Cited by 42Vagus Nerve Stimulation ResearchNeurological disorders and treatmentsTreatment of Major Depression

Neurostimulation therapies for treatment resistant depression: A focus on vagus nerve stimulation and deep brain stimulation

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Rizvi, Sakina J., Donovan, Madelin, Giacobbe, Peter, Placenza, Franca, Rotzinger, Susan, Kennedy, Sidney H.·2011·International Review of Psychiatry

Abstract

Antidepressant treatments, including pharmacotherapy and psychotherapy, do not result in remission for the majority of patients with major depressive disorder. The high prevalence of treatment resistant depression (TRD) poses a significant issue for patients as well as both societal and economic costs. Due to the limited efficacy of existing therapies in this sub-population, alternative somatic treatments are being explored. Both vagus nerve stimulation (VNS) and deep brain stimulation (DBS) are neurostimulation treatments for TRD. While VNS has Food Drug Administration approval as an adjunctive therapy for MDD, DBS is still in the experimental stages. This article will review the evidence supporting the clinical utility of these therapies.

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Crossref · 10.3109/09540261.2011.630993

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Authors
Rizvi, S. J., Donovan, M., Giacobbe, P., Placenza, F., Rotzinger, S., & Kennedy, S. H.
Affiliations
University Health Network (CA)
Corresponding author
Kennedy, Sidney H.
Venue
International Review of Psychiatry
Published
2011-10
Volume
23
Issue
5
Pages
424-436
ISSN
  • 0954-0261 (ISSN-L)
  • 1369-1627
OpenAlex
W1986341987
Cited by
42
References
104
Citations by year
2025: 1 · 2024: 4 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 9 · 2012: 4
FWCI
0.51
Type
journal article
Language
en
Open access
Locations
  • International Review of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
treatment-resistant depression, major depressive disorder, vagus nerve stimulation, deep brain stimulation, neurostimulation, adjunctive therapy, somatic treatment, antidepressant treatment failure
MeSH terms
Antidepressive Agents, Brain, Combined Modality Therapy, Humans, Psychotherapy, Remission Induction, Vagus Nerve, Randomized Controlled Trials as Topic, Treatment Outcome, Cost of Illness, Device Approval, Therapies, Investigational, Deep Brain Stimulation, Vagus Nerve Stimulation, Depressive Disorder, Treatment-Resistant

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