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Psychotic-like experiences in the general population: characterizing a high-risk group for psychosis
Open accessAbstract
Recent research shows that psychotic symptoms, or psychotic-like experiences (PLEs), are reported not only by psychosis patients but also by healthy members of the general population. Healthy individuals who report these symptoms are considered to represent a non-clinical psychosis phenotype, and have been demonstrated to be at increased risk of schizophrenia-spectrum disorder. Converging research now shows that this non-clinical psychosis phenotype is familial, heritable and covaries with familial schizophrenia-spectrum disorder. A review of the research also shows that the non-clinical phenotype is associated extensively with schizophrenia-related risk factors, including social, environmental, substance use, obstetric, developmental, anatomical, motor, cognitive, linguistic, intellectual and psychopathological risk factors. The criterion and construct validity of the non-clinical psychosis phenotype with schizophrenia demonstrates that it is a valid population in which to study the aetiology of psychosis. Furthermore, it suggests shared genetic variation between the clinical and non-clinical phenotypes. Much remains to be learned about psychosis by broadening the scope of research to include the non-clinical psychosis phenotype.
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Cites
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Metadata
- Authors
- Kelleher, I., & Cannon, M.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-05-19
- Volume
- 41
- Issue
- 1
- Pages
- 1-6
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2167339864
- Cited by
- 569
- References
- 4
- FWCI
- 28.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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