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Cited by 227Schizophrenia research and treatmentCognitive Functions and MemoryCognitive Abilities and Testing

Efficacy and specificity of computer-assisted cognitive remediation in schizophrenia: a meta-analytical study

Grynszpan, O., Perbal, S., Pelissolo, A., Fossati, P., Jouvent, R., Dubal, S., Perez-Diaz, F.·2011·Psychological Medicine
DOI 10.1017/s0033291710000607
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Abstract

Background: Cognitive remediation is frequently based on computerized training methods that target different cognitive deficits. The aim of this article was to assess the efficacy of computer-assisted cognitive remediation (CACR) in schizophrenia and to determine whether CACR enables selective treatment of specific cognitive domains. Method: A meta-analysis was performed on 16 randomized controlled trials evaluating CACR. The effect sizes of differences between CACR and control groups were computed and classified according to the cognitive domain assessed. The possible influences of four potential moderator variables were examined: participants' age, treatment duration, weekly frequency, and control condition type. To test the domain-specific effect, the intended goal of each study was determined and the effect sizes were sorted accordingly. The effect sizes of the cognitive domains explicitly targeted by the interventions were then compared with those that were not. Results: CACR enhanced general cognition with a mean effect size of 0.38 [confidence interval (CI) 0.20–0.55]. A significant medium effect size of 0.64 (CI 0.29–0.99) was found for Social Cognition. Improvements were also significant in Verbal Memory, Working Memory, Attention/Vigilance and Speed of Processing with small effect sizes. Cognitive domains that were specifically targeted by the interventions did not yield higher effects than those that were not. Conclusions: The results lend support to the efficacy of CACR with particular emphasis on Social Cognition. The difficulty in targeting specific domains suggests a ‘non-specific’ effect of CACR. These results are discussed in the light of the possible bias in remediation tasks due to computer interface design paradigms.

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  • Working memory is a core component of human cognition, enabling short-term maintenance and online manipulation of information while supporting higher-order processes including attentional regulation, executive control, and reasoning.

    “Working memory is a core component of human cognition, enabling the short-term maintenance and online manipulation of information while supporting higher-order processes including attentional regulation, executive control, and reasoning7–9.”

    From Meta-analysis of computerised working memory training: behavioural gains, training parameters, transfer mechanisms, and neural correlates (2026) · cites this paper as [9]

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Authors
Grynszpan, O., Perbal, S., Pelissolo, A., Fossati, P., Jouvent, R., Dubal, S., & Perez-Diaz, F.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Grynszpan, O.
ORCID
Venue
Psychological Medicine
Publisher
Cambridge University Press (CUP)
Published
2010-04-12
Volume
41
Issue
1
Pages
163-173
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
DOI
10.1017/s0033291710000607
OpenAlex
W2157795201
Cited by
225
References
47
Citations by year
2026: 5 · 2025: 2 · 2024: 7 · 2023: 10 · 2022: 11 · 2021: 11 · 2020: 22 · 2019: 18 · 2018: 16 · 2017: 18 · 2016: 20 · 2015: 18 · 2014: 21 · 2013: 22 · 2012: 14
FWCI
2.06
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
schizophrenia, cognitive remediation, social cognition, verbal memory, working memory, attention and vigilance, processing speed, global cognition, domain specificity, treatment efficacy, computer interface design
MeSH terms
Adult, Cognition, Humans, Neuropsychological Tests, Schizophrenia, Social Adjustment, Social Perception, Therapy, Computer-Assisted, Cognitive Behavioral Therapy, Treatment Outcome, Young Adult

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