat and rat
POIRIER, L. J., Giguère, M., & Marchand, R. (1983) · Brain Research Bulletin · doi:10.1016/0361-9230(83)90173-9 · Cited by 142 · see citing works
Prefrontal Cortical Projections to the Midbrain in Primates: Evidence for a Sparse Connection
Frankle, W., Laruelle, M., & Haber, S. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300990 · Cited by 141 · see citing works
Self-citation
Schizophrenia in Translation: The Presence of Absence: Habenular Regulation of Dopamine Neurons and the Encoding of Negative Outcomes
Shepard, D. S., Holcomb, H. H., & Gold, J. M. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj083 · Cited by 140 · see citing works
Chemotherapy in psychiatry : principles and practice
Baldessarini, R. J. (1985) · Medical Entomology and Zoology · Cited by 135 · see citing works
BOLD responses to negative reward prediction errors in human habenula
Salas (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00036 · Cited by 131 · see citing works
The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat
Kornhuber, J., Kim, J.-S., Kornhuber, M. E., & Kornhuber, H. H. (1984) · Brain Research · doi:10.1016/0006-8993(84)91189-2 · Cited by 130 · see citing works
Comparative neurobiology of the basal ganglia
Reiner, A. J. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90019-1 · Cited by 129 · see citing works
Chemotherapy in Psychiatry: Principles and Practice
Seelye, E. E. (1986) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1986.40.4.614 · Cited by 129 · see citing works
Reward-Dependent Spatial Selectivity of Anticipatory Activity in Monkey Caudate Neurons
Takikawa, Y., Kawagoe, R., & Hikosaka, O. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00288.2001 · Cited by 124 · see citing works
Neural Correlates of Rewarded and Unrewarded Eye Movements in the Primate Caudate Nucleus
Watanabe, K., Lauwereyns, J., & Hikosaka, O. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-31-10052.2003 · Cited by 118 · see citing works
The origin of forebrain afferents to the habenula in rat, cat and monkey
Parent, A., Gravel, S., & Boucher, R. (1981) · Brain Research Bulletin · doi:10.1016/s0361-9230(81)80066-4 · Cited by 117 · see citing works
Human Dorsal Striatum Encodes Prediction Errors during Observational Learning of Instrumental Actions
Cooper, J. C., Dunne, S., Furey, T., & O'Doherty, J. P. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00114 · Cited by 101 · see citing works
Studies on neuromelanin
Bazelon, M., Fenichel, G. M., & Randall, J. O. (1967) · Neurology · doi:10.1212/wnl.17.5.512 · Cited by 101 · see citing works
The Basal Ganglia
Haber, S. N., Adler, A., & Bergman, H. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374236-0.10020-3 · Cited by 90 · see citing works
Self-citation
Catecholaminergic innervation of the hippocampus in the cynomolgus monkey
Samson, Y., Wu, J. J., Friedman, A. H., & Davis, J. N. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902980209 · Cited by 64 · see citing works
The Ventral Striato-Pallidal Pathway Mediates the Effect of Predictive Learning on Choice between Goal-Directed Actions
Leung, B. K., & Balleine, B. W. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1697-13.2013 · Cited by 60 · see citing works
Calbindin D28k-containing neurons are restricted to the medial substantia nigra in humans
McRitchie, D. A., & Halliday, G. M. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00483-l · Cited by 54 · see citing works
A histological atlas of the macaque (Macaca, mulatta) substantia nigra in ventricular coordinates
François, C., Percheron, G., Yelnik, J., & Heyner, S. (1985) · Brain Research Bulletin · doi:10.1016/0361-9230(85)90196-0 · Cited by 53 · see citing works
Functions of the Cortico-Basal Ganglia Loop
Kimura, M., & Graybiel, A. M. (1995) · Springer eBooks · doi:10.1007/978-4-431-68547-0 · Cited by 53 · see citing works
Dopamine Terminal Loss and Onset of Motor Symptoms in MPTP-Treated Monkeys: A Positron Emission Tomography Study with 11C-CFT
Wüllner, U., Pakzaban, P., Brownell, A.-L., Hantraye, P., Burns, L. H., Shoup, T. M., Elmaleh, D. R., Petto, A. J., Spealman, R. D., Brownell, G. L., et al. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1069 · Cited by 51 · see citing works
The heterogeneity of the mesostriatal dopaminergic system as revealed in normal and parkinsonian monkeys.
Parent, A., & Lavoie, B. A. (1993) · PubMed · Cited by 50 · see citing works
The cortico-nigral fibre tract. An experimental Fink-Heimer study in cats.
Afifi, A. K., Bahuth, N. B., Kaelber, W. W., Mikhael, E. M., & Nassar, S. (1974) · Europe PMC (PubMed Central) · Cited by 42 · see citing works
Strionigral and Nigrostriatal Connections
Szabó, J. (1979) · Stereotactic and Functional Neurosurgery · doi:10.1159/000102324 · Cited by 31 · see citing works
The Role of Dopamine in Frontal Motor Cortical Functions of Monkeys
Sawaguchi, T. (1995) · Springer eBooks · doi:10.1007/978-4-431-68547-0_11 · Cited by 4 · see citing works
Untitled work
Yeterian (1998) · doi:10.1002/(sici)1096-9861(19980928)399:3

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Prefrontal cortex as a meta-reinforcement learning system
Wang, J. X., Kurth-Nelson, Z., Kumaran, D., Tirumala, D., Soyer, H., Leibo, J. Z., Hassabis, D., & Botvinick, M. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0147-8 · Cited by 596 · see citing works
Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis
Manjaly, Z., Harrison, N. A., Critchley, H., Tri, C., Stefanics, G., Wenderoth, N., Lutterotti, A., Müller, A. E., & Stephan, K. E. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-320050 · Cited by 324 · see citing works
Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass
Menegas, W., Bergan, J. F., Ogawa, S. K., Isogai, Y., Venkataraju, K. U., Osten, P., Uchida, N., & Watabe‐Uchida, M. (2015) · eLife · doi:10.7554/elife.10032 · Cited by 324 · see citing works
A Dopamine Hypothesis of Autism Spectrum Disorder
Pavăl, D. (2017) · Developmental Neuroscience · doi:10.1159/000478725 · Cited by 294 · see citing works
Specialized astrocytes mediate glutamatergic gliotransmission in the CNS
Ceglia, R. D., Ledonne, A., Litvin, D. G., Lind, B. L., Carriero, G., Latagliata, E. C., Bindocci, E., Castro, M. A. D., Savtchouk, I., Vitali, I., et al. (2023) · Nature · doi:10.1038/s41586-023-06502-w · Cited by 285 · see citing works
Dopamine, Oxidative Stress and Protein–Quinone Modifications in Parkinson's and Other Neurodegenerative Diseases
Monzani, E., Nicolis, S., Dell’Acqua, S., Capucciati, A., Bacchella, C., Zucca, F. A., Mosharov, E. V., Sulzer, D. L., Zecca, L., & Casella, L. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201811122 · Cited by 270 · see citing works
Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice
Menegas, W., Babayan, B. M., Uchida, N., & Watabe‐Uchida, M. (2017) · eLife · doi:10.7554/elife.21886 · Cited by 265 · see citing works
Role of Dopamine Neurons in Reward and Aversion: A Synaptic Plasticity Perspective
Pignatelli, M., & Bonci, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.04.015 · Cited by 244 · see citing works
Reinforcement learning in depression: a review of computational research
Chen, C., Takahashi, T., Nakagawa, S., Inoue, T., & Kusumi, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.005 · Cited by 233 · see citing works
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Saddoris, M. P., Cacciapaglia, F., Wightman, R. M., & Carelli, R. M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2344-15.2015 · Cited by 200 · see citing works
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Biondetti, E., Santin, M. D., Valabrègue, R., Mangone, G., Gaurav, R., Pyatigorskaya, N., Hutchison, M., Yahia‐Cherif, L., Villain, N., Habert, M., et al. (2021) · Brain · doi:10.1093/brain/awab191 · Cited by 186 · see citing works
Neurobiological basis of individual variation in stimulus-reward learning
Flagel, S. B., & Robinson, T. E. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.12.004 · Cited by 165 · see citing works
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Bell, P. T., & Shine, J. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.036 · Cited by 163 · see citing works
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Milardi, D., Quartarone, A., Bramanti, A., Anastasi, G., Bertino, S., Basile, G. A., Buonasera, P., Pilone, G., Celeste, G., Rizzo, G., et al. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2019.00061 · Cited by 162 · see citing works
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Gentile, A., Musella, A., Bullitta, S., Fresegna, D., Vito, F. D., Fantozzi, R., Piras, E., Gargano, F., Borsellino, G., Battistini, L., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0686-4 · Cited by 159 · see citing works
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Arnsten, A. F. T., Wang, M., & Paspalas, C. D. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010512 · Cited by 149 · see citing works
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“The striatum is functionally connected to the threat detection system (Haber, 2014).”
BackgroundMethod
Mesolimbic dopamine adapts the rate of learning from action
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Prasad, E. M., & Hung, S. (2020) · Antioxidants · doi:10.3390/antiox9101007 · Cited by 118 · see citing works
COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review
Schacht, J. P. (2016) · The Pharmacogenomics Journal · doi:10.1038/tpj.2016.43 · Cited by 107 · see citing works
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Pessoa, L., Medina, L., Hof, P. R., & Desfilis, E. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.021 · Cited by 105 · see citing works
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Jenkins, P., Mehta, M., & Sharp, D. (2016) · Brain : a journal of neurology · doi:10.1093/brain/aww128 · Cited by 94 · see citing works
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Olanow, C. W., Calabresi, P., & Obeso, J. A. (2020) · Movement Disorders · doi:10.1002/mds.28215 · Cited by 96 · see citing works
In vivo functional diversity of midbrain dopamine neurons within identified axonal projections
Farassat, N., Costa, K. M., Stojanovic, S., Albert, S., Kovacheva, L., Shin, J., Egger, R., Somayaji, M., Duvarci, S., Schneider, G., et al. (2019) · eLife · doi:10.7554/elife.48408 · Cited by 94 · see citing works
Executive (dys)function after traumatic brain injury: special considerations for behavioral pharmacology
Ozga, J. E., Povroznik, J. M., Engler-Chiurazzi, E. B., & Haar, C. V. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000430 · Cited by 89 · see citing works
Core Outcome Measures in Preclinical Assessment of Candidate Analgesics
Negus, S. S. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.017210 · Cited by 89 · see citing works
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Delva, N. C., & Stanwood, G. D. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221991830 · Cited by 90 · see citing works
Functional neuroanatomical review of the ventral tegmental area
Trutti, A. C., Mulder, M., Hommel, B., & Forstmann, B. U. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.01.062 · Cited by 90 · see citing works
Resting‐state functional connectivity of the striatum in early‐stage P arkinson's disease: Cognitive decline and motor symptomatology
Manza, P., Zhang, S., Li, C.-S. R., & Leung, H. (2015) · Human Brain Mapping · doi:10.1002/hbm.23056 · Cited by 79 · see citing works
Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain
Purves-Tyson, T. D., Owens, S. J., Rothmond, D. A., Halliday, G. M., Double, K. L., Stevens, J., McCrossin, T., & Weickert, C. S. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.257 · Cited by 79 · see citing works
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Amato, D., Vernon, A. C., & Papaleo, F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.027 · Cited by 80 · see citing works
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Arnts, H., van Erp, W. S., Lavrijsen, J. C. M., van Gaal, S., Groenewegen, H. J., & van den Munckhof, P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.006 · Cited by 79 · see citing works
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Gremel, C. M., & Lovinger, D. M. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12309 · Cited by 72 · see citing works
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Depierreux, F., Parmentier, É., Mackels, L., Baquero, K., Degueldre, C., Balteau, E., Salmon, É., Phillips, C. L. M., Bahri, M. A., Maquet, P., et al. (2021) · npj Parkinson s Disease · doi:10.1038/s41531-021-00199-2 · Cited by 76 · see citing works
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Dalley, J. W., & Ersche, K. D. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0145 · Cited by 74 · see citing works
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Prager, E. M., & Plotkin, J. L. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24522 · Cited by 76 · see citing works
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Martín‐Bastida, A., Lao–Kaim, N. P., Roussakis, A., Searle, G. E., Xing, Y., Gunn, R. N., Schwarz, S. T., Barker, R. A., Auer, D. P., & Piccini, P. P. (2019) · Brain · doi:10.1093/brain/awz120 · Cited by 73 · see citing works
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Fu, Z., Sajad, A., Errington, S. P., Schall, J. D., & Rutishauser, U. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00670-w · Cited by 70 · see citing works
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Weisenhorn, D. M. V., Giesert, F., & Wurst, W. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13670 · Cited by 67 · see citing works
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Ledonne, A., & Mercuri, N. B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010275 · Cited by 69 · see citing works
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Béreau, M., Waes, V. V., Servant, M., Magnin, É., Tatu, L., & Anheim, M. (2023) · Cells · doi:10.3390/cells12121599 · Cited by 66 · see citing works
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Trojano, L., & Papagno, C. (2017) · Neurological Sciences · doi:10.1007/s10072-017-3155-7 · Cited by 61 · see citing works
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Solié, C., Contestabile, A., Espinosa, P., Musardo, S., Bariselli, S., Huber, C., Carleton, A., & Bellone, C. (2022) · Nature Communications · doi:10.1038/s41467-022-28512-4 · Cited by 58 · see citing works
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Albin, R. L., & Leventhal, D. (2017) · Annals of Neurology · doi:10.1002/ana.24961 · Cited by 51 · see citing works
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Leffa, D. T., de Souza, A., Scarabelot, V. L., Medeiros, L. F., de Oliveira, C., Grevet, E. H., Caumo, W., de Souza, D. O., Rohde, L. A. P., & Torres, I. L. S. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.11.012 · Cited by 50 · see citing works
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Pellicano, C., Niccolini, F., Wu, K., O’Sullivan, S. S., Lawrence, A. D., Lees, A. J., Piccini, P. P., & Politis, M. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7892-3 · Cited by 50 · see citing works
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Raghanti, M. A., Edler, M. K., Stephenson, A. R., Wilson, L. J., Hopkins, W. D., Ely, J. J., ERWIN, J. M., Jacobs, B., Hof, P. R., & Sherwood, C. C. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23937 · Cited by 49 · see citing works
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Oldehinkel, M., Llera, A., Faber, M., Huertas, I., Buitelaar, J. K., Bloem, B. R., Marquand, A. F., Helmich, R. C. G., Haak, K. V., & Beckmann, C. F. (2022) · eLife · doi:10.7554/elife.71846 · Cited by 48 · see citing works
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Maury, E. A., Sherman, M. A., Genovese, G., Gilgenast, T. G., Kamath, T., Burris, S. J., Rajarajan, P., Flaherty, E. K., Akbarian, S., Chess, A. J., et al. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100356 · Cited by 46 · see citing works
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Mink, J. W. (2018) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2018.01.005 · Cited by 47 · see citing works
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Honma, M., Kuroda, T., Futamura, A., Shiromaru, A., & Kawamura, M. (2016) · Scientific Reports · doi:10.1038/srep25421 · Cited by 45 · see citing works
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Jiménez‐Urbieta, H., Gago, B., de la Riva, P., Delgado‐Alvarado, M., Marı́n, C., & Rodríguez‐Oroz, M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.010 · Cited by 45 · see citing works
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Bergamini, G., Sigrist, H., Ferger, B., Singewald, N., Seifritz, E., & Pryce, C. R. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.048 · Cited by 42 · see citing works
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Salvi, R., Steigleder, T., Schlachetzki, J. C. M., Waldmann, E., Schwab, S., Winner, B., Winkler, J., & Kohl, Z. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00077 · Cited by 44 · see citing works
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Doyle, T. B., Hayes, M. P., Chen, D. H., Raskind, W. H., & Watts, V. J. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.02.005 · Cited by 44 · see citing works
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Comparan‐Meza, M., Cruz, I., Jáuregui-Huerta, F., González-Castañeda, R. E., González-Pérez, Ó., & Gálvez‐Contreras, A. Y. (2021) · Brain and Behavior · doi:10.1002/brb3.2341 · Cited by 43 · see citing works
Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models
Boyle, C. C., Bower, J. E., Eisenberger, N. I., & Irwin, M. R. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105307 · Cited by 44 · see citing works
Dopamine Dysregulation in Reward and Autism Spectrum Disorder
Blum, K., Bowirrat, A., Sunder, K. R., Thanos, P. K., Hanna, C., Gold, M. S., Dennen, C. A., Elman, I., Murphy, K. T., & Makale, M. T. (2024) · Brain Sciences · doi:10.3390/brainsci14070733 · Cited by 44 · see citing works
The Aversive Agent Lithium Chloride Suppresses Phasic Dopamine Release Through Central GLP-1 Receptors
Fortin, S. M., Chartoff, E. H., & Roitman, M. F. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.220 · Cited by 40 · see citing works
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Hernández, L. F., Obeso, I., Costa, R. M., Redgrave, P., & Obeso, J. A. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.03.007 · Cited by 40 · see citing works
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Stievenard, A., Méquinion, M., Andrews, Z. B., Destée, A., Chartier-Harlin, M.-C., Viltart, O., & Vanbesien-Mailliot, C. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.021 · Cited by 39 · see citing works
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Kelly, A. L., Baugh, M. E., Oster, M. E., & DiFeliceantonio, A. G. (2022) · Appetite · doi:10.1016/j.appet.2022.106274 · Cited by 43 · see citing works
Adolescence versus adulthood: differences in basal mesolimbic and nigrostriatal dopamine transmission and response to drugs of abuse
Corongiu, S., Dessì, C., & Cadoni, C. (2020) · Addiction Biology · doi:10.1111/adb.12721 · Cited by 36 · see citing works
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Walters, J. L., Lansdell, T. A., Lookingland, K. J., & Baker, L. E. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.09.026 · Cited by 37 · see citing works
Prenatal methamphetamine exposure is associated with reduced subcortical volumes in neonates
Warton, F. L., Meintjes, E. M., Warton, C. M. R., Molteno, C. D., Lindinger, N. M., Carter, R. C., Zöllei, L., Wintermark, P., Jacobson, J. L., van der Kouwe, A. J. W., et al. (2017) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2017.10.005 · Cited by 37 · see citing works
Medial forebrain bundle structure is linked to human impulsivity
MacNiven, K. H., Leong, J. K., & Knutson, B. D. (2020) · Science Advances · doi:10.1126/sciadv.aba4788 · Cited by 36 · see citing works
Regional Selectivity of Neuromelanin Changes in the Substantia Nigra in Atypical Parkinsonism
Chougar, L., Arsovic, E., Gaurav, R., Biondetti, E., Faucher, A., Valabrègue, R., Pyatigorskaya, N., Dupont, G., Lejeune, F., Cormier‐Dequaire, F., et al. (2022) · Movement Disorders · doi:10.1002/mds.28988 · Cited by 35 · see citing works
Beta and theta oscillations track effort and previous reward in the human basal ganglia and prefrontal cortex during decision making
Hoy, C. W., de Hemptinne, C., Wang, S. S., Harmer, C. J., Apps, M. A. J., Husain, M., Starr, P. A., & Little, S. J. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322869121 · Cited by 31 · see citing works
Deep Brain Stimulation in Parkinson’s Disease: New and Emerging Targets for Refractory Motor and Nonmotor Symptoms
Anderson, D., Beecher, G., & Ba, F. (2017) · Parkinson s Disease · doi:10.1155/2017/5124328 · Cited by 34 · see citing works
Neuronal representations of reward-predicting cues and outcome history with movement in the frontal cortex
Kondo, M., & Matsuzaki, M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108704 · Cited by 31 · see citing works
Beyond the Classic VTA: Extended Amygdala Projections to DA-Striatal Paths in the Primate
Fudge, J. L., Kelly, E. A., Pal, R., Bedont, J. L., Park, L., & Ho, B. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.38 · Cited by 34 · see citing works

The Place of Dopamine Neurons Within the Organization of the Forebrain
Haber, S. N. (2002) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-56051-4_3 · Cited by 3 · see citing works
Self-citation
Corticostriatal Circuitry
Haber, S. N. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3474-4_135 · Cited by 19 · see citing works
Self-citation
The Primate Substantia Nigra and VTA: Integrative Circuitry and Function
Haber, S. N., & Fudge, J. L. (1997) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v11.i4.40 · Cited by 228 · see citing works
Self-citation
Target Striatal Cells Regulate Development of Midbrain Dopaminergic Neurones
Perrone‐Capano, C., Amadoro, G., Tino, A., Pernas-Alonso, R., Esposito, B., & di Porzio, U. (1996) · Springer eBooks · doi:10.1007/978-1-4615-5899-6_8 · Cited by 1 · see citing works
Motor-to-Limbic Design of Direct Synaptic Communication between Dopamine Neurons in the Midbrain
Hammer, N., Tian, G., Fischer, B., Stojanovic, S., Beier, K. T., & Roeper, J. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.2126-25.2026

Authors: Haber, S. N.
Affiliations: University of Rochester Medicine (US)
Corresponding author: Haber, S.N.
ORCID: Haber, S.N.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2014-12
Volume: 282
Pages: 248-257
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2014.10.008
PMC: PMC5484174
OpenAlex: W2029942338
Cited by: 364
References: 104
Citations by year: 2026: 26 · 2025: 28 · 2024: 26 · 2023: 32 · 2022: 30 · 2021: 46 · 2020: 34 · 2019: 36 · 2018: 32 · 2017: 32 · 2016: 20 · 2015: 21 · 2014: 1
FWCI: 2.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIMH (MH045573-24)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: dopamine, midbrain dopaminergic neurons, cortico-basal ganglia circuits, mesolimbic system, mesocortical pathway, nigrostriatal pathway, ventral striatum, dorsal striatum, corticostriatal connections, lateral habenula, goal-directed behavior, motivation, cognitive function, motor function, functional integration
MeSH terms: Animals, Basal Ganglia, Cerebral Cortex, Dopamine, Mesencephalon, Neural Pathways, Dopaminergic Neurons

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The place of dopamine in the cortico-basal ganglia circuit

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